Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0326 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.015 | 0.0097 |
Brugia malayi | MH2 domain containing protein | 0.0033 | 0.044 | 0.0389 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0033 | 0.044 | 0.0968 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0127 | 0.0075 |
Loa Loa (eye worm) | Smad1 | 0.0033 | 0.044 | 0.0389 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0809 | 0.302 |
Brugia malayi | N-terminal motif family protein | 0.0181 | 0.3619 | 0.3585 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.005 | 0.0809 | 0.5 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0019 | 0.015 | 0.0097 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0093 | 0.1734 | 0.6718 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.015 | 0.0097 |
Brugia malayi | Smad1 | 0.0033 | 0.044 | 0.0389 |
Schistosoma mansoni | hypothetical protein | 0.0201 | 0.4048 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0294 | 0.6042 | 0.6021 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.4048 | 0.4016 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.6042 | 0.6021 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0201 | 0.4048 | 0.4016 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.005 | 0.0809 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0033 | 0.044 | 0.0389 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0019 | 0.015 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.1734 | 0.4209 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.2556 | 0.6264 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0127 | 0.0075 |
Echinococcus granulosus | smad | 0.0033 | 0.044 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.015 | 0.0097 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0019 | 0.015 | 0.0097 |
Brugia malayi | hypothetical protein | 0.0019 | 0.015 | 0.0097 |
Schistosoma mansoni | aryl hydrocarbon receptor nuclear translocator homolog (darnt) | 0.0019 | 0.015 | 0.0242 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.044 | 0.0968 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.2556 | 0.2516 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1734 | 0.169 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0479 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0326 | 0.0274 |
Brugia malayi | MH2 domain containing protein | 0.0033 | 0.044 | 0.0389 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0093 | 0.1734 | 0.169 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.1734 | 0.4209 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.0809 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.2556 | 0.2516 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.2556 | 0.6264 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.2556 | 1 |
Echinococcus multilocularis | smad | 0.0033 | 0.044 | 0.1545 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0033 | 0.044 | 0.0389 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.2556 | 0.2516 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.044 | 0.0968 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0294 | 0.6042 | 0.6021 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0093 | 0.1734 | 0.169 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0027 | 0.0326 | 0.1089 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0181 | 0.3619 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0127 | 0.0075 |
Loa Loa (eye worm) | nuclear factor I | 0.0018 | 0.0127 | 0.0075 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0093 | 0.1734 | 0.6718 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.005 | 0.0809 | 0.302 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0033 | 0.044 | 0.1545 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.005 | 0.0809 | 0.5 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0027 | 0.0326 | 0.0274 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.2556 | 0.6264 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0033 | 0.044 | 0.1545 |
Schistosoma mansoni | smad1 5 8 and | 0.0033 | 0.044 | 0.0968 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.2556 | 0.6264 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.1734 | 0.4209 |
Echinococcus granulosus | Smad4 | 0.0033 | 0.044 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3619 | 0.3585 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0809 | 0.302 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0093 | 0.1734 | 0.6718 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0033 | 0.044 | 0.1545 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.005 | 0.0809 | 0.302 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0809 | 0.302 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.015 | 0.0097 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0479 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0294 | 0.6042 | 0.6021 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0027 | 0.0326 | 0.1089 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0033 | 0.044 | 0.0389 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0809 | 0.302 |
Brugia malayi | isocitrate dehydrogenase | 0.005 | 0.0809 | 0.076 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.2556 | 0.2516 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.0809 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.005 | 0.0809 | 0.1892 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0019 | 0.015 | 0.0097 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.005 | 0.0809 | 0.5 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0033 | 0.044 | 0.1545 |
Echinococcus multilocularis | GPCR, family 2 | 0.0093 | 0.1734 | 0.6718 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.2556 | 0.2516 |
Echinococcus granulosus | GPCR family 2 | 0.0093 | 0.1734 | 0.6718 |
Echinococcus multilocularis | Smad4 | 0.0033 | 0.044 | 0.1545 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.2556 | 0.6264 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0093 | 0.1734 | 0.6718 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.005 | 0.0809 | 0.076 |
Brugia malayi | Isocitrate dehydrogenase | 0.005 | 0.0809 | 0.076 |
Onchocerca volvulus | Protein cycle homolog | 0.0019 | 0.015 | 0.0271 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0093 | 0.1734 | 0.169 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.005 | 0.0809 | 0.5 |
Brugia malayi | RNA binding protein | 0.0131 | 0.2556 | 0.2516 |
Brugia malayi | MH1 domain containing protein | 0.0033 | 0.044 | 0.0389 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.005 | 0.0809 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.1734 | 0.4209 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.005 | 0.0809 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.0326 | 0.0764 | |
Schistosoma mansoni | Smad4 | 0.0033 | 0.044 | 0.0968 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.2556 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.015 | 0.0097 |
Schistosoma mansoni | smad | 0.0033 | 0.044 | 0.0968 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.0809 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.