Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1192 | 0.2778 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0.0662 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0.0662 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1044 | 0.0737 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0.0662 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1188 | 0.1056 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.389 | 0.389 |
Echinococcus multilocularis | peregrin | 0.0038 | 0.0846 | 0.0708 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0045 | 0.1287 | 0.2999 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.4223 | 0.4024 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1378 | 0.1378 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.3034 | 0.293 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.3313 | 0.7722 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1192 | 0.1059 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2269 | 0.2269 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0662 | 0.0662 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1044 | 0.2434 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0035 | 0.0662 | 0.0662 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0035 | 0.0662 | 0.0521 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.429 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0662 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1192 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.5814 | 0.5751 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.5814 | 0.5751 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.5814 | 0.567 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.1138 | 0.1005 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1192 | 0.5 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.0662 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.228 | 0.228 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.1549 | 0.1421 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0846 | 0.0531 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.1549 | 0.1421 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1192 | 0.0889 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.3073 | 0.3073 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0045 | 0.1287 | 0.1155 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0045 | 0.1287 | 0.2999 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1188 | 0.1056 |
Brugia malayi | PHD-finger family protein | 0.0035 | 0.0662 | 0.0341 |
Brugia malayi | jmjC domain containing protein | 0.0045 | 0.1287 | 0.0987 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1192 | 0.2778 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1192 | 0.5 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0035 | 0.0662 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1044 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.171 | 0.171 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1192 | 0.1059 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.3034 | 0.293 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0148 | 0.0346 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2269 | 0.2004 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1372 | 0.1076 |
Echinococcus granulosus | peregrin | 0.0038 | 0.0846 | 0.0708 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2269 | 0.2269 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.0662 | 0.5 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0035 | 0.0662 | 0.1543 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1562 | 0.1562 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2269 | 0.2004 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1192 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0662 | 0.1543 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0045 | 0.1287 | 0.1287 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | 3.9811 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 10.3225 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.