Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0061 | 0.0885 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0061 | 0.0058 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0061 | 0.0065 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0061 | 0.0613 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0063 | 0.0149 | 0.1395 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0061 | 0.0065 |
Onchocerca volvulus | 0.0035 | 0.0061 | 0.0577 | |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0061 | 0.0065 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0022 | 0.0019 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0041 | 0.0093 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.022 | 0.0655 | 0.0705 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.0655 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0022 | 0.0019 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.0149 | 0.1395 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0161 | 0.0465 | 0.0462 |
Onchocerca volvulus | 0.0029 | 0.0041 | 0.0288 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.3121 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0161 | 0.0465 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.022 | 0.0655 | 0.2957 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0161 | 0.0465 | 0.6992 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.022 | 0.0655 | 0.1575 |
Brugia malayi | SWIRM domain containing protein | 0.022 | 0.0655 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.022 | 0.0655 | 0.1575 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0022 | 0.0019 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0061 | 0.0058 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0063 | 0.0149 | 0.0518 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0022 | 0.0019 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0061 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.0655 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0061 | 0.0613 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0022 | 0.0019 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0061 | 0.0065 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.0604 | 0.9194 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0061 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0885 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1303 | 0.4142 | 0.414 |
Schistosoma mansoni | amine oxidase | 0.022 | 0.0655 | 0.2945 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0022 | 0.029 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.022 | 0.0655 | 0.1575 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0061 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.0655 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0022 | 0.0019 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.022 | 0.0655 | 0.2945 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0022 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.0655 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0022 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0885 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.0149 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0041 | 0.0588 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0169 | 0.0492 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0022 | 0.0024 |
Onchocerca volvulus | 0.0232 | 0.0695 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.0655 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0061 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0885 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0169 | 0.0492 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.022 | 0.0655 | 0.1575 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.022 | 0.0655 | 0.2957 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.022 | 0.0655 | 0.0705 |
Onchocerca volvulus | 0.0035 | 0.0061 | 0.0577 | |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.022 | 0.0655 | 0.2945 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0061 | 0.0065 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.022 | 0.0655 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0022 | 0.029 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0161 | 0.0465 | 0.2031 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0063 | 0.0149 | 0.2708 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0061 | 0.0613 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.2902 | 0.9292 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0169 | 0.0492 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.022 | 0.0655 | 0.2945 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0061 | 0.0065 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0061 | 0.0613 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0061 | 0.0065 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0161 | 0.0465 | 0.6992 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0063 | 0.0149 | 0.0533 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0061 | 0.0065 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.0149 | 0.1395 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.0655 | 1 |
Brugia malayi | hypothetical protein | 0.022 | 0.0655 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0022 | 0.0024 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0161 | 0.0465 | 0.6796 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0061 | 0.0058 |
Mycobacterium ulcerans | monoamine oxidase | 0.022 | 0.0655 | 0.0652 |
Mycobacterium ulcerans | oxidoreductase | 0.022 | 0.0655 | 0.0652 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0061 | 0.0093 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0022 | 0.0019 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0161 | 0.0465 | 0.6992 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0061 | 0.0613 |
Plasmodium vivax | hypothetical protein, conserved | 0.022 | 0.0655 | 0.1575 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0676 | 0.2125 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0169 | 0.0492 | 1 |
Onchocerca volvulus | 0.0035 | 0.0061 | 0.0577 | |
Leishmania major | dihydroorotate dehydrogenase | 0.0161 | 0.0465 | 0.6992 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.0149 | 0.1395 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.0149 | 0.1395 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0061 | 0.0613 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.1303 | 0.4142 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.1303 | 0.4142 | 0.4458 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1303 | 0.4142 | 0.414 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.1303 | 0.4142 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0041 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0885 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.022 | 0.0655 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0061 | 0.0065 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0061 | 0.0058 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0061 | 0.0093 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0161 | 0.0465 | 0.6796 |
Onchocerca volvulus | 0.022 | 0.0655 | 0.941 | |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0676 | 0.2125 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0161 | 0.0465 | 0.6796 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0041 | 0.0017 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.022 | 0.0655 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0061 | 0.0613 |
Echinococcus multilocularis | 0.022 | 0.0655 | 0.2945 | |
Plasmodium vivax | hypothetical protein, conserved | 0.022 | 0.0655 | 0.1575 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0161 | 0.0465 | 0.1115 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0161 | 0.0465 | 0.1115 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.022 | 0.0655 | 0.0652 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0063 | 0.0149 | 0.1488 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0161 | 0.0465 | 0.05 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.022 | 0.0655 | 0.2945 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.0604 | 0.9217 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0063 | 0.0149 | 0.0518 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0061 | 0.0139 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.022 | 0.0655 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0063 | 0.0149 | 0.201 |
Schistosoma mansoni | amine oxidase | 0.022 | 0.0655 | 0.2945 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0169 | 0.0492 | 1 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.1303 | 0.4142 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.1303 | 0.4142 | 0.414 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0063 | 0.0149 | 0.0533 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.022 | 0.0655 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0676 | 0.2125 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.0695 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0061 | 0.0885 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0885 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0061 | 0.0885 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0161 | 0.0465 | 0.6897 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.0673 | 0.0724 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0003 | 0.0003 |
Mycobacterium ulcerans | dehydrogenase | 0.022 | 0.0655 | 0.0652 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.022 | 0.0655 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.022 | 0.0655 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0061 | 0.0316 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.022 | 0.0655 | 0.1575 |
Leishmania major | UDP-galactopyranose mutase | 0.022 | 0.0655 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.1303 | 0.4142 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.