TDR Targets

Basic information

Technical information

TDR Targets ID: 908544
Name: N-(4-nitrophenyl)-2-(2H-1,2,4-triazol-3-ylsul fanyl)acetamide
MW: 279.275 | Formula: C10H9N5O3S
H donors: 2 H acceptors: 5 LogP: 0.87 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1)[N+](=O)[O-])CSc1n[nH]cn1
InChi: 1S/C10H9N5O3S/c16-9(5-19-10-11-6-12-14-10)13-7-1-3-8(4-2-7)15(17)18/h1-4,6H,5H2,(H,13,16)(H,11,12,14)
InChiKey: CWTLZEJPOXNXFQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-nitrophenyl)-2-(2H-1,2,4-triazol-3-ylthio)acetamide
N-(4-nitrophenyl)-2-(2H-1,2,4-triazol-3-ylsulfanyl)ethanamide
BIM-0042939.P001
STK323822
CBMicro_043051
ZINC04844696
STOCK3S-35428
CBMicro_049763
BIM-0049613.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0259	0.0172
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0049	0.1103	0.1006
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0988	0.1209
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0034	0.0618	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0661	0.077
Trypanosoma brucei	trypanothione reductase	0.0099	0.277	0.352
Plasmodium falciparum	thioredoxin reductase	0.0034	0.0618	0.0748
Entamoeba histolytica	protein kinase, putative	0.0112	0.3207	0.4161
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0632	0.0549
Echinococcus multilocularis	lamin dm0	0.0053	0.1248	0.1951
Echinococcus multilocularis	geminin	0.0197	0.6034	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0226	0.699	0.8917
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0299	0.0284
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0251	0.7828	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0251	0.7828	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1009	0.155
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0112	0.3207	0.5247
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0034	0.0618	0.0748
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0099	0.277	0.3465
Giardia lamblia	Kinase, CMGC GSK	0.0112	0.3207	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.1248	0.1559
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0034	0.0618	0.0695
Schistosoma mansoni	hypothetical protein	0.0197	0.6034	0.5999
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0025	0.0315	0.0418
Brugia malayi	glutathione reductase	0.0099	0.277	0.3679
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0318	0.0309
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0226	0.699	0.8874
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0299	0.0284
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0988	0.0685
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0259	0.023
Toxoplasma gondii	NADPH-glutathione reductase	0.0034	0.0618	0.1699
Entamoeba histolytica	hypothetical protein	0.0042	0.0869	0.0717
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0034	0.0618	0.0348
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0259	0.0287
Brugia malayi	nuclear hormone receptor	0.0023	0.0259	0.0344
Echinococcus granulosus	lamin dm0	0.0053	0.1248	0.1951
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0869	0.1313
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0259	0.0344
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.1009	0.134
Echinococcus granulosus	chromobox protein 1	0.0081	0.2173	0.3506
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1322	0.1092
Echinococcus multilocularis	chromobox protein 1	0.0081	0.2173	0.3506
Trichomonas vaginalis	chromobox protein, putative	0.0049	0.1103	0.0825
Plasmodium vivax	SET domain protein, putative	0.0035	0.0632	0.0767
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0242	0.753	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0259	0.0172
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0259	0.0172
Plasmodium vivax	thioredoxin reductase, putative	0.0099	0.277	0.3785
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0259	0.0344
Mycobacterium tuberculosis	Conserved protein	0.0028	0.0425	0.0435
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.1009	0.1238
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.0618	0.0695
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0259	0.0287
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0028	0.0425	0.0442
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0259	0.0172
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.4096	0.5386
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0618	0.0695
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0028	0.0425	0.0442
Onchocerca volvulus		0.0048	0.1073	0.0971
Echinococcus granulosus	thioredoxin glutathione reductase	0.0099	0.279	0.4544
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0259	0.023
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0287	0.0268
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0111	0.3168	0.3469
Onchocerca volvulus		0.0275	0.8643	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0259	0.0344
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0112	0.3207	1
Leishmania major	phosphopantetheinyl transferase-like protein	0.0027	0.0381	0.0385
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0231	0.7174	0.8212
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0259	0.0287
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0632	0.1743
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0287	0.0262
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0259	0.0287
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0111	0.3168	0.4102
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0259	0.0287
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0231	0.7174	0.8212
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0034	0.0618	0.0348
Brugia malayi	Heterochromatin protein 1	0.0081	0.2173	0.2885
Plasmodium falciparum	glycogen synthase kinase 3	0.0112	0.3207	0.4403
Trypanosoma brucei	monoglyceride lipase, putative	0.0231	0.7174	0.9298
Schistosoma mansoni	chromobox protein	0.0081	0.2173	0.2103
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0097	0.2694	0.3577
Trypanosoma brucei	protein kinase, putative	0.0112	0.3207	0.4093
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0027	0.0381	0.0414
Trichomonas vaginalis	chromobox protein, putative	0.0049	0.1103	0.0825
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0034	0.0618	0.0748
Brugia malayi	intracellular kinase	0.0112	0.3207	0.4259
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0618	0.0695
Trichomonas vaginalis	chromobox protein, putative	0.0081	0.2173	0.2127
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0259	0.023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1009	0.093
Schistosoma mansoni	hypothetical protein	0.0197	0.6034	0.5999
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0869	0.1313
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0259	0.023
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1322	0.1092
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0088	0.0117
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0048	0.1073	0.0994
Entamoeba histolytica	hypothetical protein	0.0042	0.0869	0.0717
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0259	0.0172
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0226	0.699	0.8917
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0028	0.0425	0.0064
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0287	0.0282
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0632	0.0549
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3168	0.3338
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0618	0.0695
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0632	0.0549
Toxoplasma gondii	thioredoxin reductase	0.0099	0.277	0.8598
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0632	0.0915
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0259	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0331	0.0327
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0259	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1248	0.1559
Schistosoma mansoni	intermediate filament proteins	0.0053	0.1248	0.117
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0027	0.0381	0.0941
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0287	0.064
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0259	0.0172
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0259	0.0172
Echinococcus granulosus	citrate lyase subunit beta protein	0.0028	0.0425	0.0566
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0028	0.0425	0.0566
Brugia malayi	amidase	0.0109	0.3098	0.4114
Echinococcus multilocularis	lamin	0.0053	0.1248	0.1951
Schistosoma mansoni	lamin	0.0053	0.1248	0.117
Plasmodium vivax	PST-A protein	0.0231	0.7174	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0259	0.0344
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1009	0.155
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0111	0.3168	0.5179
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0028	0.0425	0.0454
Giardia lamblia	Kinase, CMGC GSK	0.0112	0.3207	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0259	0.0287
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0034	0.0618	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0632	0.0731
Echinococcus granulosus	lamin	0.0053	0.1248	0.1951
Trypanosoma cruzi	trypanothione reductase, putative	0.0099	0.277	0.352
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0112	0.3207	0.4192
Trichomonas vaginalis	chromobox protein, putative	0.0081	0.2173	0.2127
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0034	0.0618	0.0891
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0028	0.0425	0.0064
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0226	0.699	0.8917
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3168	0.3338
Mycobacterium ulcerans	hypothetical protein	0.0231	0.7174	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0259	0.0344
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0287	0.0262
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0231	0.7174	0.8212
Trypanosoma brucei	hypothetical protein, conserved	0.0027	0.0381	0.0385
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0259	0.0287
Schistosoma mansoni	kinase	0.0057	0.137	0.1293
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0259	0.0172
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0287	0.0282
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0259	0.0344
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0259	0.0172
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0112	0.3207	0.3147
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.4096	0.5386
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.1248	0.1559
Schistosoma mansoni	fatty-acid amide hydrolase	0.0109	0.3098	0.3036
Trypanosoma brucei	polo-like protein kinase	0.0111	0.3168	0.4041
Echinococcus granulosus	chromobox protein 1	0.0081	0.2173	0.3506
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0259	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0109	0.3098	0.4044
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0259	0.023
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.3168	0.4041
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0869	0.0788
Treponema pallidum	NADH oxidase	0.0034	0.0618	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0259	0.023
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0287	0.0262
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0099	0.279	0.4544
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0259	0.0287
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0988	0.0685
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.1248	0.1657
Trichomonas vaginalis	set domain proteins, putative	0.0275	0.8643	1
Giardia lamblia	Kinase, PLK	0.0111	0.3168	0.9846
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0109	0.3098	0.5062
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3168	0.3338
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0111	0.3168	0.4138
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0331	0.0409
Trypanosoma cruzi	hypothetical protein, conserved	0.0247	0.7709	1
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0112	0.3207	0.4093
Echinococcus granulosus	intermediate filament protein	0.0053	0.1248	0.1951
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0259	0.0344
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0111	0.3168	0.5179
Loa Loa (eye worm)	glutathione reductase	0.0099	0.277	0.3604
Trichomonas vaginalis	mercuric reductase, putative	0.0034	0.0618	0.0235
Schistosoma mansoni	chromobox protein	0.0081	0.2173	0.2103
Leishmania major	monoglyceride lipase, putative	0.0231	0.7174	0.9298
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0259	0.023
Leishmania major	trypanothione reductase	0.0099	0.277	0.352
Brugia malayi	chromobox protein homolog 3	0.0045	0.0988	0.1312
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0027	0.0381	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0259	0.023
Mycobacterium tuberculosis	Probable reductase	0.0226	0.699	0.8917
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0259	0.0344
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0259	0.0287
Schistosoma mansoni	coup transcription factor	0.0023	0.0259	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0259	0.023
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0028	0.0425	0.0442
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1009	0.155
Brugia malayi	serine/threonine-protein kinase plk-2	0.0111	0.3168	0.4206
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0259	0.023
Trichomonas vaginalis	CMGC family protein kinase	0.0112	0.3207	0.3386
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0231	0.7174	0.8212
Plasmodium falciparum	esterase, putative	0.0231	0.7174	1
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3168	0.3338
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0231	0.7174	1
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0425	0.0064
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0259	0.0287
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0034	0.0618	0.1699
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0027	0.0381	0.0414
Mycobacterium tuberculosis	Probable oxidoreductase	0.0251	0.7828	1
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0088	0.0117
Trypanosoma brucei	monoglyceride lipase, putative	0.0231	0.7174	0.9298
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1215	0.1515
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0618	0.0695
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1009	0.093
Brugia malayi	Pre-SET motif family protein	0.0035	0.0632	0.0839
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3168	0.3338
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0034	0.0618	0.0695
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0259	0.0287
Schistosoma mansoni	amidase	0.0109	0.3098	0.3036
Plasmodium falciparum	lysophospholipase, putative	0.0231	0.7174	1
Brugia malayi	hypothetical protein	0.0024	0.0287	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0259	0.023
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0112	0.3207	0.4192
Trichomonas vaginalis	CMGC family protein kinase	0.0112	0.3207	0.3386
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0231	0.7174	0.8212
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0618	0.0695
Plasmodium falciparum	glutathione reductase	0.0099	0.277	0.3785
Entamoeba histolytica	hypothetical protein	0.0042	0.0869	0.0717
Brugia malayi	cytoplasmic intermediate filament protein	0.0028	0.0425	0.0565
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0259	0.023
Trypanosoma cruzi	hypothetical protein, conserved	0.0247	0.7709	1
Trichomonas vaginalis	conserved hypothetical protein	0.0231	0.7174	0.8212
Trypanosoma brucei	hypothetical protein, conserved	0.0247	0.7709	1
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0547	0.0148
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0025	0.0315	0.0418
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0034	0.0618	0.0748
Onchocerca volvulus		0.0053	0.1248	0.118
Trichomonas vaginalis	glutathione reductase, putative	0.0034	0.0618	0.0235
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0112	0.3207	0.4403
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0097	0.2694	0.2629
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0034	0.0618	1
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3168	0.3338
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0112	0.3207	0.5247
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0618	0.0695
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1009	0.155
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0259	0.023
Brugia malayi	MH2 domain containing protein	0.0139	0.4096	0.544
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0259	0.0344
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0331	0.0409
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0287	0.0282
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0231	0.7174	0.8212
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0259	0.023
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0097	0.2694	0.4383
Echinococcus granulosus	geminin	0.0197	0.6034	1
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0231	0.7174	0.9121
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0034	0.0618	0.0695
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0259	0.0287
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.3168	0.4041
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0027	0.0381	0.0379
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1009	0.093
Onchocerca volvulus		0.0036	0.0661	0.048
Entamoeba histolytica	protein kinase domain containing protein	0.0112	0.3207	0.4161
Plasmodium falciparum	glutathione reductase	0.0034	0.0618	0.0748
Mycobacterium tuberculosis	Probable dehydrogenase	0.0226	0.699	0.8917
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0259	0.023
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0589	0.0843
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0034	0.0618	0.082
Echinococcus granulosus	protein kinase shaggy	0.0112	0.3207	0.5247
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0259	0.023
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0034	0.0618	0.0748
Entamoeba histolytica	hypothetical protein	0.0042	0.0869	0.0717
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0045	0.0988	0.087
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0034	0.0618	0.0535
Plasmodium falciparum	lysophospholipase, putative	0.0231	0.7174	1
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.3168	0.3338
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0259	0.0287
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.0618	0.0695
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0547	0.0148
Brugia malayi	steroid hormone receptor	0.0023	0.0259	0.0344
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0028	0.0425	0.0064
Loa Loa (eye worm)	heterochromatin protein 1	0.0081	0.2173	0.2801
Loa Loa (eye worm)	hypothetical protein	0.0097	0.2694	0.3502
Brugia malayi	ecdysteroid receptor	0.0023	0.0259	0.0344
Brugia malayi	hypothetical protein	0.0042	0.0869	0.1154
Echinococcus multilocularis	chromobox protein 1	0.0081	0.2173	0.3506
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0259	0.0172
Trypanosoma cruzi	monoglyceride lipase, putative	0.0231	0.7174	0.9298
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0112	0.3207	0.4093
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0226	0.699	0.8917
Leishmania major	hypothetical protein, conserved	0.0247	0.7709	1
Schistosoma mansoni	serine/threonine protein kinase	0.0111	0.3168	0.3107
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0259	0.0172
Echinococcus multilocularis	musashi	0.0053	0.1248	0.1951
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0111	0.3168	0.4041
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0425	0.0064
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0618	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0251	0.7828	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0259	0.0287
Mycobacterium tuberculosis	Possible lysophospholipase	0.0231	0.7174	0.9155
Entamoeba histolytica	protein kinase domain containing protein	0.0112	0.3207	0.4161
Plasmodium vivax	glutathione reductase, putative	0.0099	0.277	0.3785
Brugia malayi	intermediate filament protein	0.0053	0.1248	0.1657
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0259	0.0287
Plasmodium falciparum	thioredoxin reductase	0.0099	0.277	0.3785
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0109	0.3098	0.5062
Onchocerca volvulus		0.0097	0.2694	0.2904
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0034	0.0618	0.0695
Echinococcus granulosus	L aminoadipate semialdehyde	0.0097	0.2694	0.4383
Brugia malayi	Pre-SET motif family protein	0.0242	0.753	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0632	0.0915
Schistosoma mansoni	hypothetical protein	0.0042	0.0869	0.0788
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0618	0.0695
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0259	0.0344
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0618	0.0695
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0632	0.0915
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0259	0.0287
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0259	0.0344
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0109	0.3098	0.5062
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0034	0.0618	0.0685
Loa Loa (eye worm)	thioredoxin reductase	0.0099	0.277	0.3604
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0618	0.0695
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0259	0.0344
Echinococcus multilocularis	protein kinase shaggy	0.0112	0.3207	0.5247
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0028	0.0425	0.0435
Onchocerca volvulus		0.0053	0.1248	0.118
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0259	0.0344
Trypanosoma cruzi	trypanothione reductase, putative	0.0034	0.0618	0.0695
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0259	0.0344
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0231	0.7174	1
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0318	0.0422
Schistosoma mansoni	lamin	0.0053	0.1248	0.117
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0259	0.0344
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0259	0.0287
Plasmodium falciparum	lysophospholipase, putative	0.0231	0.7174	1
Leishmania major	hypothetical protein, conserved	0.0024	0.0287	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0231	0.7174	0.8212
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0109	0.3098	0.5062
Onchocerca volvulus		0.0112	0.3207	0.3517
Brugia malayi	Thioredoxin reductase	0.0099	0.277	0.3679
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0618	0.0695
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0259	0.0287
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0618	1
Mycobacterium ulcerans	lysophospholipase	0.0231	0.7174	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 908544