Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0267 | 0.0267 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0391 | 0.0861 | 1 |
Brugia malayi | hypothetical protein | 0.0519 | 0.1181 | 0.1181 |
Echinococcus granulosus | smad | 0.0276 | 0.0575 | 0.228 |
Echinococcus multilocularis | smad | 0.0276 | 0.0575 | 0.228 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0063 | 0.0063 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0176 | 0.0324 | 0.1286 |
Schistosoma mansoni | smad1 5 8 and | 0.0276 | 0.0575 | 0.1261 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0233 | 0.0467 | 0.185 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0866 | 0.2048 | 0.2048 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0063 | 0.0063 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0256 | 0.0525 | 0.2083 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0176 | 0.0324 | 0.1286 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0391 | 0.0861 | 1 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0071 | 0.0063 | 0.025 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0189 | 0.0359 | 0.0359 |
Schistosoma mansoni | DNA ligase IV | 0.0071 | 0.0063 | 0.0139 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.1871 | 0.4557 | 0.4557 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0176 | 0.0324 | 0.2335 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0071 | 0.0063 | 0.1129 |
Schistosoma mansoni | topbp1 | 0.0071 | 0.0063 | 0.0139 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.0123 | 0.0194 | 0.0768 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0071 | 0.0063 | 0.1129 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.2048 | 0.2048 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0063 | 0.0063 |
Schistosoma mansoni | smad1 5 8 and | 0.0276 | 0.0575 | 0.1261 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0276 | 0.0575 | 0.1261 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0256 | 0.0525 | 0.5788 |
Schistosoma mansoni | Smad4 | 0.0276 | 0.0575 | 0.1261 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0233 | 0.0467 | 0.185 |
Mycobacterium ulcerans | glutaminase | 0.027 | 0.0559 | 0.6215 |
Brugia malayi | MH2 domain containing protein | 0.0276 | 0.0575 | 0.0575 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0063 | 0.0063 |
Brugia malayi | MH1 domain containing protein | 0.0153 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.0194 | 0.0194 |
Loa Loa (eye worm) | glutaminase 2 | 0.027 | 0.0559 | 0.0559 |
Toxoplasma gondii | hypothetical protein | 0.0135 | 0.0222 | 0.1878 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0866 | 0.2048 | 0.8123 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0519 | 0.1181 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0176 | 0.0324 | 0.1286 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.405 | 1 | 1 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0071 | 0.0063 | 0.1129 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0176 | 0.0324 | 0.0324 |
Entamoeba histolytica | hypothetical protein | 0.033 | 0.0709 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0276 | 0.0575 | 0.228 |
Brugia malayi | TAR-binding protein | 0.1055 | 0.2521 | 0.2521 |
Brugia malayi | DKFZp564C0469 protein | 0.0071 | 0.0063 | 0.0063 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.0194 | 0.0194 |
Brugia malayi | hypothetical protein | 0.0335 | 0.0722 | 0.0722 |
Brugia malayi | RNA recognition motif domain containing protein | 0.1055 | 0.2521 | 0.2521 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0391 | 0.0861 | 0.7294 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0519 | 0.1181 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.027 | 0.0559 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 0.1181 | 0.1181 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0276 | 0.0575 | 0.228 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0176 | 0.0324 | 0.2335 |
Entamoeba histolytica | hypothetical protein | 0.033 | 0.0709 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0866 | 0.2048 | 0.4494 |
Toxoplasma gondii | ATPase, AAA family protein | 0.0071 | 0.0063 | 0.0535 |
Brugia malayi | MH1 domain containing protein | 0.0276 | 0.0575 | 0.0575 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0176 | 0.0324 | 0.2745 |
Schistosoma mansoni | glutaminase | 0.027 | 0.0559 | 0.1227 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0519 | 0.1181 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0391 | 0.0861 | 0.7294 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0071 | 0.0063 | 0.1129 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.405 | 1 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0276 | 0.0575 | 0.228 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0071 | 0.0063 | 0.1129 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0071 | 0.0063 | 0.0063 |
Brugia malayi | topoisomerase | 0.0071 | 0.0063 | 0.0063 |
Brugia malayi | glutaminase DH11.1 | 0.027 | 0.0559 | 0.0559 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0071 | 0.0063 | 0.1129 |
Echinococcus multilocularis | Smad4 | 0.0276 | 0.0575 | 0.228 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0391 | 0.0861 | 0.3416 |
Brugia malayi | hypothetical protein | 0.0927 | 0.2201 | 0.2201 |
Loa Loa (eye worm) | nuclear factor I | 0.0153 | 0.0267 | 0.0267 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0176 | 0.0324 | 0.2335 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0123 | 0.0194 | 0.0194 |
Brugia malayi | MH1 domain containing protein | 0.0153 | 0.0267 | 0.0267 |
Echinococcus granulosus | GPCR family 2 | 0.0866 | 0.2048 | 0.8123 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0071 | 0.0063 | 0.0891 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0176 | 0.0324 | 0.0711 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0866 | 0.2048 | 0.2048 |
Leishmania major | hypothetical protein, conserved | 0.0519 | 0.1181 | 1 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0071 | 0.0063 | 0.025 |
Brugia malayi | Isocitrate dehydrogenase | 0.0176 | 0.0324 | 0.0324 |
Brugia malayi | Probable ClpP-like protease | 0.0391 | 0.0861 | 0.0861 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0071 | 0.0063 | 0.5 |
Brugia malayi | Smad1 | 0.0276 | 0.0575 | 0.0575 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0176 | 0.0324 | 0.2745 |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.0123 | 0.0194 | 0.0768 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0176 | 0.0324 | 0.2745 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0189 | 0.0359 | 0.1423 |
Schistosoma mansoni | tar DNA-binding protein | 0.1055 | 0.2521 | 0.5532 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0071 | 0.0063 | 0.1129 |
Schistosoma mansoni | smad | 0.0276 | 0.0575 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0927 | 0.2201 | 0.2201 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0189 | 0.0359 | 0.1423 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0071 | 0.0063 | 0.1129 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0519 | 0.1181 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0866 | 0.2048 | 0.8123 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0391 | 0.0861 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0135 | 0.0222 | 0.1878 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0063 | 0.0063 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0391 | 0.0861 | 0.189 |
Schistosoma mansoni | tar DNA-binding protein | 0.1055 | 0.2521 | 0.5532 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.033 | 0.0709 | 0.2811 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.033 | 0.0709 | 0.2811 |
Loa Loa (eye worm) | glutaminase | 0.027 | 0.0559 | 0.0559 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0071 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | Smad1 | 0.0276 | 0.0575 | 0.0575 |
Schistosoma mansoni | smad | 0.0123 | 0.0194 | 0.0425 |
Brugia malayi | MH1 domain containing protein | 0.0276 | 0.0575 | 0.0575 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0071 | 0.0063 | 0.1129 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0063 | 0.0891 |
Schistosoma mansoni | hypothetical protein | 0.1871 | 0.4557 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1871 | 0.4557 | 0.4557 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.2737 | 0.672 | 0.672 |
Loa Loa (eye worm) | hypothetical protein | 0.2737 | 0.672 | 0.672 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0071 | 0.0063 | 0.1129 |
Loa Loa (eye worm) | TAR-binding protein | 0.1055 | 0.2521 | 0.2521 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0256 | 0.0525 | 1 |
Echinococcus granulosus | nibrin | 0.0071 | 0.0063 | 0.025 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0176 | 0.0324 | 0.1286 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0176 | 0.0324 | 0.1286 |
Brugia malayi | hypothetical protein | 0.033 | 0.0709 | 0.0709 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0256 | 0.0525 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0276 | 0.0575 | 0.1261 |
Onchocerca volvulus | Mothers against decapentaplegic homolog | 0.0123 | 0.0194 | 0.0611 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0256 | 0.0525 | 0.2083 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0276 | 0.0575 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0194 | 0.0194 |
Brugia malayi | isocitrate dehydrogenase | 0.0176 | 0.0324 | 0.0324 |
Onchocerca volvulus | 0.0927 | 0.2201 | 1 | |
Echinococcus multilocularis | GPCR, family 2 | 0.0866 | 0.2048 | 0.8123 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0391 | 0.0861 | 0.3416 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.0071 | 0.0063 | 0.0535 |
Schistosoma mansoni | hypothetical protein | 0.0866 | 0.2048 | 0.4494 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0189 | 0.0359 | 0.1423 |
Loa Loa (eye worm) | RNA binding protein | 0.1055 | 0.2521 | 0.2521 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0189 | 0.0359 | 0.0787 |
Schistosoma mansoni | hypothetical protein | 0.0233 | 0.0467 | 0.1024 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0391 | 0.0861 | 0.7294 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.0123 | 0.0194 | 0.0768 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0176 | 0.0324 | 0.1286 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.1055 | 0.2521 | 0.2521 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0391 | 0.0861 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0866 | 0.2048 | 0.8123 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0276 | 0.0575 | 0.228 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0276 | 0.0575 | 0.0575 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0866 | 0.2048 | 0.8123 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0135 | 0.0222 | 0.1987 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.2737 | 0.672 | 0.672 |
Schistosoma mansoni | tar DNA-binding protein | 0.1055 | 0.2521 | 0.5532 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0189 | 0.0359 | 0.0787 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0189 | 0.0359 | 0.1423 |
Brugia malayi | RNA binding protein | 0.1055 | 0.2521 | 0.2521 |
Echinococcus multilocularis | tar DNA binding protein | 0.1055 | 0.2521 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.1055 | 0.2521 | 0.5532 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0135 | 0.0222 | 0.1878 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0176 | 0.0324 | 0.2335 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0391 | 0.0861 | 0.7294 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.0123 | 0.0194 | 0.0768 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0391 | 0.0861 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0391 | 0.0861 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0866 | 0.2048 | 0.2048 |
Loa Loa (eye worm) | hypothetical protein | 0.0767 | 0.1801 | 0.1801 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0519 | 0.1181 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0189 | 0.0359 | 0.0359 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.2737 | 0.672 | 0.672 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0519 | 0.1181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0063 | 0.0063 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0071 | 0.0063 | 0.0139 |
Echinococcus granulosus | tar DNA binding protein | 0.1055 | 0.2521 | 1 |
Schistosoma mansoni | Smad4 | 0.0123 | 0.0194 | 0.0425 |
Schistosoma mansoni | topbp1 | 0.0071 | 0.0063 | 0.0139 |
Brugia malayi | MH2 domain containing protein | 0.0276 | 0.0575 | 0.0575 |
Schistosoma mansoni | Smad4 | 0.0123 | 0.0194 | 0.0425 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0135 | 0.0222 | 0.1987 |
Brugia malayi | N-terminal motif family protein | 0.0767 | 0.1801 | 0.1801 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0176 | 0.0324 | 0.2745 |
Entamoeba histolytica | hypothetical protein | 0.033 | 0.0709 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0767 | 0.1801 | 0.8131 |
Schistosoma mansoni | hypothetical protein | 0.0866 | 0.2048 | 0.4494 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.0071 | 0.0063 | 0.0535 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0123 | 0.0194 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 0.0861 | 0.0861 |
Echinococcus multilocularis | nibrin | 0.0071 | 0.0063 | 0.025 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.033 | 0.0709 | 0.1555 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0063 | 0.0063 |
Echinococcus granulosus | Smad4 | 0.0276 | 0.0575 | 0.228 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0519 | 0.1181 | 1 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.0709 | 0.1555 |
Schistosoma mansoni | tar DNA-binding protein | 0.1055 | 0.2521 | 0.5532 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0071 | 0.0063 | 0.0535 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0391 | 0.0861 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0189 | 0.0359 | 0.0787 |
Entamoeba histolytica | hypothetical protein | 0.033 | 0.0709 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0866 | 0.2048 | 0.4494 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.