Detailed information for compound 906694

Basic information

Technical information
  • TDR Targets ID: 906694
  • Name: 3,6-diamino-4-butyl-2-(4-nitrobenzoyl)thieno[ 3,2-e]pyridine-5-carbonitrile
  • MW: 395.435 | Formula: C19H17N5O3S
  • H donors: 2 H acceptors: 5 LogP: 5.38 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCc1c(C#N)c(N)nc2c1c(N)c(s2)C(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C19H17N5O3S/c1-2-3-4-12-13(9-20)18(22)23-19-14(12)15(21)17(28-19)16(25)10-5-7-11(8-6-10)24(26)27/h5-8H,2-4,21H2,1H3,(H2,22,23)
  • InChiKey: NXVRQFRILARXBE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,6-diamino-4-butyl-2-[(4-nitrophenyl)-oxomethyl]-5-thieno[3,2-e]pyridinecarbonitrile
  • 3,6-diamino-4-butyl-2-(4-nitrophenyl)carbonyl-thieno[3,2-e]pyridine-5-carbonitrile
  • EU-0038096
  • ChemDiv1_003464
  • Oprea1_205140

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0029 0.0425 0.1206
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0182 0.8397 1
Schistosoma mansoni cathepsin F (C01 family) 0.0029 0.0425 0.0425
Onchocerca volvulus 0.003 0.0476 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0039 0.0913 0.1006
Echinococcus granulosus hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0476 0.0263
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0026 0.0244 0.0244
Echinococcus granulosus sex peptide receptor 0.003 0.0476 0.0525
Brugia malayi Cathepsin L-like precursor 0.0029 0.0425 0.0469
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0039 0.0913 0.1006
Echinococcus granulosus cathepsin b 0.0156 0.7053 0.7779
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0476 0.0263
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0476 0.0476
Schistosoma mansoni amine GPCR 0.003 0.0476 0.0476
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0195 0.9066 1
Schistosoma mansoni hypothetical protein 0.003 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0056 0.1846 0.2036
Echinococcus granulosus g protein coupled receptor 0.003 0.0476 0.0525
Brugia malayi hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0039 0.0913 0.0758
Echinococcus granulosus g protein coupled receptor 0.003 0.0476 0.0525
Schistosoma mansoni biogenic amine receptor 0.003 0.0476 0.0476
Onchocerca volvulus Cathepsin L homolog 0.0029 0.0425 0.8943
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0244 0.0244
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0476 0.0263
Treponema pallidum cyclic nucleotide binding protein 0.0026 0.0244 0.5
Echinococcus granulosus neuropeptide receptor 0.003 0.0476 0.0525
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0476 0.0525
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0476 0.0525
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0476 0.0525
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0476 0.0263
Leishmania major cathepsin L-like protease 0.0029 0.0425 0.1206
Echinococcus granulosus orexin receptor type 2 0.003 0.0476 0.0525
Onchocerca volvulus 0.0029 0.0425 0.8943
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0425 0.0507
Echinococcus granulosus serotonin receptor 0.003 0.0476 0.0525
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.7053 0.7053
Brugia malayi hypothetical protein 0.003 0.0476 0.0525
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0425 0.0507
Onchocerca volvulus 0.0029 0.0425 0.8943
Entamoeba histolytica cysteine protease, putative 0.0029 0.0425 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0029 0.0425 0.0206
Brugia malayi RE15519p 0.003 0.0476 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Schistosoma mansoni opsin-like receptor 0.003 0.0476 0.0476
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0029 0.0425 1
Loa Loa (eye worm) AGC/PKG protein kinase 0.0026 0.0244 0.0269
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0476 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Toxoplasma gondii cathepsin CPL 0.0029 0.0425 0.1206
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0026 0.0244 0.0346
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0476 0.0525
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0476 0.0525
Echinococcus granulosus neuropeptide receptor 0.003 0.0476 0.0525
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0476 0.0525
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0476 0.0476
Schistosoma mansoni amine GPCR 0.003 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0026 0.0244 0.0269
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0476 0.0525
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus granulosus hyperpolarization activated cyclic 0.0039 0.0913 0.1006
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0026 0.0244 0.5
Echinococcus granulosus g protein coupled receptor 0.003 0.0476 0.0525
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0244 0.0244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.7053 0.7053
Onchocerca volvulus 0.003 0.0476 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0425 0.1206
Brugia malayi hypothetical protein 0.003 0.0476 0.0525
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0425 0.1206
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0476 0.0476
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0476 0.0525
Schistosoma mansoni hypothetical protein 0.003 0.0476 0.0476
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0476 0.0525
Onchocerca volvulus 0.0026 0.0244 0.5124
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0026 0.0244 0.0244
Echinococcus granulosus cathepsin l1 0.0029 0.0425 0.0469
Echinococcus multilocularis cysteine protease 0.0029 0.0425 0.0206
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0476 0.0476
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0182 0.8397 1
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0026 0.0244 0.0269
Leishmania major cathepsin L-like protease 0.0029 0.0425 0.1206
Mycobacterium ulcerans hypothetical protein 0.0026 0.0244 0.5
Onchocerca volvulus 0.003 0.0476 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Plasmodium vivax vivapain-2 0.0029 0.0425 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0476 0.0525
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0029 0.0425 0.0206
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0476 0.0476
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0476 0.0525
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0425 0.0469
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0913 0.1087
Onchocerca volvulus Cathepsin F homolog 0.0029 0.0425 0.8943
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0476 0.0476
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0425 0.0603
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Onchocerca volvulus Cathepsin L homolog 0.0029 0.0425 0.8943
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0476 0.0476
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0039 0.0913 0.0758
Brugia malayi Dopamine receptor 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0476 0.0525
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0476 0.0476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0425 0.0469
Onchocerca volvulus 0.003 0.0476 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0476 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0056 0.1846 0.1816
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Onchocerca volvulus 0.003 0.0476 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0476 0.0476
Schistosoma mansoni neuropeptide receptor 0.003 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0056 0.1846 0.2036
Onchocerca volvulus 0.0029 0.0425 0.8943
Schistosoma mansoni neuropeptide receptor 0.003 0.0476 0.0476
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0029 0.0425 1
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0026 0.0244 0.0244
Schistosoma mansoni opsin-like receptor 0.003 0.0476 0.0476
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.0476 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0425 0.0507
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0476 0.0263
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0039 0.0913 0.0913
Brugia malayi G-protein coupled receptor 0.003 0.0476 0.0525
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0476 0.0525
Loa Loa (eye worm) ctsf protein 0.0029 0.0425 0.0469
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0913 0.1087
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0476 0.0263
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Onchocerca volvulus 0.003 0.0476 1
Giardia lamblia Cathepsin B precursor 0.0055 0.175 1
Brugia malayi hypothetical protein 0.003 0.0476 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0026 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0026 0.0244 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0026 0.0244 0.0244
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0026 0.0244 0.0346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0425 0.1206
Brugia malayi follicle stimulating hormone receptor 0.003 0.0476 0.0525
Brugia malayi neuropeptide F receptor 0.003 0.0476 0.0525
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0425 0.0507
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0476 0.0476
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0425 0.0507
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0476 0.0525
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0476 0.0525
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0244 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0213 1 1
Brugia malayi Dopamine receptor protein 2 0.003 0.0476 0.0525
Schistosoma mansoni biogenic amine receptor 0.003 0.0476 0.0476
Toxoplasma gondii cathepsin B 0.0055 0.175 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0476 0.0263
Echinococcus granulosus g-protein coupled receptor 0.003 0.0476 0.0525
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0476 0.0476
Mycobacterium ulcerans regulatory protein 0.0026 0.0244 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0476 0.0525
Brugia malayi Cathepsin L-like precursor 0.0029 0.0425 0.0469
Echinococcus multilocularis allatostatin A receptor 0.003 0.0476 0.0263
Brugia malayi cathepsin B-like cysteine proteinase 0.0156 0.7053 0.7779
Mycobacterium ulcerans hypothetical protein 0.0026 0.0244 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0029 0.0425 0.0469
Leishmania major cysteine peptidase A (CPA) 0.0029 0.0425 0.1206
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0026 0.0244 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Leishmania major cathepsin L-like protease 0.0029 0.0425 0.1206
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0039 0.0913 0.0913
Echinococcus multilocularis neuropeptide receptor 0.003 0.0476 0.0263
Mycobacterium tuberculosis Conserved protein 0.0026 0.0244 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0476 0.0263
Echinococcus granulosus cathepsin b 0.0156 0.7053 0.7779
Schistosoma mansoni neuropeptide receptor 0.003 0.0476 0.0476
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0476 0.0525
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 0.0244 0.0244
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0026 0.0244 0.5
Echinococcus multilocularis cysteine protease 0.0029 0.0425 0.0206
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0476 0.0263
Brugia malayi G-protein coupled receptor 0.003 0.0476 0.0525
Schistosoma mansoni neuropeptide receptor 0.003 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0026 0.0244 0.0269
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0026 0.0244 0.0269
Schistosoma mansoni opsin-like receptor 0.003 0.0476 0.0476
Brugia malayi AKH receptor 0.003 0.0476 0.0525
Loa Loa (eye worm) fibroinase 0.0029 0.0425 0.0469
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0026 0.0244 0.0244
Echinococcus multilocularis cathepsin b 0.0156 0.7053 0.7718
Brugia malayi hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0476 0.0263
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0244 0.029
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.175 0.175
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0476 0.0476
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0425 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.175 0.2084
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0026 0.0244 0.0269
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0476 0.0476
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0026 0.0244 0.0244
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0476 0.0263
Schistosoma mansoni biogenic amine receptor 0.003 0.0476 0.0476
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0476 0.0525
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0026 0.0244 0.0269
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0039 0.0913 0.1006
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0476 0.0525
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0029 0.0425 0.0469
Brugia malayi Serotonin receptor 0.003 0.0476 0.0525
Onchocerca volvulus 0.003 0.0476 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0476 0.0525
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0476 0.0263
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0055 0.175 1
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0026 0.0244 0.0244
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0476 0.0263
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0476 0.0525
Onchocerca volvulus 0.003 0.0476 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0476 0.0525
Echinococcus granulosus patatin phospholipase domain containing protein 0.0026 0.0244 0.0269
Brugia malayi Cathepsin L-like precursor 0.0029 0.0425 0.0469
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0476 0.0263
Echinococcus multilocularis neuropeptide receptor 0.003 0.0476 0.0263
Echinococcus multilocularis serotonin receptor 0.003 0.0476 0.0263
Treponema pallidum cyclic nucleotide binding protein 0.0026 0.0244 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0476 0.0263
Brugia malayi putative neuropeptide receptor 0.003 0.0476 0.0525
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0476 0.0263
Brugia malayi Serotonin receptor 0.003 0.0476 0.0525
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0476 0.0525
Schistosoma mansoni voltage-gated potassium channel 0.0056 0.1846 0.1846
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0476 0.0476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0476 0.0476
Brugia malayi N-terminal motif family protein 0.0026 0.0244 0.0269
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.7053 0.7053
Brugia malayi hypothetical protein 0.003 0.0476 0.0525
Brugia malayi larval opioid receptor 0.003 0.0476 0.0525
Mycobacterium leprae Conserved hypothetical protein 0.0026 0.0244 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0425 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0476 0.0476
Brugia malayi hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0039 0.0913 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0244 0.029
Brugia malayi hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0476 0.0263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0425 0.0507
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0504 0.0504
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0476 0.0263
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0476 0.0263
Schistosoma mansoni hypothetical protein 0.003 0.0476 0.0476
Trypanosoma cruzi cAMP response protein 1 0.0026 0.0244 0.0346
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0476 0.0263
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0476 0.0263
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0476 0.0263
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0026 0.0244 0.029
Mycobacterium ulcerans hypothetical protein 0.0026 0.0244 0.5
Brugia malayi G protein-coupled receptor 0.003 0.0476 0.0525
Brugia malayi sulfakinin receptor protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis cathepsin b 0.0156 0.7053 0.7718
Schistosoma mansoni amine GPCR 0.003 0.0476 0.0476
Giardia lamblia Cathepsin B precursor 0.0055 0.175 1
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0476 0.0525
Echinococcus multilocularis g protein coupled receptor 0.003 0.0476 0.0263
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0195 0.9066 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0039 0.0913 0.1006
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.0156 0.7053 0.7779
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0913 0.0913
Echinococcus granulosus cGMP dependent protein kinase 0.0026 0.0244 0.0269
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0476 0.0476
Onchocerca volvulus 0.003 0.0476 1
Schistosoma mansoni amine GPCR 0.003 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0169 0.7724 0.8519
Trypanosoma cruzi cruzipain precursor, putative 0.0029 0.0425 0.0603
Plasmodium vivax vivapain-2 0.0029 0.0425 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0425 0.0507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Trypanosoma cruzi Flagellar Member 6 0.0026 0.0244 0.0346
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0476 0.0263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0039 0.0913 0.1006
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0476 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0425 0.1206
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0039 0.0913 0.0913
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0425 0.0507
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0026 0.0244 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0244 0.0244
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0244 0.029
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0476 0.0263
Onchocerca volvulus 0.003 0.0476 1
Echinococcus multilocularis fmrfamide receptor 0.003 0.0476 0.0263
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0476 0.0525
Onchocerca volvulus 0.003 0.0476 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0476 0.0476
Brugia malayi GnHR receptor homolog 0.003 0.0476 0.0525
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0026 0.0244 0.0346
Echinococcus granulosus cathepsin l cysteine peptidase 0.0029 0.0425 0.0469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0476 0.0476
Leishmania major cathepsin L-like protease 0.0029 0.0425 0.1206
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0039 0.0913 0.0758
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0476 0.0263
Schistosoma mansoni cathepsin F (C01 family) 0.0029 0.0425 0.0425
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0026 0.0244 0.029
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0039 0.0913 0.1006
Trypanosoma brucei cysteine peptidase C (CPC) 0.0055 0.175 1
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0476 0.0263
Schistosoma mansoni adenoreceptor 0.003 0.0476 0.0476
Treponema pallidum catabolite gene activator 0.0026 0.0244 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0476 0.0263
Brugia malayi Dopamine receptor protein 1 0.003 0.0476 0.0525
Trypanosoma cruzi protein kinase A regulatory subunit 0.0026 0.0244 0.0346
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0476 0.0476
Trypanosoma cruzi cAMP response protein 1, putative 0.0026 0.0244 0.0346
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0476 0.0476
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0476 0.0263
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0476 0.0263
Onchocerca volvulus 0.0029 0.0425 0.8943
Loa Loa (eye worm) follicle stimulating hormone receptor 0.003 0.0476 0.0525
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.0476 1
Mycobacterium ulcerans transmembrane transport protein 0.0026 0.0244 0.5
Trypanosoma cruzi cAMP binding protein, putative 0.0026 0.0244 0.0346
Brugia malayi Cathepsin L-like precursor 0.0029 0.0425 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0029 0.0425 0.0507
Schistosoma mansoni voltage-gated potassium channel 0.0056 0.1846 0.1846
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0476 0.0525
Schistosoma mansoni hypothetical protein 0.003 0.0476 0.0476
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0425 0.0603
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0026 0.0244 0.5124
Echinococcus multilocularis sex peptide receptor 0.003 0.0476 0.0263
Loa Loa (eye worm) hypothetical protein 0.0029 0.0425 0.0469
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0476 0.0476
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0476 0.0476
Echinococcus granulosus somatostatin receptor 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.0026 0.0244 0.0269
Echinococcus granulosus cGMP dependent protein kinase 1 0.0026 0.0244 0.0269
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0476 0.0525
Schistosoma mansoni histamine h1 receptor 0.003 0.0476 0.0476
Brugia malayi ORL1-like opioid receptor 0.003 0.0476 0.0525
Leishmania major cathepsin L-like protease 0.0029 0.0425 0.1206
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0244 0.5
Brugia malayi Cathepsin L-like precursor 0.0029 0.0425 0.0469
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0476 0.0476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0425 0.1206
Echinococcus granulosus neuropeptide s receptor 0.003 0.0476 0.0525
Echinococcus granulosus allatostatin A receptor 0.003 0.0476 0.0525
Onchocerca volvulus 0.003 0.0476 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.0039 0.0913 0.1006
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0026 0.0244 0.0244
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0039 0.0913 0.0913
Echinococcus multilocularis cathepsin L cysteine protease 0.0029 0.0425 0.0206
Onchocerca volvulus 0.003 0.0476 1
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0476 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Brugia malayi Melatonin receptor type 1A 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0476 0.0525
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0476 0.0525
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0476 0.0525
Loa Loa (eye worm) cysteine protease 0.0029 0.0425 0.0469
Echinococcus multilocularis voltage gated potassium channel 0.0056 0.1846 0.1816
Plasmodium falciparum cysteine proteinase falcipain 3 0.0029 0.0425 1
Brugia malayi Egg laying defective protein 4 0.0026 0.0244 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0425 0.1206
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0055 0.175 0.2482
Leishmania major cathepsin L-like protease 0.0029 0.0425 0.1206
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0476 0.0525
Echinococcus multilocularis fmrfamide receptor 0.003 0.0476 0.0263
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0476 0.0525
Onchocerca volvulus 0.0029 0.0425 0.8943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0425 0.1206
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Leishmania major cathepsin L-like protease 0.0029 0.0425 0.1206
Giardia lamblia Cathepsin B precursor 0.0055 0.175 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0029 0.0425 0.0507
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0476 0.0525
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0029 0.0425 0.0206
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis g protein coupled receptor 0.003 0.0476 0.0263
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0056 0.1846 0.2036
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0156 0.7053 0.7053
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0244 0.0346
Onchocerca volvulus 0.003 0.0476 1
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0476 0.0525
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0425 0.0507
Echinococcus granulosus voltage gated potassium channel 0.0056 0.1846 0.2036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0425 0.1206
Mycobacterium ulcerans transcriptional regulatory protein 0.0026 0.0244 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0156 0.7053 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0425 0.1206
Schistosoma mansoni amine GPCR 0.003 0.0476 0.0476
Echinococcus granulosus fmrfamide receptor 0.003 0.0476 0.0525
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0476 0.0525
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0476 0.0263
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0026 0.0244 0.0244
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0476 0.0525
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0476 0.0476
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0425 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0425 0.1206
Onchocerca volvulus 0.003 0.0476 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0039 0.0913 0.1006
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0476 0.0525
Brugia malayi hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0476 0.0263
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0476 0.0525
Onchocerca volvulus 0.0029 0.0425 0.8943
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0476 0.0525
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0476 0.0525
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0195 0.9066 1
Echinococcus multilocularis orexin receptor type 2 0.003 0.0476 0.0263
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0195 0.9066 1
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0476 0.0525
Echinococcus multilocularis hyperpolarization activated cyclic 0.0039 0.0913 0.0758
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis somatostatin receptor 0.003 0.0476 0.0263
Onchocerca volvulus 0.0029 0.0425 0.8943
Echinococcus granulosus cGMP dependent protein kinase 1 0.0026 0.0244 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0425 0.1206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0476 0.0476
Brugia malayi hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0476 0.0263
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0026 0.0244 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0425 0.0507
Treponema pallidum catabolite gene activator (Crp) 0.0026 0.0244 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0476 0.0476
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0476 0.0525
Echinococcus multilocularis hyperpolarization activated cyclic 0.0039 0.0913 0.0758
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Echinococcus multilocularis g protein coupled receptor 0.003 0.0476 0.0263
Schistosoma mansoni myosin xvIII 0.003 0.0476 0.0476
Schistosoma mansoni hypothetical protein 0.0026 0.0244 0.0244
Echinococcus multilocularis serotonin receptor 0.003 0.0476 0.0263
Onchocerca volvulus 0.003 0.0476 1
Onchocerca volvulus 0.003 0.0476 1
Loa Loa (eye worm) cathepsin B 0.0055 0.175 0.1931
Schistosoma mansoni 60S ribosomal protein L21 0.0031 0.0504 0.0504
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0026 0.0244 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0425 0.0603
Onchocerca volvulus 0.0026 0.0244 0.5124
Brugia malayi neuropeptide F receptor 0.003 0.0476 0.0525
Mycobacterium ulcerans hypothetical protein 0.0026 0.0244 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0525
Brugia malayi Cathepsin L-like precursor 0.0029 0.0425 0.0469
Brugia malayi Cyclic-nucleotide gated cation channel 0.0039 0.0913 0.1006
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0026 0.0244 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0476 0.0476
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0476 0.0525

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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