Detailed information for compound 909181

Basic information

Technical information
  • TDR Targets ID: 909181
  • Name: N,N-bis(2-methylpropyl)-4-(morpholine-4-carbo nyl)benzenesulfonamide
  • MW: 382.518 | Formula: C19H30N2O4S
  • H donors: 0 H acceptors: 3 LogP: 2.82 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CN(S(=O)(=O)c1ccc(cc1)C(=O)N1CCOCC1)CC(C)C)C
  • InChi: 1S/C19H30N2O4S/c1-15(2)13-21(14-16(3)4)26(23,24)18-7-5-17(6-8-18)19(22)20-9-11-25-12-10-20/h5-8,15-16H,9-14H2,1-4H3
  • InChiKey: ZBRSMTZEGBIEEW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N,N-diisobutyl-4-(morpholine-4-carbonyl)benzenesulfonamide
  • N,N-diisobutyl-4-(morpholino-oxomethyl)benzenesulfonamide
  • N,N-bis(2-methylpropyl)-4-morpholin-4-ylcarbonyl-benzenesulfonamide
  • CBMicro_007410
  • Oprea1_096007
  • BIM-0007481.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.2252 1
Brugia malayi polk-prov protein 0.0019 0.0517 0.066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.2252 0.4027
Brugia malayi beta-lactamase 0.0039 0.1343 0.1743
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.2252 0.3753
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.1886 0.1436
Loa Loa (eye worm) hypothetical protein 0.0039 0.1343 0.1743
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0125 0.0146
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.1343 0.1743
Echinococcus granulosus transcription factor Dp 1 0.0039 0.1339 0.1855
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0274 0.1046
Onchocerca volvulus 0.0039 0.1343 0.1743
Onchocerca volvulus 0.0039 0.1343 0.1743
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0013 0.0257 0.0976
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0531 0.0742
Toxoplasma gondii ABC1 family protein 0.0039 0.1343 0.328
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0517 0.049
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0013 0.0257 0.0366
Loa Loa (eye worm) hypothetical protein 0.0165 0.6546 0.8564
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.1471 0.2285
Echinococcus granulosus bloom syndrome protein 0.0024 0.0743 0.1021
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0743 0.3259
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.2504 0.4229
Brugia malayi hypothetical protein 0.0165 0.6546 0.8564
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0014 0.0019
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0125 0.0156
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0152 0.0193
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.2252 0.4027
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.1343 0.0863
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.2504 1
Echinococcus granulosus dna polymerase kappa 0.0061 0.2252 0.3134
Loa Loa (eye worm) hypothetical protein 0.0012 0.025 0.031
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.3016 0.7787
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.2252 0.1822
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.1343 0.2391
Trypanosoma cruzi DNA polymerase eta, putative 0.0142 0.5572 1
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.0257 0.034
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.1343 0.5939
Trypanosoma cruzi DNA polymerase eta, putative 0.01 0.3837 0.6879
Mycobacterium ulcerans beta-lactamase 0.0039 0.1343 0.3305
Trichomonas vaginalis dullard protein, putative 0.0013 0.0257 0.1086
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0152 0.0193
Loa Loa (eye worm) hypothetical protein 0.0009 0.0125 0.0146
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0743 0.3259
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0152 0.0181
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.3016 0.4203
Echinococcus multilocularis dna polymerase kappa 0.0061 0.2252 0.3134
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0125 0.0156
Echinococcus granulosus dna polymerase eta 0.0142 0.5572 0.7782
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.2252 0.3753
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.2504 0.3487
Mycobacterium leprae Probable lipase LipE 0.0039 0.1343 0.2218
Echinococcus multilocularis 0.0013 0.0257 0.034
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0525 0.0716
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0274 0.0469
Trypanosoma brucei unspecified product 0.0042 0.1471 0.2285
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0013 0.0257 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.2252 0.3753
Brugia malayi N-terminal motif family protein 0.0192 0.7641 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0152 0.0181
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.3016 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.1343 0.1743
Loa Loa (eye worm) hypothetical protein 0.0039 0.1343 0.1743
Schistosoma mansoni DNA helicase recq1 0.001 0.0152 0.0212
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.2504 0.4229
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.1343 0.5939
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0014 0.0019
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0152 0.0193
Leishmania major DNA damage repair protein, putative 0.0019 0.0517 0.049
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.2504 0.3266
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0525 0.2285
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0257 0.1086
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.2252 0.3753
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.1343 0.0863
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0125 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.1343 0.2391
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0517 0.0722
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0866 0.2494
Loa Loa (eye worm) hypothetical protein 0.0039 0.1343 0.1743
Schistosoma mansoni DNA helicase recq5 0.001 0.0152 0.0212
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0152 0.0181
Loa Loa (eye worm) hypothetical protein 0.0039 0.1343 0.1743
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.1886 0.2621
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.2252 0.4027
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0125 0.0156
Toxoplasma gondii exonuclease III APE 0.0019 0.0525 0.1077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.2252 0.4027
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.2252 0.3753
Onchocerca volvulus 0.0039 0.1343 0.1743
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0525 0.067
Loa Loa (eye worm) hypothetical protein 0.0142 0.5572 0.7287
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.2504 0.3487
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0866 0.2209
Leishmania major hypothetical protein, conserved 0.0039 0.1343 0.2043
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.2252 0.3753
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0125 0.0156
Trichomonas vaginalis dullard protein, putative 0.0013 0.0257 0.1086
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0409 0.0764
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0517 0.0906
Trypanosoma brucei DNA polymerase eta, putative 0.0142 0.5572 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.2504 0.3266
Schistosoma mansoni DNA polymerase eta 0.0142 0.5572 0.7786
Schistosoma mansoni hypothetical protein 0.018 0.7156 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0274 0.0033
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.3016 0.4214
Schistosoma mansoni ap endonuclease 0.0019 0.0525 0.0733
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0525 0.092
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0525 0.1303
Schistosoma mansoni dishevelled 0.0009 0.0125 0.0175
Loa Loa (eye worm) hypothetical protein 0.0009 0.0125 0.0146
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0125 0.0146
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0125 0.0156
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.1886 0.1436
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.2252 0.3753
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0257 0.1086
Loa Loa (eye worm) RecQ helicase 0.0024 0.0743 0.0956
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.1343 0.3305
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0152 0.0071
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.3016 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0417 0.0581
Brugia malayi hypothetical protein 0.0009 0.0125 0.0146
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0274 0.0033
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0743 0.1021
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.1886 0.2621
Mycobacterium ulcerans lipase LipD 0.0039 0.1343 0.3305
Mycobacterium ulcerans hypothetical protein 0.0039 0.1343 0.3305
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.0257 0.034
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.3016 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0125 0.0156
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.1343 0.0863
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.2504 0.4481
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.2252 0.3753
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0517 0.1275
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0525 0.0032
Brugia malayi hypothetical protein 0.0009 0.0125 0.0146
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.1343 0.1876
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.2252 0.1822
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0517 0.0944
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0125 0.0146
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.2252 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.3016 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.1343 0.0863
Schistosoma mansoni hypothetical protein 0.018 0.7156 1
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0013 0.0257 0.0354
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.1886 0.4744
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0152 0.0181
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0125 0.0156
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.1343 0.1743
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.2252 0.3753
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.2504 0.35
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.2252 0.3753
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0125 0.0175
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0517 0.049
Onchocerca volvulus 0.0165 0.6546 0.8564
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.2252 0.6943
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.2252 0.3753
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0257 0.1086
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0621 0.1637
Giardia lamblia DINP protein human, muc B family 0.0061 0.2252 1
Schistosoma mansoni dishevelled 0.0009 0.0125 0.0175
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.2504 0.4481
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.1343 0.5939
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0125 0.0175
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.0257 0.034
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0274 0.1164
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.2252 0.3753
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.3016 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0517 0.049
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.1471 0.2285
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0257 0.1086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0517 0.066
Echinococcus multilocularis dna polymerase eta 0.0142 0.5572 0.7782
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0525 0.2053
Mycobacterium tuberculosis Conserved protein 0.0039 0.1343 0.0863
Brugia malayi beta-lactamase family protein 0.0039 0.1343 0.1743
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0866 0.137
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0125 0.0175
Toxoplasma gondii hypothetical protein 0.0027 0.0866 0.1996
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.2252 0.2934
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0517 0.1055
Loa Loa (eye worm) hypothetical protein 0.0013 0.0257 0.0319
Echinococcus multilocularis geminin 0.018 0.7156 1
Leishmania major DNA polymerase eta, putative 0.01 0.3837 0.6736
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0014 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.2252 0.3753
Loa Loa (eye worm) hypothetical protein 0.0123 0.4803 0.628
Schistosoma mansoni dep domain containing protein 0.0009 0.0125 0.0175
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.1343 0.0863
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0192 0.7641 1
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0257 0.0437
Brugia malayi DIX domain containing protein 0.0009 0.0125 0.0146
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0125 0.0156
Brugia malayi beta-lactamase family protein 0.0039 0.1343 0.1743
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0125 0.0146
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0525 0.0505
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.1343 0.1861
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.1343 0.1876
Trichomonas vaginalis dullard protein, putative 0.0013 0.0257 0.1086
Onchocerca volvulus 0.0009 0.0125 0.0146
Toxoplasma gondii ImpB/MucB/SamB family protein 0.01 0.3837 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0525 0.2285
Plasmodium vivax hypothetical protein, conserved 0.0039 0.1343 0.3937
Loa Loa (eye worm) hypothetical protein 0.0039 0.1343 0.1743
Loa Loa (eye worm) hypothetical protein 0.008 0.3016 0.3936
Mycobacterium tuberculosis Conserved protein 0.0039 0.1343 0.0863
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.2252 0.3753
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.2252 0.3147
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.1343 0.0863
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0517 0.049
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.1343 0.3305
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0125 0.0146
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0517 0.0906
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.3016 0.4203
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.1343 0.5939
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0517 0.049
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0517 0.049
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.3016 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0125 0.0146
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0125 0.0146
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0257 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0517 0.049
Leishmania major DNA polymerase kappa, putative 0.0061 0.2252 0.3753
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0517 0.049
Schistosoma mansoni ap endonuclease 0.0019 0.0525 0.0733
Loa Loa (eye worm) hypothetical protein 0.0192 0.7641 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.1343 0.0863
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.1471 0.2285
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0525 0.092
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0525 0.0505
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0525 0.0973
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0525 0.1777
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.3016 0.7787
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.1343 0.5939
Mycobacterium tuberculosis Conserved protein 0.0039 0.1343 0.0863
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.1343 0.2043
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.2252 0.3147
Trypanosoma brucei unspecified product 0.0061 0.2252 0.3753
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.2252 0.8985
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0014 0.0019
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.2252 0.3134
Brugia malayi Probable ClpP-like protease 0.008 0.3016 0.3936
Trichomonas vaginalis esterase, putative 0.0039 0.1343 0.5939
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.3016 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0152 0.0071
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0257 0.0359
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.1343 0.1861
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0125 0.0156
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0743 0.0956
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0517 0.1055
Trypanosoma brucei unspecified product 0.0042 0.1471 0.2285
Loa Loa (eye worm) beta-lactamase 0.0039 0.1343 0.1743
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.1339 0.1855
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0517 0.0906
Mycobacterium leprae conserved hypothetical protein 0.0039 0.1343 0.2218
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.2252 0.6943
Echinococcus granulosus geminin 0.018 0.7156 1
Schistosoma mansoni hypothetical protein 0.0012 0.025 0.035
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.0257 0.0319
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.2252 0.2934
Leishmania major DNA polymerase eta, putative 0.0142 0.5572 1
Giardia lamblia DNA damage repair protein 0.0019 0.0517 0.1739
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.2252 0.3134
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0525 0.0716
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0525 0.067
Brugia malayi ImpB/MucB/SamB family protein 0.0142 0.5572 0.7287
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.3016 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0152 0.0193
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0517 0.0906
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.3016 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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