Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.004 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0089 | 0.0449 | 0.0449 |
Echinococcus granulosus | sentrin specific protease 1 | 0.0046 | 0.0112 | 0.0336 |
Brugia malayi | MH2 domain containing protein | 0.0089 | 0.0449 | 0.0449 |
Schistosoma mansoni | tar DNA-binding protein | 0.0457 | 0.3335 | 0.9483 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0184 | 0.1824 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.016 | 0.1007 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0089 | 0.0449 | 0.1277 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0101 | 0.0543 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0543 | 0.0543 |
Loa Loa (eye worm) | RNA binding protein | 0.0457 | 0.3335 | 0.3335 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0231 | 0.0231 |
Schistosoma mansoni | DNA ligase IV | 0.0061 | 0.0231 | 0.0655 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0061 | 0.0231 | 0.0691 |
Brugia malayi | Smad1 | 0.0089 | 0.0449 | 0.0449 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0101 | 0.0543 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0231 | 0.0231 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0703 | 0.526 | 0.526 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.3517 | 0.3517 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0703 | 0.526 | 0.526 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.048 | 0.3517 | 0.3517 |
Schistosoma mansoni | hypothetical protein | 0.0222 | 0.1494 | 0.4248 |
Plasmodium vivax | sentrin-specific protease 1, putative | 0.0046 | 0.0112 | 0.1112 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.0231 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0222 | 0.1494 | 0.448 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0045 | 0.0106 | 0.0318 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0105 | 0.0574 | 1 |
Echinococcus multilocularis | nibrin | 0.0061 | 0.0231 | 0.0691 |
Brugia malayi | MH1 domain containing protein | 0.0049 | 0.0137 | 0.0137 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0089 | 0.0449 | 0.1347 |
Brugia malayi | MH1 domain containing protein | 0.0049 | 0.0137 | 0.0137 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0061 | 0.0231 | 0.0869 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0231 | 0.0231 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.016 | 0.1007 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0457 | 0.3335 | 0.3335 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0061 | 0.0231 | 0.0231 |
Schistosoma mansoni | tar DNA-binding protein | 0.0457 | 0.3335 | 0.9483 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.022 | 0.1476 | 0.4425 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0061 | 0.0231 | 0.0655 |
Brugia malayi | RNA binding protein | 0.0457 | 0.3335 | 0.3335 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.0231 | 1 |
Brugia malayi | DKFZp564C0469 protein | 0.0061 | 0.0231 | 0.0231 |
Echinococcus multilocularis | tar DNA binding protein | 0.0457 | 0.3335 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0105 | 0.0574 | 0.4744 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0231 | 0.0231 |
Schistosoma mansoni | topbp1 | 0.0061 | 0.0231 | 0.0655 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0457 | 0.3335 | 0.3335 |
Schistosoma mansoni | Smad4 | 0.0089 | 0.0449 | 0.1277 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1007 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0222 | 0.1494 | 0.1494 |
Schistosoma mansoni | tar DNA-binding protein | 0.0457 | 0.3335 | 0.9483 |
Brugia malayi | MH1 domain containing protein | 0.0089 | 0.0449 | 0.0449 |
Schistosoma mansoni | hypothetical protein | 0.0222 | 0.1494 | 0.4248 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0703 | 0.526 | 0.526 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0055 | 0.0184 | 0.1824 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.016 | 0.1007 | 0.3019 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0061 | 0.0231 | 1 |
Entamoeba histolytica | hypothetical protein | 0.022 | 0.1476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0703 | 0.526 | 0.526 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.016 | 0.1007 | 0.3019 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0046 | 0.0112 | 0.0318 |
Brugia malayi | hypothetical protein | 0.022 | 0.1476 | 0.1476 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1007 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0112 | 0.0112 |
Brugia malayi | TAR-binding protein | 0.0457 | 0.3335 | 0.3335 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0061 | 0.0231 | 0.2289 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0101 | 0.0543 | 0.5391 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0045 | 0.0106 | 0.0318 |
Echinococcus multilocularis | smad | 0.0089 | 0.0449 | 0.1347 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0046 | 0.0112 | 0.0318 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0055 | 0.0184 | 0.1824 |
Entamoeba histolytica | hypothetical protein | 0.022 | 0.1476 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.004 | 0.0063 | 0.0063 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1007 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0183 | 0.1186 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0101 | 0.0543 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0101 | 0.0543 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0089 | 0.0449 | 0.0449 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0222 | 0.1494 | 0.1494 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0101 | 0.0543 | 0.5391 |
Loa Loa (eye worm) | TAR-binding protein | 0.0457 | 0.3335 | 0.3335 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0231 | 0.0231 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1007 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1494 | 0.1494 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.022 | 0.1476 | 0.4425 |
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0046 | 0.0112 | 0.1112 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1007 | 0.1007 |
Schistosoma mansoni | Smad4 | 0.004 | 0.0063 | 0.0179 |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.004 | 0.0063 | 0.0189 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0061 | 0.0231 | 1 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0061 | 0.0231 | 0.4247 |
Entamoeba histolytica | hypothetical protein | 0.0061 | 0.0231 | 0.0869 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0231 | 0.0231 |
Brugia malayi | MH1 domain containing protein | 0.0089 | 0.0449 | 0.0449 |
Schistosoma mansoni | hypothetical protein | 0.0222 | 0.1494 | 0.4248 |
Brugia malayi | N-terminal motif family protein | 0.0183 | 0.1186 | 0.1186 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.0061 | 0.0231 | 0.4247 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1007 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0089 | 0.0449 | 0.0449 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0089 | 0.0449 | 0.1347 |
Schistosoma mansoni | hypothetical protein | 0.022 | 0.1476 | 0.4197 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.004 | 0.0063 | 0.0063 |
Brugia malayi | Probable ClpP-like protease | 0.016 | 0.1007 | 0.1007 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0231 | 0.0231 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0106 | 0.0302 |
Schistosoma mansoni | hypothetical protein | 0.048 | 0.3517 | 1 |
Schistosoma mansoni | topbp1 | 0.0061 | 0.0231 | 0.0655 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0061 | 0.0231 | 0.4247 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.0231 | 1 |
Loa Loa (eye worm) | nuclear factor I | 0.0049 | 0.0137 | 0.0137 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0061 | 0.0231 | 0.0691 |
Onchocerca volvulus | 0.0061 | 0.0231 | 0.1492 | |
Schistosoma mansoni | smad1 5 8 and | 0.0089 | 0.0449 | 0.1277 |
Echinococcus multilocularis | Smad4 | 0.0089 | 0.0449 | 0.1347 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0089 | 0.0449 | 0.1277 |
Schistosoma mansoni | smad1 5 8 and | 0.0089 | 0.0449 | 0.1277 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.004 | 0.0063 | 0.0189 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.0231 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0105 | 0.0574 | 0.1722 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0046 | 0.0112 | 0.0112 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.004 | 0.0063 | 0.0189 |
Schistosoma mansoni | tar DNA-binding protein | 0.0457 | 0.3335 | 0.9483 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0105 | 0.0574 | 0.1722 |
Echinococcus granulosus | tar DNA binding protein | 0.0457 | 0.3335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1186 | 0.1186 |
Brugia malayi | topoisomerase | 0.0061 | 0.0231 | 0.0231 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0231 | 0.0231 |
Echinococcus granulosus | GPCR family 2 | 0.0222 | 0.1494 | 0.448 |
Toxoplasma gondii | ATPase, AAA family protein | 0.0061 | 0.0231 | 0.2289 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0101 | 0.0543 | 0.5391 |
Echinococcus granulosus | smad | 0.0089 | 0.0449 | 0.1347 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.1307 | 1 | 1 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0061 | 0.0231 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0101 | 0.0543 | 0.5391 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0222 | 0.1494 | 0.448 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.004 | 0.0063 | 0.0063 |
Brugia malayi | hypothetical protein | 0.0101 | 0.0543 | 0.0543 |
Entamoeba histolytica | hypothetical protein | 0.022 | 0.1476 | 1 |
Entamoeba histolytica | hypothetical protein | 0.022 | 0.1476 | 1 |
Brugia malayi | hypothetical protein | 0.0065 | 0.0262 | 0.0262 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0089 | 0.0449 | 0.1347 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0061 | 0.0231 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0105 | 0.0574 | 1 |
Echinococcus granulosus | Smad4 | 0.0089 | 0.0449 | 0.1347 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.1307 | 1 | 1 |
Schistosoma mansoni | smad | 0.0089 | 0.0449 | 0.1277 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0061 | 0.0231 | 0.0231 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0061 | 0.0231 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.022 | 0.1476 | 0.4197 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.016 | 0.1007 | 1 |
Schistosoma mansoni | Smad4 | 0.004 | 0.0063 | 0.0179 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.004 | 0.0063 | 0.0189 |
Schistosoma mansoni | hypothetical protein | 0.0222 | 0.1494 | 0.4248 |
Treponema pallidum | DNA ligase (lig) | 0.0061 | 0.0231 | 0.0569 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0061 | 0.0231 | 0.4247 |
Echinococcus multilocularis | GPCR, family 2 | 0.0222 | 0.1494 | 0.448 |
Schistosoma mansoni | smad | 0.004 | 0.0063 | 0.0179 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.016 | 0.1007 | 0.2863 |
Echinococcus granulosus | nibrin | 0.0061 | 0.0231 | 0.0691 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0222 | 0.1494 | 0.448 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.0061 | 0.0231 | 0.0569 |
Plasmodium falciparum | sentrin-specific protease 1 | 0.0046 | 0.0112 | 0.1112 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0089 | 0.0449 | 0.0449 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0061 | 0.0231 | 0.4247 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0222 | 0.1494 | 0.448 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1007 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.016 | 0.1007 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0222 | 0.1494 | 0.1494 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0089 | 0.0449 | 0.1347 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.0061 | 0.0231 | 0.2289 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.0231 | 1 |
Echinococcus multilocularis | sentrin specific protease 1 | 0.0046 | 0.0112 | 0.0336 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0061 | 0.0231 | 1 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.0061 | 0.0231 | 0.2289 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.016 | 0.1007 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0457 | 0.3335 | 0.9483 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.