Detailed information for compound 907063

Basic information

Technical information
  • TDR Targets ID: 907063
  • Name: 3-chloro-N-[2-(4-fluorophenyl)-1,3-benzoxazol -5-yl]benzamide
  • MW: 366.773 | Formula: C20H12ClFN2O2
  • H donors: 1 H acceptors: 2 LogP: 4.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1oc2c(n1)cc(cc2)NC(=O)c1cccc(c1)Cl
  • InChi: 1S/C20H12ClFN2O2/c21-14-3-1-2-13(10-14)19(25)23-16-8-9-18-17(11-16)24-20(26-18)12-4-6-15(22)7-5-12/h1-11H,(H,23,25)
  • InChiKey: ZEYYHCDRHRNZGO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC04593110
  • EU-0001719
  • Oprea1_126710
  • STK027131

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tar DNA binding protein 0.0064 0.8913 0.8913
Plasmodium falciparum proteasome subunit beta type-5 0.0069 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.434 0.434
Loa Loa (eye worm) TAR-binding protein 0.0064 0.8913 0.8913
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0069 1 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.434 0.434
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.808 0.808
Brugia malayi hypothetical protein 0.0025 0.1306 0.1306
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0069 1 1
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0069 1 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.8913 0.8913
Leishmania major proteasome beta 5 subunit, putative 0.0069 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.808 0.808
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0069 1 0.5
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0069 1 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.8913 0.8913
Schistosoma mansoni tar DNA-binding protein 0.0064 0.8913 0.8913
Echinococcus multilocularis proteasome (prosome, macropain) 0.0069 1 1
Brugia malayi RNA binding protein 0.0064 0.8913 0.8913
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.8913 0.8913
Loa Loa (eye worm) hypothetical protein 0.006 0.808 0.808
Toxoplasma gondii proteasome subunit beta type, putative 0.0069 1 1
Plasmodium vivax proteasome subunit beta type-5, putative 0.0069 1 1
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0069 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.1306 0.1306
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0069 1 0.5
Schistosoma mansoni tar DNA-binding protein 0.0064 0.8913 0.8913
Brugia malayi TAR-binding protein 0.0064 0.8913 0.8913
Schistosoma mansoni tar DNA-binding protein 0.0064 0.8913 0.8913
Schistosoma mansoni hypothetical protein 0.0041 0.434 0.434
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0069 1 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.8913 0.8913
Mycobacterium ulcerans proteasome PrcB 0.0069 1 0.5
Echinococcus granulosus proteasome prosome macropain 0.0069 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.808 0.808
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0069 1 1
Loa Loa (eye worm) RNA binding protein 0.0064 0.8913 0.8913
Echinococcus granulosus tar DNA binding protein 0.0064 0.8913 0.8913
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0069 1 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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