Detailed information for compound 905080

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 483.083 | Formula: C18H10Br2FNO4
  • H donors: 0 H acceptors: 2 LogP: 4.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Oc1c(Br)cc(cc1Br)C=C1N=C(OC1=O)c1ccc(cc1)F
  • InChi: 1S/C18H10Br2FNO4/c1-9(23)25-16-13(19)6-10(7-14(16)20)8-15-18(24)26-17(22-15)11-2-4-12(21)5-3-11/h2-8H,1H3/b15-8-
  • InChiKey: GBDKHVFMXZTKQA-NVNXTCNLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0508 0.309 1
Schistosoma mansoni tar DNA-binding protein 0.045 0.2729 0.3603
Loa Loa (eye worm) MH2 domain-containing protein 0.0479 0.2913 0.9427
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1369 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0144 0.0126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0204 0.0186
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0142 0.0451
Plasmodium falciparum replication factor C subunit 1, putative 0.003 0.0112 0.2753
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0076 0.1323
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0115
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0131 0.0113
Brugia malayi MH2 domain containing protein 0.0015 0.0018 0.0059
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0161 0.0928 0.3003
Brugia malayi Pre-SET motif family protein 0.0031 0.0119 0.0386
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0018 0.005
Toxoplasma gondii thioredoxin reductase 0.0046 0.0213 0.2183
Onchocerca volvulus 0.005 0.0237 0.1207
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.003 0.0016
Echinococcus multilocularis Niemann Pick C1 protein 0.0285 0.1706 0.1691
Trichomonas vaginalis replication factor C large subunit, putative 0.003 0.0112 0.0635
Loa Loa (eye worm) TAR-binding protein 0.045 0.2729 0.883
Brugia malayi topoisomerase 0.003 0.0112 0.0361
Brugia malayi Bromodomain containing protein 0.0037 0.0159 0.0513
Schistosoma mansoni hypothetical protein 0.0083 0.0442 0.0581
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0067 0.0065
Loa Loa (eye worm) hypothetical protein 0.0185 0.108 0.3488
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0026 0.034
Brugia malayi glutathione reductase 0.0046 0.0213 0.0689
Onchocerca volvulus 0.003 0.0112 0.0561
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0127 0.0109
Schistosoma mansoni hypothetical protein 0.0161 0.0928 0.1224
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.045 0.2729 0.883
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0151 0.6778
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.034
Schistosoma mansoni smad1 5 8 and 0.0033 0.0131 0.017
Schistosoma mansoni hypothetical protein 0.0083 0.0442 0.0581
Toxoplasma gondii hypothetical protein 0.0026 0.009 0.0907
Echinococcus granulosus zinc finger protein 0.0024 0.0076 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0076 0.0245
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0213 0.0258
Schistosoma mansoni topbp1 0.003 0.0112 0.0145
Schistosoma mansoni cpg binding protein 0.0093 0.0506 0.0666
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0127 0.3142
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0034 0.0101
Schistosoma mansoni zinc finger protein 0.0024 0.0076 0.0098
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0142 0.6335
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.108 0.5554
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0127 0.1612
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0076 0.1323
Loa Loa (eye worm) hypothetical protein 0.0037 0.0159 0.0506
Brugia malayi Patched related family protein 10 0.0012 0.0003 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0119 0.0155
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0352
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.1285
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0067 0.0065
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0151 0.0175
Schistosoma mansoni hypothetical protein 0.0347 0.209 0.2758
Echinococcus multilocularis smad 0.0033 0.0131 0.0113
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.01 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0204 0.0186
Loa Loa (eye worm) hypothetical protein 0.0323 0.1942 0.628
Loa Loa (eye worm) hypothetical protein 0.0036 0.0151 0.0479
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0352
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0109 0.0354
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.1172 0.1156
Schistosoma mansoni Smad4 0.0033 0.0131 0.017
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.04 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0026 0.0592
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0076 0.079
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.04 0.0525
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0115
Loa Loa (eye worm) hypothetical protein 0.0076 0.04 0.1285
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.003 0.0112 0.0361
Brugia malayi MH1 domain containing protein 0.0033 0.0131 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0169
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0076 0.0245
Onchocerca volvulus 0.0323 0.1942 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0076 0.1323
Echinococcus granulosus GPCR family 2 0.0161 0.0928 0.1205
Entamoeba histolytica hypothetical protein 0.003 0.0112 0.0935
Schistosoma mansoni cpg binding protein 0.0093 0.0506 0.0666
Brugia malayi CHE-14 protein 0.0086 0.0461 0.1493
Schistosoma mansoni smad1 5 8 and 0.0033 0.0131 0.017
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.003 0.0112 0.2285
Schistosoma mansoni topbp1 0.003 0.0112 0.0145
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0076 0.2897
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0076 0.0628
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0101 0.0109
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0067 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0169
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0131 0.0415
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0151 0.0133
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.04 0.0505
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0213 0.5295
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0222 0.0291
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0127 0.1291
Schistosoma mansoni hypothetical protein 0.0015 0.002 0.0023
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0237 0.0289
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0049 0.0169
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0142 0.1448
Brugia malayi Latrophilin receptor protein 2 0.0161 0.0928 0.3003
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0076 0.1323
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.012
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0076 0.0245
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0131 0.0415
Loa Loa (eye worm) RNA binding protein 0.045 0.2729 0.883
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0038 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0112 0.0635
Trypanosoma brucei trypanothione reductase 0.0046 0.0213 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0127 0.3131
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.034
Brugia malayi MH1 domain containing protein 0.0033 0.0131 0.0423
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0236
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.003 0.0037
Leishmania major basic transcription factor 3a, putative 0.0034 0.0142 0.6335
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.003 0.0112 0.0624
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Echinococcus multilocularis tar DNA binding protein 0.045 0.2729 0.2716
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.04 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0112 0.4756
Schistosoma mansoni hypothetical protein 0.0083 0.0442 0.0581
Loa Loa (eye worm) transcription factor SMAD2 0.0479 0.2913 0.9427
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0142 0.1196
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0026 0.0011
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0237 0.0219
Brugia malayi hypothetical protein 0.0323 0.1942 0.6283
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0161 0.0928 0.2997
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.009 0.2211
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0112 0.4756
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0026 0.0244
Echinococcus granulosus replication factor c subunit 1 0.003 0.0112 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0169
Brugia malayi hypothetical protein 0.0012 0.0003 0.0009
Brugia malayi Patched protein homolog 1 0.0012 0.0003 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0032 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.034
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0026 0.0606
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0131 0.0149
Echinococcus granulosus dnaJ subfamily B 0.1226 0.757 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0166 0.0965 1
Echinococcus granulosus transcription factor btf3 0.0034 0.0142 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0461 0.3239
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0026 0.034
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.1172 0.3792
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0161 0.0928 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0169
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0151 0.0926
Plasmodium falciparum glutathione reductase 0.0046 0.0213 0.5302
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0142 0.0862
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0131 0.017
Schistosoma mansoni tar DNA-binding protein 0.045 0.2729 0.3603
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0049 0.0169
Schistosoma mansoni DNA ligase IV 0.003 0.0112 0.0145
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0076 0.0628
Mycobacterium tuberculosis Probable reductase 0.0105 0.0579 0.8837
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.04 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0142 0.3521
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0169
Schistosoma mansoni hypothetical protein 0.0083 0.0442 0.0581
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0222 0.0291
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0094 0.01
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0461 0.1485
Echinococcus granulosus Smad4 0.0033 0.0131 0.0149
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.04 0.4124
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0127 0.0109
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0026 0.0008
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0112 0.0635
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.034
Echinococcus granulosus cpg binding protein 0.0093 0.0506 0.0646
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0067 0.0049
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0318 0.0397
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0026 0.0085
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0579 0.8837
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0112 0.4756
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0018 0.008
Echinococcus multilocularis expressed conserved protein 0.0188 0.1096 0.108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0184 0.1072 0.1414
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0151 0.6778
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0026 0.0592
Loa Loa (eye worm) CXXC zinc finger family protein 0.0086 0.0464 0.1494
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0651 1
Brugia malayi MH2 domain containing protein 0.0033 0.0131 0.0423
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0161 0.0928 0.1205
Brugia malayi Pre-SET motif family protein 0.0204 0.1196 0.3869
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0052 0.0159
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0169
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0127 0.5556
Echinococcus multilocularis Smad4 0.0033 0.0131 0.0113
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0115
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.034
Echinococcus multilocularis replication factor c subunit 1 0.003 0.0112 0.0093
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0352
Schistosoma mansoni hypothetical protein 0.0505 0.3073 0.4058
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1196 0.3864
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0461 0.0587
Echinococcus granulosus geminin 0.0505 0.3073 0.4045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0076 0.079
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0213 0.068
Loa Loa (eye worm) hypothetical protein 0.0046 0.0215 0.0689
Onchocerca volvulus 0.0024 0.0076 0.0376
Echinococcus multilocularis transcription factor btf3 0.0034 0.0142 0.0124
Giardia lamblia Replication factor C, subunit 1 0.003 0.0112 0.686
Brugia malayi hypothetical protein 0.0012 0.0003 0.0009
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Brugia malayi DKFZp564C0469 protein 0.003 0.0112 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0151 0.0926
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0026 0.034
Schistosoma mansoni smad 0.0015 0.0018 0.0021
Trypanosoma cruzi FHA domain containing protein, putative 0.003 0.0112 0.4756
Plasmodium falciparum thioredoxin reductase 0.0046 0.0213 0.5302
Chlamydia trachomatis DNA ligase 0.003 0.0112 0.2285
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0151 1
Echinococcus granulosus tumor protein p63 0.0339 0.2041 0.2679
Schistosoma mansoni bromodomain containing protein 0.0066 0.034 0.0446
Loa Loa (eye worm) hypothetical protein 0.0347 0.209 0.6759
Brugia malayi Probable ClpP-like protease 0.0076 0.04 0.1293
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0131 0.0149
Schistosoma mansoni smad1 5 8 and 0.0033 0.0131 0.017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0026 0.034
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0076 0.1323
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0579 0.8737
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0352
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0236
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0318 0.0301
Brugia malayi hypothetical protein 0.003 0.0112 0.0361
Schistosoma mansoni hypothetical protein 0.0161 0.0928 0.1224
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0579 0.8837
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0352
Loa Loa (eye worm) hypothetical protein 0.0105 0.0582 0.1874
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0076 0.2897
Schistosoma mansoni chromosome transmission fidelity factor 0.003 0.0112 0.0145
Echinococcus granulosus neuropeptide s receptor 0.0448 0.272 0.3577
Loa Loa (eye worm) hypothetical protein 0.005 0.0237 0.0758
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.04 1
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.1285
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0204 0.0245
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0152 0.0178
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.003 0.0112 0.2285
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.003 0.0012
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0151 0.0133
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0032 0.0093
Echinococcus multilocularis protein patched 0.0086 0.0461 0.0444
Schistosoma mansoni Smad4 0.0015 0.0018 0.0021
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0151 0.6778
Schistosoma mansoni hypothetical protein 0.0161 0.0928 0.1224
Schistosoma mansoni hypothetical protein 0.0036 0.0152 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0169
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.009 0.1708
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0237 0.28
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0151 0.0196
Echinococcus multilocularis dnaJ subfamily B 0.1226 0.757 0.7566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0204 0.0266
Brugia malayi RNA binding protein 0.045 0.2729 0.8831
Brugia malayi MH2 domain containing protein 0.0033 0.0131 0.0423
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0032 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0204 0.0266
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0151 0.0175
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0651 1
Echinococcus granulosus neuropeptide receptor A26 0.0448 0.272 0.3577
Brugia malayi hypothetical protein 0.0012 0.0003 0.0009
Echinococcus multilocularis geminin 0.0505 0.3073 0.306
Brugia malayi MH2 domain containing protein 0.0479 0.2913 0.9428
Brugia malayi PHD-finger family protein 0.0029 0.0108 0.0351
Brugia malayi hypothetical protein 0.0036 0.0152 0.0493
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0038 0.0319
Brugia malayi Pax transcription activation domain interacting protein 0.003 0.0112 0.0361
Brugia malayi Calcitonin receptor-like protein seb-1 0.0508 0.309 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0651 1
Loa Loa (eye worm) Smad1 0.0033 0.0131 0.0415
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0151 0.0175
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0222 0.027
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.1172 0.1527
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0142 0.0862
Loa Loa (eye worm) hypothetical protein 0.0086 0.0461 0.1485
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0461 0.0444
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.04 0.5626
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0094 0.0076
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Plasmodium falciparum thioredoxin reductase 0.0016 0.0026 0.0606
Plasmodium falciparum glutathione reductase 0.0016 0.0026 0.0606
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0112 0.0635
Plasmodium vivax glutathione reductase, putative 0.0046 0.0213 0.5295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0204 0.0266
Brugia malayi Patched related family protein 4 0.0012 0.0003 0.0009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0119 0.0101
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.04 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.04 1
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0237 0.031
Echinococcus multilocularis neuropeptide s receptor 0.0448 0.272 0.2706
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0018 0.005
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Brugia malayi protein C24B5.3 0.0012 0.0003 0.0009
Brugia malayi protein C24B5.3 0.0012 0.0003 0.0009
Brugia malayi MH1 domain containing protein 0.0018 0.004 0.0129
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0026 0.0244
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.003 0.0112 0.1131
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0151 0.6778
Schistosoma mansoni tar DNA-binding protein 0.045 0.2729 0.3603
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0127 0.5556
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0142 0.3511
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0112 0.0635
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0076 0.1323
Brugia malayi Bromodomain containing protein 0.0078 0.0411 0.1329
Brugia malayi hypothetical protein 0.003 0.0112 0.0361
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0151 0.1269
Brugia malayi Myosin head containing protein 0.0012 0.0003 0.0009
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0237 0.3369
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0112 0.0635
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0222 0.0204
Toxoplasma gondii ATPase, AAA family protein 0.003 0.0112 0.1131
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0127 0.5556
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0127 0.0144
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.009 0.0249
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.04 1
Entamoeba histolytica hypothetical protein 0.0034 0.0142 0.1196
Schistosoma mansoni hypothetical protein 0.1226 0.757 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0127 0.0165
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0032 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0169
Brugia malayi TAR-binding protein 0.045 0.2729 0.8831
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.01 0.0108
Brugia malayi isocitrate dehydrogenase 0.0032 0.0127 0.0411
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.003 0.0112 0.0935
Brugia malayi Smad1 0.0033 0.0131 0.0423
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0119 0.0155
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0151 0.0487
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0127 0.0402
Brugia malayi MH1 domain containing protein 0.0018 0.004 0.0129
Schistosoma mansoni tar DNA-binding protein 0.045 0.2729 0.3603
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.1285
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.04 1
Brugia malayi latrophilin 2 splice variant baaae 0.0347 0.209 0.6762
Brugia malayi hypothetical protein 0.0012 0.0003 0.0009
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0152 0.0199
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.04 0.4124
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0127 0.1291
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0018 0.0059
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.005
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0151 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0112 0.0635
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0237 0.3369
Echinococcus granulosus nibrin 0.003 0.0112 0.0124
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0161 0.0928 0.0912
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0169
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0038 0.0906
Echinococcus multilocularis GPCR, family 2 0.0161 0.0928 0.0912
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0076 0.2897
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0204 0.065
Echinococcus granulosus tar DNA binding protein 0.045 0.2729 0.359
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0112 0.4756
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0076 0.0628
Echinococcus granulosus expressed conserved protein 0.0188 0.1096 0.1427
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0131 0.0113
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0067 0.0086
Plasmodium vivax SET domain protein, putative 0.0031 0.0119 0.2937
Echinococcus multilocularis zinc finger protein 0.0024 0.0076 0.0058
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0203 0.1191 0.1571
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.04 0.0382
Schistosoma mansoni transcription factor btf3 0.0034 0.0142 0.0185
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0579 0.8837
Mycobacterium ulcerans hypothetical protein 0.0024 0.0076 0.1323
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0127 0.5556
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.003 0.0037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0213 0.2985
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0038 0.0319
Loa Loa (eye worm) latrophilin receptor protein 2 0.0161 0.0928 0.2997
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0026 0.0606
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0142 0.6335
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.1285
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0651 1
Schistosoma mansoni hypothetical protein 0.0505 0.3073 0.4058
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0112 0.0635
Brugia malayi N-terminal motif family protein 0.0185 0.108 0.3494
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Brugia malayi RNA recognition motif domain containing protein 0.045 0.2729 0.8831
Loa Loa (eye worm) hypothetical protein 0.0508 0.309 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0026 0.034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0115
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0076 0.1323
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0142 0.0862
Loa Loa (eye worm) hypothetical protein 0.02 0.1172 0.3786
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0213 0.0195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0204 0.0245
Echinococcus multilocularis nibrin 0.003 0.0112 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0169
Brugia malayi Thioredoxin reductase 0.0046 0.0213 0.0689
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0127 0.0411
Trichomonas vaginalis helicase, putative 0.002 0.0049 0.0169
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0151 0.0926
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0461 0.0587
Brugia malayi Patched related family protein 12 0.0012 0.0003 0.0009
Schistosoma mansoni tar DNA-binding protein 0.045 0.2729 0.3603
Loa Loa (eye worm) hypothetical protein 0.0047 0.0222 0.0711
Loa Loa (eye worm) nuclear factor I 0.0018 0.004 0.012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0173 0.0552
Brugia malayi beta-NAC-like protein 0.0034 0.0142 0.046
Schistosoma mansoni patched 1 0.0086 0.0461 0.0607
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0026 0.034
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0112 0.0635
Schistosoma mansoni Smad4 0.0015 0.0018 0.0021
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0151 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0169
Leishmania major trypanothione reductase 0.0046 0.0213 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0579 0.8837
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0112 0.0635
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0115
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0204 0.0659
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0127 0.0109
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0094 0.0121
Schistosoma mansoni hypothetical protein 0.0161 0.0928 0.1224
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0003 0.0016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0152 0.0134
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0127 0.0109
Echinococcus granulosus Niemann Pick C1 protein 0.0285 0.1706 0.2235
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0213 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0169
Plasmodium vivax replication factor C subunit 1, putative 0.003 0.0112 0.2742
Schistosoma mansoni cpg binding protein 0.0086 0.0464 0.061
Echinococcus multilocularis tumor protein p63 0.0339 0.2041 0.2027
Echinococcus granulosus smad 0.0033 0.0131 0.0149
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0026 0.034
Loa Loa (eye worm) glutathione reductase 0.0046 0.0213 0.068
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0026 0.034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0236
Echinococcus multilocularis protein dispatched 1 0.0098 0.0537 0.052
Brugia malayi CXXC zinc finger family protein 0.0086 0.0464 0.1501
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0144 0.0167
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.034
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0127 0.5556
Onchocerca volvulus 0.0031 0.0119 0.0601
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0579 0.8837
Onchocerca volvulus 0.0086 0.0464 0.2379
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0119 0.1211
Onchocerca volvulus 0.0231 0.1369 0.7049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0169
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0161 0.0928 0.1205
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0026 0.034
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0026 0.034
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0142 0.6335
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0508 0.309 1
Schistosoma mansoni smad 0.0033 0.0131 0.017
Treponema pallidum DNA ligase (lig) 0.003 0.0112 0.2285
Echinococcus multilocularis cpg binding protein 0.0093 0.0506 0.0489
Schistosoma mansoni hypothetical protein 0.002 0.0052 0.0066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0169
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.009 0.2199
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0038 0.019
Loa Loa (eye worm) hypothetical protein 0.0069 0.0354 0.1139
Echinococcus multilocularis neuropeptide receptor A26 0.0448 0.272 0.2706
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0026 0.0032
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0352
Brugia malayi Patched family protein 0.0012 0.0003 0.0009
Loa Loa (eye worm) histone methyltransferase 0.0028 0.01 0.0315
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.1172 1
Schistosoma mansoni zinc finger protein 0.0015 0.002 0.0023
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0127 0.0109

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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