Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium channel, subfamily K, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 28 | potassium channel, subfamily K, member 3 | 394 aa | 450 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 0.0231 | 0.4503 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.4503 | 0.2269 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0171 | 0.289 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.014 | 0.2064 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 0.6017 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.4129 | 0.1743 |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 0.0231 | 0.4503 | 1 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0231 | 0.4503 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.4503 | 0.2269 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0171 | 0.289 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 0.6017 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0287 | 0.6017 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 0.6017 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 0.6017 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 0.6017 | 0.5 |
Onchocerca volvulus | 0.0435 | 1 | 0.5 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 0.6017 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.014 | 0.2064 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0287 | 0.6017 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0287 | 0.6017 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0287 | 0.6017 | 0.5 |
Leishmania major | 0.0171 | 0.289 | 0.5 | |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0171 | 0.289 | 1 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog | 0.0231 | 0.4503 | 0.2269 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 0.6017 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0171 | 0.289 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0287 | 0.6017 | 0.5 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.014 | 0.2064 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0.184 uM | PubChem BioAssay. SAR Analysis for the identification of inhibitors of the two-pore domain potassium channel TASK1 (KCNK3). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | = 0.19 uM | Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay | ChEMBL. | 25017033 |
IC50 (binding) | > 30 uM | Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay | ChEMBL. | 25017033 |
IC50 (functional) | 32.79 uM | PubChem BioAssay. SAR Analysis for the identification of selective inhibitors of the two-pore domain potassium channel TASK1 in hERG expressing cells: FluxOR Assay CRC. (Class of assay: confirmatory) | ChEMBL. | No reference |
Inhibition (binding) | = 96.6 % | Inhibition of TASK-1 (unknown origin) expressed in CHO cells at 3 uM by thallium flux assay | ChEMBL. | 25017033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.