Detailed information for compound 905433

Basic information

Technical information
  • TDR Targets ID: 905433
  • Name: 2-fluoro-N-[[2-(trifluoromethyl)phenyl]methyl ]benzenesulfonamide
  • MW: 333.301 | Formula: C14H11F4NO2S
  • H donors: 1 H acceptors: 2 LogP: 3.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1S(=O)(=O)NCc1ccccc1C(F)(F)F
  • InChi: 1S/C14H11F4NO2S/c15-12-7-3-4-8-13(12)22(20,21)19-9-10-5-1-2-6-11(10)14(16,17)18/h1-8,19H,9H2
  • InChiKey: WXPTVHNQHCQMIR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-fluoro-N-[2-(trifluoromethyl)benzyl]benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0084 0.2285 0.5
Schistosoma mansoni tar DNA-binding protein 0.0127 0.4414 0.4919
Schistosoma mansoni tar DNA-binding protein 0.0127 0.4414 0.4919
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1132 0.1262
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.4414 0.4919
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1132 0.1262
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1132 0.1262
Echinococcus multilocularis dihydrofolate reductase 0.0219 0.8973 1
Chlamydia trachomatis dihydrofolate reductase 0.0219 0.8973 0.5
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0084 0.2285 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0 0.5
Onchocerca volvulus 0.0038 0 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.4414 0.4919
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0 0.5
Trichomonas vaginalis esterase, putative 0.0038 0 0.5
Brugia malayi Dihydrofolate reductase 0.0219 0.8973 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0084 0.2285 1
Loa Loa (eye worm) RNA binding protein 0.0127 0.4414 0.4919
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.2753 0.3068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.2753 0.3068
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1132 0.1262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2753 0.3068
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0084 0.2285 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.4414 0.4919
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1132 0.1262
Loa Loa (eye worm) dihydrofolate reductase 0.0219 0.8973 1
Loa Loa (eye worm) TAR-binding protein 0.0127 0.4414 0.4919
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0084 0.2285 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2753 0.3068
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1132 0.1262
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0597 0.0666
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0597 0.0666
Schistosoma mansoni tar DNA-binding protein 0.0127 0.4414 0.4919
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2753 0.3068
Schistosoma mansoni dihydrofolate reductase 0.0219 0.8973 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1132 0.1262
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.2753 0.3068
Onchocerca volvulus 0.0038 0 0.5
Echinococcus multilocularis tar DNA binding protein 0.0127 0.4414 0.4919
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.2753 0.3068
Echinococcus granulosus tar DNA binding protein 0.0127 0.4414 0.4919
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.2753 0.3068
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1132 0.1132
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0219 0.8973 1
Brugia malayi RNA binding protein 0.0127 0.4414 0.4919
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1132 0.4955
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.2753 0.3068
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0 0.5
Brugia malayi TAR-binding protein 0.0127 0.4414 0.4919
Onchocerca volvulus 0.0038 0 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0597 0.0666
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0084 0.2285 1
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0219 0.8973 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1132 0.4955
Brugia malayi dihydrofolate reductase family protein 0.0219 0.8973 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0219 0.8973 0.8973
Loa Loa (eye worm) hypothetical protein 0.005 0.0597 0.0666
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0 0.5
Echinococcus granulosus dihydrofolate reductase 0.0219 0.8973 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.4414 0.4919

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.