Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.4826 | 0.7587 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0944 | 0.1484 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.3543 | 0.6025 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0944 | 0.7162 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0144 | 0.6071 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0133 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5182 | 0.8536 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5182 | 0.8536 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.3543 | 0.5836 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0944 | 1 |
Brugia malayi | hypothetical protein | 0.015 | 0.6361 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.5182 | 0.8536 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0944 | 0.1484 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0944 | 0.7162 |
Loa Loa (eye worm) | acetyltransferase | 0.0144 | 0.6071 | 0.9545 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0944 | 0.7162 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0944 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0944 | 0.1484 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0944 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0133 | 0.0209 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0944 | 0.0822 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0854 | 0.1343 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0944 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0445 | 0.2751 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0445 | 0.3226 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.5182 | 0.8147 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5182 | 0.8536 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0944 | 0.7162 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0944 | 0.1606 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.3543 | 0.5836 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.5182 | 0.8813 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.1266 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.3543 | 0.557 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.5182 | 0.8147 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1591 | 0.25 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0144 | 0.6071 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0133 | 0.0219 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0944 | 0.1484 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.3543 | 0.5836 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.4826 | 0.7587 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0944 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0944 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0944 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0944 | 0.1484 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0944 | 0.5 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.1099 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.3543 | 0.5836 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0944 | 0.1555 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.4826 | 0.7587 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0133 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.1266 | 1 |
Brugia malayi | RNA binding protein | 0.0125 | 0.5182 | 0.8147 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5182 | 0.8536 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0944 | 0.0822 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.1266 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0944 | 0.1484 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0854 | 0.1407 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0944 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0445 | 0.0699 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0944 | 0.0822 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.5182 | 0.8147 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.6361 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0944 | 0.0822 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0944 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0944 | 0.7162 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0944 | 0.7162 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0445 | 0.3841 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0944 | 0.1484 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0944 | 0.1555 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.1099 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0944 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0445 | 0.3226 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0445 | 0.3841 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.3543 | 0.5836 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0944 | 0.0822 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.1266 | 0.2152 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.1099 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0144 | 0.6071 | 0.9545 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5182 | 0.8536 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0944 | 0.7162 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1591 | 0.25 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.014 | 0.588 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0133 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0854 | 0.1343 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.3543 | 0.557 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0944 | 0.1484 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0944 | 0.0822 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0944 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0944 | 0.0822 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0133 | 0.0209 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.1266 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0445 | 0.3841 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.3543 | 0.6025 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.5182 | 0.8147 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0445 | 0.2751 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0944 | 0.1484 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0026 | 0.0041 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0944 | 0.0822 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0944 | 0.1555 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0944 | 0.0822 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0133 | 0.0219 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.1266 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0944 | 0.1484 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0445 | 0.3841 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1591 | 0.25 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0133 | 0.0226 |
Onchocerca volvulus | 0.015 | 0.6361 | 1 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0944 | 0.7162 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0445 | 0.0699 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.5182 | 0.8147 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0944 | 0.1484 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0944 | 0.1484 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1591 | 0.25 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.