Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0095 | 0.001 | 0.0013 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0095 | 0.001 | 0.5 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0504 | 0.3252 | 0.3511 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1142 | 0.8312 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0095 | 0.001 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1355 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0286 | 0.1525 | 0.8123 |
Leishmania major | UDP-galactopyranose mutase | 0.0095 | 0.001 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0095 | 0.001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.001 | 0.0065 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0095 | 0.001 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0095 | 0.001 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0095 | 0.001 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0095 | 0.001 | 0.0013 |
Plasmodium vivax | hypothetical protein, conserved | 0.0095 | 0.001 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0095 | 0.001 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.001 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.001 | 0.0065 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0095 | 0.001 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.1142 | 0.8312 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0095 | 0.001 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0095 | 0.001 | 0.0012 |
Brugia malayi | SWIRM domain containing protein | 0.0095 | 0.001 | 0.0053 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0286 | 0.1525 | 1 |
Brugia malayi | hypothetical protein | 0.0095 | 0.001 | 0.0053 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0095 | 0.001 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0095 | 0.001 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.001 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1483 | 0.9723 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0095 | 0.001 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.1048 | 0.7566 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0095 | 0.001 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.1048 | 0.7566 | 0.9101 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0504 | 0.3252 | 0.3245 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0095 | 0.001 | 0.0012 |
Schistosoma mansoni | thyroid hormone receptor | 0.1142 | 0.8312 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0095 | 0.001 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0286 | 0.1525 | 0.8123 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1259 | 0.9243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.001 | 0.0065 |
Schistosoma mansoni | hypothetical protein | 0.1048 | 0.7566 | 0.9101 |
Schistosoma mansoni | amine oxidase | 0.0095 | 0.001 | 0.0012 |
Onchocerca volvulus | 0.0095 | 0.001 | 1 | |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0095 | 0.001 | 0.0012 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0331 | 0.1877 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.001 | 0.0065 |
Echinococcus multilocularis | 0.0095 | 0.001 | 0.0012 | |
Schistosoma mansoni | amine oxidase | 0.0095 | 0.001 | 0.0012 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.