Detailed information for compound 909815

Basic information

Technical information
  • TDR Targets ID: 909815
  • Name: 6-cyclopropyl-2-ethylsulfanyl-4-furan-2-ylpyr idine-3-carbonitrile
  • MW: 270.349 | Formula: C15H14N2OS
  • H donors: 0 H acceptors: 2 LogP: 3.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSc1nc(cc(c1C#N)c1ccco1)C1CC1
  • InChi: 1S/C15H14N2OS/c1-2-19-15-12(9-16)11(14-4-3-7-18-14)8-13(17-15)10-5-6-10/h3-4,7-8,10H,2,5-6H2,1H3
  • InChiKey: XOPSNCJTERRGQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-cyclopropyl-2-ethylsulfanyl-4-(2-furyl)pyridine-3-carbonitrile
  • 6-cyclopropyl-2-(ethylthio)-4-(2-furyl)-3-pyridinecarbonitrile
  • 6-cyclopropyl-2-(ethylthio)-4-(2-furyl)nicotinonitrile
  • 6-cyclopropyl-2-ethylsulfanyl-4-furan-2-yl-pyridine-3-carbonitrile
  • Oprea1_425744
  • IFLab1_003392
  • MLS000534028
  • SMR000141464
  • ZINC00067463

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0071 0.0029
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0047 0.0178 0.1424
Loa Loa (eye worm) carboxylesterase 0.0085 0.0658 0.1118
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0071 0.0372
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.0042 0.0072
Echinococcus granulosus neuroligin 0.0085 0.0658 0.0618
Plasmodium vivax adenosine deaminase, putative 0.0087 0.0684 0.9032
Onchocerca volvulus 0.0036 0.0042 0.0622
Mycobacterium ulcerans superoxide dismutase [Fe] SodA 0.0048 0.0198 0.1688
Echinococcus granulosus poly ADP ribose polymerase 1 0.009 0.0723 0.0683
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0152 0.084
Schistosoma mansoni tyrosine kinase 0.0084 0.0643 0.0603
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0079 0.0579 0.304
Trypanosoma brucei poly(adp-ribose) polymerase 0.005 0.0215 0.0861
Loa Loa (eye worm) PDE1B protein 0.0079 0.0579 0.0984
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0085 0.0658 0.2288
Onchocerca volvulus 0.0036 0.0042 0.0622
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0047 0.0178 0.1424
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Onchocerca volvulus 0.0036 0.0042 0.0622
Loa Loa (eye worm) GMP reductase 0.0041 0.0105 0.0179
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Leishmania major iron superoxide dismutase, putative 0.0048 0.0198 0.0759
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0098 0.0822 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0329 0.056
Echinococcus granulosus tar DNA binding protein 0.0076 0.0551 0.051
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0036 0.004 0.0068
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.0042 0.0072
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0048 0.0198 0.1103
Brugia malayi Tyrosine-protein kinase abl-1 0.0108 0.0942 0.1541
Onchocerca volvulus 0.0085 0.0658 0.9619
Onchocerca volvulus 0.0036 0.0042 0.0622
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.0042 0.0072
Onchocerca volvulus 0.0085 0.0658 0.9619
Loa Loa (eye worm) hypothetical protein 0.0048 0.0198 0.0337
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0098 0.0822 0.4701
Loa Loa (eye worm) carboxylesterase 0.0085 0.0658 0.1118
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Schistosoma mansoni BC026374 protein (S09 family) 0.0085 0.0658 0.0618
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0152 0.1327
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0098 0.0822 0.0783
Trichomonas vaginalis iron superoxide dismutase A, putative 0.0048 0.0198 0.207
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0551 0.051
Onchocerca volvulus 0.0036 0.0042 0.0622
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Echinococcus granulosus BC026374 protein S09 family 0.0085 0.0658 0.0618
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0046 0.0167 0.0285
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Schistosoma mansoni tyrosine kinase 0.0177 0.1803 0.1768
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.005 0.0215 0.12
Echinococcus multilocularis epidermal growth factor receptor 0.0141 0.135 0.1313
Echinococcus granulosus poly adp ribose polymerase 2 0.005 0.0215 0.0173
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.0042 0.0072
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.005 0.0215 0.0365
Brugia malayi Heterochromatin protein 1 0.0074 0.0516 0.0811
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0138 0.0096
Schistosoma mansoni hypothetical protein 0.0043 0.0138 0.0096
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0152 0.084
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Brugia malayi Protein kinase domain containing protein 0.0084 0.0643 0.1028
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0079 0.0579 0.3299
Brugia malayi hypothetical protein 0.0043 0.0138 0.0164
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0092 0.0749 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.0042 0.0622
Echinococcus granulosus manganese superoxide dismutase 0.0048 0.0198 0.0156
Loa Loa (eye worm) acetylcholinesterase 1 0.0503 0.5881 1
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0098 0.0822 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0551 0.051
Loa Loa (eye worm) hypothetical protein 0.005 0.0215 0.0365
Echinococcus granulosus carboxylesterase 5A 0.0503 0.5881 0.5863
Schistosoma mansoni tyrosine kinase 0.0261 0.2854 0.2823
Trypanosoma brucei iron superoxide dismutase 0.0048 0.0198 0.0759
Brugia malayi beta-lactamase family protein 0.0038 0.0071 0.0049
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0152 0.0247
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0551 0.051
Mycobacterium ulcerans adenosine deaminase 0.0087 0.0684 0.8156
Toxoplasma gondii IMP dehydrogenas 0.0098 0.0822 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0085 0.0658 0.1118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0071 0.0029
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0516 0.7261
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0094 0.0089
Echinococcus granulosus epidermal growth factor receptor 0.0261 0.2854 0.2823
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0098 0.0822 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0098 0.0822 0.0783
Loa Loa (eye worm) hypothetical protein 0.0503 0.5881 1
Brugia malayi GMP reductase 0.0041 0.0105 0.0108
Onchocerca volvulus Putative GMP reductase 0.0041 0.0105 0.154
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0152 0.1082
Wolbachia endosymbiont of Brugia malayi superoxide dismutase, SodA 0.0048 0.0198 0.0679
Trichomonas vaginalis adenosine deaminase, putative 0.0087 0.0684 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0085 0.0658 0.0618
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0098 0.0822 0.4701
Schistosoma mansoni adenosine deaminase 0.0087 0.0684 0.0644
Entamoeba histolytica iron-containing superoxide dismutase 0.0048 0.0198 0.1025
Schistosoma mansoni poly [ADP-ribose] polymerase 0.005 0.0215 0.0173
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0071 0.0121
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0079 0.0579 0.0539
Loa Loa (eye worm) hypothetical protein 0.0059 0.0329 0.056
Onchocerca volvulus 0.0036 0.0042 0.0622
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0121
Brugia malayi Superoxide dismutase, mitochondrial precursor, putative 0.0048 0.0198 0.0266
Onchocerca volvulus 0.0036 0.0042 0.0622
Echinococcus multilocularis carboxylesterase 5A 0.0503 0.5881 0.5863
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Echinococcus multilocularis BC026374 protein (S09 family) 0.0085 0.0658 0.0618
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0551 0.087
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0551 0.051
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0094 0.0305
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0085 0.0658 0.1118
Loa Loa (eye worm) hypothetical protein 0.0085 0.0658 0.1118
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0152 0.1082
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0079 0.0579 0.0539
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.0658 0.0618
Trichomonas vaginalis superoxide dismutase, putative 0.0048 0.0198 0.207
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.0042 0.0622
Onchocerca volvulus 0.0085 0.0658 0.9619
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0033 0.0007 0.0098
Schistosoma mansoni acetylcholinesterase 0.0085 0.0658 0.0618
Trypanosoma brucei iron superoxide dismutase A, mitochondrial 0.0048 0.0198 0.0759
Trypanosoma brucei GMP reductase 0.0098 0.0822 0.4497
Echinococcus multilocularis tyrosine protein kinase Abl 0.0071 0.0488 0.0448
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0094 0.0767 0.9265
Schistosoma mansoni tyrosine kinase 0.0084 0.0643 0.0603
Echinococcus granulosus adenosine deaminase 0.0087 0.0684 0.0644
Loa Loa (eye worm) beta-lactamase 0.0038 0.0071 0.0121
Mycobacterium tuberculosis Carboxylesterase LipT 0.0085 0.0658 0.2288
Trichomonas vaginalis superoxide dismutase, putative 0.0048 0.0198 0.207
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0092 0.0749 0.903
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0048 0.0198 0.207
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Onchocerca volvulus 0.0036 0.0042 0.0622
Onchocerca volvulus Adenosine deaminase homolog 0.0087 0.0684 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.0042 0.0072
Echinococcus granulosus glycyl tRNA synthetase 0.0046 0.0167 0.0125
Brugia malayi Furin-like cysteine rich region family protein 0.0261 0.2854 0.4815
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Trichomonas vaginalis adenosine deaminase, putative 0.0087 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Leishmania major guanosine monophosphate reductase 0.0098 0.0822 0.4497
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0079 0.0579 0.6761
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0048 0.0198 0.2895
Loa Loa (eye worm) hypothetical protein 0.0059 0.0329 0.056
Trypanosoma brucei iron superoxide dismutase 0.0048 0.0198 0.0759
Onchocerca volvulus 0.0036 0.0042 0.0622
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Schistosoma mansoni superoxide dismutase [mn] 0.0048 0.0198 0.0156
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0551 0.0936
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0041 0.0105 0.0108
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0152 0.0487
Leishmania major iron superoxide dismutase 0.0048 0.0198 0.0759
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) TK/ABL protein kinase 0.0179 0.1835 0.312
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0071 0.0029
Onchocerca volvulus 0.0038 0.0071 0.1041
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0098 0.0822 0.4497
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0087 0.0684 0.8156
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0079 0.0579 0.304
Toxoplasma gondii superoxide dismutase SOD2 0.0048 0.0198 0.1688
Brugia malayi Carboxylesterase family protein 0.0503 0.5881 1
Brugia malayi Carboxylesterase family protein 0.0085 0.0658 0.1054
Brugia malayi beta-lactamase 0.0038 0.0071 0.0049
Echinococcus granulosus tyrosine protein kinase ABL1 0.0179 0.1835 0.18
Loa Loa (eye worm) hypothetical protein 0.0085 0.0658 0.1118
Loa Loa (eye worm) hypothetical protein 0.0069 0.0454 0.0771
Schistosoma mansoni tyrosine kinase 0.0138 0.1323 0.1286
Loa Loa (eye worm) hypothetical protein 0.0085 0.0658 0.1118
Schistosoma mansoni methionine-tRNA synthetase 0.0059 0.0332 0.0291
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0152 0.0487
Leishmania major cAMP-specific phosphodiesterase, putative 0.0172 0.1741 1
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0059 0.0332 0.3315
Onchocerca volvulus 0.0036 0.0042 0.0622
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0043 0.0131 0.0089
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0048 0.0198 0.2895
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.009 0.0723 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0121
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0087 0.0684 0.239
Echinococcus multilocularis 0.0081 0.0601 0.0561
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Echinococcus granulosus chromobox protein 1 0.0074 0.0516 0.0475
Brugia malayi hypothetical protein 0.0085 0.0658 0.1054
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0152 0.011
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0121
Trichomonas vaginalis superoxide dismutase [mn], putative 0.0048 0.0198 0.207
Echinococcus multilocularis glycyl tRNA synthetase 0.0046 0.0167 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0071 0.0372
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.005 0.0215 0.0173
Loa Loa (eye worm) TK/EGFR protein kinase 0.0261 0.2854 0.4852
Mycobacterium ulcerans carboxylesterase, LipT 0.0085 0.0658 0.7809
Loa Loa (eye worm) hypothetical protein 0.0085 0.0658 0.1118
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0084 0.0643 0.0603
Schistosoma mansoni tyrosine kinase 0.0141 0.135 0.1313
Echinococcus multilocularis epidermal growth factor receptor 0.0261 0.2854 0.2823
Onchocerca volvulus 0.0036 0.0042 0.0622
Brugia malayi Inositol-1 0.0045 0.0152 0.0188
Brugia malayi Carboxylesterase family protein 0.0085 0.0658 0.1054
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0152 0.1327
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Leishmania major iron superoxide dismutase, putative 0.0048 0.0198 0.0759
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0046 0.0167 0.0285
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0079 0.0579 0.7487
Schistosoma mansoni inositol monophosphatase 0.0045 0.0152 0.011
Onchocerca volvulus 0.0038 0.0071 0.1041
Brugia malayi methionyl-tRNA synthetase 0.0059 0.0332 0.0496
Loa Loa (eye worm) hypothetical protein 0.0085 0.0658 0.1118
Onchocerca volvulus 0.0036 0.0042 0.0622
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0121
Echinococcus granulosus insulin receptor 0.0084 0.0643 0.0603
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0079 0.0579 0.0539
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.005 0.0215 0.12
Schistosoma mansoni adenosine deaminase-related 0.0087 0.0684 0.0644
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0048 0.0198 0.207
Echinococcus granulosus acetylcholinesterase 0.0503 0.5881 0.5863
Mycobacterium leprae Probable superoxide dismutase SodA 0.0048 0.0198 0.1688
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0098 0.0822 0.0783
Echinococcus granulosus acetylcholinesterase 0.0503 0.5881 0.5863
Onchocerca volvulus 0.0036 0.0042 0.0622
Onchocerca volvulus 0.0036 0.0042 0.0622
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0052 0.024 0.2243
Brugia malayi WGR domain containing protein 0.005 0.0215 0.0295
Loa Loa (eye worm) hypothetical protein 0.0087 0.0684 0.1162
Brugia malayi RNA binding protein 0.0076 0.0551 0.087
Loa Loa (eye worm) hypothetical protein 0.0503 0.5881 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0172 0.1741 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0179 0.1835 0.18
Brugia malayi TAR-binding protein 0.0076 0.0551 0.087
Trypanosoma cruzi iron superoxide dismutase, putative 0.0048 0.0198 0.1103
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0138 0.0096
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0551 0.0936
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0551 0.051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0121
Echinococcus multilocularis para nitrobenzyl esterase 0.0085 0.0658 0.0618
Brugia malayi Carboxylesterase family protein 0.0085 0.0658 0.1054
Echinococcus multilocularis neuroligin 0.0085 0.0658 0.0618
Onchocerca volvulus 0.0036 0.0042 0.0622
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0141 0.135 0.1313
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Schistosoma mansoni neuroligin 3 (S09 family) 0.0085 0.0658 0.0618
Loa Loa (eye worm) TK/INSR protein kinase 0.0084 0.0643 0.1093
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0084 0.0643 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0111 0.0658
Entamoeba histolytica adenosine deaminase, putative 0.0087 0.0684 0.933
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.009 0.0723 0.0683
Treponema pallidum adenosine deaminase 0.0087 0.0684 1
Brugia malayi chromobox protein homolog 3 0.0041 0.0111 0.0118
Plasmodium falciparum adenosine deaminase 0.0087 0.0684 0.8809
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0111 0.0658
Onchocerca volvulus 0.0085 0.0658 0.9619
Echinococcus granulosus epidermal growth factor receptor 0.0141 0.135 0.1313
Schistosoma mansoni tyrosine kinase 0.0138 0.1323 0.1286
Brugia malayi glycyl-tRNA synthetase 0.0046 0.0167 0.0214
Brugia malayi Carboxylesterase family protein 0.0085 0.0658 0.1054
Trypanosoma cruzi iron superoxide dismutase, putative 0.0048 0.0198 0.1103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Schistosoma mansoni chromobox protein 0.0074 0.0516 0.0475
Chlamydia trachomatis methionine--tRNA ligase 0.0059 0.0332 1
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0087 0.0684 0.8156
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0503 0.5881 0.5863
Brugia malayi Tyrosine-protein kinase abl-1 0.0071 0.0488 0.0763
Echinococcus multilocularis insulin receptor 0.0084 0.0643 0.0603
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0085 0.0658 0.0618
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0059 0.0332 0.0291
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0516 0.0877
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0071 0.0029
Loa Loa (eye worm) hypothetical protein 0.0059 0.0332 0.0564
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0052 0.024 0.0657
Brugia malayi Carboxylesterase family protein 0.0503 0.5881 1
Echinococcus multilocularis manganese superoxide dismutase 0.0048 0.0198 0.0156
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Onchocerca volvulus 0.0036 0.0042 0.0622
Echinococcus granulosus para nitrobenzyl esterase 0.0085 0.0658 0.0618
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0046 0.0167 0.0214
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0138 0.0096
Trichomonas vaginalis spcc417.12 protein, putative 0.0085 0.0658 0.9575
Brugia malayi WGR domain containing protein 0.009 0.0723 0.1165
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) IMP dehydrogenase 1 0.0098 0.0822 0.1398
Brugia malayi Adenosine/AMP deaminase family protein 0.0087 0.0684 0.1098
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0151 0.1297
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0151 0.1297
Brugia malayi beta-lactamase family protein 0.0038 0.0071 0.0049
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0098 0.0822 0.1335
Onchocerca volvulus 0.0036 0.0042 0.0622
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Schistosoma mansoni tyrosine kinase 0.0141 0.135 0.1313
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.0658 0.0618
Schistosoma mansoni poly [ADP-ribose] polymerase 0.009 0.0723 0.0683
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.0042 0.0072
Echinococcus granulosus chromobox protein 1 0.0074 0.0516 0.0475
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0516 0.7261
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0071 0.0049
Loa Loa (eye worm) inositol-1 0.0045 0.0152 0.0259
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0079 0.0579 0.6761
Echinococcus multilocularis adenosine deaminase 0.0087 0.0684 0.0644
Loa Loa (eye worm) hypothetical protein 0.0069 0.0456 0.0776
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0152 0.1327
Toxoplasma gondii superoxide dismutase SOD3 0.0048 0.0198 0.1688
Loa Loa (eye worm) RNA binding protein 0.0076 0.0551 0.0936
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0085 0.0658 0.0618
Entamoeba histolytica adenosine deaminase, putative 0.0087 0.0684 0.933
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0042 0.0072
Onchocerca volvulus 0.0038 0.0071 0.1041
Onchocerca volvulus 0.0085 0.0658 0.9619
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0048 0.0198 0.207
Schistosoma mansoni tyrosine kinase 0.0138 0.1323 0.1286
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0098 0.0822 0.293
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0079 0.0579 0.3299
Schistosoma mansoni inositol monophosphatase 0.0045 0.0152 0.011
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0042 0.0072
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0079 0.0579 0.0919
Leishmania major inosine-5-monophosphate dehydrogenase 0.0098 0.0822 0.4497
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0121
Echinococcus multilocularis chromobox protein 1 0.0074 0.0516 0.0475
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Mycobacterium tuberculosis Superoxide dismutase [FE] SodA 0.0048 0.0198 0.0495
Echinococcus multilocularis acetylcholinesterase 0.0503 0.5881 0.5863
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.2634 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0041 0.0105 0.0108
Trypanosoma cruzi GMP reductase 0.0098 0.0822 0.4701
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.019
Schistosoma mansoni gliotactin 0.0085 0.0658 0.0618
Toxoplasma gondii superoxide dismutase 0.0048 0.0198 0.1688
Schistosoma mansoni chromobox protein 0.0074 0.0516 0.0475
Loa Loa (eye worm) hypothetical protein 0.0059 0.0329 0.056
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0085 0.0658 0.9575
Loa Loa (eye worm) carboxylesterase 0.0503 0.5881 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0079 0.0579 0.0539
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0079 0.0579 0.0539
Schistosoma mansoni glycyl-tRNA synthetase 0.0046 0.0167 0.0125
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0098 0.0822 0.4701
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0085 0.0658 0.2288
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0151 0.2203
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Plasmodium vivax superoxide dismutase [Fe], putative 0.0048 0.0198 0.1869
Trypanosoma cruzi GMP reductase 0.0098 0.0822 0.4701
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0048 0.0198 0.1103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.0042 0.0072
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0111 0.163
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0172 0.1741 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0072
Echinococcus multilocularis chromobox protein 1 0.0074 0.0516 0.0475
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0059 0.0332 0.0291
Echinococcus multilocularis acetylcholinesterase 0.0503 0.5881 0.5863
Leishmania major adenine aminohydrolase 0.0087 0.0684 0.3667
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0092 0.0749 1
Trypanosoma cruzi iron superoxide dismutase, putative 0.0048 0.0198 0.1103
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0551 0.051
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0087 0.0684 0.8156
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0152 0.011
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0042 0.0072

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2512 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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