Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH1 domain containing protein | 0.0033 | 0.0223 | 0.0223 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0033 | 0.0223 | 0.0223 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0412 | 0.0412 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2981 | 0.2981 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0.0009 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0135 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0135 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0135 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.0009 | 0.0009 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.11 | 0.11 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0009 | 0.003 |
Echinococcus multilocularis | Smad4 | 0.0033 | 0.0223 | 0.0748 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2981 | 0.2981 |
Mycobacterium ulcerans | glutaminase | 0.0824 | 1 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0479 | 0.5738 | 0.5738 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0479 | 0.5738 | 0.5738 |
Brugia malayi | MH2 domain containing protein | 0.0479 | 0.5738 | 0.5738 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.0412 | 0.0412 |
Loa Loa (eye worm) | RNA binding protein | 0.0256 | 0.2981 | 0.2981 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0135 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0015 | 0.0009 | 0.0009 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0009 | 0.003 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0009 | 0.003 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0015 | 0.0009 | 0.003 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0043 | 0.0043 |
Brugia malayi | N-terminal motif family protein | 0.0176 | 0.1996 | 0.1996 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1676 | 0.1676 |
Echinococcus granulosus | smad | 0.0033 | 0.0223 | 0.0748 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0412 | 0.0412 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0256 | 0.2981 | 0.2981 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0412 | 0.1383 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.0412 | 0.1383 |
Loa Loa (eye worm) | glutaminase 2 | 0.0824 | 1 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0043 | 0.0043 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0135 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0033 | 0.0223 | 0.0223 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2981 | 0.2981 |
Brugia malayi | MH1 domain containing protein | 0.0033 | 0.0223 | 0.0223 |
Echinococcus multilocularis | tar DNA binding protein | 0.0256 | 0.2981 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0176 | 0.1996 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0033 | 0.0223 | 0.0748 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0104 | 0.11 | 0.11 |
Schistosoma mansoni | smad | 0.0033 | 0.0223 | 0.0223 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0412 | 0.0412 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0412 | 0.1383 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0023 | 0.0023 |
Trichomonas vaginalis | glutaminase, putative | 0.0824 | 1 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0009 | 0.003 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0152 | 0.1693 | 0.1693 |
Brugia malayi | TAR-binding protein | 0.0256 | 0.2981 | 0.2981 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0152 | 0.1693 | 0.1693 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0256 | 0.2981 | 0.2981 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0135 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2981 | 0.2981 |
Loa Loa (eye worm) | TAR-binding protein | 0.0256 | 0.2981 | 0.2981 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0135 | 0.0135 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0033 | 0.0223 | 0.0748 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.0223 | 0.0223 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0412 | 0.1383 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0033 | 0.0223 | 0.0223 |
Schistosoma mansoni | glutaminase | 0.0824 | 1 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0033 | 0.0223 | 0.0223 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.0412 | 0.0412 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.0412 | 0.1383 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0033 | 0.0223 | 0.0748 |
Loa Loa (eye worm) | glutaminase | 0.0824 | 1 | 1 |
Echinococcus granulosus | Smad4 | 0.0033 | 0.0223 | 0.0748 |
Loa Loa (eye worm) | nuclear factor I | 0.0018 | 0.0043 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1996 | 0.1996 |
Brugia malayi | Smad1 | 0.0033 | 0.0223 | 0.0223 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.11 | 0.11 |
Echinococcus granulosus | tar DNA binding protein | 0.0256 | 0.2981 | 1 |
Brugia malayi | hypothetical protein | 0.015 | 0.1676 | 0.1676 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0412 | 0.0412 |
Brugia malayi | MH2 domain containing protein | 0.0033 | 0.0223 | 0.0223 |
Brugia malayi | isocitrate dehydrogenase | 0.0015 | 0.0009 | 0.0009 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1693 | 0.1693 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.0412 | 0.0412 |
Schistosoma mansoni | Smad4 | 0.0033 | 0.0223 | 0.0223 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0015 | 0.0009 | 0.003 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.0223 | 0.0223 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2981 | 0.2981 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0043 | 0.0043 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.0223 | 0.0223 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0015 | 0.0009 | 0.0009 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0152 | 0.1693 | 0.1693 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0135 | 0.0135 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0412 | 0.1383 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0135 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0033 | 0.0223 | 0.0748 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0412 | 0.0412 |
Echinococcus multilocularis | smad | 0.0033 | 0.0223 | 0.0748 |
Brugia malayi | RNA binding protein | 0.0256 | 0.2981 | 0.2981 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0033 | 0.0223 | 0.0223 |
Onchocerca volvulus | 0.015 | 0.1676 | 0.8395 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.