Detailed information for compound 905954

Basic information

Technical information
  • TDR Targets ID: 905954
  • Name: 4-chloro-N-(6-methoxy-2-oxochromen-3-yl)benza mide
  • MW: 329.734 | Formula: C17H12ClNO4
  • H donors: 1 H acceptors: 2 LogP: 3.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)cc(c(=O)o2)NC(=O)c1ccc(cc1)Cl
  • InChi: 1S/C17H12ClNO4/c1-22-13-6-7-15-11(8-13)9-14(17(21)23-15)19-16(20)10-2-4-12(18)5-3-10/h2-9H,1H3,(H,19,20)
  • InChiKey: GLFIOGFVRNWFLQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-chloro-N-(6-methoxy-2-oxo-chromen-3-yl)benzamide
  • 4-chloro-N-(6-methoxy-2-oxo-3-chromenyl)benzamide
  • 4-chloro-N-(2-keto-6-methoxy-chromen-3-yl)benzamide
  • Oprea1_636474
  • ZINC00253489
  • EU-0069958

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0071 0.1354 0.2653
Schistosoma mansoni hypothetical protein 0.0071 0.1354 0.1349
Onchocerca volvulus 0.0057 0.0987 0.1588
Schistosoma mansoni hypothetical protein 0.0031 0.0334 0.0329
Echinococcus granulosus GPCR family 2 0.0031 0.0334 0.0329
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0334 0.0329
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0006 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0351 0.0346
Echinococcus multilocularis 0.0021 0.0065 0.006
Mycobacterium tuberculosis Conserved protein 0.0024 0.0142 0.0205
Onchocerca volvulus 0.0032 0.0351 0.0493
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2722 0.2718
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0065 0.0755
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0351 0.0346
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0487 0.0822
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0117
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.2722 0.5329
Mycobacterium ulcerans dehydrogenase 0.0021 0.0065 0.0083
Echinococcus multilocularis cpg binding protein 0.006 0.107 0.1065
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0773 0.0767
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.3866 0.3863
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.2325 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0334 0.0645
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0351 0.0346
Echinococcus multilocularis dnaJ subfamily B 0.0406 1 1
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0142 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0351 0.0346
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1854 0.3634
Trypanosoma brucei glucosidase, putative 0.0037 0.0487 0.0985
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0065 0.0083
Schistosoma mansoni hypothetical protein 0.0031 0.0334 0.0329
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0351 0.0346
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.3866 0.3863
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0006 0.5
Plasmodium vivax SET domain protein, putative 0.0032 0.0351 0.4369
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0487 0.0482
Schistosoma mansoni hypothetical protein 0.0031 0.0334 0.0329
Echinococcus granulosus tar DNA binding protein 0.0124 0.2722 0.2718
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0065 0.0755
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0065 0.0755
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.2086 0.4087
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2722 0.2718
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0142 0.028
Leishmania major UDP-galactopyranose mutase 0.0021 0.0065 0.0122
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0065 0.006
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0065 0.006
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0065 0.006
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0487 0.0822
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0351 0.0346
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0487 0.3574
Loa Loa (eye worm) hypothetical protein 0.0048 0.0773 0.1505
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0298 0.7212 1
Schistosoma mansoni cpg binding protein 0.0057 0.0987 0.0982
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0006 0.5
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0142 0.028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1854 0.3627
Loa Loa (eye worm) hypothetical protein 0.0089 0.1827 0.3574
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0142 0.0205
Trypanosoma brucei hypothetical protein, conserved 0.0208 0.4895 1
Brugia malayi SWIRM domain containing protein 0.0021 0.0065 0.0128
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0487 0.0985
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0065 0.0122
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0987 0.1925
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0006 0.5
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2722 0.2718
Brugia malayi Pre-SET motif family protein 0.0216 0.5102 1
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.2722 0.5334
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0065 0.006
Brugia malayi TAR-binding protein 0.0124 0.2722 0.5334
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0117
Echinococcus granulosus cpg binding protein 0.006 0.107 0.1065
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0065 0.006
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0065 0.0258
Schistosoma mansoni cpg binding protein 0.006 0.107 0.1065
Echinococcus multilocularis tumor protein p63 0.0331 0.8055 0.8054
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0065 0.0128
Echinococcus multilocularis GPCR, family 2 0.0031 0.0334 0.0329
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0487 0.0822
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0487 0.0482
Entamoeba histolytica hypothetical protein 0.0071 0.1354 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0117
Schistosoma mansoni amine oxidase 0.0021 0.0065 0.006
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.3866 0.7577
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0117
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0065 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0117
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.2086 0.4087
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2722 0.2718
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0334 0.0329
Brugia malayi hypothetical protein 0.0032 0.0346 0.0678
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0142 0.019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0334 0.0329
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0334 0.0655
Entamoeba histolytica hypothetical protein 0.0071 0.1354 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.1354 0.1349
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0797 1
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0797 1
Leishmania major hypothetical protein, conserved 0.0049 0.0797 0.1619
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0298 0.7212 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.2656 0.2652
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.3866 0.3863
Onchocerca volvulus 0.0097 0.2035 0.3394
Trypanosoma cruzi hypothetical protein, conserved 0.0208 0.4895 1
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0065 0.0755
Loa Loa (eye worm) hypothetical protein 0.0031 0.0334 0.0645
Echinococcus multilocularis tar DNA binding protein 0.0124 0.2722 0.2718
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0487 0.0945
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0142 0.019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0117
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0065 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1854 0.185
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0487 0.3574
Trichomonas vaginalis set domain proteins, putative 0.0246 0.5869 1
Schistosoma mansoni hypothetical protein 0.0022 0.0095 0.0089
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0095 0.0089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0334 0.0329
Loa Loa (eye worm) TAR-binding protein 0.0124 0.2722 0.5329
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.5102 1
Echinococcus granulosus tumor protein p63 0.0331 0.8055 0.8054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1854 0.185
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0487 0.0822
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0487 0.0822
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1854 0.185
Schistosoma mansoni hypothetical protein 0.0068 0.1275 0.127
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0487 0.0822
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0797 0.1619
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0797 0.1619
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1854 0.185
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1275 0.2499
Brugia malayi hypothetical protein 0.0089 0.1827 0.3581
Entamoeba histolytica hypothetical protein 0.0071 0.1354 1
Brugia malayi hypothetical protein 0.0021 0.0065 0.0128
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0024 0.0154 0.0642
Schistosoma mansoni alpha glucosidase 0.0037 0.0487 0.0482
Loa Loa (eye worm) hypothetical protein 0.0049 0.0797 0.1553
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0487 0.2077
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2722 0.2718
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0334 0.0655
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0142 0.028
Loa Loa (eye worm) hypothetical protein 0.0099 0.2086 0.4081
Brugia malayi hypothetical protein 0.0049 0.0797 0.1562
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.1354 0.1349
Onchocerca volvulus 0.0048 0.0773 0.1219
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0065 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0351 0.0346
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0065 0.006
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0142 0.0137
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0142 0.019
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0797 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0487 0.0822
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0021 0.0065 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0351 0.0679
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0487 0.0985
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0487 0.0955
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0797 0.3413
Schistosoma mansoni amine oxidase 0.0021 0.0065 0.006
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.3866 0.7574
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0487 0.0822
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0065 0.0755
Trypanosoma cruzi hypothetical protein, conserved 0.0208 0.4895 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.029 0.0285
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1854 0.185
Loa Loa (eye worm) hypothetical protein 0.0068 0.1275 0.2491
Mycobacterium ulcerans hypothetical protein 0.0024 0.0142 0.019
Mycobacterium ulcerans oxidoreductase 0.0021 0.0065 0.0083
Mycobacterium ulcerans hypothetical protein 0.0024 0.0142 0.019
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0487 0.0985
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1854 0.185
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0142 0.0233
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0065 0.0122
Schistosoma mansoni hypothetical protein 0.0406 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.1354 0.1349
Schistosoma mansoni alpha-glucosidase 0.0145 0.3261 0.3258
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0277 0.6671 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.1827 0.3574
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0065 0.0755
Brugia malayi CXXC zinc finger family protein 0.0057 0.0987 0.1934
Onchocerca volvulus 0.0246 0.5869 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.2086 0.4081
Entamoeba histolytica hypothetical protein 0.0071 0.1354 1
Schistosoma mansoni cpg binding protein 0.006 0.107 0.1065
Leishmania major hypothetical protein, conserved 0.0208 0.4895 1
Schistosoma mansoni hypothetical protein 0.0031 0.0334 0.0329
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0065 0.0755
Schistosoma mansoni alpha-glucosidase 0.0145 0.3261 0.3258
Brugia malayi Pre-SET motif family protein 0.0032 0.0351 0.0689
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0797 0.1619
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0487 0.0822
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0351 0.1491
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1854 0.185
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0095 0.0089
Schistosoma mansoni eyes absent homolog 0.0089 0.1827 0.1823
Loa Loa (eye worm) RNA binding protein 0.0124 0.2722 0.5329
Brugia malayi RNA binding protein 0.0124 0.2722 0.5334
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0065 0.009

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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