Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0128 | 0.6086 | 0.6086 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0132 | 0.0132 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.002 | 0.0675 | 1 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0009 | 0.0132 | 0.0132 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0132 | 0.0217 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.6086 | 0.6086 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.6086 | 0.6086 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0463 | 0.0761 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.294 | 0.4367 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0207 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.6086 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0675 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0065 | 0.294 | 0.483 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0463 | 0.5 |
Brugia malayi | N-terminal motif family protein | 0.0188 | 0.9033 | 0.9033 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.002 | 0.0675 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0675 | 1 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0132 | 0.0132 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.002 | 0.0675 | 1 |
Giardia lamblia | Replication factor C, subunit 1 | 0.002 | 0.0675 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0675 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0463 | 0.0761 |
Onchocerca volvulus | 0.002 | 0.0675 | 0.0748 | |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.002 | 0.0675 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.6086 | 0.6086 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0675 | 0.0675 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.002 | 0.0675 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.6086 | 1 |
Schistosoma mansoni | dep domain containing protein | 0.0009 | 0.0132 | 0.0196 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.002 | 0.0675 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.294 | 0.4367 |
Brugia malayi | hypothetical protein | 0.002 | 0.0675 | 0.0675 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.002 | 0.0675 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0675 | 0.0675 |
Brugia malayi | DKFZp564C0469 protein | 0.002 | 0.0675 | 0.0675 |
Brugia malayi | hypothetical protein | 0.002 | 0.0675 | 0.0675 |
Entamoeba histolytica | hypothetical protein | 0.002 | 0.0675 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.294 | 0.4367 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0463 | 0.0463 |
Schistosoma mansoni | topbp1 | 0.002 | 0.0675 | 0.1003 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.002 | 0.0675 | 1 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.002 | 0.0675 | 0.0675 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0009 | 0.0132 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.6086 | 0.6086 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.002 | 0.0675 | 1 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0009 | 0.0132 | 0.0196 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0463 | 0.0761 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0132 | 0.0217 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.6086 | 0.904 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0132 | 0.0132 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0141 | 0.6732 | 0.6732 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.6732 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.9033 | 0.9033 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0188 | 0.9033 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.002 | 0.0675 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.294 | 0.483 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.294 | 0.294 |
Echinococcus granulosus | replication factor c subunit 1 | 0.002 | 0.0675 | 0.111 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0132 | 0.0132 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.6086 | 0.904 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0132 | 0.0196 |
Treponema pallidum | DNA ligase (lig) | 0.002 | 0.0675 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0132 | 0.0132 |
Echinococcus multilocularis | nibrin | 0.002 | 0.0675 | 0.111 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.6086 | 0.904 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0132 | 0.0132 |
Schistosoma mansoni | DNA ligase IV | 0.002 | 0.0675 | 0.1003 |
Brugia malayi | topoisomerase | 0.002 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0065 | 0.294 | 0.294 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0463 | 0.6092 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.002 | 0.0675 | 0.111 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0132 | 0.0217 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.002 | 0.0675 | 0.0675 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.002 | 0.0675 | 0.1003 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.002 | 0.0675 | 1 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0132 | 0.0217 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0009 | 0.0132 | 0.0132 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0132 | 0.0217 |
Echinococcus granulosus | nibrin | 0.002 | 0.0675 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0675 | 0.0675 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0207 | 1 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0463 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0675 | 0.0675 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0065 | 0.294 | 0.294 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.294 | 0.483 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0132 | 0.0132 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.294 | 0.4367 |
Chlamydia trachomatis | DNA ligase | 0.002 | 0.0675 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0065 | 0.294 | 0.294 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0675 | 0.0675 |
Brugia malayi | DIX domain containing protein | 0.0009 | 0.0132 | 0.0132 |
Echinococcus granulosus | GPCR family 2 | 0.0065 | 0.294 | 0.483 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0463 | 0.0463 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.6086 | 0.904 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.002 | 0.0675 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0463 | 0.6857 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0132 | 0.0217 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0009 | 0.0132 | 0.0196 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0463 | 0.6857 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.294 | 0.483 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0009 | 0.0132 | 0.0217 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0463 | 0.0463 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0463 | 0.0761 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.002 | 0.0675 | 1 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.002 | 0.0675 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0675 | 1 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0009 | 0.0132 | 0.0217 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.6732 | 0.6732 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0009 | 0.0132 | 0.0132 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.002 | 0.0675 | 1 |
Onchocerca volvulus | 0.0009 | 0.0132 | 0.0146 | |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0132 | 0.0217 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0463 | 0.6092 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0463 | 0.0761 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0132 | 0.0196 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0463 | 0.0688 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0463 | 0.0761 |
Schistosoma mansoni | regulator of G protein signaling | 0.0009 | 0.0132 | 0.0196 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.6086 | 0.904 |
Toxoplasma gondii | ATPase, AAA family protein | 0.002 | 0.0675 | 1 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.6086 | 0.6086 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.002 | 0.0675 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.002 | 0.0675 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0132 | 0.0217 |
Schistosoma mansoni | topbp1 | 0.002 | 0.0675 | 0.1003 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.294 | 0.483 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0675 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.