Detailed information for compound 908440

Basic information

Technical information
  • TDR Targets ID: 908440
  • Name: 2-bromo-N-[2-(3-chlorophenyl)-4-oxoquinazolin -3-yl]-5-methoxybenzamide
  • MW: 484.73 | Formula: C22H15BrClN3O3
  • H donors: 1 H acceptors: 2 LogP: 4.99 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)C(=O)Nn1c(nc2c(c1=O)cccc2)c1cccc(c1)Cl)Br
  • InChi: 1S/C22H15BrClN3O3/c1-30-15-9-10-18(23)17(12-15)21(28)26-27-20(13-5-4-6-14(24)11-13)25-19-8-3-2-7-16(19)22(27)29/h2-12H,1H3,(H,26,28)
  • InChiKey: APQDINWQUCBRCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-bromo-N-[2-(3-chlorophenyl)-4-oxo-quinazolin-3-yl]-5-methoxy-benzamide
  • 2-bromo-N-[2-(3-chlorophenyl)-4-oxo-3-quinazolinyl]-5-methoxybenzamide
  • 2-bromo-N-[2-(3-chlorophenyl)-4-keto-quinazolin-3-yl]-5-methoxy-benzamide
  • Oprea1_780437
  • ChemDiv1_003710

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0527 0.7082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.1145 0.13
Onchocerca volvulus 0.0036 0.0527 0.345
Brugia malayi excitatory GABA receptor EXP-1A 0.0012 0.0009 0.0009
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0009 0.001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0267 0.1394
Brugia malayi mbt repeat family protein 0.0047 0.0782 0.0782
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0009 0.001
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0782 0.0887
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0769 0.0873
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0527 0.7082
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0678 0.077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0527 0.0598
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0012 0.0009 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.4178 0.88
Schistosoma mansoni cpg binding protein 0.0029 0.0378 0.043
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0159 0.018
Trypanosoma cruzi ISWI complex protein 0.0031 0.0414 0.6949
Brugia malayi Latrophilin receptor protein 2 0.0064 0.1145 0.1145
Entamoeba histolytica hypothetical protein 0.0036 0.0539 0.2156
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0506 0.0574
Schistosoma mansoni hypothetical protein 0.0181 0.3701 0.42
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0012 0.0009 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0527 0.1109
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.4757 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0527 0.4116
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0782 0.0887
Echinococcus granulosus cpg binding protein 0.0035 0.0499 0.0566
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0267 0.117
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0009 0.001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0267 0.0267
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.001
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.1052 0.9619
Brugia malayi Cation transporter family protein 0.0081 0.1527 0.1527
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Entamoeba histolytica hypothetical protein 0.0036 0.0539 0.2156
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0134 0.0283
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0527 0.0598
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0782 0.5121
Onchocerca volvulus 0.0036 0.0527 0.345
Echinococcus granulosus biogenic amine 5HT receptor 0.0133 0.2647 0.3005
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0506 0.1065
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0159 0.0617
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0782 0.0887
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0527 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0678 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0539 0.0612
Loa Loa (eye worm) hypothetical protein 0.0052 0.0889 0.1873
Echinococcus granulosus dnaJ subfamily B 0.0414 0.881 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0756 0.0858
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0009 0.001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0134 0.0046
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.3924 0.4454
Loa Loa (eye worm) hypothetical protein 0.0228 0.4748 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0926 0.1051
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.1145 0.13
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.0009 0.001
Schistosoma mansoni patched 1 0.0043 0.0678 0.077
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1322 0.15
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.001
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.001
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0782 0.0887
Loa Loa (eye worm) beta-lactamase 0.0036 0.0527 0.1109
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0506 0.0574
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0506 0.0574
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0492 0.0558
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0506 0.0574
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.4178 0.4178
Schistosoma mansoni hypothetical protein 0.0138 0.2774 0.3149
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0009 0.0019
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0926 0.1051
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0782 0.1647
Schistosoma mansoni hypothetical protein 0.0414 0.881 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0527 0.0891
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0012 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0142 0.2852 0.6007
Schistosoma mansoni hypothetical protein 0.0041 0.0645 0.0732
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0492 0.0558
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0267 0.0615
Schistosoma mansoni cpg binding protein 0.0035 0.0499 0.0566
Echinococcus multilocularis zinc finger protein 0.0041 0.0639 0.0725
Schistosoma mansoni survival motor neuron protein 0.0047 0.0763 0.0866
Schistosoma mansoni hypothetical protein 0.0292 0.6149 0.6979
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0527 0.7082
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1088 1
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0527 0.0891
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0267 0.1394
Toxoplasma gondii ABC1 family protein 0.0036 0.0527 0.3963
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0527 0.7082
Loa Loa (eye worm) hypothetical protein 0.01 0.1924 0.4053
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.0009 0.001
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0678 0.077
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0012 0.0009 0.0009
Brugia malayi CHE-14 protein 0.0043 0.0678 0.0678
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0527 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.4178 0.4178
Mycobacterium tuberculosis Conserved protein 0.0036 0.0527 0.0891
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1958 0.2223
Onchocerca volvulus 0.0036 0.0527 0.345
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Schistosoma mansoni hypothetical protein 0.0064 0.1145 0.13
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0012 0.0009 0.001
Onchocerca volvulus 0.0081 0.1527 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0009 0.0009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0539 0.0612
Loa Loa (eye worm) hypothetical protein 0.0064 0.1145 0.2413
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0527 0.0527
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0756 0.1592
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1088 1
Onchocerca volvulus 0.0081 0.1527 1
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1924 0.2184
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Schistosoma mansoni hypothetical protein 0.0047 0.0763 0.0866
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0756 0.0858
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.2774 0.2774
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.0009 0.0009
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0081 0.1527 0.1733
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0009 0.001
Schistosoma mansoni hypothetical protein 0.0041 0.0645 0.0732
Brugia malayi beta-lactamase family protein 0.0036 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0018 0.0134 0.0283
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0009 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0267 0.1394
Loa Loa (eye worm) LGC-31 protein 0.0012 0.0009 0.0019
Trypanosoma brucei ISWI complex protein 0.0031 0.0414 0.6949
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0012 0.0009 0.0019
Brugia malayi CXXC zinc finger family protein 0.0029 0.0378 0.0378
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0926 0.1051
Onchocerca volvulus 0.0047 0.0763 0.4996
Echinococcus multilocularis protein patched 0.0043 0.0678 0.077
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0769 0.0873
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0527 0.0891
Loa Loa (eye worm) hypothetical protein 0.0087 0.1653 0.3483
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0527 0.4116
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0267 0.1394
Brugia malayi PHD-finger family protein 0.0052 0.0873 0.0873
Trypanosoma cruzi ISWI complex protein 0.0031 0.0414 0.6949
Leishmania major hypothetical protein, conserved 0.0031 0.0414 0.2754
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0769 0.0873
Schistosoma mansoni hypothetical protein 0.0181 0.3701 0.42
Schistosoma mansoni zinc finger protein 0.0041 0.0639 0.0725
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1088 0.1234
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0539 0.0612
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0756 0.0858
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0159 0.5
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0527 0.0891
Loa Loa (eye worm) hypothetical protein 0.0036 0.0527 0.1109
Echinococcus multilocularis serotonin receptor 0.0133 0.2647 0.3005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.1145 0.2413
Mycobacterium tuberculosis Conserved protein 0.0036 0.0527 0.0891
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0756 0.0858
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0678 0.077
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1924 0.1924
Loa Loa (eye worm) hypothetical protein 0.0081 0.1527 0.3216
Loa Loa (eye worm) hypothetical protein 0.0138 0.2774 0.5844
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0159 0.5
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0159 1
Echinococcus granulosus geminin 0.0181 0.3701 0.42
Loa Loa (eye worm) hypothetical protein 0.0036 0.0527 0.1109
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1088 0.1234
Echinococcus granulosus zinc finger protein 0.0041 0.0639 0.0725
Echinococcus granulosus nAChR subunit 0.0012 0.0009 0.001
Onchocerca volvulus 0.0012 0.0009 0.0059
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0527 0.0598
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1088 0.2098
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.002 0.002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0009 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1088 1
Schistosoma mansoni bromodomain containing protein 0.0129 0.2561 0.2907
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.1145 0.1145
Echinococcus multilocularis protein dispatched 1 0.0049 0.0811 0.092
Onchocerca volvulus 0.0081 0.1527 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.1145 0.13
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0159 0.0098
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0009 0.0019
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0009 0.001
Onchocerca volvulus Putative nachr subunit 0.0012 0.0009 0.0059
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.001
Onchocerca volvulus 0.0024 0.0267 0.1751
Brugia malayi Cation transporter family protein 0.0012 0.0009 0.0009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0267 0.0615
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0159 0.0254
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0081 0.1527 0.1733
Loa Loa (eye worm) hypothetical protein 0.0202 0.4178 0.88
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0756 0.0858
Onchocerca volvulus 0.0029 0.0378 0.2479
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0756 0.0858
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Onchocerca volvulus 0.0012 0.0009 0.0059
Schistosoma mansoni hypothetical protein 0.0064 0.1145 0.13
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0121 0.2403 0.2728
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1088 0.1234
Mycobacterium ulcerans lipase LipD 0.0036 0.0527 0.4116
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0649 0.1367
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0527 0.1109
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0267 0.0563
Loa Loa (eye worm) hypothetical protein 0.0024 0.0267 0.0563
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0756 0.0756
Schistosoma mansoni ap endonuclease 0.0019 0.0159 0.018
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0009 0.001
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.881 1
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0009 0.001
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.001
Schistosoma mansoni hypothetical protein 0.0041 0.0649 0.0737
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0267 0.1394
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0012 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0077 0.1429 0.301
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0012 0.0009 0.0019
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0012 0.0009 0.001
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0009 0.001
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1924 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0926 0.195
Trichomonas vaginalis esterase, putative 0.0036 0.0527 0.7082
Loa Loa (eye worm) hypothetical protein 0.0024 0.0267 0.0563
Mycobacterium leprae Probable lipase LipE 0.0036 0.0527 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0267 0.0332
Loa Loa (eye worm) hypothetical protein 0.0036 0.0527 0.1109
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0012 0.0009 0.001
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0519 0.1092
Schistosoma mansoni hypothetical protein 0.0036 0.0539 0.0612
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0678 0.1429
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0009 0.001
Brugia malayi Bromodomain containing protein 0.0152 0.3076 0.3076
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0009
Schistosoma mansoni zinc finger protein 0.0031 0.0414 0.047
Loa Loa (eye worm) hypothetical protein 0.0076 0.1403 0.2956
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0527 0.4116
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0267 0.1394
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0012 0.0009 0.001
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0009 0.0009
Brugia malayi mbt repeat family protein 0.0047 0.0782 0.0782
Schistosoma mansoni cpg binding protein 0.0035 0.0499 0.0566
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0527 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0527 0.1109
Echinococcus granulosus expressed conserved protein 0.0094 0.1792 0.2034
Onchocerca volvulus 0.0012 0.0009 0.0059
Loa Loa (eye worm) hypothetical protein 0.0133 0.2647 0.5576
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0012 0.0009 0.001
Mycobacterium ulcerans hypothetical protein 0.0024 0.0267 0.1394
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0527 0.0598
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.1145 0.13
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0012 0.0009 0.0019
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0527 0.0891
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0926 0.1051
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0782 0.0887
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.2861 0.3248
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0267 0.0615
Brugia malayi beta-lactamase family protein 0.0036 0.0527 0.0527
Brugia malayi hypothetical protein 0.0036 0.0539 0.0539
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1088 1
Brugia malayi hypothetical protein 0.0228 0.4748 0.4748
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0527 1
Entamoeba histolytica hypothetical protein 0.0036 0.0539 0.2156
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0527 0.0891
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Echinococcus granulosus GPCR family 2 0.0064 0.1145 0.13
Echinococcus multilocularis serotonin receptor 0.0133 0.2647 0.3005
Leishmania major hypothetical protein, conserved 0.0036 0.0527 0.3963
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1092 0.124
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.2861 0.3248
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0527 0.0891
Loa Loa (eye worm) hypothetical protein 0.0047 0.0782 0.1647
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0012 0.0009 0.0009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0267 0.1394
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1322 0.15
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0012 0.0009 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0267 0.0332
Loa Loa (eye worm) hypothetical protein 0.0082 0.1533 0.3229
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0009 0.001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0378 0.0797
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0678 0.1429
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0012 0.0009 0.0009
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0926 0.1051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0134 0.0283
Entamoeba histolytica hypothetical protein 0.0036 0.0539 0.2156
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1088 1
Schistosoma mansoni hypothetical protein 0.0064 0.1145 0.13
Loa Loa (eye worm) hypothetical protein 0.0133 0.2647 0.5576
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0159 0.0334
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0782 0.0887
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0009 0.001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0527 0.0891
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0763 0.0763
Brugia malayi beta-lactamase 0.0036 0.0527 0.0527
Echinococcus multilocularis GPCR, family 2 0.0064 0.1145 0.13
Loa Loa (eye worm) hypothetical protein 0.0081 0.1527 0.3216
Onchocerca volvulus 0.0047 0.0782 0.5121
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0134 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0527 0.1109
Echinococcus multilocularis nAChR subunit 0.0012 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0134 0.0283
Schistosoma mansoni hypothetical protein 0.0031 0.0414 0.047
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.3924 0.4454
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.4748 0.5389
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0159 0.5
Brugia malayi Cation transporter family protein 0.0012 0.0009 0.0009
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0492 0.0558
Schistosoma mansoni hypothetical protein 0.0041 0.0645 0.0732
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0018 0.0134 0.0283
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0159 0.018
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0267 0.117
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0527 0.7082
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0926 0.0926
Schistosoma mansoni hypothetical protein 0.0041 0.0645 0.0732
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0009 0.001
Echinococcus multilocularis expressed conserved protein 0.0094 0.1792 0.2034
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1924 0.2184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0756 0.0858
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0009 0.001
Echinococcus multilocularis cpg binding protein 0.0035 0.0499 0.0566
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0267 0.117
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0012 0.0009 0.0019
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1088 0.1234
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0527 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0019
Schistosoma mansoni ap endonuclease 0.0019 0.0159 0.018
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0009 0.001
Brugia malayi Bromodomain containing protein 0.0077 0.1426 0.1426
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0009
Mycobacterium ulcerans hypothetical protein 0.0036 0.0527 0.4116
Echinococcus multilocularis geminin 0.0181 0.3701 0.42
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0121 0.2403 0.2728
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0009 0.001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0133 0.2647 0.3005
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0492 0.0558
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.4748 0.5389
Loa Loa (eye worm) MBCTL1 0.0054 0.0926 0.195
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0267 0.0267
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0782 0.0887
Schistosoma mansoni hypothetical protein 0.0064 0.1145 0.13

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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