Detailed information for compound 906422

Basic information

Technical information
  • TDR Targets ID: 906422
  • Name: N'-(4-methylphenyl)-N-[(1-phenylsulfonylpyrro lidin-2-yl)methyl]oxamide
  • MW: 401.479 | Formula: C20H23N3O4S
  • H donors: 2 H acceptors: 4 LogP: 2.57 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)NC(=O)C(=O)NCC1CCCN1S(=O)(=O)c1ccccc1
  • InChi: 1S/C20H23N3O4S/c1-15-9-11-16(12-10-15)22-20(25)19(24)21-14-17-6-5-13-23(17)28(26,27)18-7-3-2-4-8-18/h2-4,7-12,17H,5-6,13-14H2,1H3,(H,21,24)(H,22,25)
  • InChiKey: INALPJTXMWROPL-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N'-(4-methylphenyl)-N-[(1-phenylsulfonyl-2-pyrrolidinyl)methyl]oxamide
  • N'-(4-methylphenyl)-N-[(1-phenylsulfonylpyrrolidin-2-yl)methyl]ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei antigen, putative 0.0017 0.0558 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.006 0.2701 0.2701
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0206 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0037 0.1577 1
Trypanosoma brucei calpain-like protein, putative 0.0017 0.0558 0.5
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0008 0.0111 0.0111
Echinococcus multilocularis calpain 7 (C02 family) 0.0017 0.0558 0.0558
Echinococcus granulosus calpain 5 0.0017 0.0558 0.0558
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0164 0.0164
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0164 0.0229
Schistosoma mansoni dishevelled 0.0008 0.0111 0.0155
Schistosoma mansoni hypothetical protein 0.006 0.2701 0.3772
Loa Loa (eye worm) hypothetical protein 0.0009 0.0164 0.0164
Trypanosoma cruzi kinesin, putative 0.0017 0.0558 1
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0008 0.0111 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0164 0.0164
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0111 0.0111
Onchocerca volvulus 0.0008 0.0111 0.0146
Loa Loa (eye worm) DIX domain-containing protein 0.0008 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0009 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0008 0.0111 0.0111
Onchocerca volvulus 0.0039 0.1691 0.2234
Brugia malayi nuclear hormone receptor 0.0009 0.0164 0.0164
Echinococcus multilocularis calpain A 0.0059 0.2667 0.2667
Loa Loa (eye worm) hypothetical protein 0.0056 0.2524 0.2524
Schistosoma mansoni tar DNA-binding protein 0.0056 0.2504 0.3498
Brugia malayi ecdysteroid receptor 0.0009 0.0164 0.0164
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0164 0.0164
Brugia malayi hypothetical protein 0.0008 0.0111 0.0111
Schistosoma mansoni dishevelled 0.0008 0.0111 0.0155
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0126 0.6023 0.6023
Echinococcus multilocularis calpain 0.0017 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0009 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0009 0.0164 0.0164
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0164 0.0229
Echinococcus granulosus histone acetyltransferase KAT2B 0.0037 0.1577 0.1577
Loa Loa (eye worm) calpain 0.0017 0.0558 0.0558
Brugia malayi TAR-binding protein 0.0056 0.2504 0.2504
Echinococcus granulosus calpain A 0.0017 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0149 0.7159 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0123 0.5846 0.5846
Brugia malayi calpain 5 0.0017 0.0558 0.0558
Brugia malayi latrophilin 2 splice variant baaae 0.006 0.2701 0.2701
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0164 0.0164
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0111 0.0111
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0008 0.0111 0.0146
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0037 0.1577 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0164 0.0164
Echinococcus multilocularis survival motor neuron protein 1 0.0206 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0164 0.0164
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0558 0.5
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0558 1
Schistosoma mansoni calpain-7 (C02 family) 0.0017 0.0558 0.0779
Echinococcus granulosus survival motor neuron protein 1 0.0206 1 1
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.1691 0.1691
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0558 0.5
Brugia malayi hypothetical protein 0.0008 0.0111 0.0111
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0164 0.0217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0164 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0164 0.0164
Echinococcus granulosus GPCR family 2 0.0028 0.1102 0.1102
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0164 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0056 0.2504 0.3498
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0037 0.1577 1
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0164 0.0164
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0164 0.0164
Echinococcus granulosus Pleckstrin G protein interacting region 0.0008 0.0111 0.0111
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0164 0.0164
Entamoeba histolytica protein kinase, putative 0.0017 0.0558 0.392
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0164 0.0229
Loa Loa (eye worm) hypothetical protein 0.0056 0.2524 0.2524
Brugia malayi DIX domain containing protein 0.0008 0.0111 0.0111
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0017 0.0558 1
Brugia malayi nuclear receptor NHR-88 0.0009 0.0164 0.0164
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0157 0.7569 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0164 0.0164
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0558 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.2524 0.3526
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0017 0.0558 1
Loa Loa (eye worm) acetyltransferase 0.0126 0.6023 0.6023
Loa Loa (eye worm) hypothetical protein 0.0039 0.1691 0.1691
Trypanosoma brucei calpain-like protein, putative 0.0017 0.0558 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0164 0.0229
Onchocerca volvulus 0.0009 0.0164 0.0217
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0164 0.0229
Schistosoma mansoni hypothetical protein 0.0028 0.1102 0.154
Loa Loa (eye worm) RNA binding protein 0.0056 0.2504 0.2504
Echinococcus granulosus calpain 0.0017 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0028 0.1102 0.154
Brugia malayi calpain 7 0.0017 0.0558 0.0558
Brugia malayi calpain family protein 1 0.0056 0.2524 0.2524
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0087 0.4078 0.4078
Brugia malayi Latrophilin receptor protein 2 0.0028 0.1102 0.1102
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0164 0.0164
Schistosoma mansoni dep domain containing protein 0.0008 0.0111 0.0155
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0111 0.0111
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0008 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0149 0.7159 1
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0111 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0164 0.0164
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0164 0.0164
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0037 0.1577 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.1102 0.1102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0164 0.0164
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0164 0.0229
Brugia malayi Calcitonin receptor-like protein seb-1 0.0087 0.4078 0.4078
Trypanosoma brucei calpain-like protein, putative 0.0017 0.0558 0.5
Schistosoma mansoni Mername-AA248 (C02 family) 0.0017 0.0558 0.0779
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0017 0.0558 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.1102 0.1102
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.1821 0.1821
Leishmania major kinesin, putative 0.0017 0.0558 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0164 0.0217
Loa Loa (eye worm) TAR-binding protein 0.0056 0.2504 0.2504
Echinococcus granulosus geminin 0.0149 0.7159 0.7159
Schistosoma mansoni hypothetical protein 0.0028 0.1102 0.154
Schistosoma mansoni calpain (C02 family) 0.0017 0.0558 0.0779
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0164 0.0164
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0111 0.0111
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0059 0.2667 0.2667
Loa Loa (eye worm) calpain family protein 1 0.0056 0.2524 0.2524
Giardia lamblia Histone acetyltransferase GCN5 0.0034 0.1423 0.5
Trypanosoma brucei calpain-like protein, putative 0.0017 0.0558 0.5
Echinococcus granulosus calpain A 0.0059 0.2667 0.2667
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0039 0.1691 0.1691
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.1102 0.1102
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0164 0.0164
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0017 0.0558 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0087 0.4078 0.4078
Echinococcus multilocularis hypothetical protein 0.0017 0.0558 0.0558
Brugia malayi RNA recognition motif domain containing protein 0.0056 0.2504 0.2504
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0009 0.0164 0.0164
Schistosoma mansoni calpain C (C02 family) 0.0017 0.0558 0.0779
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0087 0.4078 0.4078
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0164 0.0229
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0017 0.0558 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0164 0.0217
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0558 0.5
Schistosoma mansoni tar DNA-binding protein 0.0056 0.2504 0.3498
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0558 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0164 0.0164
Brugia malayi regulator of G-protein signaling egl-10 0.0008 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0008 0.0111 0.0111
Trypanosoma brucei kinesin, putative 0.0017 0.0558 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0111 0.0111
Echinococcus granulosus tar DNA binding protein 0.0056 0.2504 0.2504
Entamoeba histolytica calpain large subunit domain III containing protein 0.0017 0.0558 0.392
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0164 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0056 0.2504 0.3498
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0164 0.0164
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0111 0.0111
Schistosoma mansoni z-protein (S1r protein) 0.0008 0.0111 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0157 0.7569 0.7569
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0111 0.0111
Loa Loa (eye worm) calpain 5 0.0017 0.0558 0.0558
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0164 0.0229
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0111 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0164 0.0164
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0111 0.0111
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0164 0.0164
Echinococcus multilocularis calpain 5 0.0017 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0042 0.1821 0.2543
Brugia malayi acetyltransferase, GNAT family protein 0.0126 0.6023 0.6023
Loa Loa (eye worm) hypothetical protein 0.0009 0.0164 0.0164
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.2667 0.3725
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0558 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0164 0.0164
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0558 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.1102 0.1102
Echinococcus granulosus calpain 7 C02 family 0.0017 0.0558 0.0558
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0164 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0056 0.2504 0.3498
Schistosoma mansoni regulator of G protein signaling 0.0008 0.0111 0.0155
Onchocerca volvulus 0.0042 0.1821 0.2405
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0017 0.0558 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0164 0.0164
Entamoeba histolytica acetyltransferase, GNAT family 0.0034 0.1423 1
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0164 0.0229
Loa Loa (eye worm) calpain family protein 1 0.0039 0.1691 0.1691
Trypanosoma cruzi kinesin, putative 0.0017 0.0558 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0164 0.0164
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0059 0.2667 0.2667
Schistosoma mansoni calpain-7 (C02 family) 0.0017 0.0558 0.0779
Plasmodium falciparum histone acetyltransferase GCN5 0.0034 0.1423 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0037 0.1577 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0164 0.0164
Brugia malayi calpain family protein 1 0.0056 0.2524 0.2524
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0164 0.0229
Loa Loa (eye worm) hypothetical protein 0.0009 0.0164 0.0164
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0126 0.6023 0.8413
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0017 0.0558 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0164 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0164 0.0164
Brugia malayi RNA binding protein 0.0056 0.2504 0.2504
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0111 0.0111
Brugia malayi steroid hormone receptor 0.0009 0.0164 0.0164
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.1102 0.1102
Schistosoma mansoni survival motor neuron protein 0.0042 0.1821 0.2543
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0164 0.0164
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0164 0.0229
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0164 0.0164
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0164 0.0164
Echinococcus multilocularis geminin 0.0149 0.7159 0.7159
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0164 0.0164
Echinococcus multilocularis GPCR, family 2 0.0028 0.1102 0.1102
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.1102 0.1102
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0164 0.0229
Brugia malayi N-terminal motif family protein 0.0157 0.7569 0.7569
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.2667 0.3725
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0028 0.1102 0.154
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0056 0.2504 0.2504
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0164 0.0164
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.1102 0.1102
Schistosoma mansoni coup transcription factor 0.0009 0.0164 0.0229
Echinococcus multilocularis tar DNA binding protein 0.0056 0.2504 0.2504

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.