Detailed information for compound 905495

Basic information

Technical information
  • TDR Targets ID: 905495
  • Name: N-(4-chlorophenyl)-2-[3-[(4-fluorophenyl)meth yl]-1-(3-methylphenyl)-2,5-dioxoimidazolidin- 4-yl]acetamide
  • MW: 465.904 | Formula: C25H21ClFN3O3
  • H donors: 1 H acceptors: 3 LogP: 4.31 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CC1C(=O)N(C(=O)N1Cc1ccc(cc1)F)c1cccc(c1)C)Nc1ccc(cc1)Cl
  • InChi: 1S/C25H21ClFN3O3/c1-16-3-2-4-21(13-16)30-24(32)22(14-23(31)28-20-11-7-18(26)8-12-20)29(25(30)33)15-17-5-9-19(27)10-6-17/h2-13,22H,14-15H2,1H3,(H,28,31)
  • InChiKey: JGFJVMSLHGYGJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-chlorophenyl)-2-[3-[(4-fluorophenyl)methyl]-1-(3-methylphenyl)-2,5-dioxo-imidazolidin-4-yl]acetamide
  • N-(4-chlorophenyl)-2-[3-[(4-fluorophenyl)methyl]-1-(3-methylphenyl)-2,5-dioxo-4-imidazolidinyl]acetamide
  • N-(4-chlorophenyl)-2-[3-(4-fluorobenzyl)-2,5-diketo-1-(3-methylphenyl)imidazolidin-4-yl]acetamide
  • N-(4-chlorophenyl)-2-[3-[(4-fluorophenyl)methyl]-1-(3-methylphenyl)-2,5-dioxo-imidazolidin-4-yl]ethanamide
  • STK196490

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0073 0.0721 0.0649
Brugia malayi ecdysteroid receptor 0.0066 0.0612 0.0533
Brugia malayi nuclear hormone receptor 0.0066 0.0612 0.0533
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0066 0.0612 0.0859
Schistosoma mansoni retinoic acid receptor RXR 0.0436 0.5939 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0066 0.0612 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0066 0.0612 0.0533
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0066 0.0612 0.0859
Echinococcus multilocularis FTZ F1 alpha 0.0066 0.0612 0.094
Giardia lamblia DNA polymerase alpha subunit A 0.0045 0.0315 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0066 0.0612 0.0859
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0053 0.0433 0.0603
Echinococcus multilocularis ecdysone induced protein 78C 0.0066 0.0612 0.094
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0066 0.0612 0.0859
Schistosoma mansoni thyroid hormone receptor 0.0066 0.0612 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0066 0.0612 0.0533
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.0612 0.0533
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0066 0.0612 0.0859
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0066 0.0612 0.094
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0023 0 0.5
Brugia malayi hypothetical protein 0.0035 0.0165 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.0612 0.094
Schistosoma mansoni RAR-like nuclear receptor 0.0066 0.0612 0.0859
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0066 0.0612 0.0859
Schistosoma mansoni thyroid hormone receptor 0.0066 0.0612 0.0859
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0066 0.0612 0.0859
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0066 0.0612 0.094
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0066 0.0612 0.0859
Loa Loa (eye worm) hypothetical protein 0.0066 0.0612 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0066 0.0612 0.0533
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0165 0.0092
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0066 0.0612 0.094
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0066 0.0612 0.0859
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0043 0.0288 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.0612 0.0533
Plasmodium vivax DNA polymerase alpha, putative 0.0043 0.0288 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0066 0.0612 0.0533
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0436 0.5939 1
Onchocerca volvulus Bile acid receptor homolog 0.0066 0.0612 0.0506
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.0612 0.0533
Trichomonas vaginalis DNA polymerase II, putative 0.0023 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.0612 0.0533
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0023 0 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.0612 0.0859
Loa Loa (eye worm) hypothetical protein 0.0066 0.0612 0.0533
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0165 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.0612 0.0533
Onchocerca volvulus Protein ultraspiracle homolog 0.0066 0.0612 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.0612 0.0533
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0053 0.0433 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0066 0.0612 0.0533
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0035 0.0165 0.0092
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0066 0.0612 0.094
Loa Loa (eye worm) hypothetical protein 0.0066 0.0612 0.0533
Brugia malayi nuclear hormone receptor 0.0683 0.9499 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0401 0.5439 1
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0165 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0057
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0035 0.0165 0.0101
Loa Loa (eye worm) hypothetical protein 0.0652 0.9052 0.9524
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0066 0.0612 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.0612 0.0533
Brugia malayi hypothetical protein 0.0035 0.0165 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0066 0.0612 0.0533
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0066 0.0612 0.0533
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0035 0.0165 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0066 0.0612 0.0533
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0057
Loa Loa (eye worm) hypothetical protein 0.0066 0.0612 0.0533
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0057
Echinococcus granulosus FTZ F1 alpha 0.0066 0.0612 0.0859
Brugia malayi photoreceptor-specific nuclear receptor 0.0066 0.0612 0.0533
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0066 0.0612 0.0533
Loa Loa (eye worm) hypothetical protein 0.0066 0.0612 0.0533
Brugia malayi DNA polymerase alpha catalytic subunit 0.0043 0.0288 0.0188
Brugia malayi steroid hormone receptor 0.0066 0.0612 0.0533
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0053 0.0433 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0066 0.0612 0.0533
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0023 0 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.0612 0.0859
Schistosoma mansoni coup transcription factor 0.0066 0.0612 0.0859
Onchocerca volvulus 0.0066 0.0612 0.0506
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.0612 0.094
Loa Loa (eye worm) steroid hormone receptor 0.0066 0.0612 0.0533
Loa Loa (eye worm) hypothetical protein 0.0066 0.0612 0.0533
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0066 0.0612 0.0533
Echinococcus granulosus ecdysone induced protein 78C 0.0066 0.0612 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0066 0.0612 0.0533
Loa Loa (eye worm) hypothetical protein 0.0066 0.0612 0.0533
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0035 0.0165 0.0092
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0073 0.0721 0.0616
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0057
Echinococcus multilocularis thyroid hormone receptor alpha 0.0066 0.0612 0.094
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.0612 0.0533
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0683 0.9499 1
Brugia malayi nuclear receptor NHR-88 0.0066 0.0612 0.0533
Loa Loa (eye worm) hypothetical protein 0.0035 0.0165 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0066 0.0612 0.0533
Brugia malayi nuclear receptor RXR 0.0035 0.0165 0.0057
Schistosoma mansoni nuclear hormone receptor 0.0066 0.0612 0.0859
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0066 0.0612 0.0533
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0023 0 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0066 0.0612 0.0859

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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