Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0393 | 0.6351 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0182 | 0.2116 | 0.2116 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0081 | 0.0102 | 0.0214 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0081 | 0.0102 | 0.0214 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2116 | 0.2116 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0081 | 0.0102 | 0.0214 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.2116 | 0.3332 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0081 | 0.0102 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.0574 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0314 | 0.4772 | 0.4772 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0314 | 0.4772 | 0.7514 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0236 | 0.3196 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0314 | 0.4772 | 0.7514 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.3196 | 0.3196 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0574 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0314 | 0.4772 | 0.7514 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0081 | 0.0102 | 0.016 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.2116 | 0.3332 |
Echinococcus multilocularis | GPCR, family 2 | 0.0182 | 0.2116 | 0.4435 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.2116 | 0.3332 |
Echinococcus multilocularis | tar DNA binding protein | 0.0314 | 0.4772 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0182 | 0.2116 | 0.4435 |
Brugia malayi | isocitrate dehydrogenase | 0.0081 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0081 | 0.0102 | 0.0102 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0236 | 0.3196 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0081 | 0.0102 | 0.0319 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0236 | 0.3196 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0588 | 0.0926 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0314 | 0.4772 | 0.7514 |
Brugia malayi | Isocitrate dehydrogenase | 0.0081 | 0.0102 | 0.0102 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0081 | 0.0102 | 0.0214 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0182 | 0.2116 | 0.4435 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0236 | 0.3196 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0106 | 0.0588 | 0.1233 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0182 | 0.2116 | 0.2116 |
Schistosoma mansoni | tar DNA-binding protein | 0.0314 | 0.4772 | 0.7514 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0182 | 0.2116 | 0.4435 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0233 | 0.3145 | 0.3145 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0106 | 0.0588 | 0.1233 |
Leishmania major | hypothetical protein, conserved | 0.0236 | 0.3196 | 1 |
Brugia malayi | hypothetical protein | 0.0236 | 0.3196 | 0.3196 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0182 | 0.2116 | 0.4435 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0314 | 0.4772 | 0.4772 |
Loa Loa (eye worm) | RNA binding protein | 0.0314 | 0.4772 | 0.4772 |
Brugia malayi | TAR-binding protein | 0.0314 | 0.4772 | 0.4772 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0393 | 0.6351 | 0.6351 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.6351 | 0.6351 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0081 | 0.0102 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0233 | 0.3145 | 0.3145 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0081 | 0.0102 | 0.0214 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0081 | 0.0102 | 0.0319 |
Brugia malayi | hypothetical protein | 0.0152 | 0.152 | 0.152 |
Loa Loa (eye worm) | TAR-binding protein | 0.0314 | 0.4772 | 0.4772 |
Brugia malayi | RNA binding protein | 0.0314 | 0.4772 | 0.4772 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0236 | 0.3196 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0081 | 0.0102 | 0.0214 |
Echinococcus granulosus | tar DNA binding protein | 0.0314 | 0.4772 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0081 | 0.0102 | 0.0319 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0574 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0182 | 0.2116 | 0.2116 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.2116 | 0.3332 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0236 | 0.3196 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0182 | 0.2116 | 0.4435 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0236 | 0.3196 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0233 | 0.3145 | 0.3145 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.