Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0067 | 0.7172 | 0.7017 |
Schistosoma mansoni | notch | 0.0009 | 0.0517 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0578 | 0.0065 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0517 | 0.0517 |
Echinococcus granulosus | enteropeptidase | 0.0009 | 0.0578 | 0.0227 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3758 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0578 | 0.0578 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.3618 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0568 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0578 | 0.0065 |
Echinococcus multilocularis | fibropellin Ia | 0.0009 | 0.0517 | 0.0163 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.3618 | 1 |
Onchocerca volvulus | 0.0009 | 0.0578 | 0.0092 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.3125 | 0.2869 |
Giardia lamblia | High cysteine protein | 0.0009 | 0.0517 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0067 | 0.7172 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.6285 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.6285 | 0.6146 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.3758 | 0.3758 |
Schistosoma mansoni | slit | 0.0009 | 0.0517 | 0.0517 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.293 | 0.293 |
Brugia malayi | Trypsin family protein | 0.0009 | 0.0578 | 0.0065 |
Schistosoma mansoni | cell polarity protein | 0.0009 | 0.0517 | 0.0517 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0067 | 0.7172 | 0.7066 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0067 | 0.7172 | 0.7066 |
Echinococcus granulosus | protein jagged 1 | 0.0009 | 0.0517 | 0.0163 |
Brugia malayi | Kringle domain containing protein | 0.0067 | 0.7172 | 0.7017 |
Brugia malayi | Trypsin family protein | 0.0009 | 0.0578 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0578 | 0.0065 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.3125 | 0.3125 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.5828 | 0.5601 |
Echinococcus multilocularis | neural cadherin | 0.0009 | 0.0517 | 0.0163 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.006 | 0.6285 | 0.7504 |
Echinococcus multilocularis | slit 2 protein | 0.0009 | 0.0517 | 0.0163 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 1 | 1 |
Echinococcus granulosus | fibropellin Ia | 0.0009 | 0.0517 | 0.0163 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0067 | 0.7172 | 0.5 |
Brugia malayi | hypothetical protein | 0.0037 | 0.3758 | 0.3418 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.3618 | 0.466 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.3618 | 0.5 |
Brugia malayi | Inositol-1 | 0.0036 | 0.3618 | 0.327 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3758 | 1 |
Schistosoma mansoni | notch | 0.0009 | 0.0517 | 0.0517 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0517 | 0.0517 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.006 | 0.6285 | 0.6285 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.6285 | 0.6082 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0578 | 0.0065 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0009 | 0.0578 | 0.0227 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Schistosoma mansoni | septate junction protein | 0.0009 | 0.0517 | 0.0517 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0568 | 0.0054 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Onchocerca volvulus | 0.003 | 0.293 | 0.3626 | |
Echinococcus granulosus | protein jagged 2 | 0.0009 | 0.0517 | 0.0163 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0009 | 0.0578 | 0.0227 |
Leishmania major | hypothetical protein, conserved | 0.0067 | 0.7172 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.7172 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.3758 | 0.3526 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0009 | 0.0578 | 0.0065 |
Brugia malayi | Trypsin family protein | 0.0009 | 0.0578 | 0.0065 |
Echinococcus granulosus | protein jagged 2 | 0.0009 | 0.0517 | 0.0163 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0578 | 0.0578 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0009 | 0.0517 | 0.0163 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0009 | 0.0517 | 0.0163 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.293 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.7172 | 0.7017 |
Onchocerca volvulus | 0.0009 | 0.0578 | 0.0092 | |
Echinococcus granulosus | neural cadherin | 0.0009 | 0.0517 | 0.0163 |
Echinococcus multilocularis | Mastin | 0.0009 | 0.0578 | 0.0227 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.7172 | 0.7172 |
Schistosoma mansoni | notch | 0.0009 | 0.0517 | 0.0517 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0009 | 0.0578 | 0.0065 |
Onchocerca volvulus | 0.0009 | 0.0578 | 0.0092 | |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0009 | 0.0517 | 0.0517 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0009 | 0.0517 | 0.0163 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0072 | 0.7694 | 0.7694 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0009 | 0.0517 | 0.0163 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.3758 | 0.3526 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.006 | 0.6285 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0009 | 0.0517 | 0.0163 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.3618 | 0.338 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0359 | 0.0359 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0064 | 0.6765 | 0.6765 |
Echinococcus granulosus | delta-like protein 1 | 0.0009 | 0.0517 | 0.0163 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0554 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0517 | 0.0517 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0009 | 0.0578 | 0.0227 |
Schistosoma mansoni | notch | 0.0009 | 0.0517 | 0.0517 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.6285 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3758 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.3618 | 0.3618 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.3188 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.3125 | 0.3125 |
Echinococcus granulosus | Mastin | 0.0009 | 0.0578 | 0.0227 |
Echinococcus multilocularis | protein jagged 1 | 0.0009 | 0.0517 | 0.0163 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0009 | 0.0517 | 0.0517 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0517 | 0.0517 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Onchocerca volvulus | 0.0067 | 0.7172 | 1 | |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0009 | 0.0517 | 0.0163 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.6285 | 0.6146 |
Onchocerca volvulus | 0.0009 | 0.0578 | 0.0092 | |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.3618 | 0.5327 |
Loa Loa (eye worm) | trypsin family protein | 0.0009 | 0.0578 | 0.0065 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.3618 | 0.338 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0009 | 0.0517 | 0.0163 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0578 | 0.0065 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0568 | 0.0216 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0578 | 0.0065 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.293 | 0.2545 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.3618 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0578 | 0.0065 |
Echinococcus granulosus | notch | 0.0009 | 0.0517 | 0.0163 |
Brugia malayi | Trypsin family protein | 0.0009 | 0.0578 | 0.0065 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0009 | 0.0578 | 0.0227 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0009 | 0.0578 | 0.0227 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0009 | 0.0578 | 0.0227 |
Schistosoma mansoni | notch | 0.0009 | 0.0517 | 0.0517 |
Echinococcus multilocularis | notch | 0.0009 | 0.0517 | 0.0163 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0009 | 0.0517 | 0.0163 |
Brugia malayi | Protein kinase domain containing protein | 0.0067 | 0.7172 | 0.7017 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0009 | 0.0578 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0578 | 0.0065 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0067 | 0.7172 | 0.5 |
Onchocerca volvulus | 0.0009 | 0.0578 | 0.0092 | |
Echinococcus granulosus | neurogenic locus protein delta | 0.0009 | 0.0517 | 0.0163 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.3758 | 0.3758 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.3618 | 0.3618 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Onchocerca volvulus | 0.0009 | 0.0578 | 0.0092 | |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0009 | 0.0517 | 0.0163 |
Echinococcus multilocularis | protein jagged 2 | 0.0009 | 0.0517 | 0.0163 |
Schistosoma mansoni | notch | 0.0009 | 0.0517 | 0.0517 |
Echinococcus granulosus | protein jagged 1 | 0.0009 | 0.0517 | 0.0163 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0057 | 0.599 | 0.8224 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0009 | 0.0578 | 0.0578 |
Echinococcus granulosus | slit 2 protein | 0.0009 | 0.0517 | 0.0163 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0009 | 0.0578 | 0.0227 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.3618 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.3618 | 0.327 |
Echinococcus multilocularis | protein jagged 1 | 0.0009 | 0.0517 | 0.0163 |
Echinococcus multilocularis | enteropeptidase | 0.0009 | 0.0578 | 0.0227 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0009 | 0.0578 | 0.0227 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3758 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.3125 | 0.2869 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0517 | 0.0517 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0517 | 0.0517 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0517 | 0.0517 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.