TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 412.48 | Formula: C26H24N2O3
H donors: 3 H acceptors: 2 LogP: 4.16 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C1CC(=C2C(=Nc3ccccc3NC2c2cccc(c2)O)C1)O
InChi: 1S/C26H24N2O3/c1-31-20-11-9-16(10-12-20)18-14-23-25(24(30)15-18)26(17-5-4-6-19(29)13-17)28-22-8-3-2-7-21(22)27-23/h2-13,18,26,28-30H,14-15H2,1H3
InChiKey: VCUWGAPNNKGXDP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	tubulin, putative	0.0089	0.0166	0.0124
Echinococcus multilocularis	g-protein coupled receptor	0.0079	0.0123	0.0032
Brugia malayi	Serotonin receptor	0.0079	0.0123	0.0025
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0119	0.0288	1
Schistosoma mansoni	biogenic amine receptor	0.0079	0.0123	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0123	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.0288	0.0347
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0123	0.0025
Echinococcus multilocularis	wd40 repeat	0.0077	0.0118	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0539	0.1999	0.349
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus granulosus	furin	0.2501	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0118	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Schistosoma mansoni	amine GPCR	0.0079	0.0123	0.0025
Brugia malayi	celfurPC protein	0.1962	0.7803	0.7781
Echinococcus granulosus	neuroendocrine convertase 2	0.1799	0.7137	0.7109
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0079	0.0123	0.0025
Echinococcus granulosus	Tubulin beta 2C chain	0.0089	0.0166	0.0068
Schistosoma mansoni	neuropeptide F-like receptor	0.0079	0.0123	0.0025
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0119	0.0288	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0079	0.0123	0.0025
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0079	0.0123	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0123	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0539	0.1999	0.349
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0123	0.0025
Onchocerca volvulus		0.0073	0.0098	0.3425
Schistosoma mansoni	amine GPCR	0.0079	0.0123	0.0025
Echinococcus granulosus	biogenic amine 5HT receptor	0.0079	0.0123	0.0025
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0079	0.0123	0.0025
Schistosoma mansoni	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	neuropeptides capa receptor	0.0079	0.0123	0.0032
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0123	0.0025
Brugia malayi	beta-tubulin, identical	0.0089	0.0166	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus granulosus	Tubulin beta 2C chain	0.0089	0.0166	0.0068
Echinococcus multilocularis	Tubulin beta 2C chain	0.0089	0.0166	0.0087
Echinococcus granulosus	Furin 1	0.0706	0.2682	0.2609
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Toxoplasma gondii	subtilisin SUB7	0.0119	0.0288	0.6684
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0119	0.0288	0.5
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	Furin 1	0.0706	0.2682	0.3353
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0119	0.0288	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0706	0.2682	0.4744
Echinococcus granulosus	7TM GPCR rhodopsin	0.0079	0.0123	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0123	0.0025
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0119	0.0288	0.0191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0123	0.0032
Brugia malayi	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0123	0.0025
Trichomonas vaginalis	tubulin beta chain, putative	0.0089	0.0166	0.0124
Echinococcus granulosus	tubulin beta 1 chain	0.0089	0.0166	0.0068
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Echinococcus multilocularis	sex peptide receptor	0.0079	0.0123	0.0032
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0079	0.0123	0.0032
Loa Loa (eye worm)	proprotein convertase 2	0.0706	0.2682	0.2609
Onchocerca volvulus		0.0079	0.0123	0.4281
Echinococcus multilocularis	somatostatin receptor	0.0079	0.0123	0.0032
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0706	0.2682	0.2609
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Trichomonas vaginalis	tubulin alpha chain, putative	0.0089	0.0166	0.0124
Loa Loa (eye worm)	hypothetical protein	0.1141	0.4455	0.44
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0079	0.0123	0.0032
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0119	0.0288	0.5
Brugia malayi	hypothetical protein	0.0079	0.0123	0.0025
Brugia malayi	neuropeptide F receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	tubulin beta-2A chain	0.0089	0.0166	0.0068
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0089	0.0166	0.0124
Schistosoma mansoni	opsin-like receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	BEN-1 protein	0.0089	0.0166	0.0068
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	neuropeptide receptor A26	0.0079	0.0123	0.0032
Onchocerca volvulus		0.0079	0.0123	0.4281
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Schistosoma mansoni	neuropeptide receptor	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Schistosoma mansoni	neuropeptide f receptor 76f	0.0079	0.0123	0.0025
Brugia malayi	Hypothetical WD-repeat protein F21H12.1 in chromosome II	0.0077	0.0118	0.0019
Schistosoma mansoni	growth hormone secretagogue receptor	0.0079	0.0123	0.0025
Brugia malayi	sulfakinin receptor protein	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0167	0.0485	0.071
Loa Loa (eye worm)	beta-tubulin	0.0089	0.0166	0.0068
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0123	0.0032
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0254	0.0838	0.0747
Echinococcus multilocularis	tubulin subunit beta	0.0089	0.0166	0.0087
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0587	0.2197	0.3852
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.0123	0.0032
Echinococcus multilocularis	neuropeptide receptor	0.0379	0.135	0.1624
Echinococcus granulosus	biogenic amine 5HT receptor	0.0079	0.0123	0.0025
Echinococcus granulosus	neuropeptides capa receptor	0.0079	0.0123	0.0025
Echinococcus multilocularis	epidermal growth factor receptor	0.0254	0.0838	0.096
Toxoplasma gondii	subtilisin SUB5	0.0119	0.0288	0.6684
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0079	0.0123	0.0032
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.0123	0.0025
Schistosoma mansoni	tubulin subunit beta	0.0089	0.0166	0.0068
Trichomonas vaginalis	retinoblastoma binding protein, putative	0.0077	0.0118	0.0035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0123	0.0032
Loa Loa (eye worm)	tubulin beta-4 chain	0.0089	0.0166	0.0068
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0079	0.0123	0.0025
Echinococcus multilocularis	fmrfamide receptor	0.0079	0.0123	0.0032
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Echinococcus granulosus	g-protein coupled receptor	0.0079	0.0123	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.0288	0.0347
Schistosoma mansoni	hypothetical protein	0.0539	0.1999	0.192
Brugia malayi	RE15519p	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0123	0.0025
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Toxoplasma gondii	subtilisin SUB8	0.0119	0.0288	0.6684
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.0123	0.0025
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0119	0.0288	0.5
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0539	0.1999	0.349
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Toxoplasma gondii	subtilisin SUB9	0.0119	0.0288	0.6684
Mycobacterium leprae	Possible secreted protease	0.0119	0.0288	0.5
Leishmania major	subtilisin-like serine peptidase	0.0119	0.0288	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0706	0.2682	0.4744
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.1408	0.5545	0.7069
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0079	0.0123	0.0025
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0539	0.1999	0.349
Echinococcus granulosus	epidermal growth factor receptor	0.0254	0.0838	0.0747
Onchocerca volvulus		0.0079	0.0123	0.4281
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0119	0.0288	0.0191
Brugia malayi	Dopamine receptor	0.0079	0.0123	0.0025
Onchocerca volvulus		0.0079	0.0123	0.4281
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0288	0.0191
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.0123	0.0025
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0119	0.0288	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0079	0.0123	0.0025
Schistosoma mansoni	opsin-like receptor	0.0079	0.0123	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0123	0.0032
Schistosoma mansoni	tubulin subunit beta	0.0089	0.0166	0.0068
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0119	0.0288	0.0245
Schistosoma mansoni	amine GPCR	0.0079	0.0123	0.0025
Brugia malayi	G-protein coupled receptor	0.0079	0.0123	0.0025
Toxoplasma gondii	subtilisin SUB10	0.0119	0.0288	0.6684
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus granulosus	Tubulin beta 2C chain	0.0089	0.0166	0.0068
Onchocerca volvulus		0.0079	0.0123	0.4281
Schistosoma mansoni	amine GPCR	0.0079	0.0123	0.0025
Schistosoma mansoni	retinoblastoma binding protein	0.0077	0.0118	0.0019
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0123	0.0032
Plasmodium falciparum	subtilisin-like protease 3	0.0119	0.0288	1
Echinococcus granulosus	neuropeptide Y receptor	0.0079	0.0123	0.0025
Brugia malayi	GnHR receptor homolog	0.0079	0.0123	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0123	0.0032
Echinococcus granulosus	serotonin receptor	0.0079	0.0123	0.0025
Trypanosoma cruzi	subtilisin peptidase	0.0119	0.0288	1
Echinococcus granulosus	g protein coupled receptor	0.0079	0.0123	0.0025
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.0123	0.0032
Brugia malayi	G protein-coupled receptor F59B2.13	0.0079	0.0123	0.0025
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0079	0.0123	0.0032
Echinococcus granulosus	sex peptide receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Entamoeba histolytica	tubulin family protein	0.0089	0.0166	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1408	0.5545	1
Loa Loa (eye worm)	tubulin beta chain	0.0089	0.0166	0.0068
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0079	0.0123	0.0032
Onchocerca volvulus		0.0079	0.0123	0.4281
Brugia malayi	hypothetical protein	0.0079	0.0123	0.0025
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0079	0.0123	0.0025
Echinococcus granulosus	neuropeptide receptor A26	0.0079	0.0123	0.0025
Echinococcus multilocularis	dro:myosuppressin receptor	0.0079	0.0123	0.0032
Toxoplasma gondii	subtilisin SUB1	0.0119	0.0288	0.6684
Echinococcus multilocularis	orexin receptor type 2	0.0079	0.0123	0.0032
Schistosoma mansoni	biogenic amine receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0119	0.0288	0.0245
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0118	0.0035
Schistosoma mansoni	biogenic amine receptor	0.0079	0.0123	0.0025
Brugia malayi	neuroendocrine convertase 1 precursor	0.2105	0.8386	0.837
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus granulosus	tubulin subunit beta	0.0089	0.0166	0.0068
Echinococcus multilocularis	Tubulin beta 2C chain	0.0089	0.0166	0.0087
Loa Loa (eye worm)	TYRA-2 protein	0.0079	0.0123	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0123	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0539	0.1999	0.349
Brugia malayi	hypothetical protein	0.0079	0.0123	0.0025
Brugia malayi	hypothetical protein	0.0079	0.0123	0.0025
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0587	0.2197	0.3852
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0123	0.0025
Brugia malayi	putative neuropeptide receptor	0.0079	0.0123	0.0025
Trichomonas vaginalis	tubulin gamma chain, putative	0.0089	0.0166	0.0124
Loa Loa (eye worm)	melatonin receptor type 1A	0.0079	0.0123	0.0025
Echinococcus granulosus	somatostatin receptor	0.0079	0.0123	0.0025
Schistosoma mansoni	tubulin subunit beta	0.0089	0.0166	0.0068
Echinococcus granulosus	beta tubulin	0.0089	0.0166	0.0068
Brugia malayi	AKH receptor	0.0079	0.0123	0.0025
Brugia malayi	Serotonin receptor	0.0079	0.0123	0.0025
Entamoeba histolytica	tubulin family protein	0.0089	0.0166	0.5
Plasmodium vivax	subtilisin-like serine protease, putative	0.0119	0.0288	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.0123	0.0025
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.0123	0.0025
Onchocerca volvulus		0.0079	0.0123	0.4281
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.0288	0.0347
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Onchocerca volvulus		0.0119	0.0288	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0089	0.0166	0.0068
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0167	0.0485	0.039
Echinococcus granulosus	neuropeptide receptor	0.0079	0.0123	0.0025
Schistosoma mansoni	hypothetical protein	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0079	0.0123	0.0025
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0089	0.0166	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus granulosus	dro:myosuppressin receptor	0.0079	0.0123	0.0025
Brugia malayi	Dopamine receptor protein 2	0.0079	0.0123	0.0025
Echinococcus multilocularis	Tubulin beta 2C chain	0.0089	0.0166	0.0087
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.0123	0.0032
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0079	0.0123	0.0025
Brugia malayi	neuropeptide F receptor	0.0079	0.0123	0.0025
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0079	0.0123	0.0032
Brugia malayi	Tubulin beta-1 chain	0.0089	0.0166	0.0068
Echinococcus multilocularis	neuropeptides capa receptor	0.0079	0.0123	0.0032
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0706	0.2682	0.4744
Echinococcus granulosus	Tubulin beta 2C chain	0.0089	0.0166	0.0068
Toxoplasma gondii	subtilisin SUB6	0.0119	0.0288	0.6684
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0123	0.0032
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0119	0.0288	0.0191
Echinococcus multilocularis	neuropeptide s receptor	0.0079	0.0123	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus granulosus	neuropeptide Y receptor	0.0079	0.0123	0.0025
Schistosoma mansoni	neuropeptide receptor	0.0379	0.135	0.1263
Echinococcus granulosus	neuropeptide FF receptor 2	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0119	0.0288	0.0191
Onchocerca volvulus		0.0079	0.0123	0.4281
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0079	0.0123	0.0025
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0119	0.0288	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0079	0.0123	0.0025
Loa Loa (eye worm)	subtilase	0.0119	0.0288	0.0191
Loa Loa (eye worm)	BEN-1 protein	0.0089	0.0166	0.0068
Brugia malayi	ORL1-like opioid receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	endoprotease bli-4	0.2501	1	1
Brugia malayi	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	G protein coupled receptor 139	0.0379	0.135	0.1624
Echinococcus granulosus	orexin receptor type 2	0.0079	0.0123	0.0025
Echinococcus multilocularis	Tubulin beta 2C chain	0.0089	0.0166	0.0087
Giardia lamblia	Furin precursor putative serine protease	0.0587	0.2197	0.7531
Echinococcus granulosus	7tm_1 domain containing protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0079	0.0123	0.0032
Echinococcus multilocularis	neuropeptide Y receptor	0.0079	0.0123	0.0032
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	neuropeptide F receptor	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Trichomonas vaginalis	conserved hypothetical protein	0.0539	0.1999	0.349
Echinococcus multilocularis	neuroendocrine convertase 2	0.1799	0.7137	0.9136
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0079	0.0123	0.4281
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0079	0.0123	0.0025
Toxoplasma gondii	subtilisin SUB11	0.0119	0.0288	0.6684
Echinococcus multilocularis	serotonin receptor	0.0079	0.0123	0.0032
Onchocerca volvulus		0.0079	0.0123	0.4281
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Brugia malayi	G-protein coupled receptor	0.0079	0.0123	0.0025
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0079	0.0123	0.0025
Plasmodium falciparum	subtilisin-like protease 1	0.0119	0.0288	1
Onchocerca volvulus		0.0079	0.0123	0.4281
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.0123	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	tubulin beta 1 chain	0.0089	0.0166	0.0087
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0706	0.2682	0.4744
Echinococcus granulosus	fmrfamide receptor	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0089	0.0166	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	neuropeptide Y receptor	0.0079	0.0123	0.0032
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.0123	0.0032
Schistosoma mansoni	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	allatostatin A receptor	0.0079	0.0123	0.0032
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Trichomonas vaginalis	conserved hypothetical protein	0.0539	0.1999	0.349
Echinococcus granulosus	beta tubulin	0.0089	0.0166	0.0068
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0079	0.0123	0.0032
Echinococcus granulosus	g protein coupled receptor	0.0079	0.0123	0.0025
Onchocerca volvulus		0.0079	0.0123	0.4281
Trypanosoma brucei	subtilisin peptidase	0.0119	0.0288	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0079	0.0123	0.0025
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0079	0.0123	0.0025
Echinococcus multilocularis	serotonin receptor	0.0079	0.0123	0.0032
Schistosoma mansoni	tubulin subunit beta	0.0089	0.0166	0.0068
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0079	0.0123	0.0025
Echinococcus granulosus	neuropeptides capa receptor	0.0079	0.0123	0.0025
Echinococcus multilocularis	beta tubulin	0.0089	0.0166	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Brugia malayi	larval opioid receptor	0.0079	0.0123	0.0025
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0079	0.0123	0.0025
Toxoplasma gondii	subtilisin SUB4	0.0119	0.0288	0.6684
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0706	0.2682	0.4744
Trichomonas vaginalis	hypothetical protein	0.0539	0.1999	0.349
Onchocerca volvulus		0.0079	0.0123	0.4281
Onchocerca volvulus		0.0079	0.0123	0.4281
Schistosoma mansoni	amine GPCR	0.0079	0.0123	0.0025
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.0123	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0539	0.1999	0.349
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Onchocerca volvulus		0.0079	0.0123	0.4281
Brugia malayi	Subtilase family protein	0.0119	0.0288	0.0191
Schistosoma mansoni	tubulin subunit beta	0.0089	0.0166	0.0068
Echinococcus granulosus	g protein coupled receptor	0.0079	0.0123	0.0025
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0119	0.0288	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0079	0.0123	0.0025
Giardia lamblia	High cysteine membrane protein Group 2	0.0751	0.2863	1
Brugia malayi	proprotein convertase 2	0.1799	0.7137	0.7109
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.0288	0.0347
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0079	0.0123	0.0025
Echinococcus granulosus	neuropeptide s receptor	0.0079	0.0123	0.0025
Brugia malayi	Dopamine receptor protein 1	0.0079	0.0123	0.0025
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.1408	0.5545	0.5501
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Schistosoma mansoni	tubulin subunit beta	0.0089	0.0166	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Schistosoma mansoni	opsin-like receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Onchocerca volvulus		0.0079	0.0123	0.4281
Schistosoma mansoni	histamine h1 receptor	0.0079	0.0123	0.0025
Schistosoma mansoni	adenoreceptor	0.0079	0.0123	0.0025
Echinococcus multilocularis		0.1962	0.7803	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.0123	0.0025
Schistosoma mansoni	neuropeptide F-like receptor	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Brugia malayi	Melatonin receptor type 1A	0.0079	0.0123	0.0025
Onchocerca volvulus		0.0079	0.0123	0.4281
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Loa Loa (eye worm)	hypothetical protein	0.2501	1	1
Schistosoma mansoni	tyrosine kinase	0.0254	0.0838	0.0747
Brugia malayi	follicle stimulating hormone receptor	0.0079	0.0123	0.0025
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0079	0.0123	0.0025
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0079	0.0123	0.0032
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Echinococcus multilocularis	fmrfamide receptor	0.0079	0.0123	0.0032
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0119	0.0288	0.0191
Echinococcus granulosus	tubulin beta 4A class IVa	0.0089	0.0166	0.0068
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0079	0.0123	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0123	0.0025
Brugia malayi	hypothetical protein	0.0079	0.0123	0.0025
Schistosoma mansoni	myosin xvIII	0.0079	0.0123	0.0025
Plasmodium vivax	subtilisin-like protease 1	0.0119	0.0288	1
Echinococcus multilocularis	beta tubulin	0.0089	0.0166	0.0087
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0119	0.0288	1
Echinococcus granulosus	wd40 repeat	0.0077	0.0118	0.0019
Echinococcus multilocularis	Tubulin beta 2C chain	0.0089	0.0166	0.0087
Schistosoma mansoni	furin-1 (S08 family)	0.1212	0.4743	0.469
Echinococcus granulosus	allatostatin A receptor	0.0079	0.0123	0.0025
Toxoplasma gondii	subtilisin SUB2	0.0119	0.0288	0.6684
Echinococcus granulosus	neuropeptide receptor	0.0379	0.135	0.1263
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0079	0.0123	0.0032
Plasmodium vivax	subtilisin-like protease 2, putative	0.0119	0.0288	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0706	0.2682	0.4744
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0119	0.0288	1
Onchocerca volvulus		0.0079	0.0123	0.4281
Brugia malayi	Furin-like cysteine rich region family protein	0.0254	0.0838	0.0747
Toxoplasma gondii	subtilisin SUB12	0.0134	0.0348	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0079	0.0123	0.0032
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0079	0.0123	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0123	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0539	0.1999	0.349
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.2501	1	1
Schistosoma mansoni	neuropeptide receptor	0.0079	0.0123	0.0025
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0079	0.0123	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Loa Loa (eye worm)	neuropeptide F receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0119	0.0288	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0355	0.1249	0.1162
Brugia malayi	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.0123	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0539	0.1999	0.349
Echinococcus multilocularis	neuropeptide receptor	0.0079	0.0123	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Schistosoma mansoni	hypothetical protein	0.0079	0.0123	0.0025
Loa Loa (eye worm)	G-protein coupled receptor	0.0079	0.0123	0.0025
Brugia malayi	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0123	0.0025
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0079	0.0123	0.0032
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Echinococcus granulosus	hypothetical protein	0.0079	0.0123	0.0025
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0079	0.0123	0.4281
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0079	0.0123	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.0123	0.0025
Plasmodium falciparum	subtilisin-like protease 2	0.0119	0.0288	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Brugia malayi	hypothetical protein	0.0079	0.0123	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0123	0.0025
Echinococcus granulosus	membrane bound transcription factor site 1	0.0119	0.0288	0.0191
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0079	0.0123	0.0025
Brugia malayi	putative neuropeptide receptor NPR1	0.0079	0.0123	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0539	0.1999	0.349
Schistosoma mansoni	neuropeptide receptor	0.0079	0.0123	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0539	0.1999	0.349
Brugia malayi	G protein-coupled receptor	0.0079	0.0123	0.0025
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1408	0.5545	1
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0119	0.0288	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0119	0.0288	0.0347
Loa Loa (eye worm)	tubulin beta-1 chain	0.0089	0.0166	0.0068
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.0288	0.0347
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0119	0.0288	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 908362