Detailed information for compound 909242

Basic information

Technical information
  • TDR Targets ID: 909242
  • Name: N-(6-methyl-2,1,3-benzothiadiazol-7-yl)-5-(4- nitrophenyl)furan-2-carboxamide
  • MW: 380.377 | Formula: C18H12N4O4S
  • H donors: 1 H acceptors: 5 LogP: 3.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(o1)c1ccc(cc1)[N+](=O)[O-])Nc1c(C)ccc2c1nsn2
  • InChi: 1S/C18H12N4O4S/c1-10-2-7-13-17(21-27-20-13)16(10)19-18(23)15-9-8-14(26-15)11-3-5-12(6-4-11)22(24)25/h2-9H,1H3,(H,19,23)
  • InChiKey: VCYDFRKCAAGOLJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(6-methyl-2,1,3-benzothiadiazol-7-yl)-5-(4-nitrophenyl)-2-furancarboxamide
  • N-(5-methylpiazthiol-4-yl)-5-(4-nitrophenyl)-2-furamide
  • CBMicro_007488
  • BIM-0007475.P001
  • AN-465/14962030
  • Oprea1_695514
  • EU-0074462
  • ZINC00677959

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0363 0.0363
Trichomonas vaginalis chromobox protein, putative 0.0041 0.1298 0.3419
Loa Loa (eye worm) hypothetical protein 0.0021 0.0363 0.0363
Echinococcus granulosus survival motor neuron protein 1 0.0231 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0363 0.0363
Echinococcus multilocularis survival motor neuron protein 1 0.0231 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0363 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0363 0.0301
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.1691 0.1691
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0363 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.1165 0.2714
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0363 0.0363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0363 0.0363
Onchocerca volvulus 0.003 0.0788 0.3501
Loa Loa (eye worm) hypothetical protein 0.0021 0.0363 0.0363
Trichomonas vaginalis chromobox protein, putative 0.0068 0.2535 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.4994 0.4994
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0363 0.0301
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.1691 0.5
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1691 0.5508
Trypanosoma brucei protein kinase, putative 0.005 0.1691 0.5
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.2535 0.2535
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0363 0.0363
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1549 0.2127
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.1298 0.7708
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0363 0.0301
Brugia malayi steroid hormone receptor 0.0021 0.0363 0.0301
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.1691 0.5
Schistosoma mansoni serine/threonine protein kinase 0.005 0.1691 0.2381
Loa Loa (eye worm) hypothetical protein 0.0021 0.0363 0.0363
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0363 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0363 0.0301
Loa Loa (eye worm) hypothetical protein 0.0231 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.1165 0.6614
Schistosoma mansoni lamin 0.0026 0.0624 0.0469
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0363 0.0363
Onchocerca volvulus 0.0026 0.0624 0.2155
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0363 0.0301
Schistosoma mansoni chromobox protein 0.0068 0.2535 0.3896
Echinococcus granulosus lamin 0.0026 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0038 0.1165 0.1165
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0026 0.0624 0.0624
Echinococcus granulosus chromobox protein 1 0.0068 0.2535 0.2535
Echinococcus granulosus chromobox protein 1 0.0068 0.2535 0.2535
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1549 0.1549
Brugia malayi intermediate filament protein 0.0026 0.0624 0.0564
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0363 0.0301
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1691 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0363 0.0301
Echinococcus multilocularis lamin dm0 0.0026 0.0624 0.0624
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0363 0.0363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0363 0.0363
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1549 0.1549
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0363 0.0301
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0363 0.0363
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1576 0.1522
Brugia malayi Heterochromatin protein 1 0.0068 0.2535 0.2487
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0363 0.0363
Schistosoma mansoni thyroid hormone receptor 0.0143 0.5939 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.1691 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0363 0.0363
Brugia malayi chromobox protein homolog 3 0.0038 0.1165 0.1108
Brugia malayi MAP kinase sur-1 0.005 0.1691 0.1637
Echinococcus granulosus intermediate filament protein 0.0026 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0021 0.0363 0.0363
Schistosoma mansoni thyroid hormone receptor 0.0143 0.5939 1
Brugia malayi ecdysteroid receptor 0.0021 0.0363 0.0301
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1549 0.1549
Loa Loa (eye worm) hypothetical protein 0.0021 0.0363 0.0363
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.1691 0.1691
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0363 0.0363
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0363 0.0363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0363 0.0363
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1549 0.1549
Brugia malayi nuclear hormone receptor 0.0021 0.0363 0.0301
Schistosoma mansoni chromobox protein 0.0068 0.2535 0.3896
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0363 0.0301
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.1691 0.5
Brugia malayi nuclear receptor NHR-88 0.0021 0.0363 0.0301
Echinococcus granulosus lamin dm0 0.0026 0.0624 0.0624
Trichomonas vaginalis chromobox protein, putative 0.0041 0.1298 0.3419
Trichomonas vaginalis chromobox protein, putative 0.0068 0.2535 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0363 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0363 0.0301
Echinococcus multilocularis lamin 0.0026 0.0624 0.0624
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1691 0.5508
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.1691 0.1691
Schistosoma mansoni hypothetical protein 0.0122 0.4994 0.8304
Loa Loa (eye worm) hypothetical protein 0.0021 0.0363 0.0363
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0363 0.0301
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1549 0.1495
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.1691 0.5
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1691 0.5508
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0363 0.0301
Loa Loa (eye worm) hypothetical protein 0.0026 0.0602 0.0602
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1691 0.5
Schistosoma mansoni lamin 0.0026 0.0624 0.0469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0363 0.0363
Echinococcus granulosus mitogen activated protein kinase 0.005 0.1691 0.1691
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.1691 0.5
Schistosoma mansoni intermediate filament proteins 0.0026 0.0624 0.0469
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.4994 0.4994
Echinococcus multilocularis thyroid hormone receptor alpha 0.0143 0.5939 0.5939
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0624 0.0564
Onchocerca volvulus 0.0026 0.0624 0.2155
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0624 0.0624
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1549 0.1549
Schistosoma mansoni hypothetical protein 0.0047 0.1576 0.2175
Echinococcus multilocularis musashi 0.0026 0.0624 0.0624
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.1165 0.2714
Loa Loa (eye worm) hypothetical protein 0.0021 0.0363 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0363 0.0301
Echinococcus multilocularis chromobox protein 1 0.0068 0.2535 0.2535
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.1691 0.1691
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0363 0.0363
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1549 0.2127
Loa Loa (eye worm) hypothetical protein 0.003 0.0788 0.0788
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0363 0.0363
Giardia lamblia Kinase, CMGC MAPK 0.005 0.1691 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0363 0.0301
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0624 0.0624
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0363 0.0363
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1691 0.5508
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0363 0.0363
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0363 0.0301
Schistosoma mansoni survival motor neuron protein 0.0047 0.1576 0.2175
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0363 0.0301
Onchocerca volvulus 0.0047 0.1576 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0363 0.0363
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0363 0.0363
Echinococcus multilocularis chromobox protein 1 0.0068 0.2535 0.2535
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1549 0.2127
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0363 0.0363

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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