Detailed information for compound 905947

Basic information

Technical information
  • TDR Targets ID: 905947
  • Name: N-[2-(1H-benzimidazol-2-yl)ethyl]-2-(2-tert-b utylphenoxy)acetamide
  • MW: 351.442 | Formula: C21H25N3O2
  • H donors: 2 H acceptors: 2 LogP: 4.29 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1ccccc1C(C)(C)C)NCCc1nc2c([nH]1)cccc2
  • InChi: 1S/C21H25N3O2/c1-21(2,3)15-8-4-7-11-18(15)26-14-20(25)22-13-12-19-23-16-9-5-6-10-17(16)24-19/h4-11H,12-14H2,1-3H3,(H,22,25)(H,23,24)
  • InChiKey: ZDYIXPISBICJIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(1H-benzimidazol-2-yl)ethyl]-2-(2-tert-butylphenoxy)ethanamide
  • ST019487
  • ZINC00715544
  • AF-399/37112009
  • BAS 00836750
  • N-[2-(1H-Benzoimidazol-2-yl)-ethyl]-2-(2-tert-butyl-phenoxy)-acetamide
  • Oprea1_584518
  • Oprea1_590788

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0025 0.0314 0.0443
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0025 0.0318 0.0259
Trichomonas vaginalis glutaminase, putative 0.0265 0.7099 0.7076
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.2689 0.2685
Echinococcus granulosus intermediate filament protein 0.0053 0.1122 0.1755
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.2689 0.2638
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0025 0.0318 0.0312
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0771 0.1173
Loa Loa (eye worm) glutathione reductase 0.0048 0.0962 0.1356
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0318 0.025
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0318 0.2682
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0025 0.0318 0.0421
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0446 0.0633
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0257 0.0252
Schistosoma mansoni transcription factor btf3 0.0035 0.0611 0.0778
Brugia malayi PHD-finger family protein 0.0029 0.0446 0.0542
Loa Loa (eye worm) hypothetical protein 0.0025 0.0314 0.0443
Loa Loa (eye worm) hypothetical protein 0.0035 0.061 0.0859
Brugia malayi beta-NAC-like protein 0.0035 0.0611 0.0778
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0168 0.0099
Onchocerca volvulus 0.0047 0.0935 0.8027
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0368 1 1
Brugia malayi hypothetical protein 0.0017 0.0093 0.0041
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0176 0.0187
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0345 0.0278
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0025 0.0318 0.2682
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.061 0.0604
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0962 0.1491
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0025 0.0318 0.0238
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0342 0.0461
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.062 0.0923
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.061 0.0532
Schistosoma mansoni rab6-interacting 0.002 0.0176 0.016
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0356 0.0277
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.062 0.0791
Onchocerca volvulus 0.0035 0.061 0.4584
Echinococcus granulosus lamin 0.0053 0.1122 0.1755
Mycobacterium ulcerans beta-lactamase 0.0035 0.061 0.0544
Onchocerca volvulus 0.0053 0.1122 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0318 0.025
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0962 0.1356
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.061 0.0532
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0368 1 1
Schistosoma mansoni intermediate filament proteins 0.0053 0.1122 0.1503
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0345 0.0278
Schistosoma mansoni hypothetical protein 0.0047 0.0935 0.1238
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.6089 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0029
Brugia malayi Thioredoxin reductase 0.0048 0.0962 0.1277
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0303 0.0297
Schistosoma mansoni hypothetical protein 0.0029 0.0446 0.0542
Mycobacterium tuberculosis Conserved protein 0.0035 0.061 0.0604
Brugia malayi hypothetical protein 0.0026 0.0356 0.0415
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.2336 0.3771
Echinococcus multilocularis lamin dm0 0.0053 0.1122 0.1755
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0025 0.0318 0.025
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.061 0.0859
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0318 0.025
Brugia malayi hypothetical protein 0.002 0.0176 0.016
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0303 0.0297
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0345 0.034
Brugia malayi hypothetical protein 0.002 0.0176 0.016
Echinococcus multilocularis muscleblind protein 1 0.0146 0.3744 0.6107
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0082 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1036 0.1381
Echinococcus multilocularis RUN 0.002 0.0176 0.0187
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.2976 0.4834
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0303 0.0235
Mycobacterium ulcerans polyketide synthase 0.0024 0.0303 0.0235
Mycobacterium leprae Polyketide synthase Pks13 0.0036 0.0643 0.0577
Schistosoma mansoni hypothetical protein 0.0166 0.4298 0.6019
Chlamydia trachomatis oxoacy-ACP reductase 0.0025 0.0318 0.0238
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0611 0.6012
Loa Loa (eye worm) glutaminase 2 0.0265 0.7099 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0356 0.0297
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.061 0.0906
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0176 0.0187
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0104 0.0044
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0303 0.0235
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0257 0.0363
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1036 0.1381
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0962 0.0888
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0176 0.0187
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0318 0.025
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.062 0.0874
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0318 0.025
Echinococcus granulosus transcription factor btf3 0.0035 0.0611 0.0908
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.061 0.0604
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0318 0.025
Loa Loa (eye worm) hypothetical protein 0.0053 0.1122 0.158
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0345 0.0278
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0064 0.009
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0176 0.0096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.061 0.0776
Loa Loa (eye worm) hypothetical protein 0.0035 0.061 0.0859
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0422 0.0594
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0176 0.0187
Loa Loa (eye worm) oxidoreductase 0.0025 0.0318 0.0448
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0611 0.0861
Schistosoma mansoni lipoxygenase 0.0119 0.2976 0.414
Loa Loa (eye worm) hypothetical protein 0.0029 0.0446 0.0628
Onchocerca volvulus 0.0025 0.0318 0.1495
Schistosoma mansoni hypothetical protein 0.002 0.0176 0.016
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0303 0.0339
Leishmania major basic transcription factor 3a, putative 0.0035 0.0611 0.6012
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.2976 0.4834
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0318 0.025
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0082 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0035 0.061 0.0532
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.2336 0.3771
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0318 0.025
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.061 0.0604
Mycobacterium ulcerans thioesterase TesA 0.002 0.0188 0.0119
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0303 0.0235
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0082 0.0021
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.061 0.0544
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0356 0.0277
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.1122 0.1503
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0017 0.0109 0.0103
Toxoplasma gondii thioredoxin reductase 0.0048 0.0962 0.0907
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0318 0.0312
Echinococcus multilocularis muscleblind protein 0.0146 0.3744 0.6107
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0345 0.0286
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0082 0.0012
Mycobacterium ulcerans polyketide synthase Pks13 0.0036 0.0643 0.0577
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Mycobacterium ulcerans thioesterase 0.002 0.0188 0.0119
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0422 0.0508
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.009
Echinococcus granulosus peregrin 0.0029 0.0446 0.0633
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.3032 0.2983
Leishmania major oxidoreductase-like protein 0.0025 0.0318 0.2682
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0029
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0318 0.0312
Trypanosoma brucei oxidoreductase-like protein 0.0025 0.0318 0.2682
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.061 0.5996
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Brugia malayi intermediate filament protein 0.0053 0.1122 0.1503
Loa Loa (eye worm) hypothetical protein 0.0035 0.061 0.0859
Onchocerca volvulus 0.0035 0.061 0.4584
Loa Loa (eye worm) hypothetical protein 0.0026 0.0356 0.0501
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.6089 1
Plasmodium falciparum enoyl-acyl carrier reductase 0.0368 1 1
Schistosoma mansoni glutaminase 0.0265 0.7099 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.061 0.0859
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.2689 0.2685
Loa Loa (eye worm) hypothetical protein 0.0026 0.0342 0.0481
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0356 0.0277
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0303 0.0297
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0082 0.0021
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0036 0.0643 0.0638
Onchocerca volvulus 0.0053 0.1122 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1094 0.1541
Loa Loa (eye worm) hypothetical protein 0.0035 0.061 0.0859
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0025 0.0318 0.0238
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0303 0.0235
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.2689 0.2685
Loa Loa (eye worm) hypothetical protein 0.0229 0.6089 0.8577
Mycobacterium ulcerans hypothetical protein 0.0035 0.061 0.0544
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0025 0.0318 0.0448
Onchocerca volvulus 0.0025 0.0318 0.1495
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0962 1
Onchocerca volvulus 0.0023 0.0257 0.0856
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0345 0.034
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0368 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Trypanosoma brucei trypanothione reductase 0.0048 0.0962 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.2689 0.2685
Schistosoma mansoni lamin 0.0053 0.1122 0.1503
Onchocerca volvulus 0.0042 0.0812 0.6726
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0318 0.2682
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0318 0.2682
Leishmania major hypothetical protein, conserved 0.0035 0.061 0.5996
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.3032 0.3028
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0168 0.0099
Schistosoma mansoni lipoxygenase 0.0083 0.1965 0.2702
Schistosoma mansoni rab6-interacting 0.002 0.0176 0.016
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0318 0.0312
Trichomonas vaginalis esterase, putative 0.0035 0.061 0.0532
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0025 0.0318 0.0259
Loa Loa (eye worm) beta-lactamase 0.0035 0.061 0.0859
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0176 0.0187
Echinococcus multilocularis lamin 0.0053 0.1122 0.1755
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0586 0.0742
Leishmania major trypanothione reductase 0.0048 0.0962 1
Brugia malayi beta-lactamase family protein 0.0035 0.061 0.0776
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0176 0.0096
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.062 0.0791
Plasmodium vivax glutathione reductase, putative 0.0048 0.0962 0.0888
Brugia malayi beta-lactamase family protein 0.0035 0.061 0.0776
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0356 0.3115
Leishmania major pteridine reductase 1 0.0025 0.0318 0.2682
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0318 0.0312
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.2689 0.2685
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.061 0.0604
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.3018 0.4251
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0025 0.0318 0.0238
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0303 0.0235
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0855 0.7178
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0345 0.0278
Brugia malayi Doublecortin family protein 0.002 0.0176 0.016
Loa Loa (eye worm) hypothetical protein 0.0035 0.061 0.0859
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0318 0.025
Brugia malayi jmjC domain containing protein 0.0096 0.2336 0.323
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0611 0.0554
Echinococcus granulosus lamin dm0 0.0053 0.1122 0.1755
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0025 0.0318 0.0259
Echinococcus multilocularis geminin 0.0166 0.4298 0.7028
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0368 1 1
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0611 0.6012
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0356 0.3115
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0935 0.1238
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0025 0.0318 0.0361
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0025 0.0318 0.025
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.061 0.0776
Entamoeba histolytica hypothetical protein 0.0035 0.0611 1
Brugia malayi hypothetical protein 0.0229 0.6089 0.8564
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0446 0.0628
Loa Loa (eye worm) hypothetical protein 0.0041 0.077 0.1085
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0342 0.0461
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.133 0.1874
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0356 0.3115
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0025 0.0318 0.0312
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0012
Mycobacterium tuberculosis Probable reductase 0.0109 0.2689 0.2685
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.061 0.0532
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.061 0.5996
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0177 0.0172
Echinococcus granulosus muscleblind protein 0.0146 0.3744 0.6107
Schistosoma mansoni dihydropteridine reductase 0.0025 0.0318 0.0361
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0025
Mycobacterium ulcerans polyketide synthase 0.0026 0.0345 0.0278
Echinococcus multilocularis musashi 0.0053 0.1122 0.1755
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1036 0.1459
Brugia malayi glutaminase DH11.1 0.0265 0.7099 1
Echinococcus multilocularis peregrin 0.0029 0.0446 0.0633
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0188 0.0119
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0318 0.2682
Plasmodium falciparum glutathione reductase 0.0048 0.0962 0.0888
Echinococcus multilocularis transcription factor btf3 0.0035 0.0611 0.0908
Mycobacterium tuberculosis Conserved protein 0.0035 0.061 0.0604
Brugia malayi MH2 domain containing protein 0.012 0.3018 0.4198
Toxoplasma gondii ABC1 family protein 0.0035 0.061 0.0552
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0025 0.0318 0.2682
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0257 0.0275
Giardia lamblia PHD finger protein 15 0.0029 0.0446 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0025 0.0318 0.2682
Loa Loa (eye worm) hypothetical protein 0.0146 0.3744 0.5273
Onchocerca volvulus Alhambra homolog 0.0029 0.0446 0.2847
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0611 0.0534
Loa Loa (eye worm) hypothetical protein 0.005 0.1039 0.1464
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0303 0.0235
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.1122 0.158
Trypanosoma brucei pteridine reductase 1 0.0025 0.0318 0.2682
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0611 0.0534
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0611 0.0534
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0293 0.0413
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0318 0.025
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0345 0.034
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0318 0.025
Loa Loa (eye worm) doublecortin family protein 0.002 0.0176 0.0249
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.3032 0.3028
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.061 0.0604
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.061 0.5996
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.062 0.0923
Schistosoma mansoni hypothetical protein 0.0166 0.4298 0.6019
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0446 0.0367
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0281 0.0276
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0318 0.0361
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0168 0.0099
Leishmania major hypothetical protein, conserved 0.0026 0.0356 0.3115
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.061 0.0906
Mycobacterium tuberculosis Probable oxidoreductase 0.0025 0.0318 0.0312
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0368 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0318 0.0312
Echinococcus granulosus RUN 0.002 0.0176 0.0187
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.5973 0.5971
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0611 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0318 0.0361
Schistosoma mansoni polycystin 1-related 0.002 0.0176 0.016
Brugia malayi jmjC domain containing protein 0.0036 0.062 0.0791
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0446 0.0387
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0318 0.025
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0025 0.0318 0.0421
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.061 0.0604
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0446 0.0387
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0188 0.0182
Mycobacterium ulcerans glutaminase 0.0265 0.7099 0.7079
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0176 0.0187
Schistosoma mansoni jumonji domain containing protein 0.0077 0.1777 0.2435
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0345 0.0278
Loa Loa (eye worm) hypothetical protein 0.005 0.1036 0.1459
Trichomonas vaginalis hypothetical protein 0.0368 1 1
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0025 0.0318 0.0312
Mycobacterium tuberculosis Conserved protein 0.0035 0.061 0.0604
Brugia malayi Bromodomain containing protein 0.0029 0.0446 0.0542
Mycobacterium ulcerans oxidoreductase 0.0025 0.0318 0.025
Echinococcus granulosus geminin 0.0166 0.4298 0.7028
Mycobacterium leprae Probable lipase LipE 0.0035 0.061 0.0544
Brugia malayi Muscleblind-like protein 0.0146 0.3744 0.523
Loa Loa (eye worm) glutaminase 0.0265 0.7099 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.061 0.0544
Plasmodium falciparum phd finger protein, putative 0.0029 0.0446 0.0367
Brugia malayi glutathione reductase 0.0048 0.0962 0.1277
Mycobacterium ulcerans lipase LipD 0.0035 0.061 0.0544
Brugia malayi beta-lactamase 0.0035 0.061 0.0776
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0318 0.025
Schistosoma mansoni loxhd1 0.002 0.0176 0.016
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0771 0.1173
Schistosoma mansoni survival motor neuron protein 0.0047 0.0935 0.1238
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.061 0.0532
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0318 0.025
Schistosoma mansoni lamin 0.0053 0.1122 0.1503
Loa Loa (eye worm) hypothetical protein 0.0025 0.0318 0.0448
Plasmodium falciparum thioredoxin reductase 0.0048 0.0962 0.0888
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0962 0.1491
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0611 0.0534
Loa Loa (eye worm) retinol dehydrogenase 12 0.0025 0.0318 0.0448
Onchocerca volvulus 0.0035 0.061 0.4584
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.061 0.0776
Treponema pallidum NADH oxidase 0.0017 0.0082 0.5
Loa Loa (eye worm) hypothetical protein 0.0146 0.3744 0.5273
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0281 0.0276
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0036 0.0643 0.0638
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0318 0.025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0318 0.025
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.3018 0.4251
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.3032 0.3028
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.061 0.0532
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0025 0.0318 0.025
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0082 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.0249
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0962 0.0957
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0919 0.1215
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.0249
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.061 0.0604
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.061 0.0544
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0368 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.0586 0.0742
Loa Loa (eye worm) intermediate filament protein 0.0053 0.1122 0.158
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0611 0.0534
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0446 0.0542
Loa Loa (eye worm) hypothetical protein 0.0034 0.0586 0.0825
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0025 0.0318 0.025
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0446 0.0633
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0611 0.6012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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