Detailed information for compound 907872

Basic information

Technical information
  • TDR Targets ID: 907872
  • Name: (2E)-2-[[4-[(4-nitrophenyl)methoxy]phenyl]met hylidene]-[1,3]thiazolo[3,2-a]benzimidazol-1- one
  • MW: 437.511 | Formula: C23H23N3O4S
  • H donors: 0 H acceptors: 4 LogP: 5.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1/C(=C/c2ccc(cc2)OCc2ccc(cc2)[N+](=O)[O-])/SC2N1C1CCCCC1N2
  • InChi: 1S/C23H15N3O4S/c27-22-21(31-23-24-19-3-1-2-4-20(19)25(22)23)13-15-7-11-18(12-8-15)30-14-16-5-9-17(10-6-16)26(28)29/h1-13H,14H2/b21-13+
  • InChiKey: XJXGQMWBZPFZAM-FYJGNVAPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2E)-2-[[4-[(4-nitrophenyl)methoxy]phenyl]methylene]thiazolo[3,2-a]benzimidazol-1-one
  • (2E)-2-[[4-[(4-nitrophenyl)methoxy]phenyl]methylene]-1-thiazolo[3,2-a]benzimidazolone
  • (2E)-2-[4-(4-nitrobenzyl)oxybenzylidene]thiazolo[3,2-a]benzimidazol-1-one
  • BIM-0013999.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0044 0.0227 0.0191
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0227 0.0191
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0348 0.3038 0.3196
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0059
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0044 0.0227 0.0191
Echinococcus granulosus Pleckstrin G protein interacting region 0.0026 0.0059 0.0021
Echinococcus granulosus segment polarity protein dishevelled 0.0026 0.0059 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0289 0.1255
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0129 0.1008 0.1026
Brugia malayi mothers against decapentaplegic homolog 3 0.0033 0.0118 0.0118
Schistosoma mansoni survival motor neuron protein 0.0041 0.0191 0.0153
Echinococcus granulosus tumor protein p63 0.0285 0.2449 0.2574
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0044 0.0227 0.0383
Loa Loa (eye worm) hypothetical protein 0.0536 0.4772 0.4772
Schistosoma mansoni hypothetical protein 0.0034 0.0133 0.0091
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0083 0.0583 1
Echinococcus granulosus Niemann Pick C1 protein 0.0083 0.0583 0.058
Brugia malayi glutaminase DH11.1 0.0268 0.23 0.23
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0044 0.0227 0.0227
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0118 0.0118
Brugia malayi hypothetical protein 0.0152 0.1221 0.1221
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0326 0.2832 0.2832
Echinococcus multilocularis regulator of G protein signaling 7 0.0026 0.0059 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.0752 0.6777 0.6777
Loa Loa (eye worm) DIX domain-containing protein 0.0026 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0044 0.0219 0.0219
Trichomonas vaginalis glutaminase, putative 0.0268 0.23 1
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0026 0.0059 0.0124
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0051 0.0289 0.2864
Echinococcus granulosus TGF beta signal transducer SmadC 0.0073 0.0492 0.0484
Loa Loa (eye worm) hypothetical protein 0.0752 0.6777 0.6777
Brugia malayi MH2 domain containing protein 0.1074 0.9755 0.9755
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0227 0.0383
Loa Loa (eye worm) hypothetical protein 0.0044 0.0227 0.0227
Echinococcus multilocularis tar DNA binding protein 0.0326 0.2832 0.2976
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1036 0.9404 1
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0044 0.0227 0.0383
Schistosoma mansoni hypothetical protein 0.0041 0.0191 0.0153
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0056 0.033 0.033
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0057 0.0339 0.0311
Schistosoma mansoni Smad4 0.0033 0.0118 0.0075
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0044 0.0227 0.0227
Onchocerca volvulus 0.02 0.1662 0.3483
Schistosoma mansoni hypothetical protein 0.0034 0.0133 0.0091
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0044 0.0227 0.0227
Echinococcus granulosus mothers against decapentaplegic 5 0.0073 0.0492 0.0484
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0051 0.0289 0.0257
Loa Loa (eye worm) hypothetical protein 0.0152 0.1221 0.1221
Toxoplasma gondii isocitrate dehydrogenase 0.0129 0.1008 1
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0912 0.0932
Schistosoma mansoni hypothetical protein 0.0034 0.0133 0.0091
Brugia malayi MH1 domain containing protein 0.0073 0.0492 0.0492
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0036 0.0145 0.0145
Schistosoma mansoni hypothetical protein 0.0348 0.3038 0.3196
Schistosoma mansoni tar DNA-binding protein 0.0326 0.2832 0.2976
Echinococcus granulosus sterol regulatory element binding protein 0.0036 0.0145 0.0112
Schistosoma mansoni smad 0.0073 0.0492 0.0475
Loa Loa (eye worm) Smad1 0.0073 0.0492 0.0492
Schistosoma mansoni regulator of G protein signaling 0.0026 0.0059 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0044 0.0227 0.0227
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0348 0.3038 0.3038
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0044 0.0227 0.02
Echinococcus multilocularis mothers against decapentaplegic 2 0.0033 0.0118 0.0075
Schistosoma mansoni hypothetical protein 0.0752 0.6777 0.7193
Loa Loa (eye worm) isocitrate dehydrogenase 0.0129 0.1008 0.1008
Schistosoma mansoni tar DNA-binding protein 0.0326 0.2832 0.2976
Echinococcus multilocularis survival motor neuron protein 1 0.0199 0.1659 0.1722
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0227 0.0191
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0056 0.033 0.031
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0044 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.11 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.019 0.019
Loa Loa (eye worm) glutaminase 2 0.0268 0.23 0.23
Brugia malayi hypothetical protein 0.0044 0.0227 0.0227
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.1008 0.1026
Schistosoma mansoni hypothetical protein 0.0348 0.3038 0.3196
Onchocerca volvulus 0.0152 0.1221 0.256
Echinococcus multilocularis microtubule associated protein 2 0.0581 0.5195 0.5501
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0073 0.0492 0.0475
Echinococcus multilocularis Niemann Pick C1 protein 0.0083 0.0583 0.0572
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1036 0.9404 1
Entamoeba histolytica G protein alpha subunit, putative 0.0044 0.0227 0.3896
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0057 0.0339 0.032
Echinococcus multilocularis segment polarity protein dishevelled 0.0026 0.0059 0.0012
Loa Loa (eye worm) hypothetical protein 0.0044 0.0227 0.0227
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0026 0.0059 0.0059
Brugia malayi CHE-14 protein 0.0036 0.0145 0.0145
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0044 0.0227 0.0191
Schistosoma mansoni patched 1 0.0036 0.0145 0.0103
Brugia malayi N-terminal motif family protein 0.0536 0.4772 0.4772
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0044 0.0227 0.0227
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0051 0.0289 0.2864
Schistosoma mansoni dep domain containing protein 0.0026 0.0059 0.0012
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0227 0.0227
Toxoplasma gondii LsmAD domain-containing protein 0.0126 0.0983 0.9746
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1036 0.9404 1
Toxoplasma gondii aldehyde dehydrogenase 0.0051 0.0289 0.2507
Onchocerca volvulus 0.0044 0.0227 0.0476
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0044 0.0227 0.02
Toxoplasma gondii hypothetical protein 0.0026 0.0059 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.1036 0.9404 0.9404
Brugia malayi RNA binding protein 0.0326 0.2832 0.2832
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.0983 0.964
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0129 0.1008 0.1034
Echinococcus granulosus Protein patched homolog 1 0.0036 0.0145 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0326 0.2832 0.2976
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0175 0.1438 0.1438
Schistosoma mansoni smad 0.0033 0.0118 0.0075
Echinococcus multilocularis sterol regulatory element binding protein 0.0036 0.0145 0.0103
Echinococcus multilocularis tumor protein p63 0.0285 0.2449 0.2567
Mycobacterium ulcerans glutaminase 0.0268 0.23 1
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0044 0.0227 0.0191
Brugia malayi MH2 domain containing protein 0.0073 0.0492 0.0492
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0129 0.1008 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0073 0.0492 0.0492
Echinococcus granulosus transcription factor Dp 1 0.0032 0.0113 0.0079
Brugia malayi regulator of G-protein signaling egl-10 0.0026 0.0059 0.0059
Brugia malayi isocitrate dehydrogenase 0.0129 0.1008 0.1008
Schistosoma mansoni smad1 5 8 and 0.0073 0.0492 0.0475
Onchocerca volvulus 0.0042 0.0201 0.0421
Loa Loa (eye worm) hypothetical protein 0.0083 0.0583 0.0583
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0056 0.033 0.0301
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0912 0.0924
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0041 0.0191 0.0191
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0289 0.1255
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0044 0.0227 0.0383
Onchocerca volvulus 0.0026 0.0059 0.0124
Plasmodium vivax ataxin-2 like protein, putative 0.0126 0.0983 0.9746
Brugia malayi hypothetical protein 0.0126 0.0983 0.0983
Echinococcus granulosus Smad4 0.0073 0.0492 0.0484
Onchocerca volvulus 0.0025 0.0048 0.01
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1036 0.9404 1
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0044 0.0227 0.0191
Loa Loa (eye worm) transcription factor SMAD2 0.1074 0.9755 0.9755
Brugia malayi MH1 domain containing protein 0.004 0.019 0.019
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0129 0.1008 0.1026
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0044 0.0227 0.0191
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0056 0.033 0.3273
Brugia malayi RNA recognition motif domain containing protein 0.0326 0.2832 0.2832
Echinococcus granulosus expressed protein 0.0044 0.0227 0.02
Echinococcus multilocularis protein patched 0.0036 0.0145 0.0103
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0536 0.4772 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0044 0.0227 0.0227
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0044 0.0227 0.0383
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.1008 0.1026
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0044 0.0227 0.0227
Schistosoma mansoni hypothetical protein 0.0348 0.3038 0.3196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1036 0.9404 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0983 0.0983
Schistosoma mansoni GTP-binding protein alpha subunit 0.0044 0.0227 0.0191
Brugia malayi Pre-SET motif family protein 0.0175 0.1438 0.1438
Echinococcus multilocularis expressed protein 0.0044 0.0227 0.0191
Echinococcus multilocularis mothers against decapentaplegic 5 0.0073 0.0492 0.0475
Brugia malayi Calcitonin receptor-like protein seb-1 0.11 1 1
Loa Loa (eye worm) G protein alpha subunit 3 0.0044 0.0227 0.0227
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0044 0.0227 0.0191
Onchocerca volvulus 0.0044 0.0227 0.0476
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0 0.5
Brugia malayi G-protein alpha subunit 0.0044 0.0227 0.0227
Schistosoma mansoni GTP-binding protein alpha subunit 0.0044 0.0227 0.0191
Echinococcus granulosus regulator of G protein signaling 7 0.0026 0.0059 0.0021
Brugia malayi MH1 domain containing protein 0.0073 0.0492 0.0492
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.1008 1
Trichomonas vaginalis set domain proteins, putative 0.02 0.1662 0.704
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0026 0.0059 0.0012
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0129 0.1008 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0348 0.3038 0.3038
Schistosoma mansoni smad1 5 8 and 0.0073 0.0492 0.0475
Schistosoma mansoni smad1 5 8 and 0.0073 0.0492 0.0475
Echinococcus granulosus GPCR family 2 0.0348 0.3038 0.3202
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0348 0.3038 0.3202
Brugia malayi Smad1 0.0073 0.0492 0.0492
Echinococcus granulosus expressed conserved protein 0.0078 0.0536 0.0531
Echinococcus multilocularis protein dispatched 1 0.0041 0.0191 0.0153
Echinococcus multilocularis mothers against decapentaplegic 6 0.0033 0.0118 0.0075
Brugia malayi Isocitrate dehydrogenase 0.0129 0.1008 0.1008
Schistosoma mansoni dishevelled 0.0026 0.0059 0.0012
Schistosoma mansoni hypothetical protein 0.0057 0.0339 0.0311
Echinococcus granulosus survival motor neuron protein 1 0.0199 0.1659 0.1729
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0129 0.1008 1
Echinococcus multilocularis expressed conserved protein 0.0078 0.0536 0.0522
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0044 0.0227 0.0227
Echinococcus granulosus smad 0.0073 0.0492 0.0484
Brugia malayi Latrophilin receptor protein 2 0.0348 0.3038 0.3038
Loa Loa (eye worm) hypothetical protein 0.0044 0.0227 0.0227
Brugia malayi MH1 domain containing protein 0.004 0.019 0.019
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0026 0.0059 0.0059
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0227 0.0383
Loa Loa (eye worm) hypothetical protein 0.0348 0.3038 0.3038
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0044 0.0227 0.0191
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0026 0.0059 0.0059
Echinococcus granulosus mothers against decapentaplegic 2 0.0033 0.0118 0.0084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.11 1 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0073 0.0492 0.0492
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0044 0.0227 0.02
Echinococcus multilocularis transcription factor Dp 1 0.0032 0.0113 0.007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0683 0.6137 0.6508
Echinococcus granulosus mothers against decapentaplegic 6 0.0033 0.0118 0.0084
Brugia malayi Niemann-Pick C1 protein precursor 0.0083 0.0583 0.0583
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0044 0.0227 0.02
Schistosoma mansoni Smad4 0.0073 0.0492 0.0475
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0056 0.033 0.0301
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0118 0.0118
Brugia malayi MH2 domain containing protein 0.0033 0.0118 0.0118
Schistosoma mansoni cellular tumor antigen P53 0.0042 0.0201 0.0163
Brugia malayi Pre-SET motif family protein 0.0025 0.0048 0.0048
Echinococcus multilocularis smad 0.0073 0.0492 0.0475
Brugia malayi hypothetical protein 0.0081 0.0569 0.0569
Schistosoma mansoni hypothetical protein 0.0348 0.3038 0.3196
Brugia malayi MH2 domain containing protein 0.0073 0.0492 0.0492
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0044 0.0227 0.0191
Echinococcus granulosus microtubule associated protein 2 0.0581 0.5195 0.5505
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0044 0.0227 0.0191
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0044 0.0227 0.0191
Echinococcus multilocularis isocitrate dehydrogenase 0.0129 0.1008 0.1026
Schistosoma mansoni dishevelled 0.0026 0.0059 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0289 0.0257
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0033 0.0118 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1036 0.9404 1
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0044 0.0227 0.0227
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.0983 0.964
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0056 0.033 0.033
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0044 0.0227 0.02
Schistosoma mansoni tar DNA-binding protein 0.0326 0.2832 0.2976
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0289 0.0257
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0044 0.0227 0.0227
Echinococcus granulosus histone lysine methyltransferase setb 0.0025 0.0048 0.0009
Schistosoma mansoni z-protein (S1r protein) 0.0026 0.0059 0.0012
Schistosoma mansoni glutaminase 0.0268 0.23 0.2407
Schistosoma mansoni microtubule-associated protein tau 0.0581 0.5195 0.5501
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.1036 0.9404 0.9404
Loa Loa (eye worm) glutaminase 0.0268 0.23 0.23
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0227 0.0227
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0044 0.0227 0.0227
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.1008 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1036 0.9404 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0129 0.1008 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0118
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0044 0.0227 0.0191
Loa Loa (eye worm) TAR-binding protein 0.0326 0.2832 0.2832
Onchocerca volvulus 0.0041 0.0191 0.0401
Echinococcus multilocularis segment polarity protein dishevelled 0.0026 0.0059 0.0012
Loa Loa (eye worm) RNA binding protein 0.0326 0.2832 0.2832
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0073 0.0492 0.0475
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0044 0.0227 0.0191
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0044 0.0227 0.0191
Echinococcus multilocularis GPCR, family 2 0.0348 0.3038 0.3196
Echinococcus multilocularis regulator of G protein signaling 7 0.0026 0.0059 0.0012
Brugia malayi DIX domain containing protein 0.0026 0.0059 0.0059
Echinococcus multilocularis Smad4 0.0073 0.0492 0.0475
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0348 0.3038 0.3196
Loa Loa (eye worm) hypothetical protein 0.0025 0.0048 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0326 0.2832 0.2976
Loa Loa (eye worm) hypothetical protein 0.0042 0.0201 0.0201
Loa Loa (eye worm) MH2 domain-containing protein 0.1074 0.9755 0.9755
Schistosoma mansoni hypothetical protein 0.0034 0.0133 0.0091
Toxoplasma gondii isocitrate dehydrogenase 0.0129 0.1008 1
Brugia malayi hypothetical protein 0.0026 0.0059 0.0059
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0129 0.1008 1
Leishmania major hypothetical protein, conserved 0.0126 0.0983 0.9758
Echinococcus granulosus regulator of G protein signaling 7 0.0026 0.0059 0.0021
Brugia malayi TAR-binding protein 0.0326 0.2832 0.2832
Brugia malayi hypothetical protein 0.0199 0.1659 0.1659
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0289 0.1255
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0084 0.0595 0.0584
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0129 0.1008 0.1026
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0227 0.0383
Brugia malayi hypothetical protein 0.0026 0.0059 0.0059
Echinococcus granulosus tar DNA binding protein 0.0326 0.2832 0.2983
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0056 0.033 0.566
Schistosoma mansoni Smad4 0.0033 0.0118 0.0075
Trypanosoma brucei PAB1-binding protein , putative 0.0126 0.0983 0.964
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0348 0.3038 0.3202
Loa Loa (eye worm) nuclear factor I 0.004 0.019 0.019
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0026 0.0059 0.0012
Onchocerca volvulus 0.0044 0.0227 0.0476
Echinococcus granulosus segment polarity protein dishevelled 0.0026 0.0059 0.0021
Loa Loa (eye worm) hypothetical protein 0.0199 0.1659 0.1659
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0044 0.0227 0.0227
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0044 0.0227 0.0383
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0051 0.0289 0.0266
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0129 0.1008 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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