Detailed information for compound 909150

Basic information

Technical information
  • TDR Targets ID: 909150
  • Name: N-(4-bromophenyl)-4-(2-methylpropoxy)benzamid e
  • MW: 348.234 | Formula: C17H18BrNO2
  • H donors: 1 H acceptors: 1 LogP: 4.75 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(COc1ccc(cc1)C(=O)Nc1ccc(cc1)Br)C
  • InChi: 1S/C17H18BrNO2/c1-12(2)11-21-16-9-3-13(4-10-16)17(20)19-15-7-5-14(18)6-8-15/h3-10,12H,11H2,1-2H3,(H,19,20)
  • InChiKey: QOYKWQKRMGYQLD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromophenyl)-4-isobutoxy-benzamide
  • N-(4-bromophenyl)-4-isobutoxybenzamide
  • ZINC00447793
  • CBMicro_007056
  • BIM-0007129.P001
  • Oprea1_270674

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.195 0.195
Schistosoma mansoni hypothetical protein 0.0037 0.1315 0.1315
Schistosoma mansoni lamin 0.0026 0.0635 0.0635
Schistosoma mansoni zinc finger protein 0.0019 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0605 0.1815
Echinococcus multilocularis lamin dm0 0.0026 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0069 0.3331 1
Echinococcus multilocularis lamin 0.0026 0.0635 0.0635
Onchocerca volvulus 0.0026 0.0635 0.5
Entamoeba histolytica hypothetical protein 0.0037 0.1315 0.5
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0024 0.0024
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.1315 0.1315
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.195 0.195
Onchocerca volvulus 0.0026 0.0635 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.1191 0.3576
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0362 0.0362
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0024 0.0024
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.1191 0.3314
Loa Loa (eye worm) hypothetical protein 0.004 0.1483 0.4454
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0037 0.1315 0.5
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0024 0.0024
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0024 0.0024
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0362 0.0362
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.195 0.5426
Brugia malayi Bromodomain containing protein 0.0073 0.3594 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.2652 0.2652
Echinococcus multilocularis musashi 0.0026 0.0635 0.0635
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.2218 0.617
Schistosoma mansoni intermediate filament proteins 0.0026 0.0635 0.0635
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.195 0.195
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0073
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.1187 0.1187
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0062 0.0186
Loa Loa (eye worm) hypothetical protein 0.0051 0.2218 0.6658
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.1315 0.1315
Brugia malayi PHD-finger family protein 0.0024 0.0508 0.1414
Echinococcus granulosus zinc finger protein 0.0019 0.018 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0024 0.0024
Brugia malayi intermediate filament protein 0.0026 0.0635 0.1767
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0635 0.1907
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.2218 0.617
Loa Loa (eye worm) hypothetical protein 0.0037 0.1337 0.4016
Entamoeba histolytica hypothetical protein 0.0037 0.1315 0.5
Brugia malayi Bromodomain containing protein 0.0037 0.1333 0.3709
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.195 0.195
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.195 0.5855
Echinococcus granulosus intermediate filament protein 0.0026 0.0635 0.0635
Echinococcus granulosus lamin dm0 0.0026 0.0635 0.0635
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.195 0.195
Brugia malayi hypothetical protein 0.0037 0.1315 0.3658
Echinococcus multilocularis zinc finger protein 0.0019 0.018 0.018
Schistosoma mansoni hypothetical protein 0.002 0.0245 0.0245
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0174 1 1
Entamoeba histolytica hypothetical protein 0.0037 0.1315 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.1315 0.1315
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0635 0.1907
Loa Loa (eye worm) hypothetical protein 0.0041 0.1601 0.4807
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.2652 0.2652
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0635 0.1767
Schistosoma mansoni hypothetical protein 0.0174 1 1
Echinococcus granulosus lamin 0.0026 0.0635 0.0635
Schistosoma mansoni bromodomain containing protein 0.0062 0.2872 0.2872
Echinococcus multilocularis geminin 0.0174 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.1191 0.1191
Schistosoma mansoni lamin 0.0026 0.0635 0.0635
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0362 0.0362
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.195 0.195
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.1187 0.1187
Loa Loa (eye worm) hypothetical protein 0.0026 0.0635 0.1907
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.2218 0.6658
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.195 0.195
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0245 0.0735

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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