Detailed information for compound 909100

Basic information

Technical information
  • TDR Targets ID: 909100
  • Name: 4-cyano-N-(2-methyl-[1,3]thiazolo[4,5-g][1,3] benzothiazol-7-yl)benzamide
  • MW: 350.418 | Formula: C17H10N4OS2
  • H donors: 1 H acceptors: 4 LogP: 4.12 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)C(=O)Nc1nc2c(s1)c1sc(nc1cc2)C
  • InChi: 1S/C17H10N4OS2/c1-9-19-12-6-7-13-15(14(12)23-9)24-17(20-13)21-16(22)11-4-2-10(8-18)3-5-11/h2-7H,1H3,(H,20,21,22)
  • InChiKey: JGOGNCBFBCGGJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-cyano-N-(2-methylthiazolo[4,5-g][1,3]benzothiazol-7-yl)benzamide
  • 4-cyano-N-(2-methyl-7-thiazolo[4,5-g][1,3]benzothiazolyl)benzamide
  • ZINC03900170
  • T0502-8391
  • EU-0001162

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA binding protein 0.0066 0.477 0.477
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.3429 0.3429
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0 0.5
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0089
Entamoeba histolytica hypothetical protein 0.0037 0.1987 0.5
Echinococcus multilocularis GPCR, family 2 0.0016 0.0042 0.0089
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.3429 0.3429
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0042 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0066 0.477 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.477 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0042
Loa Loa (eye worm) MH2 domain-containing protein 0.012 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0042 0.0089
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.1987 0.4165
Schistosoma mansoni hypothetical protein 0.0037 0.1987 0.4165
Entamoeba histolytica hypothetical protein 0.0037 0.1987 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0042 0.0042
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.477 0.477
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.3429 0.3429
Schistosoma mansoni tar DNA-binding protein 0.0066 0.477 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0042 0.0089
Loa Loa (eye worm) hypothetical protein 0.0035 0.1862 0.1862
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.1862 0.1862
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0 0.5
Brugia malayi TAR-binding protein 0.0066 0.477 0.477
Echinococcus granulosus GPCR family 2 0.0016 0.0042 0.0089
Brugia malayi RNA binding protein 0.0066 0.477 0.477
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0042 0.0089
Schistosoma mansoni hypothetical protein 0.0035 0.1862 0.3902
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.3429 0.3429
Echinococcus granulosus tar DNA binding protein 0.0066 0.477 1
Entamoeba histolytica hypothetical protein 0.0037 0.1987 0.5
Loa Loa (eye worm) TAR-binding protein 0.0066 0.477 0.477
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.1987 0.4165
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0089
Brugia malayi hypothetical protein 0.0037 0.1987 0.1987
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.1987 0.4165
Entamoeba histolytica hypothetical protein 0.0037 0.1987 0.5
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0089
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0066 0.477 1
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0066 0.477 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0042 0.0089
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.477 0.477
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0042 0.0042
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0 0.5
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.012 1 1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.477 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.