Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | methionyl-tRNA synthetase | 0.0065 | 0.0467 | 0.038 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0065 | 0.046 | 0.1043 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.0599 | 0.0632 |
Brugia malayi | Isocitrate dehydrogenase | 0.0065 | 0.046 | 0.0374 |
Plasmodium falciparum | methionine--tRNA ligase, putative | 0.0065 | 0.0467 | 0.2694 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0171 | 0.1732 | 0.5599 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0359 | 0.3993 | 1 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0171 | 0.1732 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0599 | 0.3457 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0065 | 0.0467 | 0.5 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0312 | 0.0224 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0065 | 0.0467 | 0.102 |
Loa Loa (eye worm) | RNA binding protein | 0.0256 | 0.2753 | 0.2617 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0065 | 0.0467 | 0.2694 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0467 | 0.0287 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0611 | 0.7016 | 0.696 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0588 | 0.6736 | 0.6707 |
Schistosoma mansoni | hypothetical protein | 0.0588 | 0.6736 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0052 | 0.0312 | 0.1801 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0611 | 0.7016 | 0.696 |
Loa Loa (eye worm) | hypothetical protein | 0.0588 | 0.6736 | 0.6675 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0171 | 0.1732 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0065 | 0.046 | 0.1043 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0599 | 0.3457 |
Plasmodium vivax | hypothetical protein, conserved | 0.0065 | 0.0467 | 0.2694 |
Echinococcus granulosus | GPCR family 2 | 0.0272 | 0.2949 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0065 | 0.046 | 0.1043 |
Brugia malayi | TAR-binding protein | 0.0256 | 0.2753 | 0.2688 |
Brugia malayi | isocitrate dehydrogenase | 0.0065 | 0.046 | 0.0374 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0065 | 0.046 | 0.1216 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0065 | 0.0467 | 0.102 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0312 | 0.013 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0065 | 0.0467 | 0.1089 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0467 | 0.0287 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0065 | 0.046 | 0.0997 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0065 | 0.046 | 0.0997 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0065 | 0.0467 | 0.102 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0065 | 0.046 | 0.042 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0599 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2753 | 0.3921 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0272 | 0.2949 | 0.2816 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0065 | 0.046 | 0.2657 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0467 | 0.0287 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.086 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.2949 | 0.2816 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0185 | 0.0096 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0256 | 0.2753 | 0.2688 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0171 | 0.1732 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0185 | 0.0096 |
Echinococcus granulosus | tar DNA binding protein | 0.0256 | 0.2753 | 0.9293 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0599 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0272 | 0.2949 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0272 | 0.2949 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0599 | 0.3457 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0312 | 0.1801 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.2949 | 0.4219 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0599 | 0.3457 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0065 | 0.046 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.3993 | 0.388 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2753 | 0.3921 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0065 | 0.046 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.086 | 1 | 1 |
Brugia malayi | protein ZK524.3 | 0.0065 | 0.0467 | 0.038 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0171 | 0.1732 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0171 | 0.1732 | 0.2362 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0599 | 0.0422 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0256 | 0.2753 | 0.2617 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0065 | 0.0467 | 0.043 |
Brugia malayi | Smad1 | 0.0042 | 0.0185 | 0.0096 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0599 | 0.1045 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0065 | 0.046 | 0.1043 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.2949 | 0.4219 |
Brugia malayi | N-terminal motif family protein | 0.0359 | 0.3993 | 0.3938 |
Brugia malayi | MH1 domain containing protein | 0.0042 | 0.0185 | 0.0096 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0065 | 0.046 | 0.0281 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0052 | 0.0312 | 0.1801 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0272 | 0.2949 | 0.2885 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0272 | 0.2949 | 1 |
Brugia malayi | RNA binding protein | 0.0256 | 0.2753 | 0.2688 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0171 | 0.1732 | 0.1577 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.086 | 1 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0065 | 0.0467 | 0.7791 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0171 | 0.1732 | 1 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0065 | 0.0467 | 0.7791 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0599 | 0.1045 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0171 | 0.1732 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0599 | 0.1498 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0065 | 0.0467 | 0.2694 |
Brugia malayi | MH2 domain containing protein | 0.0611 | 0.7016 | 0.6989 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0171 | 0.1732 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0284 | 0.036 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0065 | 0.046 | 0.2657 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0171 | 0.1732 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0042 | 0.0185 | 0.0096 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0171 | 0.1732 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0272 | 0.2949 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0065 | 0.046 | 0.2657 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0171 | 0.1732 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0065 | 0.046 | 0.0997 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0171 | 0.1732 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2753 | 0.3921 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.2949 | 0.4219 |
Loa Loa (eye worm) | TAR-binding protein | 0.0256 | 0.2753 | 0.2617 |
Schistosoma mansoni | hypothetical protein | 0.0272 | 0.2949 | 0.4219 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0599 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0065 | 0.046 | 0.2657 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0284 | 0.036 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0599 | 0.1498 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2753 | 0.3921 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0171 | 0.1732 | 0.5599 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0599 | 0.1045 |
Echinococcus multilocularis | tar DNA binding protein | 0.0256 | 0.2753 | 0.9293 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0272 | 0.2949 | 0.2885 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0171 | 0.1732 | 1 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0106 | 0.0951 | 0.0781 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0312 | 0.1801 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 0.2753 | 0.3921 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0065 | 0.046 | 0.1043 |
Brugia malayi | methionyl-tRNA synthetase | 0.0171 | 0.1732 | 0.1657 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.0599 | 0.0514 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0065 | 0.0467 | 0.043 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.0599 | 0.3457 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.0284 | 0.164 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0272 | 0.2949 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0065 | 0.046 | 0.0997 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.