Detailed information for compound 905095

Basic information

Technical information
  • TDR Targets ID: 905095
  • Name: (4Z)-4-[(2-iodophenyl)methylidene]-2-phenyl-1 ,3-oxazol-5-one
  • MW: 375.161 | Formula: C16H10INO2
  • H donors: 0 H acceptors: 1 LogP: 4.21 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC(=NC1=Cc1ccccc1I)c1ccccc1
  • InChi: 1S/C16H10INO2/c17-13-9-5-4-8-12(13)10-14-16(19)20-15(18-14)11-6-2-1-3-7-11/h1-10H/b14-10-
  • InChiKey: BNLRJIBRLZANNH-UVTDQMKNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4Z)-4-[(2-iodophenyl)methylene]-2-phenyl-oxazol-5-one
  • (4Z)-4-[(2-iodophenyl)methylene]-2-phenyl-5-oxazolone
  • (4Z)-4-(2-iodobenzylidene)-2-phenyl-oxazol-5-one
  • 4-(2-Iodo-benzylidene)-2-phenyl-4H-oxazol-5-one
  • BAS 00487560
  • ZINC04714034

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.274 0.274
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.274 1
Echinococcus multilocularis lamin dm0 0.0054 0.2295 0.2295
Echinococcus multilocularis tar DNA binding protein 0.0063 0.2907 0.2907
Echinococcus granulosus lamin dm0 0.0054 0.2295 0.2295
Schistosoma mansoni tar DNA-binding protein 0.0063 0.2907 0.2907
Schistosoma mansoni lamin 0.0054 0.2295 0.2295
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.274 0.274
Echinococcus multilocularis musashi 0.0054 0.2295 0.2295
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.2074 0.7134
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0658 0.2265
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0 0.5
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.2907 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.2907 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.274 1
Brugia malayi intermediate filament protein 0.0054 0.2295 0.7893
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0063 0.2907 0.2907
Echinococcus multilocularis geminin 0.0171 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.2295 0.7893
Loa Loa (eye worm) hypothetical protein 0.0025 0.0407 0.1399
Loa Loa (eye worm) RNA binding protein 0.0063 0.2907 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.274 0.274
Schistosoma mansoni tar DNA-binding protein 0.0063 0.2907 0.2907
Onchocerca volvulus 0.0054 0.2295 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.274 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.274 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0471 0.1621
Brugia malayi TAR-binding protein 0.0063 0.2907 1
Schistosoma mansoni hypothetical protein 0.0034 0.1029 0.1029
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0471 0.0471
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0658 0.2265
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0 0.5
Schistosoma mansoni hypothetical protein 0.0171 1 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.2907 0.2907
Echinococcus granulosus tar DNA binding protein 0.0063 0.2907 0.2907
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.2074 0.7134
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.2295 0.7893
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.274 0.274
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.274 1
Schistosoma mansoni lamin 0.0054 0.2295 0.2295
Loa Loa (eye worm) intermediate filament protein 0.0054 0.2295 0.7893
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0 0.5
Echinococcus granulosus intermediate filament protein 0.0054 0.2295 0.2295
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.1029 0.3539
Echinococcus granulosus lamin 0.0054 0.2295 0.2295
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0471 0.0471
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.274 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0407 0.1399
Schistosoma mansoni intermediate filament proteins 0.0054 0.2295 0.2295
Schistosoma mansoni hypothetical protein 0.0171 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0 0.5
Onchocerca volvulus 0.0054 0.2295 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.223 0.7671
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.2074 0.7134
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.2074 0.7134
Brugia malayi RNA binding protein 0.0063 0.2907 1
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.2907 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.2295 0.7893
Loa Loa (eye worm) hypothetical protein 0.0034 0.1029 0.3539
Schistosoma mansoni tar DNA-binding protein 0.0063 0.2907 0.2907
Echinococcus multilocularis lamin 0.0054 0.2295 0.2295
Trichomonas vaginalis ap endonuclease, putative 0.0019 0 0.5
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.