TDR Targets

Basic information

Technical information

TDR Targets ID: 906650
Name: N-(2-methoxyethyl)-9H-xanthene-9-carboxamide
MW: 283.322 | Formula: C17H17NO3
H donors: 1 H acceptors: 1 LogP: 2.29 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COCCNC(=O)C1c2ccccc2Oc2c1cccc2
InChi: 1S/C17H17NO3/c1-20-11-10-18-17(19)16-12-6-2-4-8-14(12)21-15-9-5-3-7-13(15)16/h2-9,16H,10-11H2,1H3,(H,18,19)
InChiKey: XGHQVOYEKZQZCK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

EU-0004868
ZINC02309818
ST043287

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0095	0.6942	0.6942
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0045	0.2452	0.1967
Brugia malayi	Nuclear hormone receptor-like 1	0.005	0.2932	0.2932
Onchocerca volvulus		0.0045	0.2452	0.3532
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0095	0.6942	0.6942
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Brugia malayi	hypothetical protein	0.0045	0.2452	0.2452
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0045	0.2452	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0095	0.6942	0.6942
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0095	0.6942	0.6942
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0095	0.6942	0.6745
Loa Loa (eye worm)	cysteine protease	0.0024	0.0603	0.0603
Onchocerca volvulus		0.0024	0.0603	0.0869
Onchocerca volvulus	Bile acid receptor homolog	0.0095	0.6942	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0129	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0024	0.0603	0.0869
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0095	0.6942	0.6942
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0095	0.6942	0.6942
Brugia malayi	tailless protein	0.0045	0.2452	0.2452
Schistosoma mansoni	cathepsin F (C01 family)	0.0024	0.0603	0.0603
Echinococcus multilocularis	FTZ F1 alpha	0.0095	0.6942	0.6745
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0024	0.0603	0.5
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0024	0.0603	0.0603
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0095	0.6942	0.6942
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.2452	0.1967
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Echinococcus granulosus	FTZ F1 alpha	0.0095	0.6942	0.6942
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0095	0.6942	0.6745
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0045	0.2482	0.2482
Onchocerca volvulus		0.0024	0.0603	0.0869
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0045	0.2452	0.2452
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0603	0.0603
Schistosoma mansoni	retinoic acid receptor RXR	0.0095	0.6942	0.6942
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0045	0.2452	0.2452
Schistosoma mansoni	zinc finger protein	0.0045	0.2452	0.2452
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0603	0.0603
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0095	0.6942	0.6942
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Brugia malayi	nuclear receptor RXR	0.005	0.2932	0.2932
Brugia malayi	Nuclear hormone receptor-like 1	0.0095	0.6942	0.6942
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0095	0.6942	0.6942
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0095	0.6942	0.6942
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0129	1	1
Echinococcus multilocularis	cathepsin b	0.0129	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0095	0.6942	0.6942
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0024	0.0603	0.243
Echinococcus granulosus	ecdysone induced protein 78C	0.0095	0.6942	0.6942
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.005	0.2932	0.2932
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0045	0.2482	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0045	0.2452	0.2452
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0095	0.6942	0.6942
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0045	0.2452	0.1967
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.2452	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0095	0.6942	0.6942
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.005	0.2932	0.2932
Loa Loa (eye worm)	hypothetical protein	0.0095	0.6942	0.6942
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0603	0.243
Toxoplasma gondii	cathepsin B	0.0045	0.2482	1
Brugia malayi	hypothetical protein	0.005	0.2932	0.2932
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Onchocerca volvulus		0.0095	0.6942	1
Brugia malayi	nuclear receptor NHR-88	0.0095	0.6942	0.6942
Onchocerca volvulus	Cathepsin L homolog	0.0024	0.0603	0.0869
Onchocerca volvulus	Cathepsin F homolog	0.0024	0.0603	0.0869
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0603	0.243
Onchocerca volvulus		0.0045	0.2452	0.3532
Brugia malayi	conserved hypotetical protein	0.0045	0.2452	0.2452
Brugia malayi	nuclear receptor NHR-67	0.0045	0.2452	0.2452
Onchocerca volvulus	Protein ultraspiracle homolog	0.0095	0.6942	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Schistosoma mansoni	cathepsin F (C01 family)	0.0024	0.0603	0.0603
Loa Loa (eye worm)	DR-78	0.0045	0.2452	0.2452
Loa Loa (eye worm)	fibroinase	0.0024	0.0603	0.0603
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0095	0.6942	0.6942
Loa Loa (eye worm)	hypothetical protein	0.005	0.2932	0.2932
Onchocerca volvulus		0.0024	0.0603	0.0869
Loa Loa (eye worm)	hypothetical protein	0.005	0.2932	0.2932
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0129	1	1
Brugia malayi	hypothetical protein	0.0045	0.2452	0.2452
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0045	0.2452	0.2452
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0045	0.2482	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0095	0.6942	0.6942
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0095	0.6942	0.6942
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.0603	0.0603
Echinococcus granulosus	thyroid hormone receptor alpha	0.0045	0.2452	0.2452
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0045	0.2452	0.3532
Brugia malayi	hypothetical protein	0.005	0.2932	0.2932
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0095	0.6942	0.6745
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0095	0.6942	0.6745
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0024	0.0603	0.0603
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0095	0.6942	0.6942
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.005	0.2932	0.2479
Schistosoma mansoni	coup transcription factor	0.0095	0.6942	0.6942
Brugia malayi	Papain family cysteine protease containing protein	0.0024	0.0603	0.0603
Brugia malayi	ecdysteroid receptor	0.0095	0.6942	0.6942
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0129	1	1
Plasmodium vivax	vivapain-2	0.0024	0.0603	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0095	0.6942	0.6942
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0129	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.005	0.2932	0.2932
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0024	0.0603	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.6942	0.6942
Trypanosoma cruzi	cruzipain precursor, putative	0.0024	0.0603	0.0603
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0603	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0095	0.6942	0.6942
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.0603	0.0603
Entamoeba histolytica	cysteine protease, putative	0.0024	0.0603	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.2932	0.2932
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0095	0.6942	0.6745
Onchocerca volvulus		0.0024	0.0603	0.0869
Brugia malayi	nuclear hormone receptor	0.0045	0.2452	0.2452
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0095	0.6942	0.6942
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.0603	0.0603
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0095	0.6942	0.6745
Brugia malayi	Nuclear hormone receptor E75	0.0045	0.2452	0.2452
Echinococcus granulosus	cathepsin b	0.0129	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0024	0.0603	0.5
Echinococcus multilocularis	cathepsin b	0.0129	1	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.6942	0.6942
Schistosoma mansoni	RAR-like nuclear receptor	0.0095	0.6942	0.6942
Loa Loa (eye worm)	hypothetical protein	0.0095	0.6942	0.6942
Loa Loa (eye worm)	steroid hormone receptor	0.0095	0.6942	0.6942
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0095	0.6942	0.6942
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0603	0.243
Brugia malayi	Nuclear hormone receptor E75	0.0045	0.2452	0.2452
Brugia malayi	nuclear receptor NHR-88	0.0045	0.2452	0.2452
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0024	0.0603	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0603	0.243
Echinococcus multilocularis	ecdysone induced protein 78C	0.0095	0.6942	0.6745
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0603	0.0603
Brugia malayi	nuclear hormone receptor family member odr-7	0.0045	0.2452	0.2452
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0095	0.6942	0.6942
Brugia malayi	steroid hormone receptor	0.0095	0.6942	0.6942
Brugia malayi	photoreceptor-specific nuclear receptor	0.0095	0.6942	0.6942
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.005	0.2932	0.2932
Schistosoma mansoni	thyroid hormone receptor	0.0095	0.6942	0.6942
Giardia lamblia	Cathepsin B precursor	0.0045	0.2482	0.5
Giardia lamblia	Cathepsin B precursor	0.0045	0.2482	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0045	0.2452	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Loa Loa (eye worm)	hypothetical protein	0.005	0.2932	0.2932
Loa Loa (eye worm)	ctsf protein	0.0024	0.0603	0.0603
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0045	0.2482	0.2482
Schistosoma mansoni	nuclear receptor	0.0045	0.2452	0.2452
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0603	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0024	0.0603	0.243
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0095	0.6942	0.6942
Schistosoma mansoni	nuclear hormone receptor	0.0095	0.6942	0.6942
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0024	0.0603	0.0603
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.2452	0.2452
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0095	0.6942	0.6942
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0045	0.2452	0.1967
Schistosoma mansoni	nuclear receptor	0.0045	0.2452	0.2452
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0095	0.6942	0.6745
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0095	0.6942	0.6942
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0095	0.6942	0.6942
Brugia malayi	orphan nuclear receptor NR2E1	0.0045	0.2452	0.2452
Schistosoma mansoni	thyroid hormone receptor	0.0095	0.6942	0.6942
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0603	0.243
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0095	0.6942	0.6942
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0603	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.2932	0.2932
Echinococcus granulosus	cathepsin b	0.0129	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0045	0.2452	0.2452
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0603	0.243
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0095	0.6942	0.6942
Plasmodium vivax	vivapain-2	0.0024	0.0603	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0095	0.6942	0.6942
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0603	0.243
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0095	0.6942	0.6942
Onchocerca volvulus		0.0024	0.0603	0.0869
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0045	0.2452	0.2452
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0045	0.2452	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0045	0.2452	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0129	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0095	0.6942	0.6942
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0095	0.6942	0.6942
Loa Loa (eye worm)	nuclear hormone receptor	0.0045	0.2452	0.2452
Echinococcus granulosus	cathepsin l1	0.0024	0.0603	0.0603
Loa Loa (eye worm)	cathepsin B	0.0045	0.2482	0.2482
Schistosoma mansoni	nuclear receptor nhr-48	0.0045	0.2452	0.2452
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0095	0.6942	0.6942
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0045	0.2482	1
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0603	0.0603
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0095	0.6942	0.6942
Brugia malayi	Steroid receptor seven-up type 2	0.0095	0.6942	0.6942
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0024	0.0603	0.243
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0603	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2452	0.2452
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Onchocerca volvulus		0.0024	0.0603	0.0869
Echinococcus multilocularis	nuclear receptor nhr 48	0.0045	0.2452	0.1967
Giardia lamblia	Cathepsin B precursor	0.0045	0.2482	0.5
Brugia malayi	ecdysone receptor	0.0045	0.2452	0.2452
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.2452	0.2452
Brugia malayi	nuclear receptor RXR	0.0045	0.2452	0.2452
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0603	0.243
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0095	0.6942	0.6942
Brugia malayi	nuclear hormone receptor	0.0095	0.6942	0.6942
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0095	0.6942	1
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0603	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0095	0.6942	0.6942
Brugia malayi	Nuclear hormone receptor-like 1	0.005	0.2932	0.2932
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0045	0.2452	0.3532
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0603	0.0603
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0095	0.6942	0.6942
Trypanosoma cruzi	cysteine peptidase, putative	0.0024	0.0603	0.0603
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0045	0.2452	0.1967
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0095	0.6942	0.6942
Onchocerca volvulus		0.0024	0.0603	0.0869

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 906650