Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.477 | 0.477 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.3429 | 0.3429 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0042 | 0.0089 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1987 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0042 | 0.0089 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.3429 | 0.3429 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0042 | 0.0042 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.477 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.477 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0042 | 0.0089 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.1987 | 0.4165 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1987 | 0.4165 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1987 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0042 | 0.0042 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.477 | 0.477 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.3429 | 0.3429 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.477 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0042 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1862 | 0.1862 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1862 | 0.1862 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.477 | 0.477 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0042 | 0.0089 |
Brugia malayi | RNA binding protein | 0.0066 | 0.477 | 0.477 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0042 | 0.0089 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1862 | 0.3902 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3429 | 0.3429 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.477 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1987 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.477 | 0.477 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.1987 | 0.4165 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0042 | 0.0089 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1987 | 0.1987 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.1987 | 0.4165 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1987 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0042 | 0.0089 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.477 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0042 | 0.0089 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.477 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0042 | 0.0089 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.477 | 0.477 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0042 | 0.0042 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.477 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.