Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.2595 | 0.2595 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0008 | 0.0883 | 0.0883 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0008 | 0.0883 | 0.0546 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.2595 | 0.3485 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.2595 | 0.2595 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.2595 | 0.2595 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.2595 | 0.2595 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.2595 | 0.2595 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.2595 | 0.2595 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.2595 | 0.1878 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.2595 | 0.2595 |
Onchocerca volvulus | 0.0026 | 1 | 1 | |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.2595 | 0.3485 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.2595 | 0.3485 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.2595 | 0.2595 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.2595 | 0.3485 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.6737 | 0.6737 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0021 | 0.7448 | 1 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0008 | 0.0883 | 0.0546 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0008 | 0.0883 | 0.0546 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.2595 | 0.2595 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0021 | 0.7448 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.2595 | 0.2595 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0008 | 0.0883 | 0.0546 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.2595 | 0.2595 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.6737 | 0.6737 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.6737 | 0.6421 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0008 | 0.0883 | 0.0546 |
Trypanosoma brucei | ABC transporter, putative | 0.0021 | 0.7448 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0883 | 0.0883 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.2595 | 0.3485 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.2595 | 0.3485 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.6211 | 0.6071 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.6737 | 0.6737 |
Giardia lamblia | ABC transporter | 0.0021 | 0.7327 | 0.5 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0883 | 0.0546 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0021 | 0.7448 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0008 | 0.0883 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0883 | 0.0883 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.2595 | 0.3485 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0008 | 0.0883 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Schistosoma mansoni | ABC transporter | 0.0018 | 0.5874 | 0.7887 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.6737 | 0.6737 |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG84 | 0.0021 | 0.7448 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0021 | 0.7448 | 0.7201 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.2595 | 0.2595 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.2595 | 0.3485 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0008 | 0.0883 | 0.1186 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.2595 | 0.3485 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.2595 | 0.3485 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.2595 | 0.2595 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.2595 | 0.3485 |
Brugia malayi | ABC transporter family protein | 0.0018 | 0.5874 | 0.5874 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0883 | 0.0546 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.2595 | 0.3485 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0021 | 0.7448 | 0.7201 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.2595 | 0.3485 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.2595 | 0.2595 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.2595 | 0.3485 |
Trypanosoma cruzi | ABC transporter, putative | 0.0021 | 0.7448 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.2595 | 0.3485 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0021 | 0.7448 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.2595 | 0.1878 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.2595 | 0.3485 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.2595 | 0.2595 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.2595 | 0.2595 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.6211 | 0.6071 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0021 | 0.7448 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.2595 | 0.2595 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.2595 | 0.3485 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.2595 | 0.2595 |
Plasmodium vivax | ABC transporter G family member 2, putative | 0.0021 | 0.7448 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0883 | 0.0546 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.2595 | 0.3485 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.2595 | 0.2595 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Mycobacterium tuberculosis | Probable conserved transmembrane ATP-binding protein ABC transporter | 0.0017 | 0.5753 | 0.5596 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.2595 | 0.2595 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.2595 | 0.3485 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.2595 | 0.3485 |
Leishmania major | ATP-binding cassette protein subfamily G, member 4, putative | 0.0021 | 0.7448 | 0.7201 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.2595 | 0.3485 |
Loa Loa (eye worm) | oxidoreductase | 0.0008 | 0.0883 | 0.0883 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.2595 | 0.3485 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.2595 | 0.2595 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.6211 | 0.6071 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0.0883 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.2595 | 0.2595 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.2595 | 0.2595 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.2595 | 0.3485 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.2595 | 0.3485 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.2595 | 0.2595 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0.2595 | 0.1878 | |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.2595 | 0.3485 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0008 | 0.0883 | 0.1186 |
Trypanosoma cruzi | ATP-binding cassette protein, putative | 0.0021 | 0.7448 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0.0883 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.2595 | 0.2595 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0008 | 0.0883 | 0.1186 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.6737 | 0.6617 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0021 | 0.7448 | 0.7201 |
Loa Loa (eye worm) | ABC transporter | 0.0018 | 0.5874 | 0.5874 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.2595 | 0.3485 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.2595 | 0.2595 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.2595 | 0.1878 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.6737 | 0.8918 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.2595 | 0.2595 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.5753 | 0.7724 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0008 | 0.0883 | 0.0883 |
Entamoeba histolytica | ABC transporter, putative | 0.0021 | 0.7448 | 0.7201 |
Leishmania major | ATP-binding cassette protein subfamily G, member 6, putative | 0.0021 | 0.7448 | 0.7201 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.2595 | 0.2595 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.2595 | 0.3485 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0883 | 0.0546 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.2595 | 0.3485 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.2595 | 0.3485 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.2595 | 0.2595 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.0021 | 0.7448 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.2595 | 0.3485 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0021 | 0.7448 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.6211 | 0.6071 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.2595 | 0.3485 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.6737 | 0.6737 |
Trypanosoma brucei | ATP-binding cassette protein, putative | 0.0021 | 0.7448 | 1 |
Plasmodium falciparum | ABC transporter G family member 2 | 0.0021 | 0.7448 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.6737 | 0.8918 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0883 | 0.0883 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.6737 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.