Detailed information for compound 90608

Basic information

Technical information
  • TDR Targets ID: 90608
  • Name: N'-[4-[2-[(3-chlorophenyl)methylamino]ethyl]p henyl]thiophene-2-carboximidamide
  • MW: 369.911 | Formula: C20H20ClN3S
  • H donors: 2 H acceptors: 0 LogP: 4.81 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)CNCCc1ccc(cc1)NC(=N)c1cccs1
  • InChi: 1S/C20H20ClN3S/c21-17-4-1-3-16(13-17)14-23-11-10-15-6-8-18(9-7-15)24-20(22)19-5-2-12-25-19/h1-9,12-13,23H,10-11,14H2,(H2,22,24)
  • InChiKey: ZZVGLDBDDYESAB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
  • N'-[4-[2-[(3-chlorophenyl)methylamino]ethyl]phenyl]thiophene-2-carboxamidine
  • N'-[4-[2-[(3-chlorophenyl)methylamino]ethyl]phenyl]-2-thiophenecarboxamidine
  • N'-[4-[2-[(3-chlorobenzyl)amino]ethyl]phenyl]thiophene-2-carboxamidine
  • ARR
  • N-(4-{2-[(3-CHLOROBENZYL)AMINO]ETHYL}PHENYL)THIOPHENE-2-CARBOXIMIDAMIDE

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Nitric-oxide synthase, brain No references
Homo sapiens nitric oxide synthase 2, inducible Starlite/ChEMBL References
Homo sapiens nitric oxide synthase 3 (endothelial cell) Starlite/ChEMBL References
Homo sapiens nitric oxide synthase 1 (neuronal) Starlite/ChEMBL References
Mus musculus nitric oxide synthase 2, inducible No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica type A flavoprotein, putative 0.007 0.0123 0.0717
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0033 0.0033
Schistosoma mansoni jumonji domain containing protein 0.0089 0.0169 0.0169
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0545 0.131 0.3826
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.072 0.1748 0.1748
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0004
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0141 0.03 0.0416
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1532 0.3777 0.3777
Giardia lamblia Hypothetical protein 0.0162 0.0353 0.2125
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0033 0.0034
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0222 0.0502 0.3002
Brugia malayi PXA domain containing protein 0.0022 0.0004 0.0004
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0004 0.0004
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.1532 0.3777 1
Schistosoma mansoni hypothetical protein 0.0092 0.0177 0.0177
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0183 0.0405 0.0657
Trichomonas vaginalis NADPH cytochrome P450, putative 0.007 0.0123 0.1604
Schistosoma mansoni hypothetical protein 0.0118 0.0244 0.0244
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0047 0.0047
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0141 0.03 0.03
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0047 0.0049
Onchocerca volvulus 0.0111 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0235
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0102 0.0102
Chlamydia trachomatis sulfite reductase 0.0113 0.023 0.0672
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0047 0.0283
Mycobacterium ulcerans pyruvate carboxylase 0.1532 0.3777 1
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0096 0.0096
Loa Loa (eye worm) beta-lactamase 0.0111 0.0227 0.0235
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0102 0.0102
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0056 0.0056
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0096 0.0096
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0374 0.0882 0.0915
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0124 0.0128
Schistosoma mansoni ran 0.0044 0.0057 0.0057
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1532 0.3777 0.3777
Onchocerca volvulus 0.0111 0.0227 1
Echinococcus multilocularis Biotin lipoyl attachment 0.0141 0.03 0.03
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0141 0.03 0.03
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0047 0.0047
Echinococcus multilocularis snurportin 1 0.0633 0.153 0.153
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0545 0.131 0.3469
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0057 0.0057
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.0296 0.0307
Plasmodium falciparum carbamoyl phosphate synthetase 0.0346 0.0813 0.1126
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0118 0.0244 0.0253
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0545 0.131 0.131
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.4022 1 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0033 0.0033
Onchocerca volvulus 0.0032 0.0028 0.1247
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0047 0.026
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0057 0.0057
Leishmania major GTP-binding protein, putative 0.0044 0.0057 0.0057
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0004 0.0004
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0004 0.0004
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0545 0.131 0.3469
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0141 0.03 0.0795
Echinococcus granulosus cpg binding protein 0.0034 0.0033 0.0033
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0545 0.131 0.3469
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0374 0.0882 0.0915
Echinococcus granulosus Protein patched homolog 1 0.0095 0.0186 0.0186
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0014 0.0019
Schistosoma mansoni cpg binding protein 0.0034 0.0033 0.0033
Trypanosoma cruzi p450 reductase, putative 0.0183 0.0405 0.0657
Schistosoma mansoni aspartate carbamoyltransferase 0.0346 0.0813 0.0813
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0068 0.011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0227 0.0227
Echinococcus granulosus peregrin 0.0034 0.0033 0.0033
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0227 0.06
Plasmodium falciparum phd finger protein, putative 0.0034 0.0033 0.0046
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0183 0.0405 0.0405
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0121 0.0321
Schistosoma mansoni hypothetical protein 0.0256 0.0587 0.0587
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0118 0.0244 0.0253
Leishmania major cytochrome P450 reductase, putative 0.0162 0.0353 0.0353
Schistosoma mansoni hypothetical protein 0.0118 0.0244 0.0244
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0225 0.051 0.051
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0057 0.0079
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0183 0.0405 0.0405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.0332 0.0332
Echinococcus multilocularis protein patched 0.0095 0.0186 0.0186
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0141 0.03 0.03
Schistosoma mansoni hypothetical protein 0.0092 0.0177 0.0177
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.007 0.0123 0.0199
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0141 0.03 0.0678
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0034 0.0033 0.0034
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.007 0.0123 0.017
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0004 0.0004
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0004 0.0004
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0141 0.03 0.03
Treponema pallidum pyruvate carboxylase subunit B 0.0141 0.03 1
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0141 0.03 0.03
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0121 0.0121
Loa Loa (eye worm) glutaminase 2 0.0319 0.0746 0.0773
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.01 0.01
Brugia malayi Carboxyl transferase domain containing protein 0.3881 0.9648 1
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.291 0.7222 1
Echinococcus granulosus snurportin 1 0.0633 0.153 0.153
Toxoplasma gondii ABC1 family protein 0.0111 0.0227 0.0227
Echinococcus multilocularis peregrin 0.0034 0.0033 0.0033
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0227 0.0235
Echinococcus granulosus methionine synthase reductase 0.0113 0.023 0.023
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0056 0.0056
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0227 0.06
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0113 0.023 0.023
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0545 0.131 0.3469
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0633 0.153 0.1586
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0048 0.0068 0.0387
Echinococcus granulosus Niemann Pick C1 protein 0.0317 0.0739 0.0739
Brugia malayi Calcitonin receptor-like protein seb-1 0.0374 0.0882 0.0915
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0545 0.131 0.3052
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0141 0.03 0.0416
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0227 0.06
Toxoplasma gondii flavodoxin domain-containing protein 0.0091 0.0175 0.0175
Brugia malayi Niemann-Pick C1 protein precursor 0.0222 0.0502 0.052
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0033 0.0046
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0545 0.131 0.2123
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0068 0.0866
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1532 0.3777 0.3777
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0227 0.0227
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0141 0.03 0.03
Echinococcus multilocularis protein dispatched 1 0.0109 0.0219 0.0219
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0712 0.1728 0.4574
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0047 0.0125
Loa Loa (eye worm) hypothetical protein 0.0183 0.0405 0.042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.0332 0.0332
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0004 0.0004
Brugia malayi PXA domain containing protein 0.0022 0.0004 0.0004
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0111 0.0227 0.0227
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0545 0.131 0.2123
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0056 0.0058
Schistosoma mansoni hypothetical protein 0.0118 0.0244 0.0244
Brugia malayi hypothetical protein 0.0026 0.0014 0.0014
Entamoeba histolytica type A flavoprotein, putative 0.007 0.0123 0.0717
Loa Loa (eye worm) hypothetical protein 0.0059 0.0096 0.01
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0141 0.03 0.03
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.1532 0.3777 1
Trypanosoma brucei acetyl-CoA carboxylase 0.4022 1 1
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.1532 0.3777 0.3777
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0141 0.03 0.0311
Loa Loa (eye worm) hypothetical protein 0.0141 0.03 0.0311
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0686 0.1662 1
Schistosoma mansoni microtubule-associated protein tau 0.1486 0.3662 0.3662
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0141 0.03 0.0486
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0141 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0058 0.0094 0.0097
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0227 0.0235
Mycobacterium ulcerans lipase LipD 0.0111 0.0227 0.06
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0141 0.03 0.0311
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0227 0.06
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0102 0.0106
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0118 0.0244 0.0244
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0545 0.131 0.131
Schistosoma mansoni importin beta-1 0.0059 0.0096 0.0096
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0227 0.06
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0047 0.0047
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0346 0.0813 0.1318
Entamoeba histolytica type A flavoprotein, putative 0.007 0.0123 0.0717
Echinococcus granulosus importin subunit beta 1 0.0059 0.0096 0.0096
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0141 0.03 0.03
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0222 0.0502 0.052
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0227 0.0367
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0121 0.0121
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0141 0.03 0.0207
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.1532 0.3777 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0028 0.0029
Echinococcus granulosus geminin 0.072 0.1748 0.1748
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0227 0.3002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0068 0.0866
Plasmodium falciparum importin beta, putative 0.0059 0.0096 0.0133
Brugia malayi hypothetical protein 0.0022 0.0004 0.0004
Entamoeba histolytica type A flavoprotein, putative 0.007 0.0123 0.0717
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0183 0.0405 0.0657
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0183 0.0405 0.0561
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0056 0.0056
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0102 0.0102
Brugia malayi PHD-finger family protein 0.0034 0.0033 0.0034
Trichomonas vaginalis sulfite reductase, putative 0.0183 0.0405 0.5409
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0545 0.131 0.131
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0227 0.06
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0004 0.0004
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0235
Treponema pallidum flavodoxin 0.007 0.0123 0.4095
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0141 0.03 0.0416
Echinococcus multilocularis geminin 0.072 0.1748 0.1748
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0141 0.03 0.0795
Loa Loa (eye worm) FAD binding domain-containing protein 0.0113 0.023 0.0239
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.007 0.0123 0.0123
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0545 0.131 0.131
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0118 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0004
Plasmodium vivax flavodoxin domain containing protein 0.0162 0.0353 0.0489
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0227 0.06
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0057 0.0343
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0014
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0183 0.0405 0.0405
Brugia malayi flavodoxin family protein 0.0183 0.0405 0.042
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0154 0.0332 0.0344
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0141 0.03 0.0795
Leishmania major importin beta-1 subunit, putative 0.0048 0.0068 0.0068
Trichomonas vaginalis ran, putative 0.0044 0.0057 0.0716
Mycobacterium tuberculosis Conserved protein 0.0111 0.0227 0.06
Brugia malayi flavodoxin family protein 0.007 0.0123 0.0127
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0102 0.0102
Brugia malayi Importin beta-1 subunit 0.0059 0.0096 0.01
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0004 0.0004
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.007 0.0123 0.017
Schistosoma mansoni hypothetical protein 0.0092 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0256 0.0587 0.0608
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.0457 0.1091 0.1091
Leishmania major hypothetical protein, conserved 0.007 0.0123 0.0123
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0346 0.0813 0.1318
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0102 0.0106
Echinococcus granulosus expressed protein 0.0436 0.1037 0.1037
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.291 0.7222 1
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0141 0.03 0.0486
Schistosoma mansoni hypothetical protein 0.0034 0.0033 0.0033
Echinococcus multilocularis GPCR, family 2 0.0118 0.0244 0.0244
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0545 0.131 0.131
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0047 0.0125
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0004 0.0004
Mycobacterium ulcerans hypothetical protein 0.0141 0.03 0.0795
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0047 0.0065
Loa Loa (eye worm) RNA binding protein 0.0062 0.0102 0.0106
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0227 0.3002
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0346 0.0813 0.0813
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.0296 0.0307
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0004 0.0004
Brugia malayi beta-lactamase family protein 0.0111 0.0227 0.0235
Brugia malayi TAR-binding protein 0.0062 0.0102 0.0106
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0183 0.0405 0.1073
Schistosoma mansoni hypothetical protein 0.0633 0.153 0.153
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0068 0.0866
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0118 0.0244 0.0244
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0545 0.131 0.3469
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.1532 0.3777 1
Mycobacterium tuberculosis Conserved protein 0.0111 0.0227 0.06
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0096 0.0096
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0141 0.03 0.03
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0102 0.0102
Onchocerca volvulus Alhambra homolog 0.0034 0.0033 0.1461
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0346 0.0813 0.0813
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0235
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0047 0.0065
Echinococcus granulosus GPCR family 2 0.0118 0.0244 0.0244
Echinococcus granulosus Biotin lipoyl attachment 0.0141 0.03 0.03
Giardia lamblia Nitric oxide synthase, inducible 0.0162 0.0353 0.2125
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0141 0.03 0.03
Leishmania major carboxylase, putative 0.1532 0.3777 0.3777
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0004 0.0004
Echinococcus multilocularis Niemann Pick C1 protein 0.0317 0.0739 0.0739
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0227 0.3002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0057 0.0059
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0057 0.0057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0154 0.0332 0.0344
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0004 0.0004
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0141 0.03 0.0876
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0186 0.245
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0545 0.131 0.3052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.0332 0.0332
Brugia malayi MH2 domain containing protein 0.0139 0.0296 0.0307
Echinococcus granulosus tar DNA binding protein 0.0062 0.0102 0.0102
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0047 0.0076
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.1532 0.3777 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0014 0.0019
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.3881 0.9648 1
Brugia malayi hypothetical protein 0.0022 0.0004 0.0004
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0545 0.131 0.3469
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0004 0.0004
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0004 0.0004
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0227 0.06
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0004 0.0004
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0141 0.03 0.0207
Brugia malayi CXXC zinc finger family protein 0.0032 0.0028 0.0029
Trichomonas vaginalis esterase, putative 0.0111 0.0227 0.3002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0118 0.0118
Brugia malayi latrophilin 2 splice variant baaae 0.0256 0.0587 0.0608
Toxoplasma gondii carbamoylphosphate synthetase 0.0346 0.0813 0.0813
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0033 0.0033
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0141 0.03 0.03
Chlamydia trachomatis biotin carboxylase 0.1391 0.3425 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0033 0.0033
Brugia malayi Latrophilin receptor protein 2 0.0118 0.0244 0.0253
Schistosoma mansoni glutaminase 0.0319 0.0746 0.0746
Toxoplasma gondii flavodoxin domain-containing protein 0.0091 0.0175 0.0175
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0004 0.0004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0057 0.0092
Schistosoma mansoni hypothetical protein 0.072 0.1748 0.1748
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0154 0.0332 0.0332
Leishmania major hypothetical protein, conserved 0.0111 0.0227 0.0227
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0004 0.0004
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0141 0.03 0.03
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0121 0.0121
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0545 0.131 0.3469
Mycobacterium ulcerans beta-lactamase 0.0111 0.0227 0.06
Loa Loa (eye worm) hypothetical protein 0.0095 0.0186 0.0192
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0141 0.03 0.03
Brugia malayi jmjC domain containing protein 0.0043 0.0056 0.0058
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0004 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0374 0.0882 0.0915
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0154 0.0332 0.0332
Entamoeba histolytica Ran family GTPase 0.0044 0.0057 0.032
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0141 0.03 0.03
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0014 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0227 0.0314
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0004 0.0004
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0545 0.131 0.3052
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0121 0.0121
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0047 0.0047
Brugia malayi CHE-14 protein 0.0095 0.0186 0.0192
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0183 0.0405 0.0405
Schistosoma mansoni ap endonuclease 0.004 0.0047 0.0047
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.1532 0.3777 0.3777
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0066 0.0066
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0121 0.0321
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0111 0.0227 0.0227
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0346 0.0813 0.0813
Loa Loa (eye worm) flavodoxin family protein 0.007 0.0123 0.0127
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0118 0.0244 0.0244
Leishmania major acetyl-CoA carboxylase, putative 0.4022 1 1
Brugia malayi Bromodomain containing protein 0.0034 0.0033 0.0034
Schistosoma mansoni cpg binding protein 0.0034 0.0033 0.0033
Schistosoma mansoni ran 0.0044 0.0057 0.0057
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0686 0.1662 1
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0545 0.131 0.3387
Brugia malayi glutaminase DH11.1 0.0319 0.0746 0.0773
Brugia malayi jmjC domain containing protein 0.0111 0.0227 0.0235
Brugia malayi beta-lactamase 0.0111 0.0227 0.0235
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0346 0.0813 0.2055
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0004 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0121 0.0121
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0141 0.03 0.03
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.4022 1 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.0183 0.0405 0.042
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0545 0.131 0.3469
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0004 0.0004
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0141 0.03 0.0311
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0141 0.03 0.0876
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0057 0.0079
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0004 0.0004
Schistosoma mansoni regulator of G protein signaling 0.0026 0.0012 0.0012
Mycobacterium ulcerans glutaminase 0.0319 0.0746 0.1974
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0004 0.0004
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0047 0.1568
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0047 0.0049
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0141 0.03 0.03
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0141 0.03 0.0486
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0141 0.03 0.0876
Schistosoma mansoni patched 1 0.0095 0.0186 0.0186
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0141 0.03 0.0486
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0183 0.0405 0.0657
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0183 0.0405 0.0405
Brugia malayi RNA binding protein 0.0062 0.0102 0.0106
Toxoplasma gondii pyruvate carboxylase 0.1532 0.3777 0.3777
Entamoeba histolytica type A flavoprotein, putative 0.007 0.0123 0.0717
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0346 0.0813 0.1126
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0545 0.131 0.131
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0235
Leishmania major carbamoyl-phosphate synthase, putative 0.0346 0.0813 0.0813
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0183 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0235
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0227 0.0367
Plasmodium vivax importin-beta 2, putative 0.0059 0.0096 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0102 0.0102
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0346 0.0813 0.2154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0118 0.0244 0.0244
Echinococcus multilocularis expressed conserved protein 0.0208 0.0468 0.0468
Onchocerca volvulus 0.0111 0.0227 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0033 0.0033
Trypanosoma brucei unspecified product 0.1007 0.2465 0.2465
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0183 0.0405 0.0405
Echinococcus multilocularis microtubule associated protein 2 0.1486 0.3662 0.3662
Loa Loa (eye worm) hypothetical protein 0.0141 0.03 0.0311
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0141 0.03 0.0795
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0004 0.0004
Brugia malayi beta-lactamase family protein 0.0111 0.0227 0.0235
Echinococcus granulosus sterol regulatory element binding protein 0.0095 0.0186 0.0186
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0014 0.0022
Schistosoma mansoni cpg binding protein 0.0032 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0121 0.0321
Loa Loa (eye worm) glutaminase 0.0319 0.0746 0.0773
Brugia malayi FAD binding domain containing protein 0.0183 0.0405 0.042
Trichomonas vaginalis glutaminase, putative 0.0319 0.0746 1
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0545 0.131 0.2123
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0141 0.03 0.0416
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.1091 0.1091
Schistosoma mansoni acetyl-CoA carboxylase 0.4022 1 1
Echinococcus multilocularis methionine synthase reductase 0.0113 0.023 0.023
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0141 0.03 0.0678
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0154 0.0332 0.0332
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0141 0.03 0.0486
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0047 0.0581
Plasmodium vivax hypothetical protein, conserved 0.007 0.0123 0.017
Trichomonas vaginalis NADPH cytochrome P450, putative 0.007 0.0123 0.1604
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.1532 0.3777 1
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1532 0.3777 0.612
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0004 0.0004
Trypanosoma cruzi acetyl-CoA carboxylase 0.249 0.6171 1
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0141 0.03 0.0876
Echinococcus multilocularis expressed protein 0.0436 0.1037 0.1037
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0141 0.03 0.0416
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0047 0.0076
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0004 0.0004
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1532 0.3777 0.612
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0141 0.03 0.03
Brugia malayi FAD binding domain containing protein 0.0113 0.023 0.0239
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0004 0.0004
Giardia lamblia PHD finger protein 15 0.0034 0.0033 0.0199
Trichomonas vaginalis NADPH cytochrome P450, putative 0.007 0.0123 0.1604
Mycobacterium tuberculosis Conserved protein 0.0111 0.0227 0.06
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.1532 0.3777 0.3777
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0057 0.0059
Schistosoma mansoni ap endonuclease 0.004 0.0047 0.0047
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0227 0.06
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0121 0.0321
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0183 0.0405 0.0405
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0141 0.03 0.03
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.4022 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0227 0.3002
Schistosoma mansoni NADPH flavin oxidoreductase 0.0092 0.0178 0.0178
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0004 0.0004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0227 0.0227
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0162 0.0353 0.4709
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0004
Schistosoma mansoni cytochrome P450 reductase 0.0183 0.0405 0.0405
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0095 0.0186 0.0192
Trichomonas vaginalis NADPH cytochrome P450, putative 0.007 0.0123 0.1604
Echinococcus multilocularis Niemann Pick C1 protein 0.0222 0.0502 0.0502
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0141 0.03 0.0486
Echinococcus multilocularis sterol regulatory element binding protein 0.0095 0.0186 0.0186
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0102 0.0106
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0227 0.3002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0118 0.0244 0.0253
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.1532 0.3777 1
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0141 0.03 0.0795
Toxoplasma gondii exonuclease III APE 0.004 0.0047 0.0047
Echinococcus multilocularis cpg binding protein 0.0034 0.0033 0.0033
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0004 0.0004
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0004 0.0004
Schistosoma mansoni diflavin oxidoreductase 0.0091 0.0175 0.0175
Schistosoma mansoni pyruvate carboxylase 0.1532 0.3777 0.3777
Leishmania major p450 reductase, putative 0.0183 0.0405 0.0405
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0026 0.0014 0.0014
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0183 0.0405 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0004 0.0004
Echinococcus granulosus Niemann Pick C1 protein 0.0222 0.0502 0.0502
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0047 0.0581
Echinococcus granulosus dnaJ subfamily B 0.0457 0.1091 0.1091
Schistosoma mansoni hypothetical protein 0.0092 0.0177 0.0177
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0057 0.0092
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0545 0.131 0.131
Brugia malayi RNA, U transporter 1 0.0169 0.0369 0.0383
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0141 0.03 0.0486
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.007 0.0123 0.0199
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0004 0.0004
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0014 0.0014
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0004 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0227 0.0227
Echinococcus granulosus expressed conserved protein 0.0208 0.0468 0.0468
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0004 0.0004
Echinococcus granulosus microtubule associated protein 2 0.1486 0.3662 0.3662
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0141 0.03 0.03
Plasmodium falciparum nitric oxide synthase, putative 0.0183 0.0405 0.0561
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0004 0.0004
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0004 0.0004
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0141 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0111 0.0227 0.0235
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1532 0.3777 0.3777
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0051 0.0051
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0004 0.0004
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0141 0.03 0.0311
Loa Loa (eye worm) hypothetical protein 0.0116 0.0239 0.0248
Mycobacterium ulcerans hypothetical protein 0.0111 0.0227 0.06
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.007 0.0123 0.0199

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of wild type rat nNOS at 420 nM by hemoglobin capture assay ChEMBL. 19537690
IC50 (binding) = 35 nM Inhibition Assay BINDINGDB. No reference
IC50 (binding) = 3500 nM Inhibition Assay BINDINGDB. No reference
IC50 (binding) = 5000 nM Inhibition Assay BINDINGDB. No reference
IC50 (binding) = 0.035 uM Inhibitory concentration of the compound against recombinant human (neuronal nitric oxide synthase) n-NOS ChEMBL. 12781178
IC50 (binding) = 0.035 uM Inhibitory concentration of the compound against recombinant human (neuronal nitric oxide synthase) n-NOS ChEMBL. 12781178
IC50 (binding) = 3.5 uM Inhibitory concentration against recombinant human Endothelial nitric oxide synthase ChEMBL. 12781178
IC50 (binding) = 3.5 uM Inhibitory concentration against recombinant human Endothelial nitric oxide synthase ChEMBL. 12781178
IC50 (binding) = 5 uM Inhibitory concentration against human Inducible nitric oxide synthase ChEMBL. 12781178
IC50 (binding) = 5 uM Inhibitory concentration against human Inducible nitric oxide synthase ChEMBL. 12781178
Selectivity (binding) = 100 Selectivity as ratio of IC50(e-NOS)/IC50(n-NOS) ChEMBL. 12781178
Selectivity (binding) = 143 Selectivity ratio as IC50(i-NOS)/IC50 (n-NOS) ChEMBL. 12781178

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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