Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0172 | 0.2379 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0172 | 0.2379 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0172 | 0.2379 | 1 |
Onchocerca volvulus | 0.0156 | 0 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0222 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0222 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0172 | 0.2379 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0172 | 0.2379 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0222 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0172 | 0.2379 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0172 | 0.2379 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0222 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0172 | 0.2379 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0222 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0172 | 0.2379 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0172 | 0.2379 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.