Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0423 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0905 | 0.0905 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0171 | 0.3791 | 0.3791 |
Schistosoma mansoni | tar DNA-binding protein | 0.0423 | 1 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0027 | 0.0237 | 0.0237 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0054 | 0.0905 | 0.0905 |
Echinococcus granulosus | GPCR family 2 | 0.0054 | 0.0905 | 0.0905 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0905 | 0.0905 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0027 | 0.0237 | 0.0237 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0054 | 0.0905 | 0.0905 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0027 | 0.0237 | 0.0237 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.2455 | 0.2455 |
Echinococcus multilocularis | Smad4 | 0.0027 | 0.0237 | 0.0237 |
Brugia malayi | MH2 domain containing protein | 0.0397 | 0.9371 | 0.9371 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3791 | 0.3791 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0027 | 0.0237 | 0.0237 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0027 | 0.0237 | 0.0237 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0423 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0423 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0905 | 0.0905 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0905 | 0.0905 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0027 | 0.0237 | 0.0237 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0117 | 0.2455 | 0.2455 |
Schistosoma mansoni | tar DNA-binding protein | 0.0423 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0905 | 0.0905 |
Echinococcus granulosus | tar DNA binding protein | 0.0423 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0397 | 0.9371 | 0.9371 |
Schistosoma mansoni | smad1 5 8 and | 0.0027 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | RNA binding protein | 0.0423 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0027 | 0.0237 | 0.0237 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0423 | 1 | 1 |
Schistosoma mansoni | Smad4 | 0.0027 | 0.0237 | 0.0237 |
Echinococcus granulosus | Smad4 | 0.0027 | 0.0237 | 0.0237 |
Brugia malayi | MH1 domain containing protein | 0.0027 | 0.0237 | 0.0237 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0397 | 0.9371 | 0.9371 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0171 | 0.3791 | 0.3791 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0054 | 0.0905 | 0.0905 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0905 | 0.0905 |
Echinococcus multilocularis | smad | 0.0027 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.2455 | 0.2455 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | Smad1 | 0.0027 | 0.0237 | 0.0237 |
Brugia malayi | MH2 domain containing protein | 0.0027 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0054 | 0.0905 | 0.0905 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0423 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0027 | 0.0237 | 0.0237 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0171 | 0.3791 | 0.3791 |
Schistosoma mansoni | smad | 0.0027 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0027 | 0.0237 | 0.0237 |
Brugia malayi | Smad1 | 0.0027 | 0.0237 | 0.0237 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0027 | 0.0237 | 0.0237 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0905 | 0.0905 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0423 | 1 | 1 |
Echinococcus granulosus | smad | 0.0027 | 0.0237 | 0.0237 |
Schistosoma mansoni | tar DNA-binding protein | 0.0423 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0905 | 0.0905 |
Loa Loa (eye worm) | TAR-binding protein | 0.0423 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0905 | 0.0905 |
Brugia malayi | MH1 domain containing protein | 0.0027 | 0.0237 | 0.0237 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 54 % | Inhibition of human HCT116 clonogenicity after 7 days by crystal violet staining by densitometric analysis | ChEMBL. | 22456307 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.