Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0032 | 0.1047 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.167 | 0.167 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0032 | 0.1047 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0104 | 0.3903 | 0.3903 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Echinococcus granulosus | smad | 0.0008 | 0.0086 | 0.0086 |
Brugia malayi | N-terminal motif family protein | 0.0181 | 0.6983 | 0.6983 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | smad | 0.0008 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0032 | 0.1047 | 0.1047 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0032 | 0.1047 | 0.1047 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.167 | 0.167 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.167 | 0.167 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.3903 | 0.3903 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0009 | 0.0102 | 0.0102 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0086 | 0.0086 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0086 | 0.0086 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0256 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.1047 | 0.5 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0009 | 0.0102 | 0.0102 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0086 | 0.0086 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0102 | 0.0102 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.167 | 0.167 |
Brugia malayi | DIX domain containing protein | 0.0009 | 0.0102 | 0.0102 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0086 | 0.0086 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0032 | 0.1047 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0086 | 0.0086 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.1047 | 0.5 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0009 | 0.0102 | 0.0146 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0152 | 0.5827 | 0.5827 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0102 | 0.0102 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0152 | 0.5827 | 0.5827 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0102 | 0.0102 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0102 | 0.0102 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0032 | 0.1047 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.167 | 0.167 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0086 | 0.0086 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0086 | 0.0086 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0086 | 0.0086 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0086 | 0.0086 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0086 | 0.0086 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.167 | 0.167 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 1 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1047 | 0.1047 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.167 | 0.167 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0086 | 0.0086 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0086 | 0.0086 |
Schistosoma mansoni | regulator of G protein signaling | 0.0009 | 0.0102 | 0.0102 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0032 | 0.1047 | 0.1047 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.1047 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.167 | 0.167 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0102 | 0.0102 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0006 | 0 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0032 | 0.1047 | 0.1047 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.5827 | 0.5827 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0009 | 0.0102 | 0.0102 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0032 | 0.1047 | 0.1047 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0102 | 0.0102 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0102 | 0.0102 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1047 | 0.1047 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.167 | 0.167 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0102 | 0.0102 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0032 | 0.1047 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0086 | 0.0086 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0181 | 0.6983 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1047 | 0.1047 |
Loa Loa (eye worm) | TAR-binding protein | 0.0256 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.1047 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0032 | 0.1047 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.167 | 0.167 |
Brugia malayi | Isocitrate dehydrogenase | 0.0032 | 0.1047 | 0.1047 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1047 | 0.1047 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0009 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0152 | 0.5827 | 0.5827 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.6983 | 0.6983 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0256 | 1 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0102 | 0.0102 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.167 | 0.167 |
Schistosoma mansoni | dep domain containing protein | 0.0009 | 0.0102 | 0.0102 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.167 | 0.167 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0102 | 0.0102 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.4737 | 0.4737 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0102 | 0.0102 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.4737 | 0.4737 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.167 | 0.167 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0009 | 0.0102 | 0.0102 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.167 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.3903 | 0.3903 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0102 | 0.0102 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0086 | 0.0086 |
Brugia malayi | Smad1 | 0.0008 | 0.0086 | 0.0086 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0009 | 0.0102 | 0.0102 |
Entamoeba histolytica | hypothetical protein | 0.0006 | 0 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.4737 | 0.4737 |
Echinococcus granulosus | tar DNA binding protein | 0.0256 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0256 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0256 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0256 | 1 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0086 | 0.0086 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0009 | 0.0102 | 0.0102 |
Schistosoma mansoni | smad | 0.0008 | 0.0086 | 0.0086 |
Onchocerca volvulus | 0.0009 | 0.0102 | 0.0146 | |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0102 | 0.0102 |
Brugia malayi | TAR-binding protein | 0.0256 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0102 | 0.0102 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.