TDR Targets

Basic information

Technical information

TDR Targets ID: 905971
Name: N-[(4-ethoxyphenyl)methylideneamino]-2-methyl quinoline-4-carboxamide
MW: 333.384 | Formula: C20H19N3O2
H donors: 1 H acceptors: 2 LogP: 3.84 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)C=NNC(=O)c1cc(C)nc2c1cccc2
InChi: 1S/C20H19N3O2/c1-3-25-16-10-8-15(9-11-16)13-21-23-20(24)18-12-14(2)22-19-7-5-4-6-17(18)19/h4-13H,3H2,1-2H3,(H,23,24)/b21-13+
InChiKey: CMMWSAJVHDUDEH-FYJGNVAPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(4-ethoxyphenyl)methyleneamino]-2-methyl-quinoline-4-carboxamide
N-[(4-ethoxyphenyl)methyleneamino]-2-methyl-4-quinolinecarboxamide
N-[(4-ethoxybenzylidene)amino]-2-methyl-cinchoninamide
N-[(4-ethoxyphenyl)methylideneamino]-2-methyl-quinoline-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Papain family cysteine protease containing protein	0.0284	0.0637	0.1374
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0284	0.0637	0.1041
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2987	1	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0284	0.0637	0.1041
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.015	0.0172	0.0371
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0762	0.2291	0.4745
Brugia malayi	Papain family cysteine protease containing protein	0.0284	0.0637	0.1374
Brugia malayi	Cathepsin L-like precursor	0.1439	0.4638	1
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0473	0.1019
Trichomonas vaginalis	conserved hypothetical protein	0.0284	0.0637	0.1041
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1439	0.4638	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1439	0.4638	0.4544
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0478	0.1308	0.2819
Onchocerca volvulus	Cathepsin L homolog	0.0284	0.0637	0.0395
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0327	0.0787	0.1378
Echinococcus granulosus	cathepsin L	0.0284	0.0637	0.1041
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0186	0.0296	0.0278
Plasmodium vivax	vivapain-3	0.0762	0.2291	0.4745
Plasmodium vivax	serine-repeat antigen (SERA)	0.0284	0.0637	0.1041
Entamoeba histolytica	cysteine proteinase, putative	0.0762	0.2291	0.4398
Toxoplasma gondii	cathepsin CPC1	0.0284	0.0637	0.1041
Echinococcus multilocularis	cysteine protease	0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1439	0.4638	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0478	0.1308	0.2819
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0284	0.0637	0.1041
Brugia malayi	cathepsin L precursor	0.0284	0.0637	0.1374
Loa Loa (eye worm)	hypothetical protein	0.0962	0.2984	0.6433
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0284	0.0637	0.1041
Loa Loa (eye worm)	cathepsin B	0.0327	0.0787	0.1698
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1439	0.4638	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0721	0.215	0.4635
Schistosoma mansoni	hypothetical protein	0.023	0.0449	0.0621
Entamoeba histolytica	cysteine proteinase, putative	0.1439	0.4638	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0284	0.0637	0.1041
Giardia lamblia	Cathepsin B precursor	0.0327	0.0787	0.0994
Leishmania major	cysteine peptidase A (CPA)	0.1439	0.4638	0.4544
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Brugia malayi	Papain family cysteine protease containing protein	0.0762	0.2291	0.494
Brugia malayi	Cathepsin L-like precursor	0.0962	0.2984	0.6433
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Loa Loa (eye worm)	hypothetical protein	0.0478	0.1308	0.2819
Brugia malayi	fibroinase precursor	0.0284	0.0637	0.1374
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0424	0.1123	0.213
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0424	0.1123	0.0968
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.251	0.8346	0.8317
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1439	0.4638	1
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.023	0.0449	0.0621
Giardia lamblia	Cathepsin B precursor	0.0327	0.0787	0.0994
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0284	0.0637	0.1041
Leishmania major	cathepsin L-like protease	0.1439	0.4638	0.4544
Brugia malayi	Cathepsin L-like precursor	0.1439	0.4638	1
Brugia malayi	Cathepsin L-like precursor	0.1439	0.4638	1
Onchocerca volvulus	Cathepsin L homolog	0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0962	0.2984	0.6296
Toxoplasma gondii	cathepsin CPL	0.1439	0.4638	1
Onchocerca volvulus		0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0284	0.0637	0.1041
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0284	0.0637	0.1041
Loa Loa (eye worm)	hypothetical protein	0.015	0.0172	0.0371
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0284	0.0637	0.1041
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0284	0.0637	0.1374
Entamoeba histolytica	hypothetical protein	0.0284	0.0637	0.0448
Loa Loa (eye worm)	cysteine protease	0.1439	0.4638	1
Trypanosoma cruzi	cysteine peptidase, putative	0.2987	1	1
Echinococcus granulosus	cathepsin L	0.0762	0.2291	0.4745
Plasmodium falciparum	serine repeat antigen 5	0.0284	0.0637	0.1041
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Leishmania major	cathepsin L-like protease	0.1439	0.4638	0.4544
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.023	0.0449	0.0621
Brugia malayi	Cathepsin L-like precursor	0.1439	0.4638	1
Loa Loa (eye worm)	hypothetical protein	0.0478	0.1308	0.2819
Leishmania major	cathepsin L-like protease	0.1439	0.4638	0.4544
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0762	0.2291	0.4745
Schistosoma mansoni	transcription factor LCR-F1	0.023	0.0449	0.0621
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0424	0.1123	0.213
Brugia malayi	cathepsin L-like cysteine proteinase	0.0284	0.0637	0.1374
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2987	1	1
Entamoeba histolytica	cysteine protease, putative	0.0284	0.0637	0.0448
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0762	0.2291	0.2156
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0284	0.0637	0.1041
Entamoeba histolytica	cysteine protease, putative	0.0284	0.0637	0.0448
Echinococcus granulosus	caspase 2	0.0237	0.0473	0.0673
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0284	0.0637	0.1041
Entamoeba histolytica	cysteine protease, putative	0.0284	0.0637	0.0448
Schistosoma mansoni	microtubule-associated protein tau	0.0693	0.2052	0.4211
Plasmodium vivax	vivapain-1	0.0762	0.2291	0.4745
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1439	0.4638	1
Echinococcus multilocularis	caspase 2	0.0237	0.0473	0.0673
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1439	0.4638	1
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Toxoplasma gondii	cathepsin CPC2	0.0284	0.0637	0.1041
Brugia malayi	cathepsin F-like cysteine proteinase	0.0284	0.0637	0.1374
Brugia malayi	Cathepsin L-like precursor	0.1439	0.4638	1
Echinococcus granulosus	neuropeptide s receptor	0.0464	0.1261	0.2439
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0284	0.0637	0.1041
Echinococcus multilocularis	cathepsin b	0.0424	0.1123	0.213
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2987	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2987	1	1
Entamoeba histolytica	cysteine protease, putative	0.0284	0.0637	0.0448
Brugia malayi	cathepsin L-like precursor	0.0962	0.2984	0.6433
Onchocerca volvulus		0.1439	0.4638	1
Onchocerca volvulus		0.1439	0.4638	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2987	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0327	0.0787	0.0626
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0721	0.215	0.4428
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0424	0.1123	0.213
Entamoeba histolytica	cysteine protease, putative	0.1439	0.4638	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0464	0.1261	0.2439
Echinococcus multilocularis	cysteine protease	0.1439	0.4638	1
Onchocerca volvulus		0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Loa Loa (eye worm)	hypothetical protein	0.0478	0.1308	0.2819
Brugia malayi	Cathepsin L-like precursor	0.0962	0.2984	0.6433
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0533	0.115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1439	0.4638	1
Onchocerca volvulus		0.0284	0.0637	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0284	0.0637	0.1041
Plasmodium vivax	vivapain-2	0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0284	0.0637	0.1041
Plasmodium falciparum	serine repeat antigen 4	0.0284	0.0637	0.1041
Entamoeba histolytica	cysteine proteinase 2	0.0762	0.2291	0.4398
Entamoeba histolytica	cysteine proteinase, putative	0.1439	0.4638	1
Brugia malayi	Cell death protein 3 precursor	0.0237	0.0473	0.1019
Brugia malayi	Cathepsin L-like precursor	0.1439	0.4638	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0721	0.215	0.4428
Plasmodium vivax	serine-repeat antigen (SERA)	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Loa Loa (eye worm)	hypothetical protein	0.0962	0.2984	0.6433
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0284	0.0637	0.0448
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0284	0.0637	0.1041
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0424	0.1123	0.213
Schistosoma mansoni	cathepsin F (C01 family)	0.0962	0.2984	0.6296
Echinococcus multilocularis	cathepsin b	0.0424	0.1123	0.213
Leishmania major	cathepsin L-like protease	0.1439	0.4638	0.4544
Loa Loa (eye worm)	fibroinase	0.1439	0.4638	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0762	0.2291	0.2156
Schistosoma mansoni	cathepsin B (C01 family)	0.0284	0.0637	0.1041
Echinococcus multilocularis	cathepsin L	0.0762	0.2291	0.4745
Schistosoma mansoni	cathepsin C	0.0284	0.0637	0.1041
Plasmodium falciparum	serine repeat antigen 1	0.0284	0.0637	0.1041
Trypanosoma cruzi	cysteine peptidase, putative	0.2987	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0962	0.2984	0.6296
Echinococcus granulosus	neuropeptide receptor A26	0.0464	0.1261	0.2439
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0762	0.2291	0.4745
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0284	0.0637	0.1041
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1439	0.4638	1
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2987	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0284	0.0637	0.1041
Leishmania major	cathepsin L-like protease	0.2987	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.2987	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1439	0.4638	1
Leishmania major	cathepsin L-like protease	0.1439	0.4638	0.4544
Entamoeba histolytica	cysteine proteinase, putative	0.0762	0.2291	0.4398
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Echinococcus granulosus	cysteine protease	0.0762	0.2291	0.4745
Loa Loa (eye worm)	hypothetical protein	0.0284	0.0637	0.1374
Loa Loa (eye worm)	hypothetical protein	0.0284	0.0637	0.1374
Loa Loa (eye worm)	hypothetical protein	0.0284	0.0637	0.1374
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0284	0.0637	0.1041
Leishmania major	cathepsin L-like protease	0.2987	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Onchocerca volvulus		0.0962	0.2984	0.6029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2987	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0464	0.1261	0.2439
Schistosoma mansoni	cathepsin F (C01 family)	0.1439	0.4638	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0284	0.0637	0.1041
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0284	0.0637	0.1374
Plasmodium falciparum	serine repeat antigen 6	0.0284	0.0637	0.1041
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0762	0.2291	0.2156
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0762	0.2291	0.4745
Echinococcus granulosus	cathepsin l1	0.0962	0.2984	0.6296
Schistosoma mansoni	cathepsin s	0.0478	0.1308	0.2543
Echinococcus granulosus	cathepsin l1	0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0721	0.215	0.4428
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0254	0.0533	0.115
Plasmodium falciparum	serine repeat antigen 7	0.0284	0.0637	0.1041
Entamoeba histolytica	cysteine proteinase 1, putative	0.0762	0.2291	0.4398
Trypanosoma cruzi	cysteine protease, putative	0.0762	0.2291	0.2156
Entamoeba histolytica	cysteine proteinase, putative	0.0762	0.2291	0.4398
Echinococcus multilocularis	microtubule associated protein 2	0.0693	0.2052	0.4211
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Toxoplasma gondii	cathepsin B	0.0327	0.0787	0.1378
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2987	1	1
Plasmodium falciparum	serine repeat antigen 2	0.0284	0.0637	0.1041
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0284	0.0637	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0284	0.0637	0.1374
Onchocerca volvulus		0.1439	0.4638	1
Giardia lamblia	Cathepsin B precursor	0.0327	0.0787	0.0994
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0284	0.0637	0.1041
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2987	1	1
Loa Loa (eye worm)	hypothetical protein	0.0424	0.1123	0.2421
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2987	1	1
Plasmodium vivax	unspecified product	0.0478	0.1308	0.2543
Trypanosoma cruzi	cysteine peptidase, putative	0.0762	0.2291	0.2156
Loa Loa (eye worm)	hypothetical protein	0.0284	0.0637	0.1374
Trypanosoma cruzi	major cysteine proteinase, putative	0.0284	0.0637	0.0473
Echinococcus multilocularis	cathepsin L	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0284	0.0637	0.1041
Giardia lamblia	Cathepsin B precursor	0.0721	0.215	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0284	0.0637	0.1041
Echinococcus granulosus	cathepsin b	0.0424	0.1123	0.213
Trichomonas vaginalis	conserved hypothetical protein	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1439	0.4638	1
Entamoeba histolytica	cysteine proteinase, putative	0.0962	0.2984	0.6051
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0721	0.215	0.4635
Schistosoma mansoni	caspase-7 (C14 family)	0.0237	0.0473	0.0673
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0284	0.0637	0.1041
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0284	0.0637	0.1041
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0284	0.0637	0.1041
Plasmodium falciparum	serine repeat antigen 3	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1439	0.4638	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0762	0.2291	0.2156
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Trypanosoma cruzi	cysteine proteinase, putative	0.0762	0.2291	0.2156
Brugia malayi	cathepsin B-like cysteine proteinase	0.0424	0.1123	0.2421
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0478	0.1308	0.2819
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1439	0.4638	1
Loa Loa (eye worm)	hypothetical protein	0.0284	0.0637	0.1374
Plasmodium falciparum	serine repeat antigen 9	0.0284	0.0637	0.1041
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0962	0.2984	0.6433
Trypanosoma cruzi	major cysteine proteinase, putative	0.1832	0.5999	0.5929
Echinococcus granulosus	cathepsin L cysteine protease	0.0762	0.2291	0.4745
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1439	0.4638	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0327	0.0787	0.0626
Brugia malayi	Papain family cysteine protease containing protein	0.0762	0.2291	0.494
Plasmodium falciparum	serine repeat antigen 8	0.0284	0.0637	0.1041
Plasmodium vivax	unspecified product	0.0762	0.2291	0.4745
Brugia malayi	Cathepsin L-like precursor	0.0478	0.1308	0.2819
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1439	0.4638	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0478	0.1308	0.1155
Onchocerca volvulus	Cathepsin L homolog	0.1439	0.4638	1
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Plasmodium vivax	vivapain-2	0.1439	0.4638	1
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Schistosoma mansoni	cathepsin F (C01 family)	0.1439	0.4638	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1439	0.4638	1
Entamoeba histolytica	cysteine protease, putative	0.0284	0.0637	0.0448
Entamoeba histolytica	cysteine protease, putative	0.0284	0.0637	0.0448
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2987	1	1
Echinococcus granulosus	microtubule associated protein 2	0.0693	0.2052	0.4211
Onchocerca volvulus	Cathepsin F homolog	0.1439	0.4638	1
Echinococcus granulosus	cathepsin b	0.0424	0.1123	0.213
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0284	0.0637	0.1374
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0327	0.0787	0.0626
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0721	0.215	0.4635
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1439	0.4638	1
Entamoeba histolytica	cysteine proteinase, putative	0.0762	0.2291	0.4398
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0186	0.0296	0.0278
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Trypanosoma cruzi	cysteine peptidase, putative	0.2987	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0327	0.0787	0.1378
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0721	0.215	0.4428
Loa Loa (eye worm)	ctsf protein	0.1439	0.4638	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0762	0.2291	0.4745
Onchocerca volvulus		0.1439	0.4638	1
Brugia malayi	Papain family cysteine protease containing protein	0.1439	0.4638	1
Onchocerca volvulus		0.1439	0.4638	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0478	0.1308	0.1155
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0284	0.0637	0.1041
Brugia malayi	Papain family cysteine protease containing protein	0.0284	0.0637	0.1374
Loa Loa (eye worm)	hypothetical protein	0.1439	0.4638	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1439	0.4638	1
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Echinococcus multilocularis	cathepsin L cysteine protease	0.1439	0.4638	1
Loa Loa (eye worm)	hypothetical protein	0.0962	0.2984	0.6433
Entamoeba histolytica	cysteine protease, putative	0.0762	0.2291	0.4398
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1439	0.4638	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1439	0.4638	1
Brugia malayi	hypothetical protein	0.023	0.0449	0.0969
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0762	0.2291	0.4745
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0284	0.0637	0.1041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0284	0.0637	0.1041
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0284	0.0637	0.1041
Plasmodium vivax	unspecified product	0.0284	0.0637	0.1041

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 905971