Detailed information for compound 909289

Basic information

Technical information
  • TDR Targets ID: 909289
  • Name: N,N'-bis(4-fluorophenyl)-9-oxofluorene-2,7-di sulfonamide
  • MW: 526.532 | Formula: C25H16F2N2O5S2
  • H donors: 2 H acceptors: 5 LogP: 4.31 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1ccc(cc1)NS(=O)(=O)c1ccc2c(c1)C(=O)c1c2ccc(c1)S(=O)(=O)Nc1ccc(cc1)F
  • InChi: 1S/C25H16F2N2O5S2/c26-15-1-5-17(6-2-15)28-35(31,32)19-9-11-21-22-12-10-20(14-24(22)25(30)23(21)13-19)36(33,34)29-18-7-3-16(27)4-8-18/h1-14,28-29H
  • InChiKey: KSSHKQOWHWZJLV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N,N'-bis(4-fluorophenyl)-9-oxo-fluorene-2,7-disulfonamide
  • N,N'-bis(4-fluorophenyl)-9-keto-fluorene-2,7-disulfonamide
  • ZINC00623959
  • BIM-0008452.P001
  • CBMicro_008488
  • STOCK2S-43234
  • AP-845/40876799

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0318 0.6116 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.2324 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0093 0.0152
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0131 0.2365 0.2293
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0117 0.0191
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0117 0.004
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0759 0.0672
Plasmodium falciparum glutathione reductase 0.0051 0.0759 1
Loa Loa (eye worm) glutaminase 2 0.0276 0.5283 0.8612
Mycobacterium tuberculosis Probable reductase 0.0116 0.2065 0.8837
Echinococcus granulosus Protein patched homolog 1 0.0131 0.2365 0.2293
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.2065 0.8837
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0093 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.0191
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0117 0.0024
Treponema pallidum NADH oxidase 0.0018 0.0093 0.5
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0117 0.0107
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0117 0.0191
Echinococcus multilocularis sterol regulatory element binding protein 0.0131 0.2365 0.2293
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.2324 1
Trypanosoma brucei trypanothione reductase 0.0051 0.0759 0.1241
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0318 0.6116 0.6079
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0318 0.6116 0.6079
Echinococcus multilocularis geminin 0.0511 1 1
Schistosoma mansoni patched 1 0.0131 0.2365 0.2293
Leishmania major DNA polymerase eta, putative 0.0019 0.0117 0.004
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0117 0.004
Schistosoma mansoni DNA polymerase eta 0.0019 0.0117 0.0024
Echinococcus multilocularis dna polymerase eta 0.0019 0.0117 0.0024
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0318 0.6116 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0131 0.2365 0.2293
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0117 0.004
Brugia malayi Thioredoxin reductase 0.0051 0.0759 0.1106
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.2065 0.8837
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.0191
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0318 0.6116 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0131 0.2365 0.3747
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0093 0.5
Loa Loa (eye worm) glutathione reductase 0.0051 0.0759 0.1071
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0117 0.0191
Brugia malayi glutaminase DH11.1 0.0276 0.5283 0.8618
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.0191
Echinococcus granulosus sterol regulatory element binding protein 0.0131 0.2365 0.2293
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0093 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0117 0.0191
Loa Loa (eye worm) glutaminase 0.0276 0.5283 0.8612
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0759 0.1106
Echinococcus granulosus dna polymerase kappa 0.0019 0.0117 0.0024
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0117 0.0024
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0117 0.0024
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.2324 1
Trypanosoma brucei unspecified product 0.0019 0.0117 0.0191
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0318 0.6116 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0093 0.0152
Echinococcus granulosus Niemann Pick C1 protein 0.0131 0.2365 0.2293
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.0191
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0093 0.0152
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0117 0.5
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0149 0.2731 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0117 0.004
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0149 0.2731 0.5083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.0191
Echinococcus granulosus dna polymerase eta 0.0019 0.0117 0.0024
Brugia malayi glutathione reductase 0.0051 0.0759 0.1106
Echinococcus multilocularis protein dispatched 1 0.0131 0.2365 0.2293
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.2065 0.8837
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0117 0.004
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0117 0.0046
Leishmania major DNA polymerase kappa, putative 0.0019 0.0117 0.004
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0318 0.6116 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.2065 0.8837
Plasmodium falciparum thioredoxin reductase 0.0051 0.0759 1
Schistosoma mansoni glutaminase 0.0276 0.5283 0.5239
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0759 0.2985
Giardia lamblia DINP protein human, muc B family 0.0019 0.0117 0.009
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0759 1
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0318 0.6116 1
Trichomonas vaginalis glutaminase, putative 0.0276 0.5283 1
Brugia malayi CHE-14 protein 0.0131 0.2365 0.3772
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0149 0.2731 0.5083
Schistosoma mansoni hypothetical protein 0.0511 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.2365 0.4377
Loa Loa (eye worm) hypothetical protein 0.0131 0.2365 0.3747
Toxoplasma gondii thioredoxin reductase 0.0051 0.0759 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0117 0.004
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0117 0.0024
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.2065 0.8837
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0117 0.0107
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0093 0.5
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0318 0.6116 0.6079
Echinococcus multilocularis protein patched 0.0131 0.2365 0.2293
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0117 0.004
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0759 0.1071
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.0191
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0117 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.0191
Mycobacterium ulcerans glutaminase 0.0276 0.5283 0.8618
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.0191
Plasmodium vivax glutathione reductase, putative 0.0051 0.0759 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.0191
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0149 0.2731 0.5083
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0117 0.0024
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0117 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0117 0.0191
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.2324 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0759 0.0672
Leishmania major trypanothione reductase 0.0051 0.0759 0.1106
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0117 0.004
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0318 0.6116 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0117 0.0046
Schistosoma mansoni hypothetical protein 0.0511 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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