Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0432 | 0.4704 |
Echinococcus multilocularis | musashi | 0.003 | 0.0921 | 0.0892 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0921 | 0.2842 |
Echinococcus granulosus | lamin | 0.003 | 0.0921 | 0.0892 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0921 | 0.0892 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0432 | 0.0992 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0921 | 0.2561 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0432 | 0.4704 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0432 | 0.4704 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0432 | 0.4704 |
Entamoeba histolytica | Flap nuclease, putative | 0.0029 | 0.0862 | 1 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0029 | 0.0862 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0029 | 0.0862 | 1 |
Schistosoma mansoni | lamin | 0.003 | 0.0921 | 0.0511 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0921 | 0.2561 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0123 | 0.0379 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0432 | 0.4704 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0432 | 0.4704 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0432 | 0.1334 |
Schistosoma mansoni | flap endonuclease-1 | 0.0026 | 0.0702 | 0.0282 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3239 | 0.2934 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0432 | 0.4704 |
Schistosoma mansoni | lamin | 0.003 | 0.0921 | 0.0511 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0029 | 0.0862 | 0.0833 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.3239 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3239 | 0.2934 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.3239 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.3239 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.3239 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0432 | 0.4704 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0432 | 0.0402 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0029 | 0.0862 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0432 | 0.0402 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3239 | 0.2934 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0029 | 0.0862 | 0.266 |
Onchocerca volvulus | 0.003 | 0.0921 | 0.5 | |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0432 | 0.0402 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0921 | 0.0892 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0029 | 0.0862 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0432 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0921 | 0.0511 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0432 | 0.4704 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0031 | 0.0097 |
Onchocerca volvulus | 0.003 | 0.0921 | 0.5 | |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0432 | 0.4704 |
Echinococcus multilocularis | lamin | 0.003 | 0.0921 | 0.0892 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0432 | 0.4704 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0432 | 0.0402 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0432 | 0.1334 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3239 | 0.2934 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0432 | 0.0402 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0432 | 0.4704 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0921 | 0.2842 |
Brugia malayi | Flap endonuclease-1 | 0.0029 | 0.0862 | 0.2371 |
Brugia malayi | RNA binding protein | 0.007 | 0.3239 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0432 | 0.0402 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0432 | 0.4704 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0921 | 0.0892 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.3239 | 0.3217 |
Brugia malayi | TAR-binding protein | 0.007 | 0.3239 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0921 | 0.2842 |
Echinococcus multilocularis | geminin | 0.0188 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3239 | 0.2934 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.0432 | 0.5 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0029 | 0.0862 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0889 | 0.2745 |
Plasmodium falciparum | flap endonuclease 1 | 0.0029 | 0.0862 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.3239 | 0.3217 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0432 | 0.0992 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0029 | 0.0862 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0432 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0432 | 0.4704 |
Echinococcus granulosus | flap endonuclease 1 | 0.0029 | 0.0862 | 0.0833 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0432 | 0.4704 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0029 | 0.0862 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.0432 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.