TDR Targets

Basic information

Technical information

TDR Targets ID: 906612
Name: N-(2,4-dimethylphenyl)-9H-xanthene-9-carboxam ide
MW: 329.392 | Formula: C22H19NO2
H donors: 1 H acceptors: 1 LogP: 4.73 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1c2ccccc2Oc2c1cccc2)Nc1ccc(cc1C)C
InChi: 1S/C22H19NO2/c1-14-11-12-18(15(2)13-14)23-22(24)21-16-7-3-5-9-19(16)25-20-10-6-4-8-17(20)21/h3-13,21H,1-2H3,(H,23,24)
InChiKey: PTVQQUMPPIDUBM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ZINC00182629
EU-0004819
Oprea1_489728
STK096652
MLS000336132
SMR000253986

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Thioredoxin reductase 1, cytoplasmic	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Babesia bovis	thiodoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	Thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus multilocularis	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	MGC84926 protein, related	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma congolense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania major	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Theileria parva	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania infantum	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	Glutathione reductase, related	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma cruzi	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	Get druggable targets OG5_126785	All targets in OG5_126785
Toxoplasma gondii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania mexicana	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei gambiense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium hominis	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania braziliensis	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania donovani	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium parvum	thioredoxin reductase 1	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	acetoin dehydrogenase e3 component-like protein	Thioredoxin reductase 1, cytoplasmic	499 aa	497 aa	24.1 %
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	Thioredoxin reductase 1, cytoplasmic	499 aa	465 aa	27.3 %
Plasmodium knowlesi	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	519 aa	23.7 %
Plasmodium berghei	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	539 aa	22.3 %
Trypanosoma congolense	dihydrolipoamide dehydrogenase, point mutation, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	489 aa	22.7 %
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	Thioredoxin reductase 1, cytoplasmic	499 aa	506 aa	23.7 %
Trypanosoma brucei gambiense	dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	491 aa	23.2 %
Plasmodium knowlesi	dihydrolipoyl dehydrogenase, mitochondrial, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	462 aa	25.8 %
Leishmania infantum	acetoin dehydrogenase e3 component-like protein	Thioredoxin reductase 1, cytoplasmic	499 aa	497 aa	24.1 %
Trypanosoma brucei gambiense	dihydrolipoamide dehydrogenase, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	491 aa	23.6 %
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	483 aa	23.0 %
Neospora caninum	hypothetical protein	Thioredoxin reductase 1, cytoplasmic	499 aa	448 aa	27.0 %
Leishmania mexicana	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	Thioredoxin reductase 1, cytoplasmic	499 aa	452 aa	25.7 %
Plasmodium falciparum	thioredoxin reductase	Thioredoxin reductase 1, cytoplasmic	499 aa	511 aa	45.2 %
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	518 aa	24.9 %
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	Thioredoxin reductase 1, cytoplasmic	499 aa	454 aa	25.3 %
Toxoplasma gondii	NADPH-glutathione reductase	Thioredoxin reductase 1, cytoplasmic	499 aa	529 aa	31.8 %
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	Thioredoxin reductase 1, cytoplasmic	499 aa	448 aa	27.2 %
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	460 aa	25.4 %
Leishmania braziliensis	acetoin dehydrogenase e3 component-like protein	Thioredoxin reductase 1, cytoplasmic	499 aa	499 aa	22.8 %
Trypanosoma congolense	dihydrolipoamide dehydrogenase, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	492 aa	23.2 %
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	489 aa	22.9 %
Plasmodium yoelii	dihydrolipoamide dehydrogenase	Thioredoxin reductase 1, cytoplasmic	499 aa	540 aa	23.3 %
Leishmania infantum	dihydrolipoamide dehydrogenase, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	466 aa	20.6 %
Neospora caninum	Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related	Thioredoxin reductase 1, cytoplasmic	499 aa	464 aa	24.8 %
Onchocerca volvulus		Thioredoxin reductase 1, cytoplasmic	499 aa	499 aa	57.3 %
Leishmania braziliensis	dihydrolipoamide dehydrogenase	Thioredoxin reductase 1, cytoplasmic	499 aa	488 aa	21.9 %
Plasmodium yoelii	dihydrolipoamide dehydrogenase	Thioredoxin reductase 1, cytoplasmic	499 aa	465 aa	27.5 %
Neospora caninum	glutathione reductase, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	492 aa	32.7 %
Leishmania donovani	dihydrolipoamide dehydrogenase, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	466 aa	20.6 %
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	Thioredoxin reductase 1, cytoplasmic	499 aa	490 aa	23.5 %
Trypanosoma congolense	dihydrolipoamide dehydrogenase, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	492 aa	23.2 %
Leishmania mexicana	acetoin dehydrogenase e3 component-like protein	Thioredoxin reductase 1, cytoplasmic	499 aa	499 aa	24.4 %
Plasmodium berghei	dihydrolipoyl dehydrogenase, mitochondrial, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	465 aa	26.9 %
Trypanosoma congolense	dihydrolipoamide dehydrogenase, point mutation	Thioredoxin reductase 1, cytoplasmic	499 aa	489 aa	22.5 %
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	483 aa	23.0 %
Trypanosoma congolense	dihydrolipoamide dehydrogenase, point mutation	Thioredoxin reductase 1, cytoplasmic	499 aa	489 aa	22.3 %
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	489 aa	22.7 %
Plasmodium falciparum	glutathione reductase	Thioredoxin reductase 1, cytoplasmic	499 aa	500 aa	32.2 %
Trypanosoma brucei gambiense	dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative	Thioredoxin reductase 1, cytoplasmic	499 aa	490 aa	23.3 %
Leishmania braziliensis	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	Thioredoxin reductase 1, cytoplasmic	499 aa	450 aa	25.6 %
Trypanosoma brucei	dihydrolipoamide dehydrogenase	Thioredoxin reductase 1, cytoplasmic	499 aa	492 aa	23.4 %
Leishmania donovani	acetoin dehydrogenase e3 component-like protein	Thioredoxin reductase 1, cytoplasmic	499 aa	497 aa	24.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	trypanothione reductase, putative	0.0057	0.0961	0.3207
Schistosoma mansoni	neuropeptide receptor	0.003	0.0272	0.0314
Echinococcus multilocularis	neuropeptide s receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	dihydrofolate reductase	0.0356	0.8661	0.8661
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.003	0.0272	0.0314
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0011	0.0037
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.003	0.0272	0.2562
Plasmodium falciparum	thioredoxin reductase	0.0057	0.0961	0.3207
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0272	0.0314
Plasmodium vivax	vivapain-2	0.002	0.0011	0.0037
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.1302	0.4346
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Brugia malayi	Melatonin receptor type 1A	0.003	0.0272	0.0314
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.003	0.0272	0.0314
Leishmania major	cathepsin L-like protease	0.002	0.0011	0.0037
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0272	0.0272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0011	1
Brugia malayi	hypothetical protein	0.003	0.0272	0.0314
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.013	0.2845	0.3285
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0272	0.0272
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0272	0.0314
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.003	0.0272	0.0314
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Onchocerca volvulus		0.003	0.0272	0.2562
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Brugia malayi	follicle stimulating hormone receptor	0.003	0.0272	0.0314
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0011	1
Echinococcus granulosus	G protein coupled receptor 139	0.003	0.0272	0.0272
Mycobacterium tuberculosis	Probable oxidoreductase	0.0145	0.322	0.3717
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Brugia malayi	Cathepsin L-like precursor	0.002	0.0011	0.0013
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.003	0.0272	0.0314
Onchocerca volvulus		0.003	0.0272	0.2562
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.1029	0.1188
Echinococcus granulosus	fmrfamide receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0272	0.0272
Brugia malayi	Dopamine receptor protein 2	0.003	0.0272	0.0314
Loa Loa (eye worm)	thioredoxin reductase	0.0057	0.0961	0.1098
Brugia malayi	dihydrofolate reductase family protein	0.0356	0.8661	1
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0136	0.2997	1
Onchocerca volvulus		0.003	0.0272	0.2562
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0272	0.0272
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0011	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.003	0.0272	0.0314
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0272	0.0314
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1475	0.4921
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Brugia malayi	hypothetical protein	0.003	0.0272	0.0314
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Echinococcus granulosus	dro:myosuppressin receptor	0.003	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0272	0.0314
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1475	0.4921
Echinococcus multilocularis	cysteine protease	0.002	0.0011	0.0011
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0272	0.0272
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	G-protein coupled receptor, putative	0.003	0.0272	0.0272
Loa Loa (eye worm)	glutathione reductase	0.0057	0.0961	0.1098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.003	0.0272	0.0301
Onchocerca volvulus		0.003	0.0272	0.2562
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0011	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Brugia malayi	putative neuropeptide receptor NPR1	0.003	0.0272	0.0314
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0011	0.0011
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0011	0.0011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1475	0.4921
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus granulosus	tachykinin peptides receptor 99D	0.003	0.0272	0.0272
Echinococcus granulosus	g-protein coupled receptor	0.003	0.0272	0.0272
Onchocerca volvulus		0.006	0.1029	1
Brugia malayi	Dihydrofolate reductase	0.0356	0.8661	1
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0272	0.0314
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.003	0.0272	0.0301
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0272	0.0314
Schistosoma mansoni	biogenic amine receptor	0.003	0.0272	0.0314
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Brugia malayi	hypothetical protein	0.003	0.0272	0.0314
Brugia malayi	G protein-coupled receptor	0.003	0.0272	0.0314
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.003	0.0272	0.0301
Plasmodium falciparum	glutathione reductase	0.0057	0.0961	0.3207
Leishmania major	cathepsin L-like protease	0.0077	0.1475	0.4921
Brugia malayi	Cathepsin L-like precursor	0.002	0.0011	0.0013
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Echinococcus multilocularis	allatostatin A receptor	0.003	0.0272	0.0272
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0272	0.0301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0272	0.0272
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0356	0.8661	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.003	0.0272	0.0272
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0011	0.0011
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0272	0.0272
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Onchocerca volvulus		0.003	0.0272	0.2562
Schistosoma mansoni	amine GPCR	0.003	0.0272	0.0314
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Loa Loa (eye worm)	TYRA-2 protein	0.003	0.0272	0.0301
Brugia malayi	glutathione reductase	0.0057	0.0961	0.111
Brugia malayi	neuropeptide F receptor	0.003	0.0272	0.0314
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.1475	0.4921
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0272	0.0314
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0011	0.0037
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus multilocularis	neuropeptide receptor A26	0.003	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1475	0.4921
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1475	0.4921
Schistosoma mansoni	amine GPCR	0.003	0.0272	0.0314
Schistosoma mansoni	neuropeptide receptor	0.003	0.0272	0.0314
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0011	0.0037
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0011	0.0013
Brugia malayi	Serotonin receptor	0.003	0.0272	0.0314
Brugia malayi	AKH receptor	0.003	0.0272	0.0314
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0272	0.0272
Onchocerca volvulus		0.003	0.0272	0.2562
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.003	0.0272	0.0301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0272	0.0272
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.003	0.0272	0.0272
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0145	0.322	0.0644
Echinococcus granulosus	7TM GPCR rhodopsin	0.003	0.0272	0.0272
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0272	0.0272
Schistosoma mansoni	dihydrofolate reductase	0.0356	0.8661	1
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0272	0.0301
Schistosoma mansoni	amine GPCR	0.003	0.0272	0.0314
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0272	0.0314
Trypanosoma brucei	trypanothione reductase	0.0057	0.0961	0.3207
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.003	0.0272	0.0314
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.013	0.2845	0.3285
Onchocerca volvulus		0.003	0.0272	0.2562
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0272	0.0301
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0272	0.0272
Onchocerca volvulus		0.003	0.0272	0.2562
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0356	0.8661	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1475	0.4921
Echinococcus multilocularis	tumor protein p63	0.0408	1	1
Schistosoma mansoni	myosin xvIII	0.003	0.0272	0.0314
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Brugia malayi	ORL1-like opioid receptor	0.003	0.0272	0.0314
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0011	0.5
Brugia malayi	hypothetical protein	0.003	0.0272	0.0314
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0011	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0136	0.2997	1
Brugia malayi	neuropeptide F receptor	0.003	0.0272	0.0314
Echinococcus granulosus	neuropeptide s receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	G protein coupled receptor 139	0.003	0.0272	0.0272
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0272	0.0272
Echinococcus granulosus	g protein coupled receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0272	0.0272
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0272	0.0272
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.003	0.0272	0.0272
Brugia malayi	hypothetical protein	0.003	0.0272	0.0314
Echinococcus granulosus	allatostatin A receptor	0.003	0.0272	0.0272
Schistosoma mansoni	growth hormone secretagogue receptor	0.003	0.0272	0.0314
Brugia malayi	G protein-coupled receptor F59B2.13	0.003	0.0272	0.0314
Leishmania major	cathepsin L-like protease	0.002	0.0011	0.0037
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1475	0.4921
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0272	0.0272
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0136	0.2997	1
Echinococcus multilocularis	g-protein coupled receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0272	0.0272
Brugia malayi	Thioredoxin reductase	0.0057	0.0961	0.111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Brugia malayi	G-protein coupled receptor	0.003	0.0272	0.0314
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0272	0.0314
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.1475	0.4921
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.003	0.0272	0.0314
Brugia malayi	GnHR receptor homolog	0.003	0.0272	0.0314
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0272	0.0314
Echinococcus multilocularis	somatostatin receptor	0.003	0.0272	0.0272
Brugia malayi	sulfakinin receptor protein	0.003	0.0272	0.0314
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.013	0.2845	0.3285
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1475	0.4921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus granulosus	orexin receptor type 2	0.003	0.0272	0.0272
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Mycobacterium tuberculosis	Probable dehydrogenase	0.013	0.2845	0.3285
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.003	0.0272	0.0272
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0145	0.322	0.3717
Schistosoma mansoni	biogenic amine receptor	0.003	0.0272	0.0314
Treponema pallidum	NADH oxidase	0.002	0	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.003	0.0272	0.0314
Onchocerca volvulus		0.003	0.0272	0.2562
Brugia malayi	larval opioid receptor	0.003	0.0272	0.0314
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.003	0.0272	0.0314
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0272	0.0314
Schistosoma mansoni	opsin-like receptor	0.003	0.0272	0.0314
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0011	1
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0011	0.0037
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.003	0.0272	0.0314
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0011	0.0011
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.013	0.2845	0.3285
Brugia malayi	Serotonin receptor	0.003	0.0272	0.0314
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0136	0.2997	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Schistosoma mansoni	hypothetical protein	0.003	0.0272	0.0314
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Brugia malayi	Cathepsin L-like precursor	0.002	0.0011	0.0013
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0011	0.0011
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.003	0.0272	0.0301
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.105	0.3503
Schistosoma mansoni	alpha-1 adrenergic receptor	0.003	0.0272	0.0314
Echinococcus multilocularis	serotonin receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Schistosoma mansoni	hypothetical protein	0.003	0.0272	0.0314
Leishmania major	trypanothione reductase	0.0057	0.0961	0.3207
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0356	0.8661	1
Schistosoma mansoni	amine GPCR	0.003	0.0272	0.0314
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0011	0.0013
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0011	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0057	0.0961	0.111
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0272	0.0301
Echinococcus granulosus	thioredoxin glutathione reductase	0.0057	0.0961	0.0961
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.003	0.0272	0.0272
Echinococcus granulosus	g protein coupled receptor	0.003	0.0272	0.0272
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Brugia malayi	G-protein coupled receptor	0.003	0.0272	0.0314
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0272	0.0272
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0011	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus granulosus	neuropeptide receptor A26	0.003	0.0272	0.0272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0272	0.0314
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Schistosoma mansoni	opsin-like receptor	0.003	0.0272	0.0314
Entamoeba histolytica	cysteine protease, putative	0.002	0.0011	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.003	0.0272	0.0272
Schistosoma mansoni	opsin-like receptor	0.003	0.0272	0.0314
Echinococcus granulosus	somatostatin receptor	0.003	0.0272	0.0272
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.003	0.0272	0.0272
Echinococcus granulosus	serotonin receptor	0.003	0.0272	0.0272
Onchocerca volvulus		0.003	0.0272	0.2562
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.002	0	0.5
Loa Loa (eye worm)	dihydrofolate reductase	0.0356	0.8661	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0011	1
Onchocerca volvulus		0.003	0.0272	0.2562
Onchocerca volvulus		0.003	0.0272	0.2562
Schistosoma mansoni	neuropeptide f receptor 76f	0.003	0.0272	0.0314
Echinococcus granulosus	neuropeptide receptor	0.003	0.0272	0.0272
Brugia malayi	Tachykinin-like peptides receptor 99D	0.003	0.0272	0.0314
Brugia malayi	hypothetical protein	0.003	0.0272	0.0314
Leishmania major	cathepsin L-like protease	0.0077	0.1475	0.4921
Echinococcus granulosus	dihydrofolate reductase	0.0356	0.8661	0.8661
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0011	0.0011
Echinococcus multilocularis	cysteine protease	0.002	0.0011	0.0011
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.1475	0.4921
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0272	0.0314
Brugia malayi	hypothetical protein	0.003	0.0272	0.0314
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Schistosoma mansoni	biogenic amine receptor	0.003	0.0272	0.0314
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0011	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0057	0.0961	0.0961
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.003	0.0272	0.0272
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0272	0.0272
Brugia malayi	putative neuropeptide receptor	0.003	0.0272	0.0314
Onchocerca volvulus		0.003	0.0272	0.2562
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1475	0.4921
Echinococcus granulosus	peptide allatostatin:somatostatin	0.003	0.0272	0.0272
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.003	0.0272	0.0272
Echinococcus granulosus	neuropeptide receptor	0.003	0.0272	0.0272
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0136	0.2997	1
Brugia malayi	Dopamine receptor protein 1	0.003	0.0272	0.0314
Plasmodium vivax	thioredoxin reductase, putative	0.0057	0.0961	0.3207
Onchocerca volvulus		0.003	0.0272	0.2562
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0272	0.0272
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1475	0.4921
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0145	0.322	0.3717
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0272	0.0272
Onchocerca volvulus		0.003	0.0272	0.2562
Chlamydia trachomatis	dihydrofolate reductase	0.0356	0.8661	1
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0136	0.2997	1
Schistosoma mansoni	hypothetical protein	0.003	0.0272	0.0314
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0011	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0272	0.0314
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0272	0.0314
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0272	0.0272
Toxoplasma gondii	cathepsin CPL	0.002	0.0011	0.0037
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.003	0.0272	0.0272
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.1475	0.4921
Brugia malayi	hypothetical protein	0.003	0.0272	0.0314
Leishmania major	cathepsin L-like protease	0.002	0.0011	0.0037
Echinococcus multilocularis	serotonin receptor	0.003	0.0272	0.0272
Brugia malayi	hypothetical protein	0.003	0.0272	0.0314
Brugia malayi	Dopamine receptor	0.003	0.0272	0.0314
Brugia malayi	Cathepsin L-like precursor	0.002	0.0011	0.0013
Onchocerca volvulus		0.003	0.0272	0.2562
Schistosoma mansoni	histamine h1 receptor	0.003	0.0272	0.0314
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0011	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.003	0.0272	0.0314
Toxoplasma gondii	thioredoxin reductase	0.0057	0.0961	0.3207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0272	0.0314
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Mycobacterium tuberculosis	Probable reductase	0.013	0.2845	0.3285
Giardia lamblia	NADH oxidase lateral transfer candidate	0.002	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0272	0.0314
Echinococcus granulosus	hypothetical protein	0.003	0.0272	0.0272
Brugia malayi	Cathepsin L-like precursor	0.002	0.0011	0.0013
Loa Loa (eye worm)	melatonin receptor type 1A	0.003	0.0272	0.0301
Schistosoma mansoni	amine GPCR	0.003	0.0272	0.0314
Brugia malayi	Cathepsin L-like precursor	0.002	0.0011	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Schistosoma mansoni	neuropeptide receptor	0.003	0.0272	0.0314
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.1475	0.4921
Schistosoma mansoni	neuropeptide receptor	0.003	0.0272	0.0314
Loa Loa (eye worm)	hypothetical protein	0.006	0.1029	0.1176
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus granulosus	cathepsin l1	0.002	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0011	1
Brugia malayi	hypothetical protein	0.003	0.0272	0.0314
Echinococcus granulosus	g protein coupled receptor	0.003	0.0272	0.0272
Echinococcus granulosus	sex peptide receptor	0.003	0.0272	0.0272
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0272	0.0314
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0272	0.0272
Leishmania major	cathepsin L-like protease	0.0077	0.1475	0.4921
Onchocerca volvulus		0.003	0.0272	0.2562
Brugia malayi	RE15519p	0.003	0.0272	0.0314
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0011	0.0013
Echinococcus multilocularis	orexin receptor type 2	0.003	0.0272	0.0272
Echinococcus multilocularis	sex peptide receptor	0.003	0.0272	0.0272
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.003	0.0272	0.0314
Plasmodium vivax	glutathione reductase, putative	0.0057	0.0961	0.3207
Echinococcus granulosus	7tm_1 domain containing protein	0.003	0.0272	0.0272
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.003	0.0272	0.0314
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.002	0	0.5
Plasmodium vivax	vivapain-2	0.002	0.0011	0.0037
Echinococcus multilocularis	dro:myosuppressin receptor	0.003	0.0272	0.0272
Onchocerca volvulus	Neuropeptide F receptor homolog	0.003	0.0272	0.2562
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0272	0.0272
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0011	0.0037
Leishmania major	cathepsin L-like protease	0.002	0.0011	0.0037
Leishmania major	cathepsin L-like protease	0.002	0.0011	0.0037
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0272	0.0301
Schistosoma mansoni	adenoreceptor	0.003	0.0272	0.0314
Schistosoma mansoni	hypothetical protein	0.003	0.0272	0.0314
Echinococcus granulosus	alpha 1A adrenergic receptor	0.003	0.0272	0.0272
Echinococcus granulosus	neuropeptide FF receptor 2	0.003	0.0272	0.0272

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.2239 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1452146
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 906612