TDR Targets

Basic information

Technical information

TDR Targets ID: 907994
Name: 2-(2,5-dichlorophenoxy)-N-(3-methoxyphenyl)ac etamide
MW: 326.175 | Formula: C15H13Cl2NO3
H donors: 1 H acceptors: 1 LogP: 4.02 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)NC(=O)COc1cc(Cl)ccc1Cl
InChi: 1S/C15H13Cl2NO3/c1-20-12-4-2-3-11(8-12)18-15(19)9-21-14-7-10(16)5-6-13(14)17/h2-8H,9H2,1H3,(H,18,19)
InChiKey: SCKURRPDLRRERI-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-(2,5-dichlorophenoxy)-N-(3-methoxyphenyl)ethanamide
Oprea1_046022
ZINC00130339
Oprea1_513977

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	oxidoreductase	0.0754	1	1
Brugia malayi	HSF-type DNA-binding domain containing protein	0.0101	0.0805	0.0805
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Onchocerca volvulus		0.0754	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0754	1	1
Loa Loa (eye worm)	oxidoreductase	0.0754	1	1
Giardia lamblia	Aldose reductase	0.0754	1	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0218	0.2452	0.1792
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0754	1	1
Schistosoma mansoni	pol-related	0.0754	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0754	1	1
Echinococcus multilocularis	aldehyde reductase	0.0536	0.6922	0.6922
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0218	0.2452	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0754	1	1
Plasmodium vivax	aldehyde reductase, putative	0.0218	0.2452	0.5
Trypanosoma cruzi	aldo/keto reductase, putative	0.0754	1	1
Onchocerca volvulus	Heat shock factor protein 2 homolog	0.0101	0.0805	0.0805
Echinococcus granulosus	aldo keto reductase	0.0754	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0754	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0754	1	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0805	0.0805
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0218	0.2452	0.1792
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0754	1	1
Echinococcus granulosus	muscleblind protein	0.0324	0.3936	0.3936
Trypanosoma brucei	prostaglandin f synthase	0.0754	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0754	1	1
Loa Loa (eye worm)	oxidoreductase	0.0754	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Brugia malayi	Muscleblind-like protein	0.0324	0.3936	0.3936
Loa Loa (eye worm)	hypothetical protein	0.0324	0.3936	0.3936
Trichomonas vaginalis	aldo/keto reductase, putative	0.0754	1	1
Schistosoma mansoni	aldo-keto reductase	0.0754	1	1
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0218	0.2452	0.2452
Schistosoma mansoni	potassium channel beta	0.0218	0.2452	0.2452
Trichomonas vaginalis	aldo/keto reductase, putative	0.0754	1	1
Entamoeba histolytica	aldose reductase, putative	0.0754	1	1
Echinococcus multilocularis	aldo keto reductase	0.0754	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0754	1	1
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0754	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.0112	0.0112
Trichomonas vaginalis	aldo/keto reductase, putative	0.0754	1	1
Onchocerca volvulus		0.0218	0.2452	0.2452
Echinococcus multilocularis	aldo keto reductase	0.0754	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0112	0.0112
Echinococcus multilocularis	muscleblind protein	0.0324	0.3936	0.3936
Echinococcus multilocularis	aldo keto reductase	0.0754	1	1
Entamoeba histolytica	aldose reductase, putative	0.0754	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Plasmodium falciparum	aldehyde reductase, putative	0.0218	0.2452	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0112	0.0112
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0754	1	1
Loa Loa (eye worm)	hypothetical protein	0.0324	0.3936	0.3936
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Mycobacterium leprae	Conserved hypothetical protein	0.0536	0.6922	0.5922
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0754	1	1
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0218	0.2452	0.5
Trypanosoma brucei	aldo-keto reductase, putative	0.0754	1	1
Schistosoma mansoni	aldo-keto reductase	0.0754	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0754	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0112	0.0112
Echinococcus granulosus	voltage gated potassium channel subunit	0.0218	0.2452	0.2452
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Loa Loa (eye worm)	oxidoreductase	0.0754	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0754	1	1
Echinococcus granulosus	aldehyde reductase	0.0536	0.6922	0.6922
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0754	1	1
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0218	0.2452	0.2452
Leishmania major	prostaglandin f synthase, putative	0.0754	1	1
Echinococcus granulosus	aldo keto reductase	0.0754	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0112	0.0112
Echinococcus multilocularis	muscleblind protein 1	0.0324	0.3936	0.3936
Mycobacterium tuberculosis	Probable oxidoreductase	0.0754	1	1
Brugia malayi	NADH-dependent xylose reductase	0.0218	0.2452	0.2452
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0112	0.0112
Onchocerca volvulus		0.0754	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0754	1	1
Onchocerca volvulus		0.0754	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0754	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0112	0.0112
Echinococcus granulosus	aldo keto reductase	0.0754	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0754	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0754	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.0112	0.0112
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0754	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0754	1	1
Entamoeba histolytica	aldose reductase, putative	0.0754	1	1
Onchocerca volvulus		0.0754	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0754	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0754	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0754	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0754	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0754	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0754	1	1
Echinococcus multilocularis	aldo keto reductase	0.0754	1	1
Loa Loa (eye worm)	oxidoreductase	0.0754	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0754	1	1
Giardia lamblia	Aldose reductase	0.0754	1	0.5
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0754	1	1
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0754	1	1
Onchocerca volvulus		0.0754	1	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0218	0.2452	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0112	0.0112
Echinococcus granulosus	hypothetical protein	0.0754	1	1
Loa Loa (eye worm)	oxidoreductase	0.0754	1	1
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0218	0.2452	0.2452
Onchocerca volvulus		0.0754	1	1
Toxoplasma gondii	aldose reductase, putative	0.0754	1	1
Trypanosoma cruzi	aldo-keto reductase	0.0754	1	1
Leishmania major	aldo-keto reductase-like protein	0.0754	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0754	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 907994