Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.6332 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.3853 | 0.2673 |
Brugia malayi | MAP kinase sur-1 | 0.0058 | 0.6332 | 0.5628 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0058 | 0.6332 | 1 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.2145 | 0.0638 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0058 | 0.6332 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0058 | 0.6332 | 1 |
Echinococcus granulosus | lamin | 0.0031 | 0.2145 | 0.2591 |
Schistosoma mansoni | lamin | 0.0031 | 0.2145 | 0.2669 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0058 | 0.6332 | 0.8453 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.2145 | 0.2591 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.8037 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.1214 | 0.1287 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0058 | 0.6332 | 0.6717 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0058 | 0.6332 | 0.8453 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0294 | 0.0366 |
Onchocerca volvulus | 0.0031 | 0.2145 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3406 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 0.6332 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0058 | 0.6332 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4581 | 0.4769 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.2145 | 0.2059 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3406 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.6332 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0058 | 0.6332 | 0.8453 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.3406 | 0.4356 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0058 | 0.6332 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3864 | 0.3972 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.2145 | 0.2059 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0894 | 0.1112 |
Schistosoma mansoni | lamin | 0.0031 | 0.2145 | 0.2669 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.1214 | 0.151 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0058 | 0.6332 | 0.7879 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.6332 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.2145 | 0.2591 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 0.6332 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.7437 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.6332 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0397 | 0.0114 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0294 | 0.0366 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.2145 | 0.2591 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0294 | 0.0366 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.1214 | 0.1287 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.3406 | 0.4238 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4261 | 0.4413 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0717 | 0.0592 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.2145 | 0.2059 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0294 | 0.0366 |
Echinococcus multilocularis | lamin | 0.0031 | 0.2145 | 0.2591 |
Brugia malayi | hypothetical protein | 0.0039 | 0.3406 | 0.2141 |
Echinococcus multilocularis | musashi | 0.0031 | 0.2145 | 0.2591 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.7437 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0058 | 0.6332 | 0.8453 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.2145 | 0.2669 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3406 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0058 | 0.6332 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0894 | 0.0667 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0717 | 0.0891 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0058 | 0.6332 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.3456 | 0.4427 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.3406 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0717 | 0.0592 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.3456 | 0.4427 |
Onchocerca volvulus | 0.0031 | 0.2145 | 0.5 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.3406 | 0.4356 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2059 | 0.1963 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.3406 | 0.4238 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.2145 | 0.0638 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 0.6332 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.9283 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.