Detailed information for compound 906704

Basic information

Technical information
  • TDR Targets ID: 906704
  • Name: ethyl 4-oxo-7-(trifluoromethyl)-1H-quinoline- 3-carboxylate
  • MW: 285.219 | Formula: C13H10F3NO3
  • H donors: 1 H acceptors: 3 LogP: 3.49 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cnc2c(c1O)ccc(c2)C(F)(F)F
  • InChi: 1S/C13H10F3NO3/c1-2-20-12(19)9-6-17-10-5-7(13(14,15)16)3-4-8(10)11(9)18/h3-6H,2H2,1H3,(H,17,18)
  • InChiKey: YHUWNMJUAZJACG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid ethyl ester
  • 4-keto-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid ethyl ester
  • 391-02-6
  • 384356_ALDRICH
  • ST5319652
  • AG-690/37012007
  • BAS 00531722
  • ZINC00056850
  • EINECS 206-871-5
  • Ethyl 4-hydroxy-7-trifluoromethyl-3-quinolinecarboxylate
  • 3-Quinolinecarboxylic acid, 4-hydroxy-7-(trifluoromethyl)-, ethyl ester
  • ST5188736
  • 4-Oxo-7-trifluoromethyl-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
  • NSC96992

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Pleckstrin G protein interacting region 0.0018 0.0042 0.0047
Schistosoma mansoni cathepsin C 0.0043 0.0251 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0138 0.1033 0.5111
Brugia malayi cathepsin Z-like cysteine proteinase 0.0043 0.0251 0.0251
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0043 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0531 0.4262 0.4262
Brugia malayi hypothetical protein 0.0018 0.0042 0.0042
Plasmodium falciparum serine repeat antigen 1 0.0043 0.0251 0.0954
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0251 0.1239
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0251 0.0282
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0138 0.1033 0.1033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0047 0.0282 0.1396
Brugia malayi MH1 domain containing protein 0.0084 0.0585 0.0585
Loa Loa (eye worm) cathepsin B 0.0258 0.2022 0.2022
Loa Loa (eye worm) hypothetical protein 0.0039 0.0214 0.0214
Onchocerca volvulus 0.01 0.0716 0.2512
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0565 0.0944
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0251 0.0251
Onchocerca volvulus Fatty acid synthase homolog 0.0045 0.0267 0.0937
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0043 0.0251 0.0954
Echinococcus multilocularis cathepsin L 0.0043 0.0251 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0115 0.0567
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0115 0.533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0251 0.1239
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0776 0.6283 0.6283
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.074 0.5979 0.6733
Onchocerca volvulus 0.0138 0.1033 0.3625
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0251 0.0251
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0115 0.533
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0037 0.0204 0.0716
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0047 0.0282 0.0282
Leishmania major cathepsin L-like protease 0.0138 0.1033 0.4667
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0204
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0204 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0286 0.0286
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0258 0.2022 0.3382
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.1092 0.888 0.888
Trypanosoma cruzi cruzipain precursor, putative 0.0138 0.1033 0.1729
Entamoeba histolytica cysteine proteinase, putative 0.0138 0.1033 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1092 0.888 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0251 0.0251
Leishmania major cathepsin L-like protease 0.0138 0.1033 0.4667
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0042 0.0047
Echinococcus granulosus cathepsin l cysteine peptidase 0.0138 0.1033 0.1164
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0047 0.0282 0.0282
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0246 0.1917 0.1917
Trypanosoma cruzi cysteine proteinase, putative 0.0082 0.0568 0.095
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0039 0.0214 0.0214
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0115 0.481
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0047 0.0282 0.1396
Brugia malayi MH2 domain containing protein 0.0084 0.0585 0.0585
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0042 0.0047
Mycobacterium ulcerans polyketide synthase 0.0027 0.0115 0.481
Echinococcus multilocularis cathepsin L cysteine protease 0.0138 0.1033 0.1164
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0082 0.0568 0.095
Loa Loa (eye worm) MH2 domain-containing protein 0.0084 0.0585 0.0585
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0042 0.0042
Onchocerca volvulus 0.0047 0.0282 0.099
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0047 0.0282 0.0318
Loa Loa (eye worm) MH2 domain-containing protein 0.1228 1 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0047 0.0282 0.0318
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0084 0.0585 0.0658
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0062 0.172
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0138 0.1033 0.5111
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0214 0.0214
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0168 0.0168
Schistosoma mansoni dishevelled 0.0018 0.0042 0.0047
Entamoeba histolytica cysteine proteinase, putative 0.0082 0.0568 0.5496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0251 0.1239
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0018 0.0042 0.0047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1033 0.5111
Brugia malayi Cathepsin L-like precursor 0.01 0.0716 0.0716
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0258 0.2022 0.2277
Entamoeba histolytica cysteine proteinase 2 0.0082 0.0568 0.5496
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Entamoeba histolytica cysteine protease, putative 0.0043 0.0251 0.2425
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0047 0.0282 0.0318
Plasmodium falciparum cysteine proteinase falcipain 1 0.0082 0.0568 0.4621
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0565 0.4582
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0047 0.0282 0.0318
Brugia malayi cathepsin F-like cysteine proteinase 0.0039 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0036 0.0196 0.0221
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1092 0.888 1
Leishmania major cathepsin L-like protease 0.0138 0.1033 0.4667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Echinococcus granulosus smad 0.0084 0.0585 0.0658
Loa Loa (eye worm) hypothetical protein 0.01 0.0716 0.0716
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0102 0.4065
Schistosoma mansoni dishevelled 0.0018 0.0042 0.0047
Echinococcus granulosus mothers against decapentaplegic 5 0.0084 0.0585 0.0658
Brugia malayi cathepsin F-like cysteine proteinase 0.0043 0.0251 0.0251
Brugia malayi hypothetical protein 0.0018 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0246 0.1917 0.2159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0251 0.1239
Echinococcus granulosus cathepsin L 0.0043 0.0251 0.0282
Loa Loa (eye worm) fatty acid synthase 0.0025 0.0099 0.0099
Onchocerca volvulus Cathepsin F homolog 0.0138 0.1033 0.3625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1092 0.888 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1033 0.4667
Loa Loa (eye worm) hypothetical protein 0.074 0.5979 0.5979
Loa Loa (eye worm) MH2 domain-containing protein 0.0037 0.0204 0.0204
Giardia lamblia Cathepsin B precursor 0.0258 0.2022 1
Plasmodium vivax unspecified product 0.0082 0.0568 0.4621
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0168 0.083
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0096 0.4328
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0565 0.4582
Entamoeba histolytica G protein alpha subunit, putative 0.0047 0.0282 0.2731
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0258 0.2022 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0089 0.0089
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0047 0.0282 0.1396
Echinococcus granulosus mothers against decapentaplegic 6 0.0037 0.0204 0.023
Brugia malayi Smad1 0.0084 0.0585 0.0585
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0102 0.4065
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0047 0.0282 0.0318
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0096 0.4328
Schistosoma mansoni cathepsin B (C01 family) 0.0043 0.0251 0.0282
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0047 0.0282 0.1396
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0068 0.2859
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1033 0.4667
Echinococcus multilocularis mothers against decapentaplegic 2 0.0037 0.0204 0.023
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0043 0.0251 0.0954
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0043 0.0251 0.2425
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0062 0.172
Brugia malayi fibroinase precursor 0.0043 0.0251 0.0251
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0062 0.172
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0043 0.0251 0.0282
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0168 0.0189
Trypanosoma cruzi cysteine peptidase, putative 0.0039 0.0214 0.0357
Onchocerca volvulus 0.0138 0.1033 0.3625
Brugia malayi Cathepsin L-like cysteine proteinase 0.01 0.0716 0.0716
Giardia lamblia Cathepsin B precursor 0.0258 0.2022 1
Brugia malayi Papain family cysteine protease containing protein 0.0138 0.1033 0.1033
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0565 0.4582
Loa Loa (eye worm) hypothetical protein 0.0043 0.0251 0.0251
Schistosoma mansoni tar DNA-binding protein 0.02 0.1541 0.1736
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0082 0.0568 0.2809
Plasmodium falciparum serine repeat antigen 5 0.0043 0.0251 0.0954
Schistosoma mansoni hypothetical protein 0.0246 0.1917 0.2159
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0043 0.0251 0.0954
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0251 0.1239
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.074 0.5979 0.6733
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0204 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1033 0.4667
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0115 0.481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0251 0.1239
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0043 0.0251 0.2425
Loa Loa (eye worm) hypothetical protein 0.0039 0.0214 0.0214
Echinococcus multilocularis cathepsin b 0.074 0.5979 0.6733
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0168 0.0189
Brugia malayi cathepsin L-like precursor 0.01 0.0716 0.0716
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0047 0.0282 0.0318
Brugia malayi Papain family cysteine protease containing protein 0.0082 0.0568 0.0568
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0359 0.2851 1
Loa Loa (eye worm) DIX domain-containing protein 0.0018 0.0042 0.0042
Loa Loa (eye worm) transcription factor SMAD2 0.1228 1 1
Loa Loa (eye worm) ctsf protein 0.0138 0.1033 0.1033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1033 0.4667
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0115 0.481
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0168 0.0189
Toxoplasma gondii cathepsin CPC2 0.0043 0.0251 0.1238
Trypanosoma cruzi cysteine peptidase, putative 0.0082 0.0568 0.095
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0168 0.0189
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0196 0.0221
Giardia lamblia Cathepsin B precursor 0.0258 0.2022 1
Brugia malayi N-terminal motif family protein 0.0359 0.2851 0.2851
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0115 0.481
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1033 0.5111
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0102 0.4065
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0168 0.0189
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0168 0.0189
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0282
Brugia malayi RNA recognition motif domain containing protein 0.02 0.1541 0.1541
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0042 0.0047
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0043 0.0251 0.0954
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Entamoeba histolytica cysteine proteinase, putative 0.0082 0.0568 0.5496
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0047 0.0282 0.0318
Brugia malayi Cathepsin L-like precursor 0.0138 0.1033 0.1033
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.074 0.5979 0.6733
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0047 0.0282 0.0282
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0082 0.0568 0.064
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0565 0.2139
Loa Loa (eye worm) G protein alpha subunit 3 0.0047 0.0282 0.0282
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0043 0.0251 0.0282
Loa Loa (eye worm) MH1 domain-containing protein 0.0084 0.0585 0.0585
Onchocerca volvulus 0.0138 0.1033 0.3625
Brugia malayi MH1 domain containing protein 0.0046 0.0277 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0716 0.3541
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0043 0.021
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0246 0.1917 0.2159
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0047 0.0282 0.0282
Schistosoma mansoni smad 0.0084 0.0585 0.0658
Brugia malayi Cathepsin L-like precursor 0.0039 0.0214 0.0214
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0047 0.0282 0.1396
Echinococcus granulosus expressed protein 0.0047 0.0282 0.0318
Schistosoma mansoni tar DNA-binding protein 0.02 0.1541 0.1736
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0251 0.1239
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0565 0.2791
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0282
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.074 0.5979 0.6733
Brugia malayi Latrophilin receptor protein 2 0.0246 0.1917 0.1917
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0776 0.6283 0.6283
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Echinococcus granulosus cathepsin L cysteine proteinase 0.0138 0.1033 0.1164
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0168 0.0281
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0047 0.0282 0.0318
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1033 0.5111
Loa Loa (eye worm) latrophilin receptor protein 2 0.0246 0.1917 0.1917
Loa Loa (eye worm) fibroinase 0.0138 0.1033 0.1033
Brugia malayi cathepsin Z-like cysteine proteinase 0.0043 0.0251 0.0251
Brugia malayi Papain family cysteine protease containing protein 0.0082 0.0568 0.0568
Onchocerca volvulus 0.0018 0.0042 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0043 0.0251 0.0251
Schistosoma mansoni GTP-binding protein alpha subunit 0.0047 0.0282 0.0318
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1033 0.5111
Schistosoma mansoni Smad4 0.0037 0.0204 0.023
Loa Loa (eye worm) hypothetical protein 0.0046 0.0277 0.0277
Schistosoma mansoni hypothetical protein 0.0246 0.1917 0.2159
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1033 0.1729
Trypanosoma cruzi cysteine proteinase, putative 0.0082 0.0568 0.095
Brugia malayi MH2 domain containing protein 0.0084 0.0585 0.0585
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0047 0.0282 0.0282
Plasmodium vivax unspecified product 0.0043 0.0251 0.0954
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0102 0.0102
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0047 0.0282 0.0318
Toxoplasma gondii hypothetical protein 0.0018 0.0042 0.0205
Brugia malayi cathepsin B-like cysteine proteinase 0.074 0.5979 0.5979
Entamoeba histolytica cysteine protease, putative 0.0043 0.0251 0.2425
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0065 0.2692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0251 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0251 0.1239
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0042 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0251 0.1239
Trypanosoma cruzi cysteine protease, putative 0.0082 0.0568 0.095
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0043 0.0251 0.1239
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0251 0.0282
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0251 0.0282
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Brugia malayi hypothetical protein 0.0047 0.0282 0.0282
Mycobacterium ulcerans polyketide synthase 0.0025 0.0102 0.4065
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0043 0.0251 0.0282
Echinococcus multilocularis cathepsin L cysteine protease 0.0138 0.1033 0.1164
Echinococcus granulosus cathepsin l1 0.0138 0.1033 0.1164
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0047 0.0282 0.0318
Schistosoma mansoni smad 0.0037 0.0204 0.023
Loa Loa (eye worm) cysteine protease 0.0138 0.1033 0.1033
Brugia malayi cathepsin L-like cysteine proteinase 0.0043 0.0251 0.0251
Onchocerca volvulus 0.0047 0.0282 0.099
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0047 0.0282 0.0282
Brugia malayi latrophilin 2 splice variant baaae 0.0531 0.4262 0.4262
Plasmodium vivax vivapain-2 0.0138 0.1033 1
Plasmodium vivax vivapain-3 0.0082 0.0568 0.4621
Plasmodium falciparum serine repeat antigen 9 0.0043 0.0251 0.0954
Entamoeba histolytica cysteine protease, putative 0.0138 0.1033 1
Brugia malayi Cathepsin L-like precursor 0.01 0.0716 0.0716
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0047 0.0282 0.0282
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0043 0.0251 0.0251
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0047 0.0282 0.0282
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Schistosoma mansoni cathepsin F (C01 family) 0.0138 0.1033 0.1164
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.074 0.5979 1
Brugia malayi isocitrate dehydrogenase 0.0033 0.0168 0.0168
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0251 0.0282
Leishmania major cysteine peptidase A (CPA) 0.0138 0.1033 0.4667
Onchocerca volvulus 0.0138 0.1033 0.3625
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0043 0.0251 0.0954
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0047 0.0282 0.1396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1033 0.4667
Loa Loa (eye worm) hypothetical protein 0.0246 0.1917 0.1917
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0042 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1033 0.4667
Plasmodium vivax unspecified product 0.0039 0.0214 0.0527
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0043 0.0251 0.1239
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0018 0.0042 0.0146
Brugia malayi TAR-binding protein 0.02 0.1541 0.1541
Entamoeba histolytica cysteine proteinase 1, putative 0.0082 0.0568 0.5496
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0047 0.0282 0.0318
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0138 0.1033 0.1164
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0138 0.1033 0.1033
Brugia malayi cathepsin L precursor 0.0043 0.0251 0.0251
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0047 0.0282 0.0318
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0047 0.0282 0.0318
Leishmania major hypothetical protein, conserved 0.0081 0.0565 0.2139
Entamoeba histolytica hypothetical protein 0.0043 0.0251 0.2425
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0089 0.0089
Trypanosoma cruzi major cysteine proteinase, putative 0.0043 0.0251 0.0419
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1033 0.1729
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Schistosoma mansoni smad1 5 8 and 0.0084 0.0585 0.0658
Echinococcus multilocularis cathepsin b 0.074 0.5979 0.6733
Brugia malayi Calcitonin receptor-like protein seb-1 0.0776 0.6283 0.6283
Loa Loa (eye worm) hypothetical protein 0.0042 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0359 0.2851 0.2851
Loa Loa (eye worm) TAR-binding protein 0.02 0.1541 0.1541
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0047 0.0282 0.0282
Echinococcus multilocularis GPCR, family 2 0.0246 0.1917 0.2159
Schistosoma mansoni cathepsin F (C01 family) 0.0138 0.1033 0.1164
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Plasmodium falciparum serine repeat antigen 2 0.0043 0.0251 0.0954
Loa Loa (eye worm) Smad1 0.0084 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0043 0.0251 0.0251
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0043 0.0251 0.0954
Loa Loa (eye worm) RNA binding protein 0.02 0.1541 0.1541
Plasmodium vivax vivapain-2 0.0138 0.1033 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1033 0.4667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1033 0.1729
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0043 0.0251 0.0282
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0042 0.0042
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0042 0.0047
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0102 0.4659
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0251 0.1239
Toxoplasma gondii cathepsin B 0.0258 0.2022 1
Brugia malayi Cathepsin L-like precursor 0.0138 0.1033 0.1033
Schistosoma mansoni tar DNA-binding protein 0.02 0.1541 0.1736
Brugia malayi mothers against decapentaplegic homolog 3 0.0037 0.0204 0.0204
Onchocerca volvulus Cathepsin L homolog 0.0138 0.1033 0.3625
Onchocerca volvulus Cathepsin L homolog 0.0138 0.1033 0.3625
Schistosoma mansoni smad1 5 8 and 0.0084 0.0585 0.0658
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1092 0.888 1
Schistosoma mansoni hypothetical protein 0.0531 0.4262 0.4799
Schistosoma mansoni cathepsin F (C01 family) 0.01 0.0716 0.0806
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0047 0.0282 0.0282
Brugia malayi Cathepsin L-like precursor 0.0138 0.1033 0.1033
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0102 0.4065
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0138 0.1033 0.1164
Entamoeba histolytica cysteine proteinase, putative 0.0138 0.1033 1
Echinococcus multilocularis cysteine protease 0.0138 0.1033 0.1164
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0042 0.0042
Schistosoma mansoni tar DNA-binding protein 0.02 0.1541 0.1736
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0102 0.4659
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0018 0.0042 0.0047
Plasmodium falciparum cysteine proteinase falcipain 3 0.0138 0.1033 1
Plasmodium falciparum serine repeat antigen 4 0.0043 0.0251 0.0954
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0168 0.0281
Schistosoma mansoni Smad4 0.0037 0.0204 0.023
Leishmania major cathepsin L-like protease 0.0138 0.1033 0.4667
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0246 0.1917 0.2159
Plasmodium falciparum serine repeat antigen 7 0.0043 0.0251 0.0954
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0042
Entamoeba histolytica cysteine protease, putative 0.0043 0.0251 0.2425
Echinococcus granulosus Smad4 0.0084 0.0585 0.0658
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0047 0.0282 0.1396
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0043 0.0251 0.0282
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0042 0.0047
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0047 0.0282 0.0282
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0246 0.1917 0.2159
Brugia malayi Cathepsin L-like precursor 0.0138 0.1033 0.1033
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0168 0.8124
Brugia malayi MH1 domain containing protein 0.0084 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.01 0.0716 0.0716
Echinococcus granulosus TGF beta signal transducer SmadC 0.0084 0.0585 0.0658
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0084 0.0585 0.0658
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0043 0.0251 0.0954
Onchocerca volvulus 0.0023 0.0089 0.0311
Mycobacterium ulcerans thioesterase 0.0021 0.0068 0.2064
Echinococcus granulosus cathepsin L 0.0082 0.0568 0.064
Brugia malayi G-protein alpha subunit 0.0047 0.0282 0.0282
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0115 0.533
Onchocerca volvulus 0.0138 0.1033 0.3625
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0251 0.1239
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.02 0.1541 0.1541
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0251 0.1239
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1033 0.5111
Echinococcus multilocularis tar DNA binding protein 0.02 0.1541 0.1736
Echinococcus granulosus cathepsin L cysteine protease 0.0082 0.0568 0.064
Loa Loa (eye worm) hypothetical protein 0.01 0.0716 0.0716
Plasmodium vivax vivapain-1 0.0082 0.0568 0.4621
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0047 0.0282 0.0318
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0043 0.0251 0.0251
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0047 0.0282 0.0318
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0196 0.0221
Schistosoma mansoni cathepsin s 0.0039 0.0214 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1033 0.4667
Echinococcus multilocularis cathepsin L 0.0082 0.0568 0.064
Echinococcus granulosus cathepsin b 0.074 0.5979 0.6733
Brugia malayi MH1 domain containing protein 0.0046 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0042
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0043 0.0251 0.0954
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0042 0.0047
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0102 0.4065
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0068 0.2064
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0043 0.0251 0.0954
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0047 0.0282 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1033 0.4667
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0246 0.1917 0.2159
Onchocerca volvulus 0.0138 0.1033 0.3625
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0082 0.0568 0.064
Loa Loa (eye worm) nuclear factor I 0.0046 0.0277 0.0277
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0047 0.0282 0.0318
Onchocerca volvulus 0.0138 0.1033 0.3625
Echinococcus granulosus mothers against decapentaplegic 2 0.0037 0.0204 0.023
Echinococcus granulosus cysteine protease 0.0082 0.0568 0.064
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0102 0.4065
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0047 0.0282 0.0318
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0043 0.0251 0.0954
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0042 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0251 0.1239
Echinococcus granulosus GPCR family 2 0.0246 0.1917 0.2159
Entamoeba histolytica cysteine proteinase, putative 0.0082 0.0568 0.5496
Onchocerca volvulus Cathepsin L homolog 0.0043 0.0251 0.0879
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0082 0.0568 0.2809
Schistosoma mansoni Smad4 0.0084 0.0585 0.0658
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0047 0.0282 0.1396
Onchocerca volvulus 0.0047 0.0282 0.099
Echinococcus multilocularis expressed protein 0.0047 0.0282 0.0318
Trypanosoma cruzi cruzipain precursor, putative 0.0039 0.0214 0.0357
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0089 0.395
Entamoeba histolytica cysteine protease, putative 0.0043 0.0251 0.2425
Schistosoma mansoni dep domain containing protein 0.0018 0.0042 0.0047
Entamoeba histolytica cysteine protease, putative 0.0043 0.0251 0.2425
Brugia malayi hypothetical protein 0.0081 0.0565 0.0565
Toxoplasma gondii cathepsin CPL 0.0138 0.1033 0.511
Schistosoma mansoni tar DNA-binding protein 0.02 0.1541 0.1736
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0082 0.0568 0.2157
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.01 0.0716 0.1198
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0282
Plasmodium vivax serine-repeat antigen (SERA) 0.0043 0.0251 0.0954
Loa Loa (eye worm) hypothetical protein 0.0776 0.6283 0.6283
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.0282
Echinococcus multilocularis mothers against decapentaplegic 5 0.0084 0.0585 0.0658
Loa Loa (eye worm) hypothetical protein 0.0043 0.0251 0.0251
Schistosoma mansoni GTP-binding protein alpha subunit 0.0047 0.0282 0.0318
Brugia malayi MH2 domain containing protein 0.0037 0.0204 0.0204
Onchocerca volvulus 0.0044 0.0254 0.0893
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.003 0.0146
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0068 0.2064
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0047 0.0282 0.0318
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1033 0.5111
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0204 1
Leishmania major cathepsin L-like protease 0.0138 0.1033 0.4667
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0115 0.481
Echinococcus granulosus cathepsin l1 0.01 0.0716 0.0806
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0168 0.083
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0258 0.2022 1
Leishmania major cathepsin L-like protease 0.0138 0.1033 0.4667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Loa Loa (eye worm) MH1 domain-containing protein 0.0037 0.0204 0.0204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1033 0.5111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0251 0.1239
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0043 0.0251 0.1239
Leishmania major cathepsin L-like protease 0.0138 0.1033 0.4667
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0082 0.0568 0.064
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0042 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0204 1
Entamoeba histolytica cysteine proteinase, putative 0.0082 0.0568 0.5496
Brugia malayi Cathepsin L-like precursor 0.0138 0.1033 0.1033
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.1092 0.888 0.888
Toxoplasma gondii preprocathepsin c precursor, putative 0.0043 0.0251 0.1238
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1092 0.888 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0043 0.0251 0.0954
Onchocerca volvulus 0.0043 0.0251 0.0879
Echinococcus granulosus tar DNA binding protein 0.02 0.1541 0.1736
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0102 0.4659
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1092 0.888 1
Brugia malayi hypothetical protein 0.0052 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1033 0.5111
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0138 0.1033 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0037 0.0204 0.023
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0047 0.0282 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1033 0.4667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1033 0.4667
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0047 0.0282 0.0318
Loa Loa (eye worm) hypothetical protein 0.0043 0.0251 0.0251
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0168 0.0189
Echinococcus multilocularis cysteine protease 0.0138 0.1033 0.1164
Entamoeba histolytica cysteine protease, putative 0.0043 0.0251 0.2425
Loa Loa (eye worm) hypothetical protein 0.0081 0.0565 0.0565
Plasmodium falciparum serine repeat antigen 3 0.0043 0.0251 0.0954
Plasmodium falciparum serine repeat antigen 8 0.0043 0.0251 0.0954
Brugia malayi Cathepsin L-like precursor 0.0138 0.1033 0.1033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0082 0.0568 0.2157
Toxoplasma gondii cathepsin CPC1 0.0043 0.0251 0.1238
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0043 0.0251 0.1239
Plasmodium falciparum serine repeat antigen 6 0.0043 0.0251 0.0954
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0246 0.1917 0.2159
Leishmania major cathepsin L-like protease 0.0138 0.1033 0.4667
Schistosoma mansoni cathepsin S (C01 family) 0.0043 0.0251 0.0282
Loa Loa (eye worm) hypothetical protein 0.0138 0.1033 0.1033
Echinococcus multilocularis smad 0.0084 0.0585 0.0658
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1033 0.5111
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0168 0.0168
Echinococcus multilocularis Smad4 0.0084 0.0585 0.0658
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1092 0.888 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0043 0.0251 0.0419
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0043 0.0251 0.0954
Loa Loa (eye worm) hypothetical protein 0.0039 0.0214 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0716 0.3541
Echinococcus granulosus cathepsin b 0.074 0.5979 0.6733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1033 0.5111
Entamoeba histolytica cysteine protease, putative 0.0082 0.0568 0.5496
Brugia malayi DIX domain containing protein 0.0018 0.0042 0.0042
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0044 0.1618
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1033 0.1729
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0047 0.0282 0.0318
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0043 0.0251 0.0954
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0043 0.0251 0.0251
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0138 0.1033 1
Entamoeba histolytica cysteine proteinase, putative 0.01 0.0716 0.6929
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0047 0.0282 0.0318
Brugia malayi RNA binding protein 0.02 0.1541 0.1541
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0043 0.0251 0.1239
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0565 0.0944
Trypanosoma brucei cysteine peptidase C (CPC) 0.0258 0.2022 1
Schistosoma mansoni smad1 5 8 and 0.0084 0.0585 0.0658
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0043 0.0251 0.0954

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antitrypanosomal activity against Trypanosoma brucei brucei TC221 infected in mouse J774.1 cells after 48 hrs by alamar blue assay ChEMBL. 22376072
Activity (functional) Antitrypanosomal activity against Trypanosoma brucei brucei TC221 infected in mouse J774.1 cells after 72 hrs by alamar blue assay ChEMBL. 22376072

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.