Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.0123 | 0.0254 |
Echinococcus granulosus | tar DNA binding protein | 0.0663 | 0.2967 | 0.6145 |
Schistosoma mansoni | Smad4 | 0.0065 | 0.0094 | 0.0143 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.0271 | 0.2086 |
Schistosoma mansoni | tar DNA-binding protein | 0.0663 | 0.2967 | 0.4478 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.0164 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0659 | 0.295 | 0.6111 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0123 | 0.0123 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.006 | 0.007 | 0.0146 |
Brugia malayi | hypothetical protein | 0.0455 | 0.1968 | 0.1968 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.0164 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.0271 | 0.2086 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0065 | 0.0094 | 0.0094 |
Brugia malayi | Smad1 | 0.0145 | 0.0479 | 0.0479 |
Brugia malayi | MH1 domain containing protein | 0.008 | 0.0168 | 0.0168 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0079 | 0.0164 | 0.034 |
Brugia malayi | glutaminase DH11.1 | 0.0315 | 0.1298 | 0.1298 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.105 | 0.4827 | 0.4827 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.0271 | 0.0409 |
Echinococcus multilocularis | tar DNA binding protein | 0.0663 | 0.2967 | 0.6145 |
Echinococcus multilocularis | smad | 0.0145 | 0.0479 | 0.0993 |
Loa Loa (eye worm) | glutaminase | 0.0315 | 0.1298 | 0.1298 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0659 | 0.295 | 0.6111 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.1968 | 0.1968 |
Echinococcus granulosus | GPCR family 2 | 0.0659 | 0.295 | 0.6111 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0145 | 0.0479 | 0.0993 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0659 | 0.295 | 0.295 |
Brugia malayi | MH2 domain containing protein | 0.0145 | 0.0479 | 0.0479 |
Schistosoma mansoni | tar DNA-binding protein | 0.0663 | 0.2967 | 0.4478 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0216 | 0.082 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.0164 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0216 | 0.082 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0145 | 0.0479 | 0.0724 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.2128 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0659 | 0.295 | 0.295 |
Trichomonas vaginalis | glutaminase, putative | 0.0315 | 0.1298 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0133 | 0.0423 | 0.2775 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0102 | 0.0271 | 0.0271 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.0025 | 0.019 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0133 | 0.0423 | 0.3947 |
Echinococcus granulosus | smad | 0.0145 | 0.0479 | 0.0993 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0216 | 0.082 | 0.1239 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0102 | 0.0271 | 0.0271 |
Schistosoma mansoni | smad | 0.0145 | 0.0479 | 0.0724 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0133 | 0.0423 | 0.2775 |
Loa Loa (eye worm) | Smad1 | 0.0145 | 0.0479 | 0.0479 |
Schistosoma mansoni | smad1 5 8 and | 0.0145 | 0.0479 | 0.0724 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0145 | 0.0479 | 0.0724 |
Brugia malayi | MH2 domain containing protein | 0.0145 | 0.0479 | 0.0479 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0133 | 0.0423 | 0.3947 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.0065 | 0.0094 | 0.0196 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0079 | 0.0164 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0168 | 0.0168 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0576 | 0.2548 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0659 | 0.295 | 0.4453 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0123 | 0.4533 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0145 | 0.0479 | 0.0479 |
Brugia malayi | hypothetical protein | 0.0086 | 0.0196 | 0.0196 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0216 | 0.082 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.2128 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0216 | 0.082 | 0.17 |
Onchocerca volvulus | Mothers against decapentaplegic homolog | 0.0065 | 0.0094 | 0.0371 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.105 | 0.4827 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0216 | 0.082 | 0.17 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.105 | 0.4827 | 0.7287 |
Loa Loa (eye worm) | hypothetical protein | 0.0576 | 0.2548 | 0.2548 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.1383 | 0.2088 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.0164 | 0.5 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0145 | 0.0479 | 0.0993 |
Schistosoma mansoni | Smad4 | 0.0145 | 0.0479 | 0.0724 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0164 | 0.0164 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0133 | 0.0423 | 0.3947 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0052 | 0.0033 | 0.0068 |
Schistosoma mansoni | hypothetical protein | 0.0659 | 0.295 | 0.4453 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0079 | 0.0164 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0423 | 0.0423 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0145 | 0.0479 | 0.0993 |
Schistosoma mansoni | kinase | 0.0052 | 0.0031 | 0.0047 |
Loa Loa (eye worm) | glutaminase 2 | 0.0315 | 0.1298 | 0.1298 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0102 | 0.0271 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1425 | 0.6625 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0102 | 0.0271 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0094 | 0.0094 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0659 | 0.295 | 0.6111 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0123 | 0.4533 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0052 | 0.0033 | 0.0068 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.007 | 0.0106 |
Onchocerca volvulus | 0.0455 | 0.1968 | 0.7725 | |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.0065 | 0.0094 | 0.0196 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.105 | 0.4827 | 0.7287 |
Brugia malayi | isocitrate dehydrogenase | 0.0216 | 0.082 | 0.082 |
Brugia malayi | MH1 domain containing protein | 0.008 | 0.0168 | 0.0168 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0065 | 0.0094 | 0.0094 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0123 | 0.4533 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0659 | 0.295 | 0.6111 |
Brugia malayi | MH2 domain containing protein | 0.0065 | 0.0094 | 0.0094 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0145 | 0.0479 | 0.0993 |
Schistosoma mansoni | tar DNA-binding protein | 0.0663 | 0.2967 | 0.4478 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0659 | 0.295 | 0.6111 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0216 | 0.082 | 0.082 |
Schistosoma mansoni | smad | 0.0065 | 0.0094 | 0.0143 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.0025 | 0.019 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0216 | 0.082 | 0.17 |
Brugia malayi | N-terminal motif family protein | 0.0576 | 0.2548 | 0.2548 |
Brugia malayi | MH1 domain containing protein | 0.0145 | 0.0479 | 0.0479 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0216 | 0.082 | 0.17 |
Loa Loa (eye worm) | RNA binding protein | 0.0663 | 0.2967 | 0.2967 |
Mycobacterium ulcerans | glutaminase | 0.0315 | 0.1298 | 1 |
Brugia malayi | TAR-binding protein | 0.0663 | 0.2967 | 0.2967 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0102 | 0.0271 | 0.0561 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0216 | 0.082 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0145 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0659 | 0.295 | 0.295 |
Schistosoma mansoni | glutaminase | 0.0315 | 0.1298 | 0.1959 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.105 | 0.4827 | 0.4827 |
Loa Loa (eye worm) | hypothetical protein | 0.2084 | 0.9791 | 0.9791 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.0123 | 0.0185 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0663 | 0.2967 | 0.2967 |
Echinococcus multilocularis | Smad4 | 0.0145 | 0.0479 | 0.0993 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.105 | 0.4827 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.105 | 0.4827 | 0.7287 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.0271 | 0.2086 |
Giardia lamblia | Kinase, PLK | 0.0102 | 0.0271 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0216 | 0.082 | 0.17 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.0271 | 0.2086 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.105 | 0.4827 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0123 | 0.0185 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.0065 | 0.0094 | 0.0196 |
Echinococcus multilocularis | geminin | 0.0333 | 0.1383 | 0.2865 |
Schistosoma mansoni | hypothetical protein | 0.0659 | 0.295 | 0.4453 |
Echinococcus granulosus | geminin | 0.0333 | 0.1383 | 0.2865 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0102 | 0.0271 | 0.0561 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.1383 | 0.2088 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 0.295 | 0.295 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.2084 | 0.9791 | 0.9791 |
Leishmania major | hypothetical protein, conserved | 0.0133 | 0.0423 | 0.2775 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.0065 | 0.0094 | 0.0196 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0216 | 0.082 | 1 |
Brugia malayi | RNA binding protein | 0.0663 | 0.2967 | 0.2967 |
Schistosoma mansoni | Smad4 | 0.0065 | 0.0094 | 0.0143 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0079 | 0.0164 | 0.0248 |
Loa Loa (eye worm) | TAR-binding protein | 0.0663 | 0.2967 | 0.2967 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.006 | 0.007 | 0.0146 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0216 | 0.082 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.0271 | 0.2086 |
Schistosoma mansoni | tar DNA-binding protein | 0.0663 | 0.2967 | 0.4478 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.0271 | 0.2086 |
Schistosoma mansoni | hypothetical protein | 0.0659 | 0.295 | 0.4453 |
Brugia malayi | Probable ClpP-like protease | 0.0079 | 0.0164 | 0.0164 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0123 | 0.4533 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0216 | 0.082 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0133 | 0.0423 | 0.2775 |
Schistosoma mansoni | tar DNA-binding protein | 0.0663 | 0.2967 | 0.4478 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.105 | 0.4827 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0216 | 0.082 | 0.17 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.0123 | 0.0254 |
Brugia malayi | MH1 domain containing protein | 0.0145 | 0.0479 | 0.0479 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0216 | 0.082 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0216 | 0.082 | 0.082 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0065 | 0.0094 | 0.0094 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0216 | 0.082 | 1 |
Echinococcus granulosus | Smad4 | 0.0145 | 0.0479 | 0.0993 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.2084 | 0.9791 | 0.9791 |
Loa Loa (eye worm) | hypothetical protein | 0.1425 | 0.6625 | 0.6625 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.2084 | 0.9791 | 0.9791 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.1425 | 0.6625 | 0.6625 |
Loa Loa (eye worm) | nuclear factor I | 0.008 | 0.0168 | 0.0168 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.0271 | 0.2086 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0663 | 0.2967 | 0.2967 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0133 | 0.0423 | 0.3947 |
Schistosoma mansoni | smad1 5 8 and | 0.0145 | 0.0479 | 0.0724 |
Brugia malayi | hypothetical protein | 0.0133 | 0.0423 | 0.0423 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0216 | 0.082 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.