TDR Targets

Basic information

Technical information

TDR Targets ID: 906560
Name: N-[2-(3,4-dimethylphenyl)-4-oxoquinazolin-3-y l]-2-methylbenzamide
MW: 383.442 | Formula: C24H21N3O2
H donors: 1 H acceptors: 2 LogP: 4.79 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(ccc1C)c1nc2ccccc2c(=O)n1NC(=O)c1ccccc1C
InChi: 1S/C24H21N3O2/c1-15-12-13-18(14-17(15)3)22-25-21-11-7-6-10-20(21)24(29)27(22)26-23(28)19-9-5-4-8-16(19)2/h4-14H,1-3H3,(H,26,28)
InChiKey: JLDAGTHWJWDDAS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(3,4-dimethylphenyl)-4-oxo-quinazolin-3-yl]-2-methyl-benzamide
N-[2-(3,4-dimethylphenyl)-4-oxo-3-quinazolinyl]-2-methylbenzamide
N-[2-(3,4-dimethylphenyl)-4-keto-quinazolin-3-yl]-2-methyl-benzamide
Oprea1_688546

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0028	0.0622	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0074	0.154
Brugia malayi	Carboxylesterase family protein	0.0022	0.0483	0.1119
Echinococcus multilocularis	cpg binding protein	0.0029	0.0662	0.0578
Trichomonas vaginalis	spcc417.12 protein, putative	0.0022	0.0483	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0074	0.154
Brugia malayi	TAR-binding protein	0.0061	0.1476	0.4271
Loa Loa (eye worm)	RNA binding protein	0.0061	0.1476	0.4266
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0132	0.3281	0.327
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0483	0.0468
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.009	0.0074
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0133	0.0044
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0133	0.0044
Brugia malayi	Carboxylesterase family protein	0.0132	0.3281	1
Echinococcus granulosus	acetylcholinesterase	0.0132	0.3281	0.322
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0483	0.1111
Brugia malayi	Carboxylesterase family protein	0.0022	0.0483	0.1119
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0022	0.0483	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1476	0.1463
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0483	0.1111
Schistosoma mansoni	cpg binding protein	0.0029	0.0662	0.0648
Echinococcus granulosus	para nitrobenzyl esterase	0.0022	0.0483	0.0397
Echinococcus multilocularis	carboxylesterase 5A	0.0132	0.3281	0.322
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0622	0.1561
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0483	0.1111
Brugia malayi	Carboxylesterase family protein	0.0022	0.0483	0.1119
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0022	0.0483	0.0397
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0022	0.0483	0.0468
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0074	0.154
Echinococcus multilocularis	neuroligin	0.0022	0.0483	0.0397
Echinococcus multilocularis	acetylcholinesterase	0.0132	0.3281	0.322
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1476	0.1463
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0483	0.1111
Echinococcus multilocularis	para nitrobenzyl esterase	0.0022	0.0483	0.0397
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0022	0.0483	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0483	0.1111
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0074	0.154
Mycobacterium ulcerans	carboxylesterase, LipT	0.0022	0.0483	0.5
Loa Loa (eye worm)	hypothetical protein	0.0132	0.3281	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0074	0.154
Brugia malayi	hypothetical protein	0.0022	0.0483	0.1119
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0074	0.154
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.1476	0.1399
Loa Loa (eye worm)	acetylcholinesterase 1	0.0132	0.3281	1
Echinococcus granulosus	cpg binding protein	0.0029	0.0662	0.0578
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0022	0.0483	0.0397
Schistosoma mansoni	acetylcholinesterase	0.0022	0.0483	0.0468
Schistosoma mansoni	cpg binding protein	0.0028	0.0622	0.0608
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0074	0.154
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0074	0.154
Echinococcus granulosus	BC026374 protein S09 family	0.0022	0.0483	0.0397
Echinococcus multilocularis	acetylcholinesterase	0.0132	0.3281	0.322
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0074	0.154
Echinococcus granulosus	acetylcholinesterase	0.0132	0.3281	0.322
Schistosoma mansoni	hypothetical protein	0.0396	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0483	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0483	0.1111
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0022	0.0483	0.0397
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.1476	0.4266
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0074	0.154
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0074	0.154
Loa Loa (eye worm)	hypothetical protein	0.0132	0.3281	1
Brugia malayi	Carboxylesterase family protein	0.0132	0.3281	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0483	0.1111
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0074	0.154
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0622	0.1554
Trichomonas vaginalis	helicase, putative	0.0006	0.0074	0.154
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0022	0.0483	0.5
Loa Loa (eye worm)	carboxylesterase	0.0132	0.3281	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0483	0.1111
Echinococcus granulosus	tar DNA binding protein	0.0061	0.1476	0.1399
Brugia malayi	RNA binding protein	0.0061	0.1476	0.4271
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1416	0.1403
Schistosoma mansoni	cpg binding protein	0.0029	0.0662	0.0648
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.1476	0.4266
Echinococcus granulosus	neuroligin	0.0022	0.0483	0.0397
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0074	0.154
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0074	0.154
Brugia malayi	Carboxylesterase family protein	0.0022	0.0483	0.1119
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1476	0.1463
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1476	0.1463
Schistosoma mansoni	gliotactin	0.0022	0.0483	0.0468
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.1256	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.1476	0.4271
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0074	0.154
Echinococcus multilocularis	dnaJ subfamily B	0.0396	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0483	0.0468
Schistosoma mansoni	BC026374 protein (S09 family)	0.0022	0.0483	0.0468
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0022	0.0483	0.5
Echinococcus granulosus	carboxylesterase 5A	0.0132	0.3281	0.322
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0074	0.154
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0483	0.1111
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1476	0.1463
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0074	0.154

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 906560