Detailed information for compound 905215

Basic information

Technical information
  • TDR Targets ID: 905215
  • Name: N-(4-dimethylaminophenyl)-2,3,4,5,6-pentameth ylbenzenesulfonamide
  • MW: 346.487 | Formula: C19H26N2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.39 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc(cc1)NS(=O)(=O)c1c(C)c(C)c(c(c1C)C)C)C
  • InChi: 1S/C19H26N2O2S/c1-12-13(2)15(4)19(16(5)14(12)3)24(22,23)20-17-8-10-18(11-9-17)21(6)7/h8-11,20H,1-7H3
  • InChiKey: CKXCYBWXNYHVJO-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-dimethylaminophenyl)-2,3,4,5,6-pentamethyl-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0225 0.0941
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0051 0.0097
Mycobacterium leprae Polyketide synthase Pks13 0.004 0.0212 0.0263
Schistosoma mansoni hypothetical protein 0.0281 0.2137 0.406
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0051 0.0097
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0245 0.1031
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0101 0.0107
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0051 0.0214
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Loa Loa (eye worm) hypothetical protein 0.012 0.0849 0.3563
Brugia malayi hypothetical protein 0.012 0.0849 0.3562
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0245 0.1032
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0115 0.0126
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0713 0.299
Schistosoma mansoni hypothetical protein 0.0032 0.0155 0.0294
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0007
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0098 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0075
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1068 0.1047
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0225 0.0941
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0051 0.0302 0.1265
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0047 0.0031
Brugia malayi nuclear receptor NHR-88 0.0019 0.0051 0.0214
Loa Loa (eye worm) hypothetical protein 0.0041 0.0225 0.0942
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0225 0.098
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0225 0.0426
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2295 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0155 0.0653
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0628
Schistosoma mansoni coup transcription factor 0.0041 0.0225 0.0426
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.006 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Echinococcus multilocularis geminin 0.0333 0.2546 0.4105
Onchocerca volvulus Fatty acid synthase homolog 0.0051 0.0302 0.1265
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0196
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0098 0.0426
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1268 1 1
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Onchocerca volvulus 0.0026 0.0107 0.0446
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2295 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0196
Onchocerca volvulus 0.0028 0.012 0.0504
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Onchocerca volvulus Chorion peroxidase homolog 0.0028 0.012 0.0504
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0051 0.0097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0225 0.0942
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0195
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0051 0.0215
Schistosoma mansoni nuclear receptor 0.0019 0.0051 0.0097
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1268 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0051 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0115 0.0126
Schistosoma mansoni nuclear receptor 0.0019 0.0051 0.0097
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0155 0.0649
Echinococcus multilocularis GPCR, family 2 0.0032 0.0155 0.025
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0051 0.0097
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0225 0.0426
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0225 0.0426
Echinococcus granulosus heat shock protein 0.0032 0.0149 0.0283
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0155 0.0654
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0149 0.0628
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0225 0.0426
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0047 0.0196
Onchocerca volvulus 0.0028 0.012 0.0504
Loa Loa (eye worm) hypothetical protein 0.012 0.0849 0.3563
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0149 0.065
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.012 0.0505
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.107 0.4503
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.2295 0.2219
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0662 0.1067
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0149 0.0627
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0098 0.0074
Schistosoma mansoni heat shock protein 0.0032 0.0149 0.0283
Loa Loa (eye worm) heat shock protein 75 0.0013 0 0.0001
Leishmania major DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Onchocerca volvulus Peroxidase homolog 0.0028 0.012 0.0504
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0155 0.0653
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0225 0.0942
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0115 0.0126
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0098 0.0426
Schistosoma mansoni peroxidasin 0.0028 0.012 0.0228
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Echinococcus granulosus GPCR family 2 0.0032 0.0155 0.0294
Brugia malayi MH2 domain containing protein 0.0117 0.0825 0.346
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0225 0.0941
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0225 0.0942
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0051 0.0082
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.007 0.0292
Schistosoma mansoni hypothetical protein 0.0032 0.0155 0.0294
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0051 0.0097
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0101 0.0107
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0051 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0225 0.0426
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0225 0.0941
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0051 0.0097
Echinococcus granulosus microtubule associated protein 2 0.0674 0.5263 1
Brugia malayi Endoplasmin precursor 0.0032 0.0149 0.0626
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0225 0.0426
Echinococcus granulosus endoplasmin 0.0025 0.0098 0.0186
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0093 0.5957
Onchocerca volvulus Dual oxidase homolog 0.0028 0.012 0.0504
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0047 0.0203
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0662 0.2777
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0225 0.0941
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0225 0.0428
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0115 0.0126
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Loa Loa (eye worm) hypothetical protein 0.0045 0.0253 0.1063
Echinococcus granulosus geminin 0.0333 0.2546 0.4838
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.091 0.7152 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0713 0.299
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.2375 1
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0225 0.0428
Loa Loa (eye worm) DR-78 0.0019 0.0051 0.0215
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0047 0.0203
Brugia malayi hypothetical protein 0.0028 0.012 0.0504
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.0084 0.0083
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0047 0.0088
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.012 0.0505
Brugia malayi Animal haem peroxidase family protein 0.0028 0.012 0.0504
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0149 0.0457
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.2295 1
Mycobacterium ulcerans polyketide synthase 0.0026 0.0101 0.0076
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.2375 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0107 0.0115
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0155 0.0184
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0115 0.0126
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0051 0.0214
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0101 0.0107
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0155 0.0649
Mycobacterium tuberculosis Polyketide synthase Pks13 0.004 0.0212 0.0263
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0225 0.0426
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0628
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Echinococcus granulosus tumor protein p63 0.0365 0.2803 0.5326
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0225 0.0426
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0225 0.0426
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0027 0.0115 0.0126
Schistosoma mansoni hypothetical protein 0.0333 0.2546 0.4838
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0245 0.1031
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.004 0.0212 0.0263
Onchocerca volvulus Peroxidasin homolog 0.0028 0.012 0.0504
Brugia malayi conserved hypotetical protein 0.0019 0.0051 0.0214
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Brugia malayi Pax transcription factor protein 2 0.026 0.1967 0.8249
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0098 0.0411
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0051 0.0214
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0051 0.0214
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0093 0.039
Brugia malayi nuclear receptor RXR 0.0019 0.0051 0.0214
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0057 0.0032
Giardia lamblia Grp94/Hsp90 0.0025 0.0098 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0225 0.0941
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1068 0.1465
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0155 0.0294
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0115 0.009
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0098 0.0228
Loa Loa (eye worm) hypothetical protein 0.0096 0.0662 0.2778
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0155 0.0651
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0101 0.0076
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0225 0.0362
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0662 0.1258
Onchocerca volvulus 0.0028 0.012 0.0504
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0098 0.0411
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0662 0.2885
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0155 1
Schistosoma mansoni endoplasmin 0.0032 0.0149 0.0283
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.007 0.0112
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0225 0.0941
Mycobacterium ulcerans polyketide synthase Pks13 0.004 0.0212 0.0188
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.012 0.0505
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0047 0.0088
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.107 0.4503
Brugia malayi Peroxidasin 0.0028 0.012 0.0504
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0149 0.0628
Onchocerca volvulus 0.0312 0.2384 1
Onchocerca volvulus 0.0049 0.0288 0.1206
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.012 0.0505
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2295 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0101 0.0421
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0155 0.025
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0293
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0149 0.0628
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0027 0.0115 0.0126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0225 0.0362
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0196
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0047 0.0195
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0047 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0225 0.0941
Mycobacterium ulcerans thioesterase TesA 0.0024 0.0084 0.006
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0042 0.0154
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.007 0.0132
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0051 0.0097
Trypanosoma brucei unspecified product 0.0019 0.0047 0.0196
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0107 0.0447
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0047 0.0196
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0155 0.0565
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0155 0.025
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Echinococcus multilocularis protein patched 0.0041 0.0225 0.0363
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Plasmodium falciparum endoplasmin, putative 0.0019 0.0052 0.3317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0225 0.0942
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0245 0.1031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0155 0.025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2295 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0155 0.025
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0225 0.0426
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Leishmania major hypothetical protein, conserved 0.0025 0.0093 0.0389
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0051 0.0215
Brugia malayi nuclear receptor NHR-67 0.0019 0.0051 0.0214
Onchocerca volvulus 0.0019 0.0051 0.0214
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1202 0.1653
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0225 0.0941
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0098 0.0186
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0225 0.0363
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Schistosoma mansoni hypothetical protein 0.007 0.0455 0.0864
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0098 0.0103
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0051 0.0214
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0047 0.0088
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.007 0.0132
Brugia malayi Animal haem peroxidase family protein 0.0028 0.012 0.0504
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0093 0.0389
Echinococcus multilocularis X box binding protein 1 0.0281 0.2137 0.3445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0225 0.0942
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0225 0.0941
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0107 0.0446
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0149 0.0628
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0225 0.0362
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0455 0.1907
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0101 0.0107
Loa Loa (eye worm) hypothetical protein 0.0041 0.0225 0.0942
Schistosoma mansoni heat shock protein 0.0032 0.0149 0.0283
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0225 0.0426
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Schistosoma mansoni hypothetical protein 0.0032 0.0155 0.0294
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0155 0.0652
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0052 0.0224
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0225 0.0426
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0225 0.0426
Onchocerca volvulus 0.0041 0.0225 0.0941
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0155 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0051 0.0214
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.007 0.0132
Brugia malayi steroid hormone receptor 0.0041 0.0225 0.0941
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0047 0.0203
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0115 0.009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0155 0.065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2295 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0225 0.0362
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0225 0.0362
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0225 0.0426
Echinococcus multilocularis expressed conserved protein 0.009 0.0616 0.0993
Mycobacterium ulcerans polyketide synthase 0.0027 0.0115 0.009
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1068 0.1465
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0405
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0293
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0155 0.065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0155 0.0294
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0051 0.0097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.5263 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0047 0.0196
Echinococcus multilocularis tumor protein p63 0.0365 0.2803 0.4519
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0051 0.0214
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0093 0.5957
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0225 0.0941
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.2295 1
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Mycobacterium ulcerans thioesterase 0.0024 0.0084 0.006
Brugia malayi Animal haem peroxidase family protein 0.0028 0.012 0.0504
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0225 0.0362
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0225 0.0941
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0225 0.0362
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0225 0.0941
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0293
Brugia malayi tailless protein 0.0019 0.0051 0.0214
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0155 0.0654
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Onchocerca volvulus Huntingtin homolog 0.012 0.0849 0.3562
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2295 1
Brugia malayi hypothetical protein 0.0022 0.007 0.0292
Echinococcus granulosus expressed conserved protein 0.009 0.0616 0.117
Brugia malayi CHE-14 protein 0.0041 0.0225 0.0944
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0051 0.0082
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0155 0.0565
Loa Loa (eye worm) hypothetical protein 0.0025 0.0093 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0225 0.0941
Loa Loa (eye worm) pax transcription factor protein 2 0.026 0.1967 0.825
Loa Loa (eye worm) fatty acid synthase 0.0028 0.0118 0.0497
Brugia malayi ecdysteroid receptor 0.0041 0.0225 0.0941
Echinococcus granulosus heat shock protein 90 0.0032 0.0149 0.0283
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0051 0.0082
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0149 0.0628
Onchocerca volvulus Peroxidase homolog 0.0028 0.012 0.0504
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0225 0.0362
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0322 0.0612
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0058 0.0047
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.2295 1
Brugia malayi isocitrate dehydrogenase 0.0032 0.0155 0.0651
Brugia malayi hypothetical protein 0.0022 0.007 0.0292
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0149 0.0628
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0149 0.0628
Onchocerca volvulus Peroxidasin homolog 0.0028 0.012 0.0504
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0047 0.0196
Brugia malayi Animal haem peroxidase family protein 0.0028 0.012 0.0504
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0674 0.128
Echinococcus granulosus dna polymerase eta 0.0019 0.0047 0.0088
Loa Loa (eye worm) hypothetical protein 0.0041 0.0225 0.0942
Echinococcus granulosus heat shock protein 90 0.0025 0.0098 0.0186
Echinococcus multilocularis dna polymerase eta 0.0019 0.0047 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Brugia malayi nuclear receptor NHR-88 0.0041 0.0225 0.0941
Loa Loa (eye worm) blistered cuticle protein 3 0.0028 0.012 0.0505
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0093 0.0337
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0225 0.0426
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.5263 0.8485
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.091 0.7152 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0155 0.025
Echinococcus multilocularis heat shock protein 0.0032 0.0149 0.0241
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0101 0.0076
Onchocerca volvulus 0.0019 0.0051 0.0214
Brugia malayi hypothetical protein 0.0025 0.0093 0.0388
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0293
Loa Loa (eye worm) hypothetical protein 0.0041 0.0225 0.0942
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.107 0.4503
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0051 0.0097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0225 0.0942
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0225 0.0941
Loa Loa (eye worm) hypothetical protein 0.0102 0.0713 0.2991
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0357 0.2745 0.2727
Echinococcus granulosus dna polymerase kappa 0.0019 0.0047 0.0088
Brugia malayi Blistered cuticle protein 3 0.0028 0.012 0.0504
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0046 0.0192
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0155 0.0295
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0098 0.0411
Loa Loa (eye worm) hypothetical protein 0.0041 0.0225 0.0945
Brugia malayi nuclear hormone receptor 0.0019 0.0051 0.0214
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0051 0.0215
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0825 0.3461
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2295 1
Schistosoma mansoni zinc finger protein 0.0019 0.0051 0.0097
Loa Loa (eye worm) endoplasmin 0.0032 0.0149 0.0627
Echinococcus multilocularis peroxidasin 0.0028 0.012 0.0194
Brugia malayi Animal haem peroxidase family protein 0.0028 0.012 0.0504
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Schistosoma mansoni patched 1 0.0041 0.0225 0.0428
Plasmodium falciparum heat shock protein 90 0.0032 0.0149 0.9614
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2295 1
Brugia malayi ecdysone receptor 0.0019 0.0051 0.0214
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.007 0.0293
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Leishmania major DNA polymerase eta, putative 0.0019 0.0047 0.0196
Loa Loa (eye worm) hypothetical protein 0.0053 0.0322 0.1351
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0628
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0225 0.0426
Onchocerca volvulus 0.026 0.1967 0.8249
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0101 0.0107
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0155 0.0295
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0047 0.0022
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0321 0.1352
Echinococcus granulosus X box binding protein 1 0.0281 0.2137 0.406
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0057 0.0032
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0991 0.1882
Loa Loa (eye worm) hypothetical protein 0.0051 0.0299 0.1255
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0225 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0225 0.0942
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0149 0.065
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0357 0.2745 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Brugia malayi hypothetical protein 0.0016 0.0023 0.0096
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0155 0.025
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0057 0.0045
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0225 0.0362
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0052 0.0224
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.2375 1
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0149 0.065
Brugia malayi nuclear receptor RXR 0.0022 0.007 0.0292
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.0084 0.0083
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0155 0.0653
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0225 0.0426
Mycobacterium ulcerans hypothetical protein 0.0164 0.1202 0.1181
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.007 0.0292
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.001 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Schistosoma mansoni peroxidasin 0.0028 0.012 0.0228
Echinococcus multilocularis endoplasmin 0.0025 0.0098 0.0158
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1268 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0713 0.2991
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0225 0.0426
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0225 0.0945
Brugia malayi hypothetical protein 0.0019 0.0051 0.0214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0155 0.025
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0093 0.0389
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0628
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0149 0.9614
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0628
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0057 0.0206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0791 0.6203 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0225 0.0942
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Loa Loa (eye worm) hypothetical protein 0.0312 0.2384 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0047 0.0088
Plasmodium vivax endoplasmin, putative 0.0032 0.0149 0.9614
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0225 0.0426
Schistosoma mansoni hypothetical protein 0.0032 0.0155 0.0294
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0098 0.0426
Loa Loa (eye worm) hypothetical protein 0.007 0.0455 0.1908
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0505
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0093 0.5957
Onchocerca volvulus 0.0053 0.0322 0.135
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0149 0.0544
Brugia malayi nuclear hormone receptor 0.0041 0.0225 0.0941
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0051 0.0097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0225 0.0941
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0047 0.0031
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0628
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Onchocerca volvulus Huntingtin homolog 0.012 0.0849 0.3562
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Brugia malayi heat shock protein 90 0.0032 0.0149 0.0626
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0149 0.0544
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0225 0.0426
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0047 0.0196
Echinococcus granulosus peroxidasin 0.0028 0.012 0.0228
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0628
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0115 0.0416
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Schistosoma mansoni endoplasmin 0.0032 0.0149 0.0283
Leishmania major heat shock protein 83-1 0.0032 0.0149 0.0628
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0825 0.3461
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0115 0.0126
Echinococcus multilocularis protein dispatched 1 0.0047 0.0272 0.0438
Loa Loa (eye worm) hypothetical protein 0.0041 0.0225 0.0942
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0047 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0225 0.0941
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0225 0.0942
Schistosoma mansoni hypothetical protein 0.0333 0.2546 0.4838
Echinococcus multilocularis heat shock protein 90 0.0025 0.0098 0.0158
Toxoplasma gondii hypothetical protein 0.005 0.0296 0.1079
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0225 0.0942
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0991 0.1597
Trypanosoma brucei heat shock protein, putative 0.0032 0.0149 0.0628
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0149 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0225 0.0941
Brugia malayi hypothetical protein 0.0312 0.2384 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0225 0.0942
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0225 0.0941
Brugia malayi hypothetical protein 0.0019 0.0051 0.0214
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.2375 1
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0051 0.0214
Echinococcus multilocularis heat shock protein 90 0.0032 0.0149 0.0241
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0357 0.2745 0.3817

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.