Detailed information for compound 908320

Basic information

Technical information
  • TDR Targets ID: 908320
  • Name: N-[2-(1H-benzimidazol-2-yl)ethyl]-3-bromobenz amide
  • MW: 344.206 | Formula: C16H14BrN3O
  • H donors: 2 H acceptors: 2 LogP: 3.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)C(=O)NCCc1nc2c([nH]1)cccc2
  • InChi: 1S/C16H14BrN3O/c17-12-5-3-4-11(10-12)16(21)18-9-8-15-19-13-6-1-2-7-14(13)20-15/h1-7,10H,8-9H2,(H,18,21)(H,19,20)
  • InChiKey: HKYPRNSPCNMSQK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(1H-benzimidazol-2-yl)ethyl]-3-bromo-benzamide
  • A3445/0146287
  • BIM-0030673.P001
  • MLS000684837
  • SMR000268306
  • CBMicro_030716
  • ZINC00120551
  • Oprea1_461106
  • Oprea1_792060

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei oxidoreductase-like protein 0.004 0.0373 1
Onchocerca volvulus 0.0036 0.0329 0.5375
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0354
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0115 0.0115
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0146 0.0048
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0224 0.0951
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0174 0.0039
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0612 0.0612
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.004 0.0373 1
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1572 0.1851
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1446 0.1446
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Brugia malayi TAR-binding protein 0.0062 0.0658 0.2787
Entamoeba histolytica hypothetical protein 0.0109 0.1245 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.2361 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0787 0.0927
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0011 0.0011
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.004 0.0373 0.0976
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0587 0.7244 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.004 0.0373 0.0064
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0362 0.4635
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.1684 0.1983
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0146 0.0048
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0767 0.0767
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.004 0.0373 0.0064
Onchocerca volvulus 0.0036 0.0329 0.5375
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.1397 0.3658
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.004 0.0373 0.0064
Trypanosoma brucei pteridine reductase 1 0.004 0.0373 1
Echinococcus multilocularis cpg binding protein 0.003 0.0253 0.0253
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.004 0.0373 0.0064
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.004 0.0373 0.0366
Schistosoma mansoni hypothetical protein 0.0063 0.0661 0.0778
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0587 0.7244 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.004 0.0373 1
Brugia malayi jmjC domain containing protein 0.0019 0.0112 0.0474
Loa Loa (eye worm) acetyltransferase 0.0144 0.1684 0.4408
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0112 0.0132
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.1572 0.1572
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0373 0.0064
Entamoeba histolytica hypothetical protein 0.0109 0.1245 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.229 0.2697
Schistosoma mansoni hypothetical protein 0.0063 0.0661 0.0778
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0406 0.0478
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.004 0.0373 0.0366
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0174 0.236
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.2361 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.018 0.2592
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0661 0.0661
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.004 0.0373 1
Echinococcus multilocularis snurportin 1 0.0314 0.382 0.382
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0612 0.0701
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.047
Mycobacterium tuberculosis Possible oxidoreductase 0.004 0.0373 0.0064
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0406 0.0412
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0612 0.0701
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.004 0.0373 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0612 0.0701
Brugia malayi beta-lactamase family protein 0.0036 0.0329 0.1393
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0329 0.1393
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0658 0.0775
Schistosoma mansoni hypothetical protein 0.0135 0.1574 0.1854
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Brugia malayi CXXC zinc finger family protein 0.0029 0.0232 0.0985
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.004 0.0373 0.0064
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0329 0.8308
Leishmania major hypothetical protein, conserved 0.0036 0.0329 0.8308
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0658 0.0775
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0243 0.5038
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0373 0.0064
Leishmania major GTP-binding protein, putative 0.0022 0.0146 0.1299
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Brugia malayi hypothetical protein 0.0016 0.0071 0.0302
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.018 0.2592
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.0861
Echinococcus multilocularis geminin 0.0169 0.2002 0.2002
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0658 0.2787
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.004 0.0373 0.0366
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0329 0.0329
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.004 0.0373 0.0064
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0491 0.0579
Schistosoma mansoni dihydropteridine reductase 0.004 0.0373 0.0439
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0587 0.7244 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0146 0.1299
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1446 0.1703
Brugia malayi jmjC domain containing protein 0.0019 0.0112 0.0474
Plasmodium vivax importin-beta 2, putative 0.0029 0.0243 0.0184
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0658 0.0775
Schistosoma mansoni cpg binding protein 0.003 0.0253 0.0298
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.004 0.0373 0.0366
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0373 0.0064
Leishmania major oxidoreductase-like protein 0.004 0.0373 1
Schistosoma mansoni hypothetical protein 0.0059 0.0612 0.072
Echinococcus multilocularis tumor protein p63 0.0336 0.4093 0.4093
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.004 0.0373 0.0439
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0329 0.0258
Loa Loa (eye worm) hypothetical protein 0.0063 0.0661 0.173
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0329 0.0258
Brugia malayi beta-lactamase family protein 0.0036 0.0329 0.1393
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.018 0.0095
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0587 0.7244 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0011 0.0013
Plasmodium falciparum importin beta, putative 0.0029 0.0243 0.0184
Echinococcus granulosus phd:f box containing protein 0.0019 0.0112 0.0132
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0137 0.0035
Mycobacterium tuberculosis Probable oxidoreductase 0.004 0.0373 0.0064
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0373 0.0064
Loa Loa (eye worm) hypothetical protein 0.0101 0.1139 0.2981
Onchocerca volvulus 0.0049 0.0491 0.8035
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0612 0.1601
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.004 0.0373 0.0064
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0146 0.0382
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.278 0.3546
Echinococcus granulosus tar DNA binding protein 0.0062 0.0658 0.0775
Brugia malayi PHD-finger family protein 0.0059 0.0612 0.2591
Echinococcus granulosus microtubule associated protein 2 0.0686 0.8491 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0658 0.1722
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0329 0.0258
Onchocerca volvulus 0.004 0.0373 0.6097
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.004 0.0373 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0329 0.8308
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0329 0.0304
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.0861
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0329 0.0387
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.0861
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.004 0.0373 0.0064
Loa Loa (eye worm) hypothetical protein 0.0198 0.2361 0.6181
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.0861
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0587 0.7244 1
Leishmania major 3-oxoacyl-ACP reductase, putative 0.004 0.0373 1
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0901 0.0901
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0658 0.0775
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.018 0.0095
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0587 0.7244 1
Schistosoma mansoni hypothetical protein 0.0407 0.4982 0.5867
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0612 0.072
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0112 0.0293
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.1245 0.1466
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0658 0.0775
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0406 0.0412
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.8491 0.8491
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0658 0.0658
Loa Loa (eye worm) beta-lactamase 0.0036 0.0329 0.0861
Leishmania major dehydrogenase/oxidoreductase-like protein 0.004 0.0373 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0146 0.0172
Toxoplasma gondii ABC1 family protein 0.0036 0.0329 0.0304
Brugia malayi jmjC domain containing protein 0.0019 0.0112 0.0474
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.004 0.0373 0.0064
Entamoeba histolytica hypothetical protein 0.0109 0.1245 1
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0174 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0598 0.0681
Echinococcus granulosus dnaJ subfamily B 0.0407 0.4982 0.5867
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0146 0.0618
Onchocerca volvulus 0.004 0.0373 0.6097
Brugia malayi jmjC domain containing protein 0.0073 0.0787 0.3335
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0661 0.173
Brugia malayi jmjC domain containing protein 0.0192 0.229 0.9701
Echinococcus granulosus peregrin 0.0062 0.0656 0.0772
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0112 0.0132
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.004 0.0373 0.0439
Trichomonas vaginalis esterase, putative 0.0036 0.0329 0.0258
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0787 0.0927
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0634 0.0747
Loa Loa (eye worm) hypothetical protein 0.004 0.0373 0.0976
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0137 0.0035
Loa Loa (eye worm) oxidoreductase 0.004 0.0373 0.0976
Plasmodium falciparum phd finger protein, putative 0.0059 0.0612 0.0701
Entamoeba histolytica hypothetical protein 0.0024 0.0174 0.0252
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.1245 0.1245
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0329 0.0258
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0112 0.0132
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0373 0.0064
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0612 0.072
Onchocerca volvulus 0.0029 0.0232 0.38
Loa Loa (eye worm) hypothetical protein 0.0135 0.1574 0.412
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0132 0.0156
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0112 0.0132
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.004 0.0373 0.2067
Plasmodium falciparum enoyl-acyl carrier reductase 0.0587 0.7244 1
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.004 0.0373 0.0064
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0661 0.2799
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.2361 0.6181
Echinococcus granulosus geminin 0.0169 0.2002 0.2358
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Schistosoma mansoni hypothetical protein 0.0063 0.0661 0.0778
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.004 0.0373 0.0064
Schistosoma mansoni hypothetical protein 0.0063 0.0661 0.0778
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0243 0.5038
Trichomonas vaginalis hypothetical protein 0.0587 0.7244 1
Brugia malayi RNA binding protein 0.0062 0.0658 0.2787
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0329 0.0387
Schistosoma mansoni hypothetical protein 0.0169 0.2002 0.2358
Loa Loa (eye worm) hypothetical protein 0.0059 0.0612 0.1601
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0787 0.2061
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.018 0.0095
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0115 0.0004
Schistosoma mansoni ran 0.0022 0.0146 0.0172
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.004 0.0373 0.158
Entamoeba histolytica hypothetical protein 0.0109 0.1245 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0661 0.0661
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0132 0.0132
Schistosoma mansoni cpg binding protein 0.0029 0.0232 0.0274
Schistosoma mansoni jumonji domain containing protein 0.0153 0.1794 0.2112
Echinococcus granulosus tumor protein p63 0.0336 0.4093 0.4821
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0112 0.0112
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.1574 0.6667
Loa Loa (eye worm) RNA binding protein 0.0062 0.0658 0.1722
Leishmania major pteridine reductase 1 0.004 0.0373 1
Onchocerca volvulus 0.0036 0.0329 0.5375
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.1633 0.1923
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0112 0.0112
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0406 0.0367
Leishmania major importin beta-1 subunit, putative 0.0024 0.0174 0.236
Brugia malayi hypothetical protein 0.0024 0.018 0.0761
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0329 0.8308
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.004 0.0373 0.0064
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0587 0.7244 1
Mycobacterium ulcerans oxidoreductase 0.004 0.0373 0.0064
Brugia malayi Importin beta-1 subunit 0.0029 0.0243 0.1031
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0146 0.0146
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0112 0.0293
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.018 0.2592
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0373 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0661 0.2799
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.004 0.0373 0.158
Brugia malayi RNA, U transporter 1 0.0084 0.0925 0.3918
Schistosoma mansoni hypothetical protein 0.0019 0.0115 0.0135
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.1684 0.1684
Brugia malayi jmjC domain containing protein 0.0019 0.0112 0.0474
Loa Loa (eye worm) hypothetical protein 0.0029 0.0243 0.0637
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0112 0.0132
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.018 0.0095
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0243 0.0184
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0115 0.0004
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0049 0.0491 0.1286
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0329 0.0387
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0406 0.0367
Schistosoma mansoni hypothetical protein 0.0109 0.1245 0.1466
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.4982 0.4982
Schistosoma mansoni hypothetical protein 0.0125 0.1446 0.1703
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0787 0.0927
Echinococcus granulosus GPCR family 2 0.0063 0.0661 0.0778
Brugia malayi Bromodomain containing protein 0.0062 0.0656 0.2778
Schistosoma mansoni hypothetical protein 0.0169 0.2002 0.2358
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0112 0.0132
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0146 0.1299
Leishmania major hypothetical protein, conserved 0.0024 0.018 0.2592
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0362 0.035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.004 0.0373 0.0373
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.004 0.0373 0.0064
Echinococcus granulosus snurportin 1 0.0314 0.382 0.4498
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0661 0.0778
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0661 0.0778
Schistosoma mansoni ran 0.0022 0.0146 0.0172
Echinococcus multilocularis GPCR, family 2 0.0063 0.0661 0.0661
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0146 0.0048
Echinococcus multilocularis peregrin 0.0062 0.0656 0.0656
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.004 0.0373 0.0064
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0362 0.1965
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0901 0.1061
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0204 0.024
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.004 0.0373 0.0064
Schistosoma mansoni importin beta-1 0.0029 0.0243 0.0287
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.382 1
Onchocerca volvulus Alhambra homolog 0.0059 0.0612 1
Echinococcus granulosus cpg binding protein 0.003 0.0253 0.0298
Brugia malayi beta-lactamase 0.0036 0.0329 0.1393
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0373 0.0064
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.1245 0.1466
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.229 0.229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.004 0.0373 0.0064
Mycobacterium tuberculosis Possible oxidoreductase 0.004 0.0373 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0135 0.1572 0.1851
Giardia lamblia PHD finger protein 15 0.0059 0.0612 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0112 0.0293
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0329 0.0861
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0373 0.0064
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0329 0.0258
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0658 0.1722
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.004 0.0373 0.0366
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.1684 0.7132
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0115 0.0115
Brugia malayi PHD-finger family protein 0.0021 0.0135 0.0573
Schistosoma mansoni hypothetical protein 0.0314 0.382 0.4498
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.0861
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.0861
Leishmania major dehydrogenase/oxidoreductase-like protein 0.004 0.0373 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0243 0.0287
Brugia malayi AF-10 protein 0.0019 0.0115 0.0487
Loa Loa (eye worm) retinol dehydrogenase 12 0.004 0.0373 0.0976
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.8491 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0146 0.1299
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0174 0.0039
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0112 0.0112
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0232 0.0609
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0406 0.0412
Brugia malayi hypothetical protein 0.0109 0.1245 0.5272
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0112 0.0132
Schistosoma mansoni cpg binding protein 0.003 0.0253 0.0298
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0112 0.0132
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0373 0.0064

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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