Detailed information for compound 907097

Basic information

Technical information
  • TDR Targets ID: 907097
  • Name: N-[2-[2-[(5-chloro-3-methyl-1-phenylpyrazol-4 -yl)methylidene]hydrazinyl]-2-oxoethyl]-2-hyd roxybenzamide
  • MW: 411.842 | Formula: C20H18ClN5O3
  • H donors: 3 H acceptors: 4 LogP: 3.7 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CNC(=O)c1ccccc1O)N/N=C/c1c(C)nn(c1Cl)c1ccccc1
  • InChi: 1S/C20H18ClN5O3/c1-13-16(19(21)26(25-13)14-7-3-2-4-8-14)11-23-24-18(28)12-22-20(29)15-9-5-6-10-17(15)27/h2-11,27H,12H2,1H3,(H,22,29)(H,24,28)/b23-11+
  • InChiKey: LPHIPHIGOXGZGT-FOKLQQMPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(2E)-2-[(5-chloro-3-methyl-1-phenylpyrazol-4-yl)methylidene]hydrazinyl]-2-oxoethyl]-2-hydroxybenzamide
  • N-[2-[N'-[(5-chloro-3-methyl-1-phenyl-pyrazol-4-yl)methylene]hydrazino]-2-oxo-ethyl]-2-hydroxy-benzamide
  • N-[2-[(N'E)-N'-[(5-chloro-3-methyl-1-phenyl-pyrazol-4-yl)methylene]hydrazino]-2-oxo-ethyl]-2-hydroxy-benzamide
  • N-[2-[N'-[(5-chloro-3-methyl-1-phenyl-4-pyrazolyl)methylene]hydrazino]-2-oxoethyl]-2-hydroxybenzamide
  • N-[2-[(N'E)-N'-[(5-chloro-3-methyl-1-phenyl-4-pyrazolyl)methylene]hydrazino]-2-oxoethyl]-2-hydroxybenzamide
  • N-[2-[N'-[(5-chloro-3-methyl-1-phenyl-pyrazol-4-yl)methylene]hydrazino]-2-keto-ethyl]-2-hydroxy-benzamide
  • N-[2-[(N'E)-N'-[(5-chloro-3-methyl-1-phenyl-pyrazol-4-yl)methylene]hydrazino]-2-keto-ethyl]-2-hydroxy-benzamide
  • N-[2-[(2E)-2-[(5-chloro-3-methyl-1-phenyl-pyrazol-4-yl)methylidene]hydrazinyl]-2-oxo-ethyl]-2-hydroxy-benzamide
  • N-[2-[2-[(5-chloro-3-methyl-1-phenyl-pyrazol-4-yl)methylidene]hydrazinyl]-2-oxo-ethyl]-2-hydroxy-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0135 0.7061 0.7061
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.5774 0.5774
Loa Loa (eye worm) RNA binding protein 0.0135 0.7061 1
Brugia malayi 6-phosphofructokinase 0.0113 0.5774 0.8178
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.5774 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.5774 0.8178
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.1984 0.281
Brugia malayi MH2 domain containing protein 0.0125 0.6438 0.9118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1984 0.1984
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.5774 1
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.5774 1
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0845 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.5774 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0845 0.5
Echinococcus multilocularis geminin 0.0184 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.5774 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.5774 0.8178
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.1984 0.281
Brugia malayi phosphofructokinase 0.0113 0.5774 0.8178
Schistosoma mansoni tar DNA-binding protein 0.0135 0.7061 0.7061
Schistosoma mansoni hypothetical protein 0.0184 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1984 0.1984
Brugia malayi TAR-binding protein 0.0135 0.7061 1
Schistosoma mansoni hypothetical protein 0.0184 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.1137 0.1137
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.5774 0.5774
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.2117 0.2999
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.5774 0.5774
Schistosoma mansoni tar DNA-binding protein 0.0135 0.7061 0.7061
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.7061 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.5774 0.5
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.5774 0.5
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0845 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.7061 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.5774 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1984 0.1984
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.2117 0.2999
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1984 0.1984
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0845 0.5
Brugia malayi 6-phosphofructokinase 0.0113 0.5774 0.8178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1984 0.1984
Echinococcus multilocularis tar DNA binding protein 0.0135 0.7061 0.7061
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.5774 1
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0845 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.5774 1
Brugia malayi RNA binding protein 0.0135 0.7061 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1984 0.1984
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.5774 0.5
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0845 0.5
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.5774 0.5
Loa Loa (eye worm) phosphofructokinase 0.0113 0.5774 0.8178
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.5774 0.5774
Loa Loa (eye worm) hypothetical protein 0.0036 0.1137 0.1611
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.6438 0.9118
Loa Loa (eye worm) TAR-binding protein 0.0135 0.7061 1
Echinococcus granulosus tar DNA binding protein 0.0135 0.7061 0.7061
Schistosoma mansoni tar DNA-binding protein 0.0135 0.7061 0.7061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1984 0.1984
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0845 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.2117 0.2999
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.6438 0.9118
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.5774 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.5774 0.5
Schistosoma mansoni tar DNA-binding protein 0.0135 0.7061 0.7061
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0845 0.5
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0845 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.2117 0.2999
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.1137 0.1611
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0845 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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