Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0134 | 0.0134 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0134 | 0.0153 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0751 | 0.086 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.2081 | 0.2081 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0134 | 0.0134 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0134 | 0.0153 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.4649 | 0.4649 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0134 | 0.0153 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.2081 | 0.2081 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0134 | 0.0134 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.2081 | 0.2381 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0134 | 0.0153 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0134 | 0.0153 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0134 | 0.0134 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.4649 | 0.532 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0751 | 0.086 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.2081 | 0.2081 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0751 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0134 | 0.0134 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0134 | 0.0153 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0134 | 0.0153 |
Onchocerca volvulus | 0.001 | 0.0134 | 0.5 | |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0751 | 0.0751 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0107 | 0.8157 | 0.8157 |
Brugia malayi | RNA binding protein | 0.0065 | 0.4649 | 0.4649 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.2081 | 0.2381 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0751 | 0.086 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.4649 | 0.532 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0134 | 0.0153 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.2081 | 0.2381 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0751 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0134 | 0.0153 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0134 | 0.0153 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.8739 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0134 | 0.0134 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.2081 | 0.2381 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0134 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0134 | 0.0153 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0751 | 0.086 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0751 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.5345 | 0.5345 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0751 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.5345 | 0.5345 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0134 | 0.0153 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0751 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.2081 | 0.2381 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0134 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0134 | 0.0134 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0134 | 0.0153 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0134 | 0.0134 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0134 | 0.0134 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0134 | 0.0134 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0134 | 0.0134 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0134 | 0.0134 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0134 | 0.0153 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0751 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2081 | 0.2081 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0114 | 0.8739 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0751 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.2081 | 0.2381 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0751 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.8157 | 0.8157 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0107 | 0.8157 | 0.8157 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0134 | 0.0134 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0134 | 0.0153 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.5345 | 0.6116 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0134 | 0.0153 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.2081 | 0.2381 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0751 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.8739 | 0.5 |
Brugia malayi | hypothetical protein | 0.0114 | 0.8739 | 0.8739 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0134 | 0.0153 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.4649 | 0.4649 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0134 | 0.0153 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0751 | 0.0751 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0134 | 0.0153 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0134 | 0.0153 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.4649 | 0.4649 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0134 | 0.0153 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0134 | 0.0153 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0751 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.4649 | 0.532 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.4649 | 0.4649 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.2081 | 0.2381 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0751 | 0.086 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0107 | 0.8157 | 0.8157 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0134 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0134 | 0.0153 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.2081 | 0.2381 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0134 | 0.0134 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0751 | 0.086 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0134 | 0.0153 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0134 | 0.0153 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0134 | 0.0134 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.4649 | 0.532 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0134 | 0.0134 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0114 | 0.8739 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.8739 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0114 | 0.8739 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.8739 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0134 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.8739 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0751 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0134 | 0.0153 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0134 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0134 | 0.0134 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0751 | 0.0751 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0134 | 0.0134 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.4649 | 0.4649 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0134 | 0.0153 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.4649 | 0.532 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.2081 | 0.2381 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0134 | 0.0153 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.4649 | 0.532 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0134 | 0.0134 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.4649 | 0.532 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0134 | 0.0153 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0134 | 0.0134 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0134 | 0.0153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.